SENSITIVITIES OF IMPORT DEMAND AND EXPORT SUPPLY IN AN OPEN DEVELOPING ECONOMY : THE EVIDENCE FROM TAIWAN , 1961 - 1994

WANG, ERIC C. 한국국제경제학회 1998 International Economic Journal Vol.12 No.1

Antimicrobial therapies for chronic pain (part 1): analgesic mechanisms

Eric J. Wang,Jay Karri,Nuj Tontisirin,Steven P. Cohen 대한통증학회 2023 The Korean Journal of Pain Vol.36 No.3

There is increasing evidence that the relationship between chronic pain and infections is complex and intertwined. Bacterial and viral infections can cause pain through numerous mechanisms such as direct tissue damage and inflammation, the induction of excessive immunologic activity, and the development of peripheral or central sensitization. Treating infections might relieve pain by attenuating these processes, but a growing body of literature suggests that some antimicrobial therapies confer analgesic effects, including for nociceptive and neuropathic pain symptoms, and affective components of pain. The analgesic mechanisms of antimicrobials are indirect, but might be conceptualized into two broad categories: 1) the reduction of the infectious burden and associated pro-inflammatory processes; and 2) the inhibition of signaling processes (e.g., enzymatic and cytokine activity) necessary for nociception and maladaptive neuroplastic changes via off-target effects (unintended binding sites). For the former, there is evidence that symptoms of chronic low back pain (when associated with Modic type 1 changes), irritable bowel syndrome, inflammatory bowel disease, chronic pelvic pain, and functional dyspepsia might be improved after antibiotic treatment, though significant questions remain regarding specific regimens and dose, and which subpopulations are most likely to benefit. For the latter, there is evidence that several antimicrobial classes and medications exert analgesic effects independent of their reduction of infectious burden, and these include cephalosporins, ribavirin, chloroquine derivatives, rapalogues, minocycline, dapsone, and piscidin-1. This article aims to comprehensively review the existing literature for antimicrobial agents that have demonstrated analgesic efficacy in preclinical or clinical studies.

Antimicrobial therapies for chronic pain (part 2): the prevention and treatment of chronic pain

Eric J. Wang,Edward Dolomisiewicz,Jay Karri,Nuj Tontisirin,Steven P. Cohen 대한통증학회 2023 The Korean Journal of Pain Vol.36 No.3

The discovery and development of antimicrobial therapies represents one of the most significant advancements in modern medicine. Although the primary therapeutic intent of antimicrobials is to eliminate their target pathogens, several antimicrobials have been shown to provide analgesia as a secondary benefit. Antimicrobials have demonstrated analgesic effects in conditions that involve dysbiosis or potential subclinical infection (e.g ., chronic low back pain with Modic type 1 changes; chronic prostatitis/chronic pelvic pain; irritable bowel syndrome; inflammatory bowel disease; functional gastrointestinal disorders/dyspepsia; myalgic encephalomyelitis/chronic fatigue syndrome), and might even prevent the chronification of pain after acute infections that are associated with excessive systemic inflammation (e.g ., post COVID-19 condition/long Covid, rheumatic fever). Clinical studies often assess the analgesic effects of antimicrobial therapies in an observational manner, without the ability to identify causative relationships, and significant gaps in the understanding remain regarding the analgesic potential of antimicrobials. Numerous interrelated patient-specific, antimicrobial-specific, and disease-specific factors altogether contribute to the perception and experience of pain, and each of these requires further study. Given worldwide concerns regarding antimicrobial resistance, antimicrobials must continue to be used judiciously and are unlikely to be repurposed as primary analgesic medications. However, when equipoise exists among several antimicrobial treatment options, the potential analgesic benefits of certain antimicrobial agents might be a valuable aspect to consider in clinical decision-making. This article (the second in a two-part series) aims to comprehensively review the evidence on the prevention and treatment of chronic pain using antimicrobial therapies and suggest a framework for future studies on this topic.

