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피부질환에 상피세포내 Transglutaminase E 변동에 관한 면역조직화학적 관찰
조윤화,송계용,노병인,박상철 ( Yoon Whoa Cho,Kye Yong Song,Byung In Ro,Sang Chul Park ) 대한피부과학회 1991 大韓皮膚科學會誌 Vol.29 No.6
N/A The εN-(?-L-glutamyl)-L-lysine cross-links in cornified envelope of the stratum corneum are formed by specific enzymes termed transglutaminase(TG). TG are calcium dependent enzymes that catalyse an acyl transfer reaction. Among them transglutaminase E(TGE) type is distributed in the granular layer and is also known as termiral differentiation marker of keratinocyte. This study was done to observe the distrubution pattern of TGE in the epidermis of various skin diseases by immunohistochemical PAP method using antihuman TGE antibody. Results were as follows : 1. Staining reaction for the TGE is strongest in the granular layer of the normal epidermis-TGE positive keratinocytes numbers are increased in the thickened granular and upper stratum spinosum in the dermatoses accompanying acanthosis with orthohyperkeratosis wherease decreased of absent in the dermatoses accompanying ?canthosis with parakeratosis. Atrophic epidermis shows decreased TGE staining reaction. 2. Staining reaction for the TGE is negative or weakly positive in dysplastic or atypical keratinocytes. Nonkeratinizing squamous cell carcinoma cells are negatively stained whereas keratinizing cells are positively stained according to the degree of keratinizing. Basal cells, whether in benign or malignant conditions were very weakly or negatively stained. Therefore, immunohistochemical staining for the TGE reveals the most abundant distribution in the granular layer and upper spinous layer in normal conditions and shows variation in its distribution with processes related to acanthosis, cornification and its terminal differentiation of keratinocytes.
조윤화(Yoon Whoa Cho),최병익(Byeung Ik Choi),홍창권(Chang Kwun Hong),송계용(Kye Yong Song),노병인(Byung In Ro),장진요(Chin Yo Chang) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.5
Tattooing has been performed the for cosmetic purpose by many beautician in the beauty parlors without having been any medicalknowledge. This has resulted in various serious complications. One patient is a 56-year-old female, who had been developed pruritic erythernstous indurated plaques on the tattooing sites about 3 months after getting tattoo. Skin biopsy findings revealed granulomatous inflamrnation and patch test showed positive reaction to potsssiurn dichromate. The other patient is a 55-year-old female, who had been developed erythematous papules on the both lips of tattooing sites about 1 year after getting tattoo. Skin biopsy findings revealed lichenoid resction. Patch test showed positive reactions to reornycin eulfate and nickel sulfate. Patch test of as is revealed positive reactions to red color.
조윤화(Yoon Whoa Cho),홍창권(Chang Kwun Hong),송계용(Kye Yong Song),노병인(Byung In Ro),장진요(Chin Yo Chang) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.3
We report a case of X-linked ichthyosis in a 19 year-old male patient who has been covered with brown to black colored thick scales on the lateral aspect of chest, upper abdomen and inner aspect of both extremities since one month at, birth. Histopathologic findings showed hyperkeratosis and papillomatosis with normal granular cell layers in the epidermis. On electron microscopy, multilayered keratins with increased melanosomes in the stratum corneum were noted. In his family, his cousin is also affected by the same disease. (Kor J Dermatol 28(3): 368 372, 1990)
건선과 습진성 피부질환에서 Proliferating Cell Nuclear Antigen 과 Epidermal Growth Factor Receptor의 면역조직화학적 연구
조윤화(Yoon Whoa Cho),김명남(Myeung Nam Kim),송계용(Kye Yong Song),노병인(Byung In Ro) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.1
Psoriasis and eczematous dermatitis are two major different inflarnmtory dermatitis but differential diagnosis is sometimes difficult by histologic patterns. The object of this study is to find out whether there are any differences in the expressions of proliferation related pntein between psoriasis and eczematous dermatitis by chronological evaluation on the proliferating cell nuclear antigen(PCNA) and epidermal growth factor receptor(EGFR). The detections of PCNA and EGFR were done by immunohistoc.ienical methods(alkaline phosphatase anti-alkaline phosphatase method with new fuchsin substrated usir g respective polyclonal antibod ies in the paraffin embedded tissue from psoriasis(21 cases) and eczomtous dermatitis(26 cases). The labelling indeces of PCNA were 2.4+0.9% in normal. Indece; were 27.3+2.9% in acute, 20.7+ 3.7% in chronic psoriasis, while 12.4+5.6% in acute and 21.8% 5.0% in chronic eczematous dermtitis. The expressions of EGFR were very weak in normal, and increased in acute psoriasis and chronic eczematous dermatitiy. Our immunohistochemical results of PCNA and EGFR suggest that activated proliferation is rather pronounced in acute psoriasis and chronic eczemat.ous dermatitis, thouh proliferative activity is more marked in psoriasis. (Kor J Dermatal 1993; 31 (1): 58-64)
