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간장 ( 肝臟 ) 및 담도 ( 膽道 ) : Yttrium - 90와 Iodine - 131 Radioimmuno - Globulin을 이용한 간암치료에 대한 실험적 연구
주상언(Sang Aun Joo) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.2
N/A Therapeutic trials were performed on the HepG2 human hepatoblastoma implanted s.c. in the athymic nude mouse. Animals were treated with polyclonal and monoclonal antiferritin and control antibodies labeled with either Iodine-131 or Yttrium-90. Administration of 400 uCi of Y-labeled polyclinal antiferritin or 300 uCi of Y-labeled polyclonal antiferritin significantly increased survival (p<0,001). There were no tumor cures with radiolabeled polyclonal antibody. Animals treated with 200 or 300 uCi of I -labeled monoclonal antiferritin did not show increased survival compared to controls. Monoclonal antiferritin labeled with 'Y significantly prolonged survival of animals (p <0. 001) at doses of 100, 200 or 300 uCi compared with untreated controls. Fifty percent of the animals treated with 200 uCi and 75% of the animals treated with 300 uCi showed no evidence of disease at 140 days following treatment. Four hundred uCi of 'Y-labeled monoclonal antibody proved toxic to the animals. Increased survival was accompanied by a decrease in tumor mitotic rate and an increase in cellular polymorphism as determined by pathological examination. The radiation dose absorbed in the tumor reveals that monoclonal antiferritin antibody to Y deposits 8.4 times than does rabbit polyclonal antiferritin labeled in an identical manner and 7.3 times than dose delivered by the same antibodies labeled with I .
위의 양성 및 전암성 병변에서 Telomerase 활성화와 Helicobacter pylori 감염의 연관성
장현주(Hyun Joo Jang),김정한(Jung Han Kim),홍수진(Su Jin Hong),강승식(Seung Sik Kang),계세협(Sea Hyub Kae),이 진(Jin Lee),주상언(Sang Aun Joo) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.1
Background/Aims: It has been considered that motor abnormalities of the oropharynx might play a role in the pathogenesis of oropharyngeal dysphagia. This study aimed to evaluate the motility change in patients with oropharyngeal dysphagia using circumferential solid state manometry. Methods: Nineteen patients with oropharyngeal dysphagia and 12 healthy volunteers of similar age underwent circumferential solid state manometry and lateral videofluoroscopic studies to assess oropharyngeal motility. The patients were divided into 3 groups by videofluoroscopic findings: group 1, patients with delayed oral transit; group 2, patients with increased pharyngeal residue; group 3, patients with aspiration alone. Results: The group 2 showed less upper esophageal sphincter relaxation and lower amplitude of hypopharyngeal contractions. The time interval from the onset of hypopharyngeal contractions to the onset of complete upper esophageal sphincter relaxation was delayed in the group 3. Post-swallow aspiration was caused by high pharyngeal residue in patients with oropharyngeal dysphagia. Conclusions: These results suggest that a high pharyngeal residue is related to a weak contraction of the hypopharynx, and aspiration is related to a slowed swallow response, presumably with delayed laryngeal closure. (Korean J Gastroenterol 2001;38:9-14)
이문희(Moon Hee Lee),홍성표(Sung Pyo Hong),현인규(In Gyu Hyun),이진(Jin Lee),손주현(Joo Hyun Sohn),곽상택(Sang Taek Kwak),주상언(Sang Aun Joo),김이수(Lee Su Kim),최원진(Won Jin Choi),최철순(Choi Chul Soon) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.1
Benign and malignant tumors are rarely encountered in the small intestine. Moreover small bowel metastases arising from the lung carcinoma are very unusual. Previous studies reported that the most common metastatic site of lung carcinoma was the esophagus and the most common histologic type was the squarnous cell carcinoma type. This case was duodenal and jejunal metastases from squamous cell carcinoma of the lung. The patient in this case com- plained of hematemesis and presence of movable mass in the lower left abdomen. N odular ul- cerative mass on the duodenal bulb was found by duodenoscopy, and an endoscopic biopsy re- vealed squamous cell carcinoma. A bronchoscopic biopsy determined squamous cell carcinoma of the lung. Abdominal exploration confirmed multiple metastases on duodenum, two sites of jejunum and Douglas pouch. So we report the case of multiple small bowel metastases from primary squamous lung carcinoma. (Korean J Gastronterol 1994; 26: 191 196)
박충기(Choong Kee Park),임규성(Kyu Sung Rim),김진민(Jin Min Kim),손희철(Hie Chul Son),주상언(Sang Aun Joo),한덕종(Duck Jong Han),윤대원(Dai Won Yoon) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.2
Pancreatic lithiasis occurs in a significant percentage of patients with chronic alcoholic pancreatitis. We report here a case of chronic pancreatitis with pancreatic lithiasis. A 42-year-old woman was admitted to the Hangang Sacred Heart Hospital, Hallym Medical College because of RUQ pain, nausea and vomiting. 3 years before admission, she was diagnosed as acute pancreatitis, D.M. and gallstone at another hospital. She have experienced intermittent colicky abdominal pain after eating meats. There was no diarrhea and steatorrhea. On examination she appeared acutely ill. There was mild tenderness over the RUQ & epigastrium. Simple x-ray films of the abdomen showed multiple calcified stone densities. Abdominal ultrasound and ERCP showed markedly dilated pancreatic duct with multiple stones. 3 stones, about 1.5 x 1.5, 0.6 x 0.8, 0.3 x 0.3 cm, were removed by operation. The patient discharged in good general condition without complcation.
