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症例(증례) : 골수에서 발생한 CD34, CD99를 동반 발현하는 원시성 신경외배엽 종양
임호영 ( Ho Young Yhim ),김성식 ( Sung Sik Kim ),민경훈 ( Kyung Hoon Min ),이나리 ( Na Ri Lee ),송은기 ( Eun Kee Song ),곽재용 ( Jae Yong Kwak ),최삼임 ( Sam Im Choi ),임창열 ( Chang Yeol Yim ) 전북대학교 의과학연구소 2004 全北醫大論文集 Vol.28 No.1
Primitive neuroectodermal tumor (PNET) is a small round cell neoplasm that develops in children and young adults. The identification of immunoreactivity for CD99 is important for diagnosis of PNET. But, there have been no reports that PNET is immunoreactive for CD34. Therefore, we report a case of PNET developed in a 26 year-old man, which occurred primarily in the bone marrow. He was presented with hypercalcemia and pancytopenia. Bone marrow aspiration biopsy revealed that tumor cells were composed of round cells with hyperchromatic unclear chromatin and minimal eosinophilic cytoplasm. Rosette formations were occasionally observed. The tumor cells were diffusely immunopositive for CD99 and CD34, while they were immunonegative for vimentin, neuron specific enolase, cytokeratin, desmin, leukocyte common antigen, synaptophysin. He was treated with chemotherapy after general medical supportive care, and still alive during the 6 months of follow-up.
증례 : 형액종양 ; 진행성 골수섬유화증을 동반한 역형성 대세포 림프종 환자에게 시행된 자가 말초혈액 조혈모세포 이식 1예
이나리 ( Na Ri Lee ),송은기 ( Eun Kee Song ),임호영 ( Ho Young Yhim ),장규윤 ( Kyu Yun Jang ),최삼임 ( Sam Im Choi ),임창열 ( Chang Yeol Yim ),곽재용 ( Jae Yong Kwak ) 대한내과학회 2010 대한내과학회지 Vol.79 No.1
Myelofibrosis is a myeloproliferative neoplasm characterized by abnormal bone marrow megakaryocyte proliferation with reticulin and collagen fibrosis, leukoerythroblastosis, anemia, increased level of serum lactate dehydrogenase and splenomegaly. Myelofibrosis associated with malignant lymphoma is rare and survival rates appear to have been poor. Herein, we describe our experience in a patient who remained in complete remission with high-dose therapy (HDT) with autologous peripheral blood stem cell transplantation (PBSCT) for ALK-negative ALCL presenting with rapidly progressing myelofibrosis. (Korean J Med 79:77-81, 2010)
혈액질환치료에 있어 동종말초조혈모세포와 배양확장된 간엽모세포(Mesenchymal Stem Cell)의 동시이식 2예
강석윤,김재홍,박준성,김현수,최진혁,임호영,양말숙,김영진,김효철 대한조혈모세포이식학회 2001 대한조혈모세포이식학회지 Vol.6 No.1
Human bone marrow contain two kinds of stem cells. One is hematopoietic stem cell, and the other is multipotential mesenchymal stem cells which are capable of differentiating into a number of mesenchymal cell lineages. These mesenchymal stem cells are shown to secrete hematopoietic cytokines and support hematopietic progenitors in vitro. Animal models suggest that the transplantation of healthy stromal elements, including mesenchymal stem cells, may enhance the ability of the bone marrow microenvironment to support hematopoiesis after stem cell transplantation. Therefore, We hypothesized that cotransplantation of hematopoietic stem cells and mesenchymal stem cells after high dose chemotherapy would facilitate engraftment of hematopietic stem cells and reduce complications caused by delayed engraftments. And we investigated the safety, feasibility, side effects and hematopoietic effects of in vitro-expanded mesenchymal stem cells in hematologic malignancies receiving allogeneic peripheral stem cell transplantation.