이상준,정민자,조윤화,한지윤,김정례 ( Sang Jun Lee,Min Ja Jung,Yoon Whoa Cho,Jee Yoon Han,Jeong Rye Kim ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.3
We report two cases of recurrent extramarnmary Pagets disease after wide local excision. Both cases involved the scrotum and the penoserotal junction, respectively. On histopathological examination, we could observed many Paget cells confined to the epidermis and the hair follicle, but not invading the underlying dermis in both cases. There was no evidence of internal malignancy. Both cases were treated with wide local reexcision. (KOr J Dermatol 1997;35(3): 561 565)
이학규(Hak Kyu Lee),조윤화(Yoon Whoa Cho),노병인(Byung In Ro) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.3
Trichotillomania is the cllinical syndrome of alopecia resulting from the repetative pulling, plueking and breaking of ones own hair. We report four cases of trichotillomania in 10 year old children. The lesions were limited to the scalp. All of them had psychiatric problems in the school or home according to a psychiatric consultation. The histopathologic examinatiorii revealed a normal number of hair follices, empty hair follicles and no inflammatory reaction. The treatment led to hair growth in three cases but one case did not respond to the treatment. (Kor J Dermatol 1993; 31(3): 421-425)
원형 탈모증 환자에서 증식 세포에 대한 Proliferating Cell Nuclear Antigen의 면역조직화학적 연구
이학규(Hak Kyu Lee),조윤화(Yoon Whoa Cho),노병인(Byung In Ro),송계용(Kye Yong Song) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.3
Backgroud : The number of proliferating cell populations in the hair is follicles is closely related to the regulation of hair growth. Destruction of hair germ cells and the loss of proliferating cells have been suggested to be of major pathogenetic significance in alopecia areata Objective : The purpose of this study is to compare the growth frrections in proliferating cells of normal hair follicles with those in alopecia. Methods : An immunohiatochemical study was done to detect the proliferating cells in hair follicles using a monoclonal antibody against proliferating cell nuclear antigen(PCNA) in the scalp biopsy of an alopecia patient on the peraffin embedded sections. Results : A significant decrease of the labelling indeces of PCNA were observed in the hair follicles of alopecia compared with normal condition. But we could not find significant differences of labelling index in the clinical types of alopecia, responses to treatment, anc systemic immunologic state. Conclusions : Whole the above results confirmed that significant decreases of proliferating cells in the hair follicle could explain the part of the pathogenetic mechanism in alopecia, its direct cause which inhibit the proliferation of cells is not clear. (Kor J Dermatol 1994; 32(3): 391-398)
이상준 ( Sang Jun Lee ),정민자 ( Min Ja Jung ),조윤화 ( Yoon Whoa Cho ),한지윤 ( Jee Yoon Han ),송계용 ( Kye Yong Song ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.2
Kaposis sarcoma is a multicentric neoplastic vascular tumor involving the skin or internal organs. We report a case of classic Kaposis sarcoma in a 69-year-old male who had positive serum cytomegalovirus antibodies and disseminated multiple erythematous to purplish colored confluent papules and edema on both lower legs. The histopathological finding showed abnormally proliferated and dilated vessels, vascular spaces, spindle cells, and extravasated erythrocytes. He was treated with radiotherapy, but died due to ventricular tachycardia. (Korean J Dermatol 1998;36(2): 300-303)
정민자 ( Min Ja Jung ),이상준 ( Sang Jun Lee ),조윤화 ( Yoon Whoa Cho ),한지윤 ( Jee Yoon Han ),송계용 ( Kye Yong Song ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.3
The monoclonal antibody Ki-1(CD30) was first described in 1982 and was reported to react selectively with Reed-Sternberg cells in Hodgkins disease, highly activated B and T cells and large cell lymphomas of both T-and B-cell origin. Lymphomatoid papulosis(LyP) is characterized by recurrent erythematous papules or nodules that undergo spontaneous healing with hyperpigmentation and scarring. Histologically, two major types of LyP can be distinguished: type A is characterized by the presence of variable numbers of Ki-1+ large, atypical lymphocytes with some Reed-Sternberg like cells and type B is characterized by Ki-1- atypical cerebriform mononuclear cells similar to those in mycosis fungoides. We report a case of Ki-1+ lymphomatoid papulosis which was histopathologically recognized as a type B lesion but represented a Ki-1 positive reaction, (Korean J Dermatol 1998;36(3): 540-544)