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개 자가부분 간이식에서 이식간 초기 기능 지표로서 혈청 젖산 및 아미노산의 단계별 대사 변화
김상준(Sang Joon Kim),서경석(Kyung Suk Suh),이건욱(Kuhn Uk Lee),최재운(Jae Won Choi),안세현(Sae Hyun Ahn),정성은(Sung Eun Jung),배수동(Soo Tong Pai),김주섭(Joo Seop Kim),조홍래(Hong Rae Cho),정중기(Jung Kee Chung),이우정(Woo Jung Lee 대한소화기학회 1993 대한소화기학회지 Vol.25 No.5
N/A Living-related segmental liver transplantation is currently accepted as one method of treatments of pediatric endstage liver diseases. Immediate recovery of graft function is prerequisite for patients survival, In case of graft failure, early prediction is necessary for retransplantation to avoid decease. Since amino acids and lactic acid are metabolized in liver, levels of those components lin plasma are frequently used as indicators for hepatic graft function. we have investigated the wequential changes of amino acids and lactic acid following autologous segmental liver transplantation in canine to identify the significance of these indicators. Ten mongrel dogs were prepared by harvesting the left lobe frorn experimental dogs, removing the rest of liver using total vascular exclusion and veno-venous bypass, and implanting the left lobe taken at first stage in the orthotopic position. The plasma amino acids and lactic acid concentrations in arterial blood obtained at preoperative period, anhepatic phase, reperfusion-15 min., 1 hour, 3 hours, 6 hours, were measured on Beckman system 6300 amino acid analyzer and Kodak Ektachem 700 XR, Among ten dogs, five of them died within 20 hours (Group 1), and the rest of them died after 20 hours (Group 2). The results indicate: (1) ln both Group, all plasma amino acid levels were increased in anhepatic phase except Valine, Isoleucine, and Arginine. Most highly increased amino acid was Alanine. (2) In group 1, most amino acids were slightly decreased till reperfusion 1 hour, and then increased to the level of anhepatic phase in reperfusion 6 hours. (3) In group 2, most plasma amino acid levels were decreased to preoperative values within 6 hours following reperfusion. (4) The changing patterns of TFPAA (total free plasma amino acid), BCAA/AAA ratio (Branched chain amino acid/aromatic amino acid ratio), and severaI amino acids (Phenylalanine, alanine Proline, Tyrosine) revealed statistically significant difference between two Groupe. (5) While plasma concentration of lactate continued to rise until 6 hours after reperfusion in Group 1, already increased plasma concentration of lactate in anhepatic phase reached plateau during 6 huurs after reperfusion in Group 2. The above changing pattern of plasma concentration of lactate showed statistically significant difference between both Groups (p<0.05). (6) Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were increased equally during operation and reperfusion in two Groups. Therefore, the sequential changes of plasma amino acids and lactic acid are useful indicators for detection of early graft function in canine autologous segmental liver transplantation
간장 및 담도 : 개의 동종 간이식에 있어서 단계별 아미노산 대사에 변화
김상준(Sang Joon Kim),김수태(soo Tae Kim),이건욱(Kuhn Uk Lee),조흥래(Hong Rae Cho),정중기(Joong Ki Chung),서경석(Kyunng Suk Suh),박규주(Kyu Joo Park),안세현(Sae Hyun Ahn),배성환(Sung Han Bae),김진규(Jin Q Kim) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.1
N/A ln an attempt to determine the function of hepatic allografts, we studied the metabolic changes of plasma amino acids intraoperatively in 3 cases of hepatic transplantation in dogs for indicators of hepatic function.The operation was divided into four sampling periods; baseline, hepatectomy (portal vein and inferior vena cava clamping time) anhepatic, and reperfusion.1) During the baseline period & anhepatic period, there was no significant change in labaratory data except slight increasing of SGOT and lower level of total protein and albumin. 2) During the anhepatic period, total free plasma amino acids levels (TFPAA) rose significant statistically (p<0.01), but the branched chain amino acids (valine, leucine, isoleucine) and methionine did not rise but reduce or remain steady. And during reperfusion period, TFPAA had a tendency to decrease. 3) The molar ratio of BGAA/aromatic amino acids had a trend to decrease in anhepatic period. 4) There was no different change between essential amino acids and non-essential amino acids in anhepatic period.