고지혈증에서 유전적 지표 및 생화학적 지표를 이용한 식사요법 및 심바스타틴 치료 효과의 분석

임정은(Jung eun Yim),조여원(Yoe Won Choue),김영설(Young Seol Kim),오승준(Seung Jun Oh),팽정령(Jeong Ryung Paeng) 한국지질동맥경화학회(구 한국지질학회) 2000 韓國脂質學會誌 Vol.10 No.2

N/A N/A

궤양성 손톱주위염 양상으로 발생한 경성하감 1예

임정은 ( Jung Eun Yim ),권형목 ( Hyeong Mok Kwon ),김혜리 ( Hye Ri Kim ),신동훈 ( Dong Hoon Shin ),최종수 ( Jong Soo Choi ) 대한피부과학회 2021 대한피부과학회지 Vol.59 No.1

Syphilis is a highly contagious sexually transmitted disease, and early diagnosis and prompt treatment significantly affect the prognosis. Syphilis usually presents with genital lesions in the early stages; therefore, extragenital syphilitic lesions can easily be misdiagnosed. A 20-year-old man presented with a 1-month history of a worsening hyperkeratotic black crusted ulcerative plaque on the right 4^th finger, with distorted periungual structures. Histopathological examination showed epidermal hyperplasia, mild endothelial swelling, and numerous plasma cells in the dermis. Excessive dermal infiltration of plasma cells suggested primary syphilis, which necessitated additional serological tests; the patient showed positive results on Venereal Disease Research Laboratory and Treponema pallidum hemagglutination testing. The lesion significantly improved after an intramuscular injection of 2.4 million units of benzathine penicillin G. We report a rare case of primary syphilis involving the finger in a patient with clinical features of ulcerative paronychia. (Korean J Dermatol 2021;59(1):67∼69)

우리나라 다빈도 섭취 과일의 당 함량 및 혈당지수에 관한 연구

유지현(Ryu Ji-Hyun),임정은(Yim Jung-Eun),석완희(Suk Wan-Hee),이한송이(Lee Hansongyi),안혜진(Ahn HyeJin),김영설(Kim Young-Seol),박천석(Park Cheon-Seok),조여원(Choue Ryowon) 韓國營養學會 2012 Journal of Nutrition and Health Vol.45 No.2

Fruits are generally recommended for a balanced meal, as they are good sources of vitamins, minerals, and fiber, which may improve blood glucose control. However, fruits have simple sugars with a wide glycemic index (GI) range. The purpose of this study was to analyze the sugar content and composition and to determine the glycemic indices of the most frequently consumed fruits in Korea, including apple, tangerine, pear, water melon, persimmon, grape, oriental melon, and peach. The sugar content and composition of the fruits were analyzed by high performance anion-exchange chromatography (Dinonex model DX-600). The GI of the fruits was measured in 13 healthy subjects (seven females and six males) after permission was received from the University Hospital institutional review board (KHU-IRB 1114-06). The subjects consumed 50 g of glucose as a reference and carbohydrate portions of eight fruits. Blood samples were collected at 0, 30, 60, 90, and 120 min after consuming the fruits. The GI values for the fruits were calculated by expressing the increase in the area under the blood glucose response curve for each subject. As a result, the total sugar contents of 100 g fruits were: grape (13.9 g), apple (12.3 g), persimmon (11.9 g), oriental melon (11.2 g), watermelon (9.3 g), tangerine (8.9 g), peach (8.6 g), and pear (8.3 g). The GI values of the fruits were as follows: GI value of peach (56.5 ± 14.17), watermelon (53.5 ± 18.07), oriental melon (51.2 ± 18.14), tangerine (50.4 ± 15.16), grape (48.1 ± 14.05), persimmon (42.9 ± 18.92), pear (35.7 ± 14.38), and apple (33.5 ± 11.92). These findings will help individuals choose fruit for controlling blood sugar. (Korean J Nutr 2012; 45(2): 192 ~ 200)

한국 과체중 및 비만 여성의 휴식대사량 측정 및 예측값의 비교

박지숙(Ji-Sook Park),임정은(Jung-Eun Yim) 대한지역사회영양학회 2018 대한지역사회영양학회지 Vol.23 No.5

연구논문 : 한국인 다빈도 섭취 과일의 영양관련 지수 분석

유지현 ( Ji Hyun Ryu ),임정은 ( Jung Eun Yim ),임현정 ( Hyun Jung Lim ),조여원 ( Ryo Won Choue ) 한국식생활문화학회 2014 韓國食生活文化學會誌 Vol.29 No.6