급성 담석성 및 알콜성 췌장염에서 췌장괴사의 지표로써 LDH/AST비의 유용성
김정한(Jung Han Kim),김창억(Chang Uck Kim),장형주(Hyun Joo Jang),박원종(Won Jong Bahk),박진철(Jin Cheol Park),강승식(Seung Sick Kang),계세협(Sea Hyub Kae),이진(Jin Lee),김용범(Yong Bum Kim),주상언(Sang Aun Joo) 대한내과학회 2000 대한내과학회지 Vol.58 No.2
N/A Background : Lactate dehydrogenase (LDH) has been reported to be a sensitive indicator of pancreatic necrosis (PN), and some studies suggested that an elevation of the ratio of LDH to AST (LDH/AST ratio) woud be more accurate indicator of PN in acute biliary pncreatitis (BP). However, there were no studies in alcoholic pancreatitis (AP). The aim of this study was to assess the clinical usefulness of LDH/AST ratio in alcoholic pancreatitis (AP) as a indicator of PN. Methods : On the basis of CT scan findings, the patients were categorized into two groups as having PN or non-PN. The plasma levels of the LDH, AST and LDH/AST ratio over two weeks postadmission period were evaluated and compared with in two groups of patients with BP (consiting of 12 PN and 34 non-PN patients), and with AP (consisting of 14 PN and 38 non-PN patients). Results : In acute BP, on post-admission days 1 and 2, the LDH/AST ratio were low in both groups without significant difference. In the group with PN, thereafter, the LDH/AST ratio increased gradually, reached peak values at the 7th days and decreased. In the non-PN patients, the LDH/AST ratio increased gradually, but remained below the control range. The LDH/AST ratios were significantly higher from post-admission day 3 in the group with PN than in the non-PN group. In acute AP, the LDH levels were significantly higher over two weeks from admission day in the PN patients. The LDH/AST ratios were remained within or below the control range in both groups, though with statistically significnat difference. Conclusion : The LDH/AST ratio could be used as an indicator of PN in acute BP. In acute AP, however, LDH was a more useful indicator from the early stage in the course. (Korean J Med 58:161-169, 2000)
Holter 심전도 모니터를 이용한 만성 폐쇄성 폐질환 환자에 있어서의 부정맥에 대한 연구 - 만성 폐쇄성 폐질환에 있어서의 부정맥에 대한 연구
이정균 ( Chung Kyun Lee ),이정희 ( Chung Hee Lee ),박성수 ( Sung Soo Park ),이방헌 ( Bang Hun Lee ),주상언 ( Sang Aun Joo ),김순길 ( Soon Gill Kim ),신승호 ( Seung Ho Shin ),황흥곤 ( Hweung Kon Hwang ),정효철 ( Hyo Chul Chung ) 대한내과학회 1984 대한내과학회지 Vol.27 No.11
만성 C 형 간염의 조직학적 특징 : 만성 B 형 및 혼합 B , C 형 간염과의 비교 분석
김지훈(Ji Hoon Kim),이오영(Oh Young Lee),주상언(Sang Aun Joo),최호순(Ho Soon Choi),함준수(Joon Soo Hahm),박경남(Kyung Nam Park),기춘석(Choon Suhk Kee),이중달(Jung Dal Lee) 대한내과학회 1994 대한내과학회지 Vol.47 No.4
N/A Objectives: The aims of this study are to compare the differences in histologic findings between chronic hepatitis C (CH-C), mixed chronic hepatitis B and C (CH-B&C) and chronic hepatitis B (CH-B) and to evaluate histopathologic features characteristic of CH-C for diagnostic significance. Methods: Twelve liver needle biopsy specimens from 12 patients with hepatitis C were selected for histologic evaluation. Four specimens of the 12 were not inadequate, and 8 cases were selected for the study. All 8 patients were negative for HBsAg, HRsAb and HBcAb. The specimens were histologically classified as CPH in 5 cases and CAH in 3 cases. Control groups were divided into two. One was CH-B consisted of 20 patients who had negative tests for anti-HCV and positive tests for HBsAg, The 20 CH-B were classified as CAH in 11 cases (CAH-B), and CPH in 9 cases (CPH-B). The other group (CH-B&C) consisted of 14 patients who had positive tests for both anti-HCV and anti-HBs or anti-HBc. Results: 1) Portal inflammation was more frequent in the CH-C group than in the CH-B group (7/8 vs 1/20). However, the difference in portal inflammatory reaction between CH-C and CH-B8rC was not different significantly (7/8 vs 12/14). 