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자간전증 임부의 혈청내 산화질소와 혈소판 활성화인자의 변화
제구화(Goo Hwa Je),이병재(Byoung Jae Lee),황태웅(Tae Woong Hwang),백동훈(Dong Hoon Baek),차문석(Moon Seok Cha) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.7
목적 : 자간전증 환자들의 말초 혈액 내에서 산화질소 (Nitric oxide, NO)와 혈소판 활성화인자 (Platelet activating factor, PAF)의 농도를 측정하여 정상 임신과의 차이를 알아보고자 하였다. 방법 : NO의 농도는 Stuehr의 방법을 사용하여 측정하였고, PAF의 농도는 [3H]PAF scintillation proximity assay (SPA) system (Amersham Pharmacia Biotech)로 측정되었다. 결과 : NO의 농도는 정상 임신군 2.036±0.744 umol/L, 경증 자간전증 5.891±0.481 umol/L, 중증 자간전증 5.535±0.343 umol/L로 측정되어 정상 임신군에 비해 자간전증에서 높은 결과를 보였고 (p<0.05), 경증과 중증의 자간전증 임부간에는 통계학적으로 유의한 차이가 없었다 (p>0.05). PAF의 농도는 정상 임신군 435.8±59.5 ng/㎖, 경증 자간전증군 789.1±63.9 ng/㎖, 중증 자간전증 928.9±32.3 ng/㎖로 측정되어 정상 임신군에 비해 자간전증에서 높게 측정되었고 (p<0.05), 경증과 중증의 자간전증 임부간에는 통계학적으로 유의한 차이가 없었다 (p>0.05). NO와 PAF농도간에의 상관계수 (R)는 0.44012 (p<0.05)로 유의한 양적 상관관계를 보였다. 출생시 태아 체중은 정상 임신군 3242.5±374.1 gm, 경증 자간전증 2195.6±630.3 gm, 중증 자간전증 1655.9±557.9 gm으로 각 군 상호간에 통계학적으로 유의한 차이를 보였다 (p<0.05). NO와 출생시 태아 체중간에의 상관계수 (R)는 -0.59237 (p<0.05)로 유의한 음적 상관관계가 있었고, PAF와 출생시 태아 체중간에의 상관계수 (R)는 -0.33906 (p<0.05)로 유의한 음적 상관관계가 있었다. 결론 : NO와 PAF는 자간전증의 병태생리에 관여할 것으로 사료되며, PAF는 자간전증의 조기발견에 유용한 예측 인자로서 사용할 수 있을 것으로 사료된다. Objective : The aim of this study is to determine whether any association exists between preeclampsia and the maternal serum level of nitric oxide (NO) and platelet activating factor (PAF). Methods : NO concentrations were measured using Stuehr`s method and PAF concentrations were measured with [3H]PAF scintillation proximity assay (SPA) system (Amersham Pharmacia Biotech). Data were analyzed with SAS windows version 6.12, with significance established at p<0.05. Results : The mean (±SD) maternal serum concentrations of NO were significantly higher in the group with severe preeclampsia (5.535±0.343 ug/㎖) and mild preeclampsia (5.891±0.481 ug/㎖) than in the normotensive pregnancy group (2.036±0.744 ug/㎖) (p<0.05). The mean (±SD) maternal serum concentrations of PAF were significantly higher in the group with severe preeclampsia (928.9±32.3 ng/㎖) and mild preeclampsia (789.1±63.9 ng/㎖) than in the normotensive pregnancy group (435.8±59.5 ng/㎖) (p<0.05). The mean birth weight was lower in the mild and severe preeclampsia groups than in the normotensive pregnancy group (p<0.05). Conclusion : Maternal serum NO and PAF concentrations were more increased in preeclampsia than normotensive pregnancy group. NO may therefore serve as compensatory mechanism for vasoconstriction of preeclampsia and PAF as a marker for the risk of preeclampsia.
송근아(Geun A Song),제구화(Goo Hwa Je),차문석(Moon Seok Cha),황태영(Tai Young Hwang),김현호(Hyun Ho Kim),김경희(Kyoung Hee Kim),한진영(Jin Yeong Han) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.12
Plasmapheresis has been used for some conditions during pregnancy and puerperium, such as hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome. We present one case of the HELLP syndrome which was treated with plasmapheresis and also review the indications, complications and guidelines for repetitive plasma exchange.
