두개인두종에 대한 감마나이프 방사선수술

장종희,장진우,박용구,정상섭,Chang, Jong Hee,Chang, Jin Woo,Park, Yong Gou,Chung, Sang Sup 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.5

Objective : The purpose of this study are to evaluate the effectiveness of Gamma Knife radiosurgery(GKS) as a treatment of craniopharyngioma and to investigate the proper dose planning technique in GKS for craniopharyngioma. Method : Between May 1992 and March 1999, seven Gamma Knife radiosurgical procedures were done for residual tumor mass of 6 patients with craniopharyngioma after microsurgical resection. Conventional radiation therapy was not performed. In this study, their clinical, radiological and radiosurgical data were analyzed and the radiation dosage to the optic pathway, hypothalamus, pituitary stalk, and cavernous sinus were calculated and correlation with clinical outcome was evaluated. The mean follow-up period was 33.5 months(12.3-55.2 months). Result : The mean tumor volume was 4.4cc(0.4-18.0cc) and the maximum radiation dose ranged from 14 to 32 Gy(mean 20.9Gy). The radiation was given with isodose curve, 50-90% and the marginal dose varied within 8-22.4Gy(mean 12.7Gy). The mean number of isocenter was 4.3(1-12). The tumor was well controlled in all cases. In 5 of 7 cases, the size of tumor decreased to 10-50% of pre-GKS volume and remaining two showed no volume change. The mean dose to optic pathway was 5.7Gy(5.1-11.2Gy) and there were no complications. Conclusion : GKS seems to be effective for control of craniopharyngioma as an adjuvant treatment after microsurgical resection and even suboptimal dose for tumor margin is considered to be enough for tumor control. It is safe with careful dose planning to protect surrounding important structures, especially optic pathway. We believe conventional radiation therapy should be avoided because it has limitation for dose planning of additional treatments such as radiosurgery or intracystic instillation of radioisotope in case of recurrence.

외식업 종사자의 감정부조화가 잔류의도에 미치는 영향

장진우(Chang, Jin-Woo),박진영(Park, Jin-Yung),김명희(Kim, Myung-Hee) 한국호텔외식관광경영학회 2015 호텔경영학연구 Vol.24 No.7

호텔구성원이 지각하는 직무불안이 이직의도에 미치는 영향 -사회적 교환관계 질을 조절변수로-

박진영 ( Jin Young Park ),장진우 ( Jin Woo Chang ),전병철 ( Byung Chul Jeon ) 경기대학교 관광종합연구소 2016 여가관광연구 Vol.25 No.-

본 연구에서는 호텔구성원 들의 직무불안과 익직의도에 대한 집중적 검증을 위하여 인지적 직무불안, 정서적 직무불안의 두 가지 관점으로 일반화 하여 이직의도와의 관계를 검증 하였다 또한 이들의 관계에 영향을 미치는 사회적 교환관계의 POS, LMX, TMX에 따라 조절관계를 알아보았다. 연구결과는 인지적 직무불안과 정서적 직무불안은 이직의도에 정적인 영향을 미치는 것으로 나타났으며 구성원들은 인지적, 정서적 직무불안이 느낄수록 이직 의도는 높아진다. 사회적 교환관계인 POS는 인지적, 정서적 직무불안과 이직의도 간의조절효과에 대해 기각되었으며 LMX, TMX는 조절효과를 나타내 채택되었다. 따라서 조직은 개인의 직무불안 문제를 단순한 차원이 아니라 조직적 차원과 연결시켜 생각해 보아야 할 것이다. Also affecting the social relationship of these in this study were verified to assist the separation of the two terms of the relationship between generalized anxiety cognitive affective job job insecurity, in order to verify the degree of focus on ikjik of hotel member job insecurity and the exchange relationship POS, evaluate the relationship adjustment in accordance with the TMX, LMX,. Findings appeared to affect positively the cognitive task of separation anxiety and affective job insecurity and cognitive, affective job insecurity increased turnover intention members feel better. LMX, TMX was adopted showed a moderating effect of social exchange relationship that POS is cognitive, affective job insecurity and turnover of dismissal was for a moderating effect between. Therefore, you should consider the organizational dimension by dimension rather than a simple connection problem of job insecurity is a private organization.