Fruits are good sources of vitamins, minerals, fiber, and phytochemicals, which are known to reduce serum lipids, oxidative damage, and blood pressure as well as improve blood glucose control. The purpose of this study was to estimate nutrient quality indices of fruits by carrying out a critical analysis of pre-existing methods according to their nutritional compositions. Four methods were used to assess the nutrient indices of 26 fruits, which are frequently consumed by Koreans based on the fourth Korean National Health and Nutrition Examination Survey (2009). Naturally nutrient rich score (NNR), nutrient rich food (NRF), nutrient adequacy score (NAS), and nutrient density score (NDS) were used to calculate nutrient quality indices. The Korean Nutrition Society Food Composition database of fruits based on 100 g edible portions was used. The algorithm of each method included the mean percentage of daily values (Dietary Reference Intakes for Koreans, 2010) for particular nutrients based on consumption of 1,900 kcal/day. The relative score indicated that strawberries, kumquat, and lemon had high nutrient quality indices. In addition, mango, lemon, persimmon, strawberry, apricot, and tangerine fruits are rich in antioxidant nutrients such as β-carotene, vitamin C, vitamin E, and selenium. However, scores of nutrient quality indices did not imply that higher scores of particular fruits are superior. We suggest moderate seasonable consumption a variety of fruits. Our results can be used as a reference for consumers when they choose fruits.

아토피피부염 영아에서 유아식 유형에 따른 임상증상, 영양상태 및 면역지표의 변화

조여원 ( Ryo Won Choue ),이은영 ( Eun Young Lee ),류경아 ( Kyoung A Ryu ),임정은 ( Jung Eun Yim ),이하백 ( Ha Baik Lee ),오재원 ( Jae Won Oh ) 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.1

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease that commonly begins in the early age of life, and AD and food allergy often simultaneously occur in the same patient. Objective: The purpose of this study was to investigate the effects of soy formula as compared with extensively hydrolyzed cow`s milk formula in infants with AD. Method: Subjects were supplemented with extensively hydrolyzed cow`s milk formula (HCF group, n=16) or soy formula (SF group, n=13) through dietary counseling for 12 weeks. The degree of severity of AD symptoms were measured using the scoring atopic dermatitis (SCORAD) index. Cow`s milk allergy was confirmed on the basis of a history of allergic reaction to cow`s milk, a positive result from skin prick test (SPT), and the presence of immunoglobulin E (IgE) antibodies to cow`s milk. Dietary assessment were performed. Anthropometric indices were compared with standard values of growth and development for Korean children. Blood samples were collected to analyze RBC fatty acids composition and immune markers. Result: The AD infants` weights and heights were within normal range. The SCORAD index after 12 weeks improved significantly (P<0.01). The composition of DHA of erythrocyte decreased in the HCF and SF groups. There were no significant differences in changes of total serum IgE concentration between both groups. Serum levels of IL-5, IL-13 and TNF-α decreased significantly after the supplementation of extensively hydrolyzed cow`s milk. Conclusion: Extensively hydrolyzed cow`s milk and soy formulas may support normal growth of infants and improved the symptoms of AD to the same degree. Prospective long-term studies are needed to investigate the significant effects and the mechanism of each formula in AD infants. (Korean J Asthma Allergy Clin Immunol 2007;27:33-42)

한국성인의 제2형 당뇨병 유무에 따른 체액 조성 차이 및 영양소 섭취량 분석

김유경(Yu-Gyeong Kim),최하늘(Ha-Neul Choi),임정은(Jung-Eun Yim) 한국영양학회 2023 Journal of Nutrition and Health Vol.56 No.4