IT ISN’T FOR ME: CHINESE YOUNG MALE CONSUMERS’ INTERPRETATION OF SOCIAL MEDIA LUXURY ADVERTISING

Huan Chen,Ye Wang,Eric Haley 글로벌지식마케팅경영학회 2017 Global Fashion Management Conference Vol.2017 No.07

“Today I was persuaded to spend more than $200 on a lotion in Barneys. The price difference (between online and store) is $75. However, the store salesman told me that it is only few dollars way! I felt humiliated by the upscale society.” Lawrence, a 22 years old male Chinese who is an international undergraduate student studying marketing in a public U.S. university, posted the above status on his WeChat moments. With its fast growing economy and huge population, China has become one of the most lucrative markets for luxury brands (Zhan and He 2012). In fact, China has surpassed Japan and become the No.1 luxury products’ spender in the world, accounting more than one-quarter of the global luxury brand expenditure (Yousuf 2012). According to Bian & Company’s study (2016), $ 17.6 billion were spent on Chinese luxury market in 2015. In the past, the core Chinese luxury consumers are female middle-class and up-class consumers (Zhan and He 2012). In recent years, the faces of Chinese luxury consumers have gradually changed: more and more Chinese luxury goods buyers are males, and they actually spend more money on average than women do (Chen, 2016). In addition, the Chinese culture is different from the Western culture (Li, Li and Kambelle 2012). Accordingly, Chinese luxury consumption follows its own patterns and trends, which may not always resemble those of the Western world (Li, Li and Kambelle 2012). Previous studies have revealed unique characteristics of Chinese luxury consumers, in terms of motivations, for example, Mianzi (prestigious face) (Li and Su 2007; Wang and Ahuvia 1998), subcultures (Wang, Sun and Song 2011), public meaning (Wang, Sun and Song 2011), gift giving (Li and Su 2007), and reference groups (Li and Su 2007). All of those studies emphasized the cultural and social dimensions of luxury brands’ consumption. Given these distinctive characteristics of the Chinese market, Western luxury brands have made use of all possible communication methods to connect with Chinese consumers. One of the seemingly promising channels is the Internet. The Internet breaks down geographical and temporal boundaries (Kozinets 1999), and enables Western luxury brands to connect with overseas markets. Among all the digital advertising tools, social media have become increasingly important in the Chinese market (Kim and Ko 2012). In 2015 alone, there were 574 million active mobile social media users in China (Kemp 2015). Due to the large number of social media users, Western luxury brands, like Burberry (Phan, Thomas, and Heine 2011), have started practicing social media advertising (Okonkwo 2009). Accordingly, several challenges emerge. With the rising popularity of social media, Chinese consumers increasingly demand Western luxury brands’ social presence online. Looking at the bright side, social media allows Western luxury brands to show a desirable brand image (Okonkwo 2009; Tynan, McKechnie, and Chhoun 2010) and maintain customer relationship (Kim and Ko 2012). However, concerns about negative consumer comments and their potential impact on brand images (Britten 2013; Macnamara and Zerfass 2012; Singer 2014) loom large. Thus, it remains a question whether and to what extent Western luxury brands embrace the interactive media. Moreover, it is unclear how Chinese consumers perceive their social media advertising effort. In particular, how Chinese young males, the new market segment, interpret luxury brands’ social media advertising presence is an untapped research field. Thus, the purpose of this study is to fill the research gap by exploring how Chinese young male consumers understand and interpret luxury brands’ social media advertising. Given the exploratory nature of the study, a qualitative research approach is adopted (Creswell 2013).

ALMA/ACA CO (1-0) observations of group galaxies

Bumhyun Lee,Jing Wang,Aeree Chung,Luis C. Ho,Ran Wang,Li Shao,Tomonari Michiyama,Shun Wang,Eric W. Peng,Virginia Kilborn 한국천문학회 2020 天文學會報 Vol.45 No.1

Efficient Synthesis of Functionalized 1-oxo-1-phenyl-2-acetic Acids through Ru(II)-catalyzed Transfer Hydrogenation

Wang, Xiaowei,Yan, Yunnan,Gong, Binwei,Tang, Xiaobo,Li, Qiu,Meng, Yanqiu,Xu, H. Eric,Yi, Wei Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.10

Characterization of Choristoneura fumiferana Genes of the Sixth Subunit of the Origin Recognition Complex: CfORC6

Wang, Xaiochun,Carstens, Eric B.,Feng, Qili Korean Society for Biochemistry and Molecular Biol 2006 Journal of biochemistry and molecular biology Vol.39 No.6

A new protein was cloned and identified as the sixth subunit of Choristoneura fumiferana origin recognition complex (CfORC6). The newly identified 43 kDa protein CfORC6 is much bigger than DmORC6 (25.7 kDa) and HsORC6 (28.1 kDa), though it's 23.85% identical to DmORC6 and 23.81% identical to HsORC6. Although the molecular weight of CfORC6 is close to ScORc6 (50 kDa), CfORC6 is only 14.03% identical to ScORC6. By alignment, it was found that the N-terminal of CfORC6 has about 30% identities with other ORC6s, but about 100aa of C-terminal of CfORC6 has no identity with other ORC6s. Like ScORC6, CfORC6 has many potential phosphorylation sites, (S/T)PXK. Like DmORC6, CfORC6 has leucine-rich region in the relevant site. Northern Blot showed that CfORC6 mRNA is about 2,000nt. Southern Blot confirmed that there is one copy of CfORC6 gene in spruce budworm genome. Western blot showed that infection of Cf124T cells with CfMNPV didn't affect the expression levels of CfORC6, at least up to 26 hr post infection.

