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조직학적으로 확진한 결핵성 복막염 환자의 복수 Adenosine deaminase ( ADA ) 활성도에 관한 연구
배선우(Seon Woo Bae),진춘조(Choon Jo Jin),심영학(Young Hak Shim),신계철(Kye Chul Shin),권상옥(Sang Ok Kwon),김남동(Nam Dong Kim),차신웅(Shin Woong Cha),이광훈(Kwang Hoon Lee),장우익(Woo Ick Jang) 대한내과학회 1989 대한내과학회지 Vol.36 No.1
N/A Recent investigations have suggested that the measurement of ADA activities in various body fluids is useful in the diagnosis of tuberculous effusion. In this study, ascitic fluid ADA activities were measured in 18 cases of tuberculous peritonitis, 18 cases of malignant ascites and 33 cases of liver cirrhosis with ascites. The results obtained were as fallows: 1) The mean ADA activity in tuberculous peritonitis was 184.96±27.55U/L, in malignant ascites 22.35±3.10U/L and in liver cirrhosis 7.37±0.61U/L. 2) The ADA activity in tuberculous effusion was significantly higher than in the rest of the groups(p<0.001). 3) The malignant effusion show no significant difference with transudative effusion(p>0.05). 4) As a screening test for tuberculous peritonitis, the ADA activities above 50-70U/L had a sensitivity and specificity of 100%. In conclusion, the measurement of ascitic fluid ADA activity may be a simple and reliable screening test for the diagnosis of tuberculous peritonitis.
결핵성 뇌막염 진단에 있어서 뇌척수액 Adenosine Deaminase 활성도에 관한 연구
배선우(Seon Woo Bae),김원천(Won Tsen Kim),전근재(Geun Jae Jeon),성낙억(Nak Uk Sung),최경규(Kyung Gui Choi),최일생(Il Saing Choi) 대한내과학회 1988 대한내과학회지 Vol.34 No.4
N/A The prognosis of tuberculous meningitis is closely linked to the stage at which treatment is started. The cerebrospinal fluid findings, however, are often ambiguous, It has been suggested by recent investigations that ADA activities in cerebrospinal fluid may help differentiate tuberculous meningitis from aseptic meningitis. In this study, cerebrospinal fluid adenosine deaminase activities were measured in 23 cases of tuberculous meningitis, 9 cases of aseptic meningitis, 9 cases of purulent meningitis, 24 cases of miscellaneous neurologic conditions and 23 cases of normal controls. The results obtained were as follows: 1) The mean ADA activity in tuberculous meningitis was 17.39±10,34 U/L, in bacterial meningitis 7.87±8.52 U/L, in aseptic meningitis 2.83±1.92U/L, in miscellaneous neurologic conditions 2.80±5.61U/L and in control 1,09±0.51U/L. 2) The ADA activitiies in tuberculous meningitis showed significantly higher values than in other groups (P<0.001), 3) Cerebrospinal fluid ADA activities differentiated tuberculous meningitis from those with aseptic meningitis being higher than 4.5U/L in all and higher than 6.5U/L in 96% case of tuberculous meningitis, but lower than 6,5U/L in aseptic meningitis and less than 3.5U/L in normal controls. 4) In tuberculous meningitis, ADA activities showed significant correlation with protein in cerebrospinal fluid (P<0.01), but in other groups, no significant correlation with available routine parameters in cerebrospinal fluid. It is suggested that measurement of ADA activity in cerebrospinal fluid is a available test which is relatively easily performed for diagnosis of tuberculous meningitis, especially differential diagnosis with aseptic meningitis.