본 연구는 한국인을 대상으로 제2형 당뇨병 환자와 질병이 없는 정상대조군을 비교하여 성별에 따른 체액 불균형 정도와 영양소 섭취량을 평가하고자 하였다. 조사대상자는 총 57명으로, T2DM이 있는 T2DM군 (n = 36)과 T2DM이 없는 정상대조군 (n = 21)으로 나누어 분석하고, 성별에 따른 체액량의 차이를 고려하여 남성 T2DM군 (n = 24), 남성 정상대조군 (n = 9), 여성 T2DM군 (n = 12), 여성 정상대조군 (n = 12)으로 세분화하여 지표들의 특징을 분석하였다. BIA를 통하여 연구대상자의 체액 조성을 분석한 결과, ECW/ICW는 T2DM군이 정상대조군보다 유의적으로 높았고, 부종지수를 나타내는 ECW/TBW는 T2DM군이 정상대조군보다 유의적으로 높게 나타났다. 성별에 따른 체액 조성을 분석한 결과, 남성과 여성 모두 T2DM군은 정상대조군보다 높은 ECW/ICW, ECW/TBW를 보이며 동일한 체수분율 양상이 나타났다. 식사일기를 통해 연구대상자의 영양소 섭취량을 분석한 결과, 1,000 kcal 당 탄수화물, 식이섬유, 비타민 A, 비타민 C, 나트륨, 칼륨 섭취량은 T2DM군이 정상대조군보다 많았고, 1,000 kcal 당지방, 콜레스테롤 섭취량은 T2DM군이 정상대조군보다 적었다. 본 연구를 통해 T2DM 환자에게서 체액 불균형이 나타날 가능성이 높음을 알 수 있었으며 추후 당뇨 합병증의 평가, 진단의 기초 자료로 널리 활용될 것으로 사료된다. Purpose: Diabetes mellitus (DM) causes body fluid imbalance because of hyperglycemia, but there is a lack of research on the relationship between DM and body fluid imbalance in the Korean population. This study compared the differences in body fluid composition and dietary intake between individuals with type 2 DM (T2DM) and a normal control (NC) group without the disease. Methods: In this study, 36 subjects with T2DM and 21 without diabetes were divided into the T2DM and NC groups. The subjects were divided into four subgroups to assess differences in body fluid volume according to sex: men T2DM group (n = 24), men NC group (n = 9), women T2DM group (n = 12), and women NC group (n = 12). The body fluid composition was measured using bioelectrical impedance analysis, including intracellular water (ICW), extracellular water (ECW), total body water (TBW), ECW/ICW, and ECW/TBW. Nutrient intake was evaluated using their dietary records. Results: The results showed that the ECW/ICW and the ECW/TBW were significantly higher in the T2DM group compared to the NC group. Both men and women in the T2DM group showed significantly higher ECW/ICW and ECW/TBW than the respective NC group. The T2DM group had a higher carbohydrate, dietary fiber, vitamin A, vitamin C, sodium, and potassium intake per 1,000 kcal and lower total daily energy, fat, and cholesterol intake per 1,000 kcal than the NC group. Conclusion: These results suggest a positive association between T2DM and body fluid imbalance. This study can be used widely as basic data for the evaluation and diagnosis of diabetic complications in the future.

비만과 고도비만 한국 여성의 혈청 페리틴과 비타민 D 수준의 비교

강난희(Nan Hui Kang),박지숙(Ji Sook Park),이홍찬(Hongchan Lee),임정은(Jung-Eun Yim) 한국영양학회 2020 Journal of Nutrition and Health Vol.53 No.4

본 연구는 국내 비만과 고도비만 여성의 혈청 영양소 수준을 관찰하고자 시행하였다. 본 연구 결과를 통해 비만인과 고도비만인의 비만 예방 및 관리 지표로서의 혈청 영양소와의 관련성을 파악하고자 하였다. 본 연구의 대상자의 연령은 만18세 이상에서 59세 이하 성인 여성이며 서울 B 외과의원 비만클리닉에서 제공된 ID에 의하여 판별되는 2차 가공된 자료로 병원에서 환자의 동의를 받고 후향적으로 자료를 분석하여 총 44명을 대상자로 선정하였다. 본 연구는 BMI의 지표를 활용하여 BMI가 25.0–29.9 ㎏/㎡의 비만을 비만군, 30.0 ㎏/㎡ 이상의 고도 비만을 고도비만군으로 구분하여 비만군 23명, 고도비만군 21명을 분석하였다. 연구 대상자들의 신장과 체중, BMI, SMM, BFM, PFM을 체성분 분석을 통해 조사하였고, 혈중 생화학적 지표와 엽산, 비타민 B12, 25(OH)D₃, 철, 페리틴 수준을 분석하였다. 비만군과 고도 비만군의 연령, 체중, BMI 및 체조성 중 체지방량, 체지방률은 비만군이 유의적으로 낮게 나타났으며 신장은 고도 비만군에서 유의적으로 낮게 나타났다. 생화학적 지표 검사결과 AST, ALT, 당화혈색소, 총 콜레스테롤, 중성지방은 대부분 정상 범위에 해당하였으며 두 군 사이의 유의적 차이가 나타나지 않았다. 비만과 관련된 혈청 영양소 수준을 조사한 결과 혈청 엽산, 비타민 B12, 25(OH)D₃, 철, 페리틴의 수치는 대부분 정상 범위에 해당하며 두 군 간의 유의적인 차이는 없었다. 본 연구에서 비만과 고도비만 성인 여성의 혈청 영양소 수준은 유의적 차이가 없는 것으로 나타났다. 국내에서 비만 예방이나 치료를 위한 근거를 마련하기 위해서 비만과 영양소의 관련성에 대해 보다 심도 깊은 전향적 연구가 필요할 것으로 사료된다. Purpose: This study examined the relationships among serum ferritin, vitamin D, folate, iron, and vitamin B12 as indicators of obesity. The results provide the basic data for the prevention and treatment of obese and severely obese people. Methods: This study selected 44 people from 18 years of age or older to 59 years. This study used the indicators of the body mass index (BMI) to analyze obesity as the obesity group (BMI of 25.0–29.9 ㎏/㎡) and as the severe obesity group (BMI ≥ 30.0 ㎏/㎡). Of the 44 subjects, 23 and 21 subjects were in the obesity and severe obesity groups, respectively. Their height, weight, body fat, skeletal muscle mass measured using bioimpedance analysis, and measured serum nutrients and biochemical parameters. Results: The obesity group showed a significantly lower age, body weight, BMI and body composition, body fat mass, and body fat percentage, and the height was significantly lower in the severe obesity group. The results of the biochemical parameters of the subjects showed that the levels of aspartate transaminase, alanine transaminase, hemoglobin A1c, total cholesterol, and triglyceride were within the normal range, and there was no significant difference between the 2 groups. The levels of folate, vitamin B12, 25-hydroxyvitamin D3, iron, and ferritin were almost normal, and there was no significant difference between the 2 groups. Conclusion: This study revealed an association with the serum nutrients and obesity, but there was no difference between the obesity group and severe obesity group. Observations of the nutrient levels in not only the blood in obesity and severe obesity but also in red blood cells and tissues will be necessary.

