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安明姬,閔得映,鄭孝哲,李康映 한양대학교 의과대학 1988 한양의대 학술지 Vol.8 No.1
A case of human anisakiasis involving stomach is presented. A 31 years old Korean male working at fishery visited to the clinic with severe epigastric pain. Two days before the onset of illness he had eaten raw fish. On gastrofiberscopic examination a mass measuring 1×0.5cm was observed on the antrum: a glistening whitish worm was demonstrated on the center of the mass with redness and bleeding. The white larva of Nematoda measuring 9×0.4mm without tail part was submitted. For parasitic identification, it immersed in the lactophenol solution (phenol 10gm, glycerol 10.6ml, lactic acid 8.2ml, D.W. 10.0ml) for 10days and after that stained H and E. Mouth was surrounded by three lips with multiple irregular sized dentricles. Esophagus was measured total lenth, 1.13×0.15mm, anterior muscular portion, 0.53×0.15mm, and postericr ventricular portion 0.83×0.15mm. Cecum and ventricular appendage were absent, and tail part and terminal mucron were cut off. Excretory pore was seen betweem sibventral lips as base. The cut section of the parasite showed a hyalinized smooth cuticle, polymyarian style muscular layer, esophagus (muscular and ventricular) and Y-shaped lateral chord. Intestinal portion was degenerated and was amorphous. It was suggested that this worm seems to be a larva of Anisakis spp., type unknown.
폐장의 편평세포암종 및 전암병소에서의 c-myc 암유전자의 발현 동태에 관한 연구
신동호,이중달,박성수,이동후,정효철,이정희 한양대학교 의과대학 1991 한양의대 학술지 Vol.11 No.1
In order to elucidate the dynamic changes of oncogene expression in presumably precancerous lesions such as squamous metaplasia and dysplasia, and squamous cell carcinoma of the bronchial epithlium, hybridization in situ was employed with a biotinylated oncogene probe. The expression of c-myc was localized exclusively in nuclei. While normal bronchial epithelium revealed no disernible clumps of c-myc grains, except occasional grains less then 3 per cell, squamous metaplasia showed increased number of grains and a few clusters of c-myc grains. In dysplasia, c-myc expression was more intensive than in squamous metaplasia. Approximately, 1/3 to 2/3 of tumor cell populations of squamous cell carcinomas of the lung revealed tremendously increased c-myc expression. In addition clumpy grains of c-myc in squamous cell carcinoma appeared more frequently than in squamous metaplasia or dysplasia. The c-myc expression was found to vary between different samples and within each cancer, and not all cancer cells expressed c-myc. These data indicate that c-myc oncogene plays it's role on reprogramming for growth contol of cell populations particularly in multistage carcinogenesis and progression of lung cancer. These dynamic alterations of c-myc expression suggest that neoplastic transformation may occur conceivably at the dysplastic phase eventually resulting in carcinoma in situ. This means, in turn, squamous dysplasia is a putative precancerous lesion of the human lung.