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배의 씨방 및 과피의 알콜 발효 추출물이 피부에 미치는 영향
김형우 ( Hyung Woo Kim ),김경윤 ( Kyung Yoon Kim ),김병주 ( Byung Joo Kim ),강수우 ( Suo Yue Chiang ),도윤호 ( Yoon Ho Do ),남내이 ( Nai Lee Nam ),정현우 ( Hyun Woo Jeong ),최정식 ( Jeong Sik Choi ),조수인 ( Su In Cho ) 대한본초학회 2009 大韓本草學會誌 Vol.24 No.1
Objectives: This study was designed to investigate the effects of alcoholic fermentation extract from ovary and rind of pear on human skin. Methods: We investigated the effects of samples on human skin in terms of clinical trial. 32 of healthy volunteers, who lived in mokpo participated in clinical trial. Effects of sample on hygroscopicity and water-holding capacity were investigated. Sebum, moisture, scabrousness and desquamation were also investigated. Facial massages were conducted 8 times in each volunteers. Results: Single treatment group showed elevated levels of hygroscopicity (Normal: 106.4±2.1%, vs Pear: 114.1±6.2) and water-holding capacity (Normal: 87.1±4.4%, vs Pear: 96.2±1.3) on forearm of 16 volunteers respectively. In addition, massage group using sample showed elevated moisture (Control: 3.8±5.8%, vs Sample: 15.2±4.7%) and lowered scabrousness levels (Control: -12.3±4.4%, vs Sample: -22.0±5.2%) significantly. However, the levels of sebum did not affected by sample. Conclusions: These result suggest that alcoholic fermentation extract from ovary and rind of pear has moisturizing effect on human skin.
소엽(蘇葉) 추출물이 백서(白鼠)의 뇌허혈에 미치는 효과
김형우,김부여,조수진,정현우,조수인,Kim, Hyung-Woo,Kim, Bu-Yeo,Cho, Su-Jin,Jeong, Hyun-Woo,Cho, Su-In 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.3
Objectives : Folium perillae (FP) can relieve superficial pathogenic factors to dissipate cold and promote the circulation of qi and regulate the function of the stomach and is often used for interior qi-stagnation. We hypothesized that FP could rescue cerebral ischemia in rats. Methods : The present study was carried out to investigate the effects of FP on cerebral ischemia in terms of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in rats. Finally, lactate dehydrogenase (LDH) release was investigated, too. Results : In this study, treatment with FP elevated rCBF and MABP levels in dose-dependent manner. Pre-treatment with indomethacin, an inhibitor of cyclooxygenase, inhibited rCBF increase induced by FP effectively. However, FP did not affect stability during cerebral reperfusion. Finally, FP significantly inhibited LD H activity in vitro Conclusions : These results suggest that FP is useful to treat patient with diseases related to cerebral ischemia, because FP can increase rCBF and MABP.