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메틸수은으로 손상된 골모세포에 대한 홍와의 효과에 관한 연구
민부기,홍기연,오연균,신용일,한선희,이상복,신민교,전병훈,송호준,류도곤,박승택 대한동의생리학회,대한동의병리학회 2002 동의생리병리학회지 Vol.16 No.4
To evaluate the osteotoxic effect of methylmercuric chloride(MMC) on cultured mouse osteoblasts, cytotoxic effect was measured by MTT assay after cultured mouse osteoblasts were incubated with various concentrations of MMC for 20 hours. The protective effect of Flos Carthami(FC) against MMC-induced osteotoxicity was also examined in these cultures. MMC decreased cell viability of cultured mouse osteoblasts remarkably in a dose- and time-dependent manners. In protective effect of FC was remarkably effective in blocking the osteotoxicity induced by MMC. From aboved the results, it is suggested that MMC induce osteotoxicity, and the selective herba extract such as FC is very effective in blocking MMC-mediated neurotoxicity on cultured mouse osteoblasts.