Intralesional collagenase Clostridium histolyticum vs. verapamil injections in males with Peyronie’s Disease: A prospective, matched-pair, non-blinded, randomised clinical study comparing clinical outcomes and patient satisfaction rates

Eric Chung,Juan Wang 대한비뇨의학회 2022 Investigative and Clinical Urology Vol.63 No.5

Purpose: To compare clinical outcomes and patient satisfaction rates between intralesional verapamil (ILV) and collagenase Clostridium histolyticum (CCH) injections in males with Peyronie’s disease (PD). Materials and Methods: Following ethics approval, PD patients were prospectively enrolled in this open-label non-blinded study. Patients were randomised to receive ILV or CCH injections with penile remodelling every fortnightly for 6 courses. Patient demographics, change in penile curvature, International Index of Erectile Function-15 and Peyronie’s Disease Questionnaire (PDQ) scores as well as overall patient satisfaction and Patient Global Impression of Improvement (PGI-I) scores were recorded at pre-treatment and 6-, 12- and 24-month post-treatment. Results: A total of 50 males were recruited and divided into ILV (n=25) and CCH (n=25) groups. The mean changes in penile curvature were -16.8 (standard deviation [SD] 7.65) degrees in ILV and -28.2 (SD 11.5) degrees in CCH groups (p<0.01). Patients in the CCH group scored better than the ILV group on the PDQ psychosexual symptoms (-2.14 vs. -2.9; p<0.01) and symptom bother score (-3.88 vs. -4.16; p=0.08). Minor treatment-related adverse events were more common in the CCH group. The overall satisfaction rate on a 5-point scale was 4.1 in ILV and 4.5 in CCH groups, and there was no statistically significant difference in the PGI-I scores between the 2 groups (p=0.14). Conclusions: CCH therapy is more effective than ILV to treat a carefully selected group of males with PD, with a reasonable safety profile and a higher high level of patient satisfaction rate in the short term.

Can malleable penile prosthesis implantation improve voiding dysfunction in men with concurrent erectile dysfunction and buried penis?

Eric Chung,Brian Ng Hung Shin,Juan Wang 대한비뇨의학회 2021 Investigative and Clinical Urology Vol.62 No.3

Purpose: A buried penis causes voiding dysfunction and limits penetrative sexual intercourse. This pilot study evaluates the urinary outcomes in men with buried penis following insertion of malleable penile implants. Materials and Methods: Men with buried penis and co-existing urinary problems and erectile dysfunction underwent malleable penile prosthesis implantation were reviewed in a prospective ethics approved database. Patient demographics, flow rate (Qmax), International Prostate Symptom Score (IPSS), Patient Global Impression of Improvement (PGI-I) score, International Index of Erectile Function (IIEF)-5 score, Sexual Encounter Profile (SEP) and overall satisfaction score (on a 5-point scale) were recorded. Results: A total of 12 men (age 55 to 72 years) were reviewed, and the average gain in penile length post-implant, as measured from the pubis to the tip of the glans penis, was 6.8 (3 to 8) cm. There was a significant improvement in IIEF-5 score (8.2 vs. 22.5; p=0.029) post-implant, and more than half of patients were able to resume normal sexual intercourse and positive SEP-2 and SEP-4 were reported in 9 (75%) and 8 (67%) patients. There were no significant intraoperative or postoperative complication. Significant improvement in Qmax (8.4 ml/s vs. 18.6 ml/s; p=0.042) and IPSS (24.5±5.5 vs 15.5±3.5; p=0.038) were observed. More than two-thirds (83%) reported PGI-I score at 1 or 2, while 9 (75%) patients scored a 5/5 in overall satisfaction rate. Conclusions: Malleable penile implants increases penile length and improves urinary function in a highly select group of men with a buried penis and erectile dysfunction.

Efficient Synthesis of Functionalized 1-oxo-1-phenyl-2-acetic Acids through Ru(II)-catalyzed Transfer Hydrogenation

Xiaowei Wang,Yunnan Yan,Binwei Gong,Xiaobo Tang,Qiu Li,Yanqiu Meng,H. Eric Xu,Wei Yi 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.10