유리 산소 기 청소제가 자외선 B에 의한 생쥐 표피 Langerhans 세포의 ATPase 표현에 미치는 영향

전성진,서기석,김상태 ( Seong Jin Jeon,Kee Suck Suh,Sang Tae Kim ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.5

N/A The Effect of Free Oxygen Radical Scavengers on the Expression of ATPase of Mouse Epidermal Langerhans Cells After UVB Irradiation Seong Jin Jeon, M.D., Keo Suck Suh, M.D., Sang Tae Kim, M.D. Department of Dermatology, Kosin Medical College, Pusan, Korea Langerhans cells are dendritic cells with specific granules in their cytoplasm, and Ia antigen and receptors for Fc portion of IgG and C3 on their cell surface. They are known to perform immunological functions such as processing and presentation of antigen to T cells in delayed type contact hypersensitivity, and surveillance of virus and cancer. It is known that Langerhans cells are damaged functionally and morphologically by UVB irradiation, but the mechanisms are still not known or are largely speculative, though keratinocytes are known to be damaged by reactive oxygen species generated by UV irradiation. It was the investigator`s idea that reactive oxygens generated by UVB exposure on skin could also play a role in Langerhans cell damage and that free oxygen radical scavengers would prevent the damage of Langerhans cells from UVB. Free radical scavengers used in this experiments were superoxide dismutase(SOD), α-tocopherol acetate(α-TCA) and sodium azide(SA), and these chemicals were known to inactivate O_2^-, OH and 1^O_2 respectively. Groups of BALB/c mice were injected intraperitoneally wth 0.2㎖ of SOD(0.1 or 1.0mg/㎖), α-TCA(10^4 or 10^2mole) or SA(10^4 or 10^2mole) just before or immediately after UVB irradiation(40mJ/㎠). Control mice given saline, saline plus UVB irradiation or free oxygen radical scavengers without UVB. Seventy two hours after the irradiation of UVB, biopsy specimens were taken from the ears of mice. Number, area and perimeter of Langerhans cells were evaluated using ATPase-stained epidermal sheets. The results were as follows : 1. The number of Langerhans cells was significantly decreased by UVB irradiation(p<0.01). 2. The area and perimeter of Langerhans cells were significantly increased by UVB irradiation(p<0.01). 3. SOD could prevent Langerhans cell damage significantly from UVB(p<0.05). 4. For α-TCA, only high dose(10^2mole) and treatment immediately before UVB irradiation showed protective effect from Langerhans cell damage(p<0.05). 5. SA had no protective effect regardless of the doses or time of administration(p>0.05).

두경부 종양의 토모치료 시 정위적방사선수술 마스크의 유용성 평가에 대한 연구

전성진,김철종,권동열,김종식,Jeon, Seong Jin,Kim, Chul Jong,Kwon, Dong Yeol,Kim, Jong Sik 대한방사선치료학회 2014 대한방사선치료학회지 Vol.26 No.2