2) Piecemeal necrosis was more prominent in the CAH-B group than in the CH-C group (11/11 vs 4/8). 3) Lymphocyte aggregates in the potal tracts were more frequent in the CH-C and CH-B&C (6/8 vs 13/14) than in the CAH-B group (4/11). However, two cases of CH-C and one case of CH-B&C group did not show lymphocyte aggregates in the portal tracts. 4) Bile duct damage and loss of bile duct in the portal tracts were more prominent in the CH-C than in the CH-B (6/8 vs 2/20). However, the difference between CH-C group and CH-B&C was not noted significantly. (6/8 vs 12/14). 5) There was no significant difference in lobular changes such as ballooning degeneration of hepatocytes, focal hepatic necrosis and steatosis between the CH-C and the control (CH-B and CH-B&C group). Conclusion: Portal inflammation with aggregates lymphocytes was more prominent and frequent in the CH-C than in the control (CH-B and CH-B&C). Bile duct damage and/or bile duct loss in portal tracts due to lymphocytes infiltrate were histologic findings chracterisic of CH-C, although not specific for the diagnosis. No significant differences in histologic features of liver needle biopsy specimens between the CH-C and CH-B&C were noted.
간경변증 환자의 수분 전해질 평형 및 신기능에 있어서 혈청 Endothelin - 1 의 역할
이진(Jin Lee),박철수(Cheol Soo Park),박철희(Cheol Hee Park),계세협(Sea Hyub Kae),곽상택(Sang Taek Kwak),주상언(Sang Aun Joo),김호중(Ho Jung Kim),기춘석(Choon Suhk Kee) 대한내과학회 1997 대한내과학회지 Vol.52 No.4
N/A Objectives: It has been recently known that endotheUn-1 is a potent vasoconstrictor. The purpose of the present study was to clarify the possible correlation of endothelin-1 with other vasoactive neurohormonal activities and its effects on fluid- electrolyte balance and renal function in patients with liver cirrhosis. Mcthods: In 35 patients of liver cirrhosis with (n=19) and without (n=16) ascites and in 12 normal controls, plasma and urine levels of endothelin-1 were measured by specific radioimmunoassay, and serum sodium, serum albumin and other blood chemistries, renal functions with creatinine clearance, urinary sodium excretion, plasma renin activity, plasma aldosterone and plasma norepinephrine were measured at the same time. Results: The plasma endothelin-1 level was significantly higher in ascitic group than nonascitic group (mean±SD; 16.4±10.6 VS. 7.5±4.1pg/mL, p=0.0000), and there was no significant difference in plasma endothelin-1 level between nonascitic group and normal controls(4.8±1.9pg/mL). The urine endothelin-1 level also was significantly higher in ascitic group than non-ascitic group (140.3±74.3 VS. 58.5±37.4 pg/mL, p=0.0000), there was no significant difference in urine endothelin-1 level between nonascitic group and normal controls (19.5±112pg/mL). In patients with cirrhosis, the plasma endothelin-1 concentration showed significant negative correlation with creatinine clearance (r=-0.55), serum albumin (r=-0.56%) and serum sodium concentrtion (r=-0.62), and significant positive correlation with plasma renin activity (r=0.63), plasma aldosterone (r=0.68) and norepinephrine (r=0.70). The factors that influence on plasma concentration of endothelin-1 were plasma norepinephrine (p=0.0000), serum sodium (p=0.0169), plasma aldosterone (p=0.0176), serum albumin (p=0.0213) and plasma renin activity (p=0.0329) in statistically significant order. Conclusion: The elevated plasma endothelin-1 level along with the increased activity of other neurohormonal substances including plasma renin, aldosterone and norepinephrine induces sodium and water retention in decompensated liver cirrhosis. Thus, the plasma endothelin-1 level seems to have an important role in the development of functional renal impairment in decompensated liver cirrhosis by inducing renal vasoconstriction.