2.4/5.8GHz 이중 대역 코프래너 급전 평면형 모노폴 능동 안테나 설계

김준일,장진우,이원택,지용,Kim, Joon-Il,Chang, Jin-Woo,Lee, Won-Taek,Jee, Yong 대한전자공학회 2007 電子工學會論文誌-TC (Telecommunications) Vol.44 No.8

본 논문은 2.4/5.8GHz 이중 대역 수신용 능동 안테나 설계 구조를 제시하였다. 제시된 능동 안테나는 한 개의 초광대역(Ultra Wideband, UWB) 안테나를 이용하여 2.4GHz 영역과 5.2GHz 영역에서 수신 및 증폭이 동시에 이루어지게 하는 구조이다. 각 동작 영역에서 초광대역 안테나의 출력단과 능동 소자 입력단 사이의 상호 임피던스 정합은 직접 연결법에 의해 이루어지게 하였으며 직접 연결법에 의한 동작 주파수에서의 임피던스 정합은 평면형 초광대역 안테나의 급전선로 길이를 변화시켜 구현하였으며 안테나의 코프래너 급전선로 길이는 $1/20{\lambda}0$(@5.8GHz) 이내로 설정하였다. 구현된 수신용 능동 안테나의 주파수 대역폭$(VSWR{\leq}2)$은 2.4GHz 동작 주파수에서 $2.0\sim3.1GHz$, 5.8GHz 대역에서 $5.25\sim5.9GHz$로 이루어졌다. 실험 결과 2.4GHz에서 17.0dB 및 5.2GHz에서 15.0dB의 이득(gain)이 측정되었고 1.5dB의 잡음지수(noise figure, NF)가 측정되었다. This paper presents design methods for dual-frequency(2.4/5.8GHz) active receiving antennas. The proposed active receiving antennas are designed to interconnect the output port of a wideband antenna to the input port of an active device of High Electron Mobility Transistor directly and to receive RF signals of 2.4GHz and 5.2GHz simultaneously where the impedance matching conditions are optimized by adjusting the length of $1/20{\lambda}_0$(@5.8GHz) CPW transmission line in the planar antenna The bandwidth of implemented dual-frequency active receiving antennas is measured in the range of 2.0GHz to 3.1GHz and 5.25GHz to 5.9GHz. Gains are measured of 17.0dB at 2.4GHz and 15.0dB at 5.2GHz. The measured noise figure is 1.5dB at operating frequencies.

터어키안 주변종양에 대한 감마나이프 방사선 수술

장종희,장진우,박용구,정상섭,Chang, Jong Hee,Chang, Jin Woo,Park, Yong Gou,Chung, Sang Sup 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.10

Objective : Around the sellar area, there are many important structures. But, the optimal radiation dosage for minimal toxicity to surrounding neural tissue has not been firmly established. The purpose of this study is to evaluate the radiosurgical outcome of juxtasellar tumors and to investigate the relationship between radiation dosage and toxicity to neural tissue. Method : Between May 1992 and June 2000, we treated 65 juxtasellar tumors by using the Leksell Gamma Knife. Among them, 52 patients who could be followed more than 1 year were included in this study. The radiosurgical dosage to the optic pathway, cavernous sinus, Meckel's cave, hypothalamus, pituitary gland and stalk, and brain stem was analyzed and correlated with clinical outcome. The mean follow-up period was 33.5 months(range 12.2- 99.0 months). Result : The clinical response rate was 69.2%. The volume response rate was 61.0% and the radiologic control rate was 92.7%. There were 4 complications(7.7%) of 2 trigeminal neuropathy, 1 abducens nerve palsy, and 1 trigeminal and transient abducens nerve palsy. The optic apparatus appeared to tolerate doses greater than 10Gy. The risk of cranial nerve complications in cavernous sinus seemed to be related to doses of more than 16Gy. In 3 of 4 patients who received more than 16Gy to cavernous sinus, the abducens or trigeminal neuropathy occurred. Also, one patient who received more than 15Gy to the Meckel's cave, trigeminal neuropathy developed. The hypothalamus, pituitary gland and stalk, and brain stem were relatively tolerable to radiation. Conclusion : Gamma Knife radiosurgery seems to be an effective method to control the growth of juxtasellar tumors. To avoid injury to surrounding important neural tissue, careful dose planning and further study for radiation toxicity to neural tissue were needed.