목 적 : 두경부 치료 시 환자의 고정을 위해 고정용 열성형가면(Thermoplastic mask, mask)을 사용한다. 치료 중 변동의 오차가 적은 정위적방사선수술에 사용되는 특수 제작된 마스크를 토모치료에 적용 했을 때 표면선량의 변화의 경향을 알아보고 유용성을 평가해보고자 한다. 대상 및 방법 : 일반적인 마스크(conventional mask, C-mask)와 정위적방사선수술 마스크(SRS mask, S-mask)를 이용하여 인체팬텀(rando phantom)을 동일한 중심선으로 고정한 후 모의 치료를 실시하였다. 획득한 영상은 치료계획시스템(treatment planning system, TPS)을 이용하여 안와부와 침샘부위를 치료 부위로 설정하여 각 각의 토모치료계획을 세웠다. 마스크의 특성에 따른 표면선량 측정을 위해 정위적방사선수술 마스크를 기준으로 치료부위에 주변에 위치한 두꺼운 부분과 얇은 부분을 관심영역으로 설정하여 마스크의 종류에 따른 동일한 위치의 표면 선량을 비교해보았다. 그리고 토모치료기를 이용하여 모의치료와 동일한 조건으로 인체팬텀을 위치시키고 치료계획에서 설정된 관심영역의 위치에 Gafchromic EBT3 필름을 팬텀 표면에 부착 하여 마스크를 착용한 후 치료 조사하였다. 선량 농도 분석 시스템(RIT)을 이용하여 조사된 필름의 표면선량을 측정하여 마스크의 종류에 따른 표면선량 변화의 양상을 비교해보았다. 결 과 : TPS에서 마스크의 종류에 의한 표면선량 변화는 안와에서 0.65~2.53 Gy, 타액선에서 0.85~1.84 Gy의 측정 변화값을 보여주었다. Gafchromic EBT3 필름을 이용한 표면선량 측정에서는 안와에서 -0.2~+3.46 Gy, 타액선에서 1.04~3.02 Gy의 측정 변화값을 보여 주었다. Smask를 적용하였을 때 C-mask를 기준으로 하였을 때 TPS에서 최대 4.26% Gafchromic EBT3 필름에서 최대 5.82%의 각 각의 표면선량 증가 경향을 나타내었다. 결 론 : S-mask의 사용으로 인한 표면선량은 무작위적으로 변하였으나 대체적으로 유효한 범위 안에 들어옴을 알 수 있었다. 본 연구에서는 표면선량의 변화값을 극대화 하기 위해 표면에 위치한 표적을 실험 하였으며 치료 표적이 심부에 위치할 경우와 치료 계획의 조건에 따라 표면 선량은 더 감소할 것으로 생각되어지며 이는 마스크에 따른 표면선량의 차이는 피부 부작용에 영향을 미치지 않을 것으로 사료된다. 그리고 치료 중 또는 치료 간 위치변화 감소의 장점은 치료 표적이 작고 결정 장기가 밀접한 경우 S-mask의 두경부 치료 적용은 유용할 것으로 사료된다. Purpose : When head&neck cancer radiation therapy, thermoplastic mask is applied for patients with fixed. The purpose of this study is to evaluate usefulness of thermoplastic mask for SRS in tomotherapy by conparison with the conventional mask. Materials and Methods : Typical mask(conventional mask, C-mask) and mask for SRS are used to fix body phantom(rando phantom) on the same iso centerline, then simulation is performed. Tomotherapy plan for orbit and salivary glands is made by treatment planning system(TPS). A thick portion and a thin portion located near the treatment target relative to the mask S-mask are defined as region of interest for surface dose dosimetry. Surface dose variation depending on the type of mask was analyzed by measuring the TPS and EBT film. Results : Surface dose variation due to the type of mask from the TPS is showed in orbit and salivary glands 0.65~2.53 Gy, 0.85~1.84 Gy, respectively. In case of EBT film, -0.2~3.46 Gy, 1.04~3.02 Gy. When applied to the S-mask, in TPS and Gafchromic EBT3 film, substrantially 4.26%, 5.82% showed maximum changing trend, respectively. Conclusion : To apply S-mask for tomotherapy, surface dose is changed, but the amount is insignificant and be useful when treatment target is close critical organs because decrease inter and intra fractional variation.

Mycobacterium fortuitum에 의한 피부감염증

전성진,서기석,김상태,유경식,박인달,장명웅 ( Seong Jin Jeon,Kee Suck Suh,Sang Tae Kim,Gyung Sig Yoo,In Dal Park,Myung Woong Chang ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.5

We report a case of cutaneous Mycobacterium fortuitum infection occurring in a 53-year-old man with multiple subcutaneous nodules on his right thigh and right lower leg. He has been treated with long-term systemic corticosteroids for his nephrotic syndrome. He had no constitutional symptoms and no lymphadenopathy. Laboratory findigs were within normal limits except for abnormal values for nephrotic syndrome. The skin biospy specimen showed a mixed pattern of epithelioid granuloma with micropseudocyst containing acid-fast bacilli. Methenamine silver stain was negative. The cultures from the skin biopsy specimens on Ogawa media(3% KH_2PO_4) at 24℃, 32℃, 37℃, yielded colonies of M. fortuitum after 4 days. Culture on Sabouraud media revealed no growth. DOPA reaction was negative. Nitrate reduction test was positive and Tween 80 hydrolysis test was negative. Urine and sputum cultures for atypical mycobacteria were negative. This M. fortuitum was sensitive to amikacin or tetracycline. Four months later, the skin lesions regressed without therapy.

국가과학기술종합정보서비스(NTIS)-지역기술혁신지원서비스

전성진,Jeon, Seong-Jin 한국과학기술정보연구원 2008 지식정보인프라 Vol.30 No.-

구입경로가 다른 두 종류의 육미지황탕을 투여한 흰쥐의 혈액분석연구

전성진,이선동,박해모,최종환,이현우,Jeon, Seong-Jin,Lee, Sun-Dong,Park, Hae-Mo,Choi, Jong-Hhan,Lee, Hyean-Woo 대한예방한의학회 2005 대한예방한의학회지 Vol.9 No.2

Traditional herbal medicine is widely used among the Korean people, and other eastern Asian countries employ similar therapies as well. In recent years, due to increasing interest in herbal medicine, many researches have been made on the toxicity and adverse drug reactions of herbal medications. Through private and public media, there have been many opinions that taking herbal medicine is very harmful, especially, to liver and kidney. We face upon evaluation of herbal medication, safe, and efficacy. Furthermore, we need to control quality of herbs. This study aims to verify the evidence that taking herbal medicine will yield equal reaction in 2 lab animal groups (A and B). One frequently prescribed herbal medication, Yugmijihwangtang, was used to test the evaluation of quality on lab animals (SD-Rat). There were no significant differences in body, visceral weight, and serum analysis test results after herbal medication for 1 month. But, AST and ALT scores were raised in 2 subjects in group A (over reference range). It seems to be an adverse drug reaction, and this finding was restricted in group A herbal medicine. These results suggest that we need to qualify herbal plants in Korea, and study which herbs would cause specific reactions in human.

