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자궁경부암 환자의 혈중 Interleukin - 6 ( IL- 6 ) 의 정량분석
이규완(K . W . Lee),김종오(J . O . Kim),장기훈(K. H . Chang),이용호(Y . H . Lee),이낙우(N . W . Lee),박용균(Y . K . Park),조윤정(Y . J . Cho),김영태(Y . T . Kim) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.9
목적 : 혈중 IL-6의 과발현은 다발성 골수종, 악성 흑색종, 신경 교아종, 난소암, 신장암과 림프종에서의 예후와 관련이 있다고 알려져 있는데 자궁경부암 환자의 혈중 IL-6의 농도를 정량화하여 대조군과 상피내암 및 자궁경부암에서 혈중 IL-6의 상관관계를 알아 보고자 본 연구를 시행하였다. 연구방법 : 1997년 6월부터 1998년 6월까지 자궁경부 편평상피암 29명, 자궁경부 상피내암 14명, 대조군 15명을 대상으로 혈액 시료를 채취 후 분석시까지 -70℃에 보관하였으며 ELISA(BioSource International) kit를 이용하여 IL-6를 정량 분석하였다. 결과 : 혈중 IL-6의 평균농도는 대조군 4.4±1.7 pg/ml, 자궁경부 상피내암 5.3±1.7 pg/ml, 자궁경부 편평상피암 5.6±4.1 pg/ml로 자궁경부 편평상피암에서 혈중 IL-6가 증가하는 경향을 보였으나 각 군간의 통계적 의의는 없었다(p=0.478).결론 : 정상 대조군에 비하여 자궁경부 편평상피암과 자궁경부 상피내암에서 혈중 IL-6의 농도가 증가되는 것을 확인할 수 있었으나 통계적 유의성은 관찰할 수 없었으며 더 많은 예를 중심으로 연구가 필요하리라 사료된다. Objective : To evaluate the relationship between the level of serum IL-6 and the prognosis of cervical cancer patients, because high level of IL-6 has been reported to be related with adverse prognosis in multiple myeloma, renal cancer, glioblastoma, ovarian cancer and lymphoma. Methods : From June, 1997 to June 1998, total 58 patients including 29 patients with cervical cancer, 14 Carcinoma in situ, 15 control were enrolled in this study. We examined these patients of serum IL-6 by ELISA. Result : The mean serum IL-6 was 4.35±1.68pg/ml on control, 5.29±1.72pg/ml on carcinoma in situ and 5.57±4.10pg/ml in cervical cancer patients.Conclusion : Detectable serum IL-6 levels were more often in patients with cervical cancer and carcinoma in situ than in control group, but the difference was not statistically significant because of the small number of patients.
김용세(Y. S. Kim),김성아(S. A. Kim),Eric Wang,박범진(B. J. Park),전경자(K. J. Jeon),조윤정(Y. J. Cho) 한국정밀공학회 2004 한국정밀공학회 학술발표대회 논문집 Vol.2004 No.10월
The knowledge-based society of the 21st century requires effective education and learning methods in each professional field because the development of human resource determines its competence more than any other factors. It is highly desirable to develop an intelligent tutoring system, which meets ever increasing demands of education and learning. Such a system should be adaptive to each individual learner"s demands as well as the continuously changing state of the learning process, thus enabling the effective education. The development of a learning environment based on learner modeling is necessary in order to be adaptive to individual learning variants. An intelligent learning environment is being developed targeting the heritage education, which is able to provide a customized and refined learning guide by storing the content of interactions between the system and the learner, analyzing the correlations in learning situations, and inferring the learning preference from the learner"s learning history. This paper proposes a heritage learning system of Bulguksa temple, integrating the ontology-based learner modeling and the learning preference which considers perception styles, input and processing methods, and understanding process of information.
류마티스 환자를 대상으로 한 NSAID제제의 부작용 비교
조윤정,문순란,박경호,조남춘,송영욱 한국병원약사회 1998 병원약사회지 Vol.15 No.2
Comparative side effects of NSAIDs, such as salsalate, choline magnesium trisalicylate, fenoprofen, naproxen, aspirin and indomethacin was assessed using the Stanford Toxicity Index (STI) consisting of weighted symptoms, laboratory abnormalities in 100 rheumatoid arthritis patients from out patient clinic of Seoul National University Hospital. All patients were enrolled in one physician who is recording any side-effects of drug on patient's medical chart. Two pharmacists evaluated the randomly selected patient's medical chart, and checked the recording of side effects, such as dizziness, pruritus, rash, edema, tinnitus, hearing difficulty, nausea, upper abdominal pain, constipation, dyspepsia, ear fullness, epigastric fullness, mild liver toxicity, hyperuricemia and headache. From the results of this study, it was found that common side effects were tinnitus, hearing difficulty and ear fullness for salsalate, gastrointestinal disturbances for choline magnesium trisalicylate, fenoprofen and naproxen, and gastrointestinal disturbances and hearing difficulty for aspirin, and headache for indomethacin. Scores of STI ranged from 0.32 for aspirin to 2.56 for salsalate. Also occurrence rate of side effects of NSAIDs was evaluated according to period of drug administration. It was noted that most of side effects were common within 1 year of drug administration, but naproxen and indomethacin had even distributional occurrence of side effects according to period of drug administration.