초광대역(UWB) Coplanar Waveguide 급전 L자 평면형 모노폴 안테나 설계

김준일,이원택,장진우,지용,Kim, Joon-Il,Lee, Won-Taek,Chang, Jin-Woo,Jee, Yong 한국전자파학회 2007 한국전자파학회논문지 Vol.18 No.1

본 논문에서는 집적회로 구성을 위 한 초광대역(ultra wideband: UWB) coplanar waveguide(CPW) 급전 L자 평면형 모노폴 안테나 구조를 제시한다. 제안된 CPW 급전 초광대역 L자 평면형 모노폴 안테나는 유전체 기판(${\varepsilon}_{r}=3.38,\;@10\;GHz$)을 이용하여 설계 및 제작되었으며 안테나의 $50{\Omega}$ 급전 선로와 방사면이 RFIC 설계에 적합하도록 동일한 평면 위에서 인쇄되었다. 설계된 안테나의 임피던스 대역폭($VSWR{\leq}2$)은 3.0 GHz로부터 11.0 GHz였으며 전형적인 모노폴 안테나의 방사 패턴이 측정되었다. 안테나의 임피던스 대역폭에 해당하는 주파수 이득(gain)은 $1.4{\sim}4.6\;dBi$로 측정되었고 RFIC 설계에 적합한 초광대역 안테나로 동작하고 있음을 확인할 수 있었다. This paper presents a coplanar waveguide fed L-planar type monopole antenna which covers ultra wideband(UWB) region of 3.1 GHz to 10.6 GHz. The proposed UWB L-planar type monopole antenna is designed and implemented on the organic substrates( ${\varepsilon}_{r}=3.38,\;@10\;GHz$). The radiation elements, feed line, and ground planes of the antenna are printed on the same conductive layer of the substrates. The bandwidth of the proposed antenna is measured in the range of 3.0 GHz to 11.0 GHz. The measured radiation patterns are symmetrical in E-plane and omni-directional in H-plane. Antenna gains ranges from 1.4 dBi to 4.6 dBi. The proposed UWB antenna shows that the structure is adequate for the design of RFIC.

반측성 안면경련증 환자에서 안면신경의 미세혈관감압술 후에 시행한 자기공명영상의 역할

한인보,장종희,장진우,박용구,김동익,정상섭,Han, In Bo,Chang, Jong Hee,Chang, Jin Woo,Park, Yong Gou,Kim, Dong Ik,Chung, Sang Sup 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.1

Objectives : The objective of this study was to investigate the role of postoperative three dimensional short-range magnetic resonance angiography(3D-TOF MRA) in predicting the clinical outcomes following microvascular decompression(MVD) for the treatment of a hemifacial spasm(HFS). Material and Method : Postoperative magnetic resonance(MR) imaging was performed on 123 patients with a HFS between March 1999 and May 2000. All patients who had postoperative MR imaging were undertaken preoperative MR imaging. Of the 123 patients, 122 patients were included in this retrospective study. The degree of the detachment of vascular contact, and change of the position of offender were determined by pre- and postoperative 3D-TOF MRA. These findings were compared with the surgical findings and clinical outcomes. Results : Of 122 patients who had successful MVD, clear decompression of offenders of the root entry zone(REZ) of facial nerve was found in 106 patients(86.9%), partial decompression in 10 patients(8.2%) and contact of offenders to the REZ of facial nerve in 6 patients(4.9%) by the postoperative 3D-TOF MRA. Our patients demonstrated that the types of offender did not influence with the degree of decompression of REZ of facial nerve and with surgical outcomes(p>0.05). Also, there was no significant relationship between the degree of decompression of the REZ of facial nerve from offenders and an improvement of symptoms(p>0.05). Futhermore, there was no significant relationship between the degree of decompression of the REZ of facial nerve from offenders and an improvement time (p>0.05). Conclusion : Our data suggests that MVD of facial nerve alone may not be sufficient to resolve the symptoms in all patients with hemifacial spasm. Therefore, another unknown factors besides vascular compression may be involved to cause symptoms in certain patients and it may be necessary to remove these factors with MVD simultaneously to obtain the resolution of symptom.

아데노 바이러스 Cytosine Deaminase/Thymidine Kinase 융합 유전자의 항 종양효과

김영우,최재영,장진우,박용구,정상섭,Kim, Young Woo,Choi, Jae Young,Chang, Jin Woo,Park, Yong Gou,Chung, Sang Sup 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.1

