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인체 폐암 세포주에 대한 무의 에탄올 추출물의 세포독성
임효빈(Hyo-Bin Yim),이건순(Gunsoon Lee),채희정(Hee Jeong Chae) 한국식품영양과학회 2004 한국식품영양과학회지 Vol.33 No.2
무의 에탄올 추출물을 이용하여 폐암에 대한 세포 독성을 조사하였다. 청운 무를 무줄기와 무뿌리로 나누어 수세, 정선, 탈수한 후 에탄올과 물(5 : 5, v/v)의 혼합용매로 추출하고 폐암 세포주 A-549를 사용하여 MTT(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide)법을 사용하여 항암 활성을 분석하였다. 각 well의 570 nm에서의 흡광도를 측정하고 대조군의 흡광도에 대한 백분율을 산출하였다. 실험 결과 무줄기 추출물과 무뿌리 추출물은 모두 A-549에 대한 세포 독성을 가지고 있었다. 무줄기 추출물의 IC_(50)(50% inhibitory concentration)은 0.015%이었고 무뿌리 추출물의 IC_(50)은 0.03%이었다. 동일 농도(0.01%)에서 무줄기 추출물이 무뿌리 추출물보다 A-549에 대한 항암활성이 더 뛰어났다. This study was designed to investigate the cytotoxic effect of ethanonl extract of radish, Raphanuse sativus on human lung cancer cell lines (A-549) using MTT(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay. Radish trunk and radish root were extracted by a mixed solvent of water and ethanol (5 : 5, v/v) after drying. The extracts were used for anticancer activity assay. IC_(50) (50% inhibitory concentration) of radish trunk and radish root were 0.015% and 0.03%, respectively. Radish trunk extract showed higher anticancer activity than radish root extract at the same concentration of 0.01%.
납에 노출된 흰쥐에서 Chlorella 섭취가 혈청내 지방성분 및 효소활성에 미치는 영향
김성조,백승화,이주돈,김운성,문광현,임효빈,허종욱,정성윤 한국식품영양학회 2001 韓國食品營養學會誌 Vol.14 No.2
This study was performed to investigate the influence of Chlorella which effected the change of Pb contents, enzyme activity and lipid compounds on the rats fed the beverage involved Pb and the different contented Chlorella added-diets for 18weeks. The rat's weight of 200ppm Pb group was decreased 6.04% and the cause of that was Pb intake. But the rat's weight of Chlorella added-diets+200ppm Pb group was increased 4.02%(p<0.01). When feeding the different(0%, 2%, 5%, 10%) Chlorella added-diets with the Pb contented beverage to the rats, we could know that the Pb contents accumulated on tissue were decreased to 20.70(0%), 12.88(2%), 14.83 (5%) and 19.56(10%), compared with the quantity of Pb taken in. Total-cholesterol, triglyceride, glucose content and AST, ALT, ALP, LDH enzyme activity in serum were the highest on 200ppm Pb group and those were decreased by the order of different (2%∼5%>10%) Chlorella contents +200ppmPb group. A significance was recognized on the level of 1%. Therefore, when rats were exposed to Pb, it was thought that the amount of Chlorella intake was adequate on content 2∼5% for reducing the lead toxicity.