고지혈증에서 유전적 지표 및 생화학적 지표를 이용한 식사요법 및 심바스타틴 치료 효과의 분석

임정은,조여원,김영설,오승준,팽정령 한국지질학회 2000 韓國脂質學會誌 Vol.10 No.2

영양상담 및 약물 ( HMG Co A reductase inhibitor ) 의 병용치료가 고지혈증 환자의 혈중 지질농도에 미치는 영향

조여원,임정은,김영설 한국지질학회 1998 韓國脂質學會誌 Vol.8 No.1

Background: The purpose of this study was to examine the effects of dietary counceling and drug therapy on the blood levels of lipids, lipoproteins, apolipoprotein, and Lp(a), atherogenic index, and coronary risk factor values. Study subjects consisted of 34 hyperlipidemic out-patients of Kyung Hee Medical Center, Seoul, Korea. Methods: Dietary counceling was carried out by the experienced nutritionist every 2 weeks for 3 monthes. Nutrient intakes were measured by 24-h recall method of 2 weekdays and one weekend through a personal interview. The patients were instructed to follow a hypolipidemic and hypocholesterolemic diets. Compliances were monitored through food diary and personal interviews. Results: The dietary patterns of the patients were changed, white meat and fish were substituted for fatty- and red-meat products; increased consumption of vegetables, legume, and fruits; reduced egg consumption; and avoid sweets and pastries. Compared with the basal diet, the aftered diets have less calories, fats, and cholesterol, and more complex carbohydrates and fiber. Serum triglyceride levels were decreased by 11% and 22% after dietary counceling and drug (simvastatin, 10㎎) threapy, respectively. After dietary counceling, the reductions in total cholesterol, LDL-cholesterol, Apo A-I, Apo B were 5%, 7%, 4%, and 8%, respectively. After drug treatments, reductions in total cholesterol, LDL-cholesterol, Apo B were 11%, 19%, and 17%, respectively. Serum HDL-choletserol was increased by 5% and 31% after dietary counceling and drug treatments, respectively. Serum Lp(a) was increased by 7% and 14% after dietary counceling and drug treatments, respectively. Atherogenic index was decreased by 12% and 36% after dietary counceling and drug treatments, respectively. Coronary risk factor value was decreased by 23% and 38% after dietary counseling and drug treatments, respectively. Conclusion: As a conclusion, dietary therapy should be done prior to drug therapy and concomittantly with drugs to treat hyperlipidemic patients. During the dietary counseling, the food habits and food selection patterns of the patients were changed, and the changes lead to a positive effect on serum lipid profiles. Retricting total daily calories and cholesterol through dietary counseling prior to drug therapy could be very effective to lower the serum triglyceride level. The drug thrapy showed the distinctive reductions in serum Mglyceride, total cholesterol, LDL-cholesterol, and Apo B levels. In addition, Coronary risk factors can be used with Atherogenic Index as a new hyperlipidmic risk index.