Rapid Diagnosis of CMT1A Duplications and HNPP Deletions by Multiplex Microsatellite PCR

최병옥,정기화,Joonki Kim,Kyung Lyong Lee,Jin Seok Yu,Jung Hee Hwang 한국분자세포생물학회 2007 Molecules and cells Vol.23 No.1

인성교육을 위한 교육과정 운영방안 탐색

최병옥 한국내러티브교육학회 2017 내러티브와 교육연구 Vol.5 No.3

본 연구는 오늘날 강조되고 있는 인성교육의 내실화를 위해 학교교육과정의 운영방안 을 탐색한 것이다. 먼저 인성과 인성교육의 의미를 탐색하였으며, 학교교육과정에서 인 성교육의 변천, 인성교육의 방안으로 강조된 범교과학습의 의미와 한계를 고찰하였다. 인성교육이 범교과학습이나 교과 외 활동을 통해서보다는 교과를 통해 이루어져야 한 다는 입장을 전제하였다. 따라서 인성교육을 위해서는 무엇보다 교과가 강조되어야 한 다는 점, 인성의 요소가 강조될 수 있도록 교육과정의 융합이나 통합이 필요하다는 점, 그리고 인성교육을 위한 교육과정 설계의 방안으로 백워드 설계를 살펴보았다. 또한 교 과를 학습하는 과정에서 자연스럽게 인성을 함양할 수 있기 위해서는 교사가 길러야할 인성 역량이 중요함을 인식하면서 예비교사 교육에서 고려할 점을 모색하였다. 그리고 인성교육의 효과를 의미 있게 밝히기 위한 평가 상의 고려 점을 탐색하였다. This study was intended to explore the implementation of school curriculum in order to improve the substance of character education which took on an added emphasis these days. First, this study explored the meaning of both personality and character education, examined the changes in character education based on school curriculum, and investigated the significance and limitations of cross-curricular learning being emphasized as the measure for character education. In this study, we assumed that character education should be provided through subjects rather than cross-curricular learning or extra-curricular activities. Therefore, it is suggested that subjects should be emphasized above all for character education while the convergence or integration of curriculum would be needed to emphasize the elements of personality, and furthermore, the backward design was proposed as a meaningful design method. In addition, this study suggested that the pre-service of teacher’s education is more important than anything else in order to nurture personality naturally in the process where the subjects are studied. Moreover, this study explored the considerations in evaluation which would be required to clarify the effect of character education meaningfully.

슬개대퇴관절의 해부학과 생체역학에 관한 문헌적 고찰

최병옥,Choi, Byung-Ok 대한물리치료과학회 2001 대한물리치료과학회지 Vol.8 No.2

The patellofemoral pint is formed by the articulation of the patella and femoral condyles in the trochlear groove. The complexity of the patellofemoral pint is magnified by the fact that the tibiofemoral pint works in conjunction with the patellofemoral pint. Additionally, other pints such as the subtalar pint., hip and sacroiliac pints indirectly contribute to the function of the patellofemoral pint. This pint has little bony stability, Soft tissue surrounds the pint to increase stability. The patellofemoral pint increases the mechanical advantage of the quadriceps muscles and resists mechanical loading. In patellofemoral dysfunction, patellofemoral contact pattern is disrupted. leading to excessive compression at the pint. When you treat the patellofemoral dysfunction, you should evaluate anatomic and biomechanic components and find factors of patellofemoral dysfunction. Hamstring tightness. weakness of VMO and tightness of lateral retinaculum lead to flexed knee and abnormal patella tracking and patellofemoral pint reaction force and patellofemoral dysfunction. A through understanding of the anatomy and biomechanics may assist the clinician in the recognition and treatment of patients with patellofemoral pain. Therefore physical therapists should apply modality as well as therapeutic exercise, stretching and strengthening. In this paper, I will discuss the germane anatomical structures and biomechanics of the patellofemoral pint.

Booker형 근이양증에세 근육생검 소견의 비균일성

최병옥,선우일남,이진성,김태승,박경호,이숭현 대한신경과학회 1998 대한신경과학회지 Vol.16 No.5

國軍의 正統性을 論함

崔炳鈺 국방부 군사편찬연구소 1990 군사 Vol.- No.21

韓國의 歷代 對外戰爭에 대한 認識

崔炳鈺 국방부 군사편찬연구소 1992 군사 Vol.- No.25

X-linked Charcot-Marie-Tooth 환자에서 새로이 발견된 Connexin32 유전자의 Missense 돌연변이 Cys168Arg

최병옥,선우일남,박기덕,김용재,최경규,이미선,황정희,정기화 대한신경과학회 2004 대한신경과학회지 Vol.22 No.1

X-linked Charcot-Marie-Tooth (CMTX) disease is a clinically heterogeneous hereditary motor and sensory neuropathy. The X-linked inheritance showed an absence of male-to-male transmission and a more severe disease phenotype in affected males compared to that in affected female. A missense mutation, Cys168Arg, was found in connexin 32 gene (Cx32/GJB1) from a patient with CMTX neuropathy. The familial history of this patient also suggested that the disease is X-linked CMT. Thus, we report a CMTX family having the novel Cys168Arg mutation in the Cx32 gene.

