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김계엽,정현우,김경윤,Kim, Gye-Yeop,Jeong, Hyun-Woo,Kim, Kyung-Yoon 대한동의생리학회 2006 동의생리병리학회지 Vol.20 No.6
This experimental study was carried out to investigate the immunostimulating effect of Acanthopanax, as Oriental rhizomata herbs, on jejunal survival, endogenous spleen colony formation, apoptosis in jejunal crypt cells and lipid peroxidation in the liver of mice following Gamma-ray irradiation. The subject of this study includes 72 mice which were divided into each 7 groups. Acanthopanax experiment groups were Acanthopanax. Gamma-ray(lOGy), Acanthopanax. Gamma-ray(3Gy), Acanthopnax. Gamma-ray(1Gy), Gamma-ray control(1OGy), Gamma-ray control(3Gy), Gamma-ray control(1Gy), Normal groups. The results of this study were as follows : Treatment with Acanthopanax showed significantly increased(p<0.05) on the cell death apoptosis in crypt, intestine crypts survival of intestine in mice following low-dose(1Gy) Gamma-ray radiation. And that significantly increased(p<0.05) on jejunal crypt survival and reduced(p<0.05) on lipid peroxidation in mice following high-dose(1OGy) Gamma-ray radiation. The above results suggest that Acathopanax were immunostimulating effectively reduced Gamma-ray irradiation.
국내에서 분리된 돼지 유행성 설사증 바이러스 접종자돈의 병리학적 소견
김계엽,박남용,정치영,박영석,Kim, Gye-Yeop,Park, Nam-Yong,Chung, Chi-Young,Park, Young-Seok 한국수의병리학회 1998 한국수의병리학회지 Vol.2 No.2
Twelve colostrum-deprived piglets were inoculated oral1y with porcine epidemic diarrhea virus isolated from Korea. The piglets were euthanatized from at 12 hour postinoculation(PI) at 6-hour intervals. At 24 to 36 hours PI, all infected piglets showed severe yellowish to watery diarrhea, dehydration, depression, and anorexia. At necropsy, the intestinal wall looked thin, mesenteric vessels congested, and mesenteric lymph nodes edematous. The histological findings showed marked villous atrophy and fusion, severe degeneration of enterocytes and monomuclear cell infiltration in the lamina propria. On electron microscopy, villous epithelial cells of infected jejunum contained viral particles at 18 hour PI. The viral particles were pleomorphic spheres with a mean diameter of 95∼180nm including 18nm projections.
김계엽,Kim, Gye-Yeop 대한수의학회 2001 大韓獸醫學會誌 Vol.41 No.4
The chicks from 6 field broiler farms revealed peripheral neuropathy including leg weakness, curled toes and drooped wings. Grossly distinctive enlargements of sciatic nerve, branchial nerve and lumbar nerve were observed in the chicks. Histologically nerve lesions consisted of demyelination of myelin sheaths, Schwann cell proliferation and swelling, and interstitial edema in the peripheral nerves of all birds examined. Axonal swelling and infiltration of small lymphocytes were observed, but not a primary lesion. After treatment of riboflavin, neurological disorder was markedly recovered. From these results, it is suggested that the peripheral nerve lesions in these cases were caused by dietary riboflavin deficiency.
지구성 운동과 키토산 소금이 정상 백서의 혈압에 미치는 영향
김계엽 ( Gye Yeop Kim ),정준환 ( Jun Hwan Jung ),김수근 ( Soo Keun Kim ),조지은 ( Ji Eun Cho ),이정민 ( Jeong Min Lee ) 한국운동영양학회 2004 Physical Activity and Nutrition (Phys Act Nutr) Vol.8 No.2
This study is to execute endurance exercise for 8 weeks and diet with chitosan salt in order to examine the effect that the endurance exercise and the diet with chitosan salt affect on blood pressure in the rats. And then it is to measure blood pressure, blood inorganic ion (Na^(+), Cl^(-)), total cholesterol (TC), and the thickness of aorta wall. Also the endurance exercise was executed by using a treadmill in 10% of gradient at a speed of 17 m/min by three times a week and by 15 minutes a time. As experimental animals, it is to use 42 rats that has the weight of 300±50g and the age of 16 weeks and is maleness Sprangue-Dawely rat. The experiment is divided into a control group (non treatment; n=7), an experimental group Ⅰ (feed diet added 0% commercial salt; n=7), an experimental group Ⅱ (feed diet added 0% commercial salt and endurance exercise; n = 7), an experimental group Ⅲ (feed diet added 3% chitosan salt; n = 7), an experimental group Ⅳ (feed diet added 3% chitosan salt and endurance exercise; n = 7), an experimental group Ⅵ(feed diet added 3% commercial salt; n = 7), and an experimental group Ⅵ (feed diet added 3% commercial salt and endurance; n = 7). As for the change of blood pressure, it presented a trend decreased in the experimental group Ⅱ, Ⅲ, and Ⅳ. In particular, the trend decreased in the experimental N was most prominent. Also, it presented that the endurance exercise and the diet with chitosan salt decreased the blood pressure much significantly in the rats with normal blood pressure (p<0.05). The Na^(+) value among sera increased as an order of an experimental group Ⅴ, Ⅲ, and Ⅳ compared with the control group, but there was no statistical significance in the experimental group Ⅳ paralleling the endurance exercise with the diet with chitosan salt (p<0.05). The Cl^(-) value among sera decreased as an order of experimental group Ⅳ, Ⅱ, Ⅲ, and I compared with the control group, but there was statistical significance in the experimental group Ⅳ paralleling the endurance exercise with the diet with chitosan salt (p<0.05). These results suggest that, it presented that the endurance exercise for 8 weeks and the diet of 3% chitosan salt made the normal rats` blood pressure, blood inorganic ion Cl^(-), and the total blood cholesterol decreased. Therefore, it is considered as the continuous endurance exercise and the proper diet with chitosan salt made the increase of blood pressure controlled.