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간장 및 담도 : 개의 동종 간이식에 있어서 단계별 아미노산 대사에 변화
김상준(Sang Joon Kim),김수태(soo Tae Kim),이건욱(Kuhn Uk Lee),조흥래(Hong Rae Cho),정중기(Joong Ki Chung),서경석(Kyunng Suk Suh),박규주(Kyu Joo Park),안세현(Sae Hyun Ahn),배성환(Sung Han Bae),김진규(Jin Q Kim) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.1
N/A ln an attempt to determine the function of hepatic allografts, we studied the metabolic changes of plasma amino acids intraoperatively in 3 cases of hepatic transplantation in dogs for indicators of hepatic function.The operation was divided into four sampling periods; baseline, hepatectomy (portal vein and inferior vena cava clamping time) anhepatic, and reperfusion.1) During the baseline period & anhepatic period, there was no significant change in labaratory data except slight increasing of SGOT and lower level of total protein and albumin. 2) During the anhepatic period, total free plasma amino acids levels (TFPAA) rose significant statistically (p<0.01), but the branched chain amino acids (valine, leucine, isoleucine) and methionine did not rise but reduce or remain steady. And during reperfusion period, TFPAA had a tendency to decrease. 3) The molar ratio of BGAA/aromatic amino acids had a trend to decrease in anhepatic period. 4) There was no different change between essential amino acids and non-essential amino acids in anhepatic period.
김수태(Soo Tae Kim),김건표(Keon Pyo Kim),정승용(Seung Yong Jeong),한세환(Se Hwan Han),민승기(Seung Gee Min),정중기(Joong Ki Chung),이건욱(Kuhn Uk Lee),이효석(Hyo suk Lee),오용석(Yong Seok Oh),이상형(Sang Hyung Lee),김현집(Hyon Jip Ki 대한소화기학회 1995 대한소화기학회지 Vol.27 No.6
Partial resection of liver is the standard treatment modality in hepatocellular carcinoma(HCC). But the resection of liver is impossible in large HCC, especially with the cirrhotic liver. An alternative treatment for such patients would be orthotopic liver transplantation. We experienced a case of liver transplantation for HCC patient with far advanced disease. The patient had no clinical evidence of distant metastasis preoperatively. We did liver transplantation from a donor who was diagnosed as brain death due to traffic accident. The blood type was compatible and operation was finished successfully. Immunosuppressive treatment with cyclosporine was done and the recipient was known to have hepatitis B. Hepatitis B immune globulin was administered. Immediate postoperative recovery was uneventful but the failure in the of alpha-fetoprotein to normal level was observed. Multiple hot uptake of bone was detected on the bone scan during the follow up and the recipient was expired after 7 months. (Korean J Gastroenterol 1995;27:744 - 748)
외과계 감염증에 대한 Sulperazon(Sulbactam/cefoperazone) 및 Cefoperazone의 임상효과 비교연구
박규주,노동영,김상준,권오중,정중기,홍인규 대한화학요법학회 1990 대한화학요법학회지 Vol.8 No.2
Despite recent advances in development of antibiotics and antiseptic techniques, infection still remains to be one of the major problems in the surgical field. Due to development of bacterial resistance to commonly used antibiotics, there is always a need to develop a new antimicrobial agent which would overcome such resistance. Sulperazon (Sulbactam/Cefoperazone) is a combination drug of potent β-lactamase inhigitor, sulbactam, and cefoperazone which has broad antibacterial spectrum, which was developed to combat against β-lactamase producing microorganisms. In an effort to evaluate the efficacy and safety of sulperazone, we have randomly divided 40 patients (12 with perforated appendicitis, 10 with peritionitis, 6 with GB empyema, 6 with periproctal abscess, 3 with wound infection, 1 liver abscess, 1 pancreatic abscess, and 1 acute cholangitis) into 2 groups (20 patients in each group). One group received daily dose of 2 to 3 grams of sulperazon and the other group received daily dose of 2 to 3 grams of cefoperazone. Following results were obtained : 1. Clinical effect of sulperazon was cure in 16 patients (80%), improvement in 3 patients (15%), compaired to cure in 14 patients (70%), improvement in 4 patients (20%) for the cefoperazone group. 2. Using disc diffusion method, sulperazon was sensitive to all of the isolated microorganisms except β-hemolytic streptococci, which was moderately sensitive. Cefoperazone was sensitive to only E. coli, Pseudomonas aeruginosa and Serratia. 3. Microbiological effect of sulperazon was eradication of offending microorganisms in 16 patients (80%), compared to 14 patients (70%) in Cefoperazone group. 4. Overall clinical efficacy of sulperazon was 95%, compared to 80% for cefoperazone. 5. Adverse effects due to sulperazon was nausea and diarrhea which occurred in 1 patient respectively. 2 patients receiving cefoperazone experienced diarrhea. It can be concluded that sulperazon is a safe and effective antibiotic agent which can be used in surgical infection patients.