한국인 Charcot-Marie-Tooth 환자에서 Myelin Protein Zero (MPZ) 유전자 돌연변이 분석-임상 및 전기생리학적 특성-

최병옥,정기화,조현지,박기덕,이광수,김승민,선우일남 대한신경과학회 2005 대한신경과학회지 Vol.23 No.2

Background: Mutations in the myelin protein zero (MPZ) gene, which is located on chromosome 1q21-q22, is present in Charcot-Marie-Tooth disease type 1B (CMT1B), CMT type 2, Dejerine-Sottas syndrome, and congenital hypomyelination neuropathy. It is proposed that the nature and position of the MPZ mutations mainly determine the axonal and demyelinating phenotypes. In this study, we investigated to determine the clinical and electrophysiological characteristics in CMT patients with mutations in the MPZ gene. Methods: We examined mutations of MPZ, in 62 Korean families diagnosed as having CMT disease. Mutations were confirmed by through both strands sequencing. Nerve conduction studies were carried out in CMT patients having each mutation. Results: The three mutations (Asp118Asn, c.449-1G>T (3'-splice site), Lys236Glu), determined to be novel, were not detected in the 105 healthy controls. The mutation frequency of MPZ was similar as those found in several European populations. Electrophysiologically, 3'-splice site mutation (449-1G>T) showed the conduction block and moderate slowing nerve conduction velocities like that of CMT1B. However, the other mutations represented the electrophysiological features of CMT type 2. Conclusions: We report the identified three novel MPZ mutations in Korean CMT patients and the phenotype-genotype correlations based on nerve conduction studies.

전신방사선조사 프로그램 개발

최병옥,장지선,강영남,최일봉,신성균,Choi Byung Ock,Jang Ji Sun,Kang Young Nam,Choi Ihl Bohng,Shin Sung Kyun 한국의학물리학회 2005 의학물리 Vol.16 No.3

In total body irradiation (T81) for leukemia, we have a two methode. One is a AP (anterior-posterior) method and the other is a Lateral methode. Our hospital used lateral methode. T81 must consider about body contour, because of homogeneous dose distribution. For compensation about irregular body contour, we use compensator. For T81 treatment, we must be considered, accurate manufacture of compensator and accurate calculation of dose. We developed the automatic program for T81. This program accomplished for compensator design and dose calculation for irregular body. This program was developed for uses to use in a windows environment using the IDL language. In this program, it use energy data for each energy: TMR, output factor, inverse square law, spoiler, field size factor. This program reduces the error to happen due to the manual. As a development of program, we could decrease the time of treatment plan and care the patient accurately. 전신방사선조사(total body irradiation)는 크게 두 가지가 있는데 첫 번째는 전후 이문대향조사방법(anterior-posterlor total body irradiation)이고 두 번째는 좌우 이문대향조사방법(lateral total body irradiation)이다. 본 병원에서 시행 중인 방법은 환자의 좌우 이문대향조사방법으로서 환자의 측면에서 방사선이 조사되기 때문에 인체의 윤곽에 따른 방사선의 분포가 각 부분에 대해서 다르게 나타나게 된다. 전신 방사선 치료에서 보상체(Compensator)를 사용하여 몸 전체에 균일한 방사선 분포를 만들어내게 한다. 하지만 이런 보상체의 제작은 인체의 모든 부위에서의 수치, 각 부분의 깊이와 길이가 필요한데 특히 머리 부위와 다리 부위 수치에 대한 세밀한 고려가 중요시 되며 또한 조사되는 방사선량의 정확성이 요구된다. 본 연구에서는 기존에 수작업으로 각 부분을 계산하는 방법에서 방사선데이터 및 환자의 각 부분을 데이터화하여 윈도우 환경에서 사용이 용이한 전신방사선조사 계산 프로그램을 개발하였다. 개발된 프로그램은 보상체의 제작 및 방사선량을 계산할 수 있도록 하였다. 본 연구에서는 프로그램 개발을 위하여 IDL 6.0 (Intersys, USA)과 Visual C++ (Microsoft, USA)를 사용하였다. 전신방사선치료시 사용하는 각 에너지별 최대조직선량비(Tissue Maximum Ratio, TMR), 출력인수(output factor), 거 리 역제곱법 칙(Inverse square law), 빔 스포일 러(beam speller), 조사면(field size) 등의 인수를 데 이 터 베이스화함으로써 환자별 보상체의 자동화 제작 및 방사선량 계산을 할 수 있도록 하여 수작업으로 인해 발생할 수 있는 오차와 시간을 줄일 수 있었다. 개발된 전신방사선조사 프로그램을 활용하여 수작업으로 인한 오차를 줄이고 정확한 수치 및 데이터의 적용으로 전신방사선조사에 대한 치료계획을 최적화한다.

Cx32 유전자에서 새로이 발견된 돌연변이 V136A와 EGR2 유전자 돌연변이 R359W를 보인 Charcot-Marie-Tooth 환자

최병옥,정기화,김승민,박기덕,이미선,신상희,이지용,선우일남 대한신경과학회 2004 대한신경과학회지 Vol.22 No.1

Mutations of the CMT genes develop a variety of distinct phenotypes. Cx32 gene mutations cause the X-linked form of CMT disease, and mutations in EGR2 are associated with CMT type 1, DSS, and congenital hypomyelination neuropathy. Her parents, grandmother and sister did not show the V136A mutation in Cx32. We report the first CMT patient with EGR2 and Cx32 mutations.