김지현 ( Ji Hyun Kim ),전효정 ( Hyo Jeong Jun ),제구화 ( Goo Hwa Je ),나서희 ( Seo Hee Rha ),김대철 ( Dae Chul Kim ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.4
Vulvar glassy cell carcinoma (GCC) is a very rare neoplasm. Although GCC is considered to be a poorly differentiated variant of adenosquamous carcinoma, its real nature is still debatable. We report a case of GCC of the vulva in a 53-year-old woman and re
난소에서 일차적으로 기원한 저등급 자궁내막기질육종 1예
이우희 ( Woo Hee Yi ),신규식 ( Kyu Sik Shin ),제구화 ( Goo Hwa Je ),이화선 ( Hwa Sun Lee ),백경돈 ( Kyung Don Baik ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.9
자궁내막기질육종은 자궁육종의 비교적 드문 형태로 자궁에서 발생하는 악성 종양의 약 0.2%를 차지하고 있다. 저등급 자궁내막기질육종의 약 40%에서는 자궁외 부위에 전이된 상태로 진단된다. 난소에서 발생하는 자궁내막기질육종은 매우 희귀한 질환이며, 많은 경우에서 자궁내막증 또는 자궁에서 유사한 종양이 발견된다. 저자들은 난소에만 국한되어 명확히 난소 기원이라 할 수 있는 저등급 자궁내막기 질육종 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Endometrial stromal sarcoma (ESS) is a relatively rare form of uterine sarcoma. ESS of the myometrium compose just 0.2% of uterine malignant tumors, Low-grade ESS has extended beyond the uterus in 40% of cases at the time of diagnosis. ESS of ovary is very rare. Most of ovarian ESS is concomitant with endometriosis or same tumor in uterus. We have experienced a primary ovarian low-grade ESS, and that sarcoma is localized in ovary. So, we report this case with review of literature.
t(111)(q32q23) 균형전좌 임부에서 반복 발생한 Partial Trisomy 1q
송근아(Geun A Song),곽봉규(Bong Gyu Kwak),차문석(Moon Seok Cha),제구화(Goo Hwa Je),한진영(Jin Yeong Han),(Lisa G. Shaffer) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.2
Abnormal offsprings from balanced translocation carriers usually inherit only one of the translocated products and are therefore partially trisomic for one chromosome and partially monosomic for another. Partial trisomy 1q usually demonstrates fetal growth restriction and anomalies of head, face, urogenital tract, heart, finger and toes with a wide range of characteristics and severities. It has been reported in a few individuals in the world and this is the first report of partial trisomy 1q in Korea. We present the case of recurrent partial trisomy 1q in maternal balanced translocation which was prenatally diagnosed by amniocentesis with fluorescence in situ hybridization(FISH) based on abnormal ultrasonographic findings and poor obstetric history.
임신 초기 모체 혈액내 증가된 유핵 적혈구의 산과적 의미
송근아(Geun A . Song),이상훈(Sang Hoon Lee),백동훈(Dong Hoon Baek),제구화(Goo Hwa Je),한진영(Jin Yeong Han) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.10
N/A Objective : During early pregnancy, CD71 and glycophorin A positive cells in peripheral blood of pregnant women were studied, to assess the relationship between increased numbers of nucleated RBC (NRBC) in maternal blood and pregnant outcomes. Methods : Peripheral venous blood samples were obtained from 47 primigravidas of 14∼16 weeks gestation. Triple screening tests were routinely performed. Blood samples were incubated with monoclonal anti-CD71 and monoclonal anti-glycophorin antibodies, and analyzed by flow cytometry using FACSort (Becton Dickinson, USA) for checking the NRBC count. Results : A total of 47 pregnant women were enrolled at 14-16 weeks gestation; one pregnancy had anemia and was excluded from the test, the outcome was unknown for 2 other pregnancies, and twelve pregnancies had 1-4% of NRBC in the maternal blood. In the remaining 32 pregnant women, grouped according to their percentage of NRBC, the group with more than 4% of NRBC was termed the study group, and less than 1% of NRBC was termed the control group. The results were as follows: 1) The study group showed lower fetal birth weight than the control group, which was statistically negatively significant (y=-62.219x + 3,401.6, R2=0.2146, p<0.05). 2) There was no significant correlation between the percentage of NRBC of maternal blood and maternal serum AFP level in the study and the control groups (y=-0.0206x + 1.2763, R2 =0.0096, p>0.05). 3) There were two complications in the study group: one was a preterm delivery at 35 weeks of gestational age with birth weight of 2,300 gm and the other was a case of pregnancy-induced hypertension. Conclusion : It can be concluded that increased NRBC count in maternal blood during the early second trimester has a significant correlation with fetal birth weight but can't predict high risk pregnancies such as preeclampsia, preterm labor or intrauterine fetal growth restriction. In order to obtain a higher predictive value, further studies with more participants and with high risk pregnancies of known risk factors are needed.