버드나무가지 열분해 생성물(바이오차)을 이용한 Cu 제거에 관한 연구

전성진 ( Seong Jin Jeon ),양재규 ( Jae Kyu Yang ),장윤영 ( Yoon Young Chang ) 한국물환경학회(구 한국수질보전학회) 2011 공동 추계학술발표회 Vol.2011 No.-

단일 큐비트 parity check 를 이용한 양자 얽힘 정화기법 분석

전성진(Jeon Seong Jin),정혜단(ZHENG HUIDAN),허준(Heo Jun) 한국통신학회 2023 한국통신학회 학술대회논문집 Vol.2023 No.6

Annular Elastolytic Giant Cell Granuloma

전성진(Seong Jin Jeon),서기석(Kee Suck Suh),김상태(Sang Tae Kim) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.1

Annular elastolytic giant cell granuloma(AEGC(3) has been called as atypical necrcibiosis lipoidica, Mieschers granuloma of the face and scalp, and actinic granu- Joma and needs differen(iation from granuloma annulare, elastosis perforans serpiginosa and nerrobiosis lipoidica. We report a case of AECCG occurring in a 53-year-old male. The patient. had an annular erythematous plaque measuring 4 cm in diameter with serpiginous raised edges and slightly atrophic centers on the right forearm for 5 years. The histopathologic finding showed patchy dermal infiltration of lymphocytes, histiocytes, and multinucleated giant cells engulfing elastic fibers. The. skin lesion cleared after intrader mal injection cf cortieosteroids. (Kor J Dermatol 29(1): 86--90, 1991)

특발성 치은 섬유종증 및 다모증

전성진(Seong Jin Jeon),김광(Kwang Kim),채영수(Young Soo Chae),서기석(Kee Suck Suh),김상태(Sang Tae Kim) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.1

Idiopathic gingival fibromatosis is associated with other abnorma ities of which the most striking is hypertrichosis of variable degree. Gorlin and Pindborg described this condition as a distinct syndrome termed idiopathic gingival fibromatosis and hypertrichosis. We report a case of idiopathic gingival fibromatosis and hypertrichosis occuring in 34-year-old woman with enlarged gingival tissue, hypertrichosis, and enlargenment of the breasts, ears and nose. Laboratory tests including hormonal and chromosomal studies were all within normal limits. Histologically, the gingival hyperplastic tissue showed thick bundle of collagen fibers with few fibroblasts or capillaries and little or no inflammatory infiltrate. (Kor J Dermetol 1993; 31(1): 118-122)

십전대보탕과 육미지황탕이 실험동물의 태자에 미치는 독성학적 연구

한상백,전성진,신헌태,박해모,이선동,박철수,Han, Sang-Baek,Jeon, Seong-Jin,Shin, Heon-Tae,Park, Hae-Mo,Lee, Sun-Dong,Park, Chul-Soo 대한예방한의학회 2008 대한예방한의학회지 Vol.12 No.3

Purpose : To evaluate safety of Sibjeondaebotang and Yugmijihwangtang in rats' fetus Methods : Female Sprague-Dawley rats were orally administered with the Sibjeondaebotang and Yugmijihwangtang at dose of 5mg/kg/day for 20 days. Pregnant rats were sacrificed at 20th day of gestation. Approximately live fetuses in the 20th day of gestation were randomly selected and fixed in 95% ethanol. To observe skeletal malformations, fetuses were stained with alcian blue and alizarin red S. Results : Neonatal body weight and number of fetus of Sibjeondaebotang, Yugmijihwangtang group were increased to those of control group. The fetuses treated with Sibjeondaebotang, Yugmijihwangtang didn't showed external malformation. Vertebral and sternal skeletal variations were observed in Sibjeondaebotang, Yugmijihwangtang administered group, but compared to the control, those skeletal variations were insignificant. There were no significant changes in number of ribs, cervical, thoracic, lumbar, sacral and caudal vertebrae Conclusion : From these results, it can be concluded that Sibjeondaebotang, Yugmijihwangtang shows no toxicity effects on fetus body weight and number of live fetuses. Although skeletal variations were shown in vertebrate and sternum, Sibjeondaebotang, Yugmijihwangtang did not show significant changes in bone malformation.