Objective : We investigated the feasibility of a double suicide gene/prodrug therapy, involving direct introduction of the herpes simplex virus Type 1 thymidine kinase(TK) gene and the Escherichia coli cytosine deaminase(CD) gene, via a recombinant adenoviral vector and ganciclovir(GCV) and/or 5-fluorocytosine(5-FC) treatment, in C6 glioma cells. Methods : Efficient gene transfer and transduction of C6 glioma cells via a recombinant adenovirus were evaluated by infecting cells with adenovirus bearing the ${\beta}$-galactosidase gene and then staining cells with 5-bromo-4-chloro-3-indolyl-13-D-galactoside. CD/TK expression in cells infected with adenovirus bearing the CD/TK gene(ad-CD/TK) was examined by immunoblotting analysis. For in vitro cytotoxicity experiments, the cells were infected with ad-CD/TK or ad-${\Delta}E1$(as a control). After addition of a variety of concentrations of GCV and 5-FU, either separately or in combination, cell viability was determined by staining the cells with crystal violet solution 6 days after infection. Result : C6 glioma cells were efficiently transduced with recombinant adenoviral vector at multiplicities of infection of 200 or more. In vitro cytotoxicity of GCV and/or 5-FC, either alone or in combination, was exclusively observed in the cells transduced with ad-CD/TK. Obvious cytotoxicity(>50% inhibition) was observed in the presence of 5-FC at concentrations greater than 30ug/ml or GCV at concentrations greater than 0.3ug/ml at a multiplicity of infection of 100. Additionally, cytotoxicity in the presence of both GCV and 5-FC was greater than that after sinlge-prodrug treatments, indicating additive effects of the prodrug treatments. Conclusion : The administration of a double-suicide gene/prodrug therapy might have great potential in the treatment of brain tumors.

초광대역 평면형 모노폴 안테나를 이용한 능동 안테나 다이플렉서의 설계

김준일,이원택,장진우,지용,Kim, Joon-Il,Lee, Won-Taek,Chang, Jin-Woo,Jee, Yong 한국전자파학회 2007 한국전자파학회논문지 Vol.18 No.9

본 논문은 초광대역 코프래너 급전 모노폴 안테나를 이용한 능동 안테나 다이플렉서 구조를 제안한다. 제안된 다이플렉서 구조는 초고주파 시스템 집적 패키지 기술(RF System on Package: RF-SoP)을 이용한 것으로서 평면형 초광대역 모노폴 안테나와 능동 소자를 직접 연결법에 의해 연결하여 다이플렉서(diplexer)를 형성하는 방식이다. 이는 안테나 회로 성분과 능동 소자의 패키지 회로 성분으로 형성되는 통과 대역을 이용함으로써 별도로 추가된 대역 통과 필터 등의 회로 구조 없이 다이플렉서를 내장하여 구성하는 방식이다. 따라서 입력된 수신 신호의 주파수 대역에 따라 동작 회로가 분리되며, 분리된 수신 신호가 능동 소자의 동작에 의해 증폭되는 능동 안테나 다이플렉서(diplexer)로서 구성된다. FR-4 에폭시 기판 위에서 제작된 능동 안테나 다이플렉서의 특성을 측정한 결과, 2.4 GHz 수신 단자에서는 0.9 dB의 삽입 손실(insertion loss), 1.1 GHz(2.0{\sim}3.1\;GHz)$ 대역폭, 17.0 dB의 수신 신호 증폭 특성을 보여주었으며, 5.8 GHz 수신 단자에서는 0.8 dB의 삽입 손실, 650 MHz$(5.25{\sim}5.9\;GHz)$ 대역폭, 15.0 dB의 수신 신호 증폭 특성을 보여주었다 또한 -10.0 dB 이상의 주파수 분리(isolation) 특성과 -20.0 dB 이상의 고조파 성분(harmonics) 감쇄 특성을 나타내어, 제시된 능동 안테나 다이플렉서 구조가 설계된 동작을 하고 있음을 알 수 있었다. This paper presents active antenna diplexers implemented into an ultra-wideband CPW(Coplanar Waveguide) fed monopole antennas. The proposed active antenna diplexer is designed to direct interconnect the output port of a wideband antenna to the input port of two active(HEMT) devices, where the impedance matching conditions of the proposed active integrated antenna are optimized by adjusting CPW(Coplanar Waveguide) feed line to be the length of 1/20 $\lambda_0$(@5.8 GHz) in planar type wideband antenna. The measured bandwidth of the active integrated antenna shows the range from 2.0 GHz to 3.1 GHz and from 5.25 GHz to 5.9 GHz. The measured peak gains are 17.0 dB at 2.4 GHz and 15.0 dB at 5.5 GHz.

골화를 동반한 만성 경막외혈종 - 증례보고 -

심규원,장종희,장진우,박용구,김태승,정상섭,Shim, Kyu Won,Chang, Jong Hee,Chang, Jin Woo,Park, Yong Gou,Kim, Tai Seung,Chung, Sang Sup 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.7

We report a case of 15 year-old female patient with a ossified chronic epidural hematoma. She had had head trauma 10 weeks previously and conservative care for delayed onset epidural hematoma at other hospital. Ossification was identified about 4 weeks after head injury and then progressed rapidly. We removed the chronic epidural hematoma with thick capsule and newly formed bone. The mechanism of the ossification associated with cephalhematoma and chronic subdural hematoma is reviewed and discussed.