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한국인 뚜렛장애에서 환자군과 가족군간의 COMT 유전자 다형성의 연관성
임원석(Won Seok Lim),임명호(Myung Ho Lim),송은영(Eun Young Song),박미영(Mi Young Park),김종완(Jong Wan Kim),김태현(Tae Hyun Kim),심세훈(Se Hoon Shim),박태원(Tae Won Park),김현우(Hyun Woo Kim) 대한소아청소년정신의학회 2009 소아청소년정신의학 Vol.20 No.1
Objectives : Tourette disorder is known to be a disease with a strong genetic trait. There has been some recent research on the relationship between the allelic frequency distribution and Tourette disorder. In Korea, the relationship between the genetic type and the alleles for the COMT gene has been studied in Tourette patients. Methods : Seventy two patients who were diagnosed with Tourette disorder according to the DSM-IV diagnostic criteria were selected for this study. The diagnosis and clinical features were confirmed by the Yale Global Tic Severity Scale. For the control group, the parents of the patients were chosen. Blood samples were taken from the 289 subjects. DNA was extracted from the blood lymphocytes and PCR was performed for assessing COMT gene. Results : On comparing the Tourette disorder transmitted group and the not-transmitted group, no significant difference was seen between the COMT genetic type and the allelic distribution. Conclusion : Even though this result is viewed that there is no relationship between Tourette disorder and the COMT gene, it is difficult to firmly accept this negative result. Follow up studies with a larger patient population or pure subgroups are expected in the future.
일광 비노출 부위에 발생한 Papular Elastolytic Giant Cell Granuloma
임원석 ( Won Suk Lim ),김도훈 ( Do Hun Kim ),진상윤 ( Sang Yun Jin ),최윤석 ( Yun Seok Chol ),이애영 ( Ai Young Lee ),노지현 ( Ji Hyeon Rho ),이승호 ( Seung Ho Lee ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.8
Papular elastolytic giant cell granuloma is an unusual variant of annular elastolytic giant cell granuloma, characterized by the development of asymptomatic, multiple, small erythematous papules on both sun-exposed and non-sun-exposed area. Histopathologically, it shows a granulomatous infiltration, accompanied by the absence of the elastic tissue and phagocytosis of elastic fibers by multinucleated giant cell. An 83-year-old man was presented with a 1 year history of multiple erythematous papules on his abdomen and lower legs. Histopathologic finding showed a non-palisading granulomatous infiltration with multinucleated giant cells and engulfing elastic fibers. We, herein, report an unusual case of papular elastolytic giant cell granuloma, which occurred on non-sun-exposed skin.
박형우,임원석,배명진,Park, Hyung-Woo,Lim, Won-Seok,Bae, Myung-Jin 한국음향학회 2012 韓國音響學會誌 Vol.31 No.6
현대사회를 살아가는 사람들은 버스나 지하철과 같은 대중교통에서나 백화점이나 할인점 같은 다수의 사람이 모이는 환경에서 순전히 타의에 의해 온갖 소음에 노출된다. 이런 환경에서 휴대전화나 PMP 등 개인 휴대용 단말기 사용이 늘어나면서 공공장소에서 소음 문제는 점점 심각해지고 있다. 사람들은 소음환경 속에서 휴대기기를 이용해 원활한 정보교환을 위해 일반적으로 소음보다 15 dB이상 큰 음압으로 휴대기기를 구동하고 있다. 이러한 휴대기기의 음압을 측정해보면 110 dB까지 발생하고 있으며, 이렇게 발생한 음압은 사용자에게 소음성 난청을 유발시키고, 주변사람에게 또 다른 소음문제를 발생시킨다. 이러한 문제를 해결하기 위해 골전도 시스템을 이용한 방법을 제안한다. 본 논문에서는 휴대전화에 일반스피커와 함께 골전도 스피커와 골전도 마이크를 사용해 피드백을 통한 보상을 하였고, 이 방법에 의해 주변 소음의 영향을 줄이고 휴대전화 음질 향상하는 방법을 제안한다. 제안한 방법으로 휴대전화 사용자 주변의 소음에 대한 영향을 줄이고 통화 음질을 향상해 약 17 dB의 성능 향상효과를 확인하였다. Today, people are exposed to the various noisy environments, such as in the buses, subway and supermarkets where there are a lot of people. The noise issue is getting more serious as people want to use portable sound equipment and mobile phones even under this noisy condition. People want to use the portable equipment to exchange the information freely and they set the volume as 15dB higher than the noise around them, which almost reach at 110 dB. That amount of sound can cause noise induced deafness to the users and another issue to the others as additional noise source. A Bone-conduction system can be a solution to reduce noise and enhance voice signal of mobile phone. In this paper, we propose the way of cancelling noise and enhancing speech signal of mobile phones, by installing bone-conduction feedback system with ordinary mobile phones. With this system, we can reduce the environment noise and enhance the voice quality of mobile phones. Using this method, we can enhance the signal by around 17 dB.
정전사고 사례분석을 통한 고속도로 운영 위험비용 산정에 대한 연구
권용훈,김경주,임원석,박찬진,채명진,Kwon, Yong-Hoon,Kim, Kyong-Ju,Lim, Won-Seok,Park, Chan-Jin,Chae, Myung-Jin 한국건설관리학회 2009 건설관리 : 한국건설관리학회 학회지 Vol.4 No.3
오늘날 고속도로 운영은 IT를 기반으로 하는 복잡한 Digital Infrastructure이다. 이러한 IT의 활용은 점점 많아지고 있는데, 예측 불가능한 운영위험이 발생할 경우 IT의 편리함만큼이나 피해가 예상외로 커질 수 있다. 고속도로 운영 위험은 도로의 운영이 중단되어 도로이용자들이 서비스를 제공받지 못하는 것이다. 운영위험은 예상하지 못한 과다한 운영관리비 및 유지관리비의 발생으로 계획된 운영비를 초과하는 것이며, 운영수입의 손실을 가져온다. 그 결과 이용자 안전의 위험과 운영자의 부실을 초래하게 되는데, 기존의 연구는 이를 추정할 수 있는 방법에 대한 연구가 미흡한 실정이다. 따라서 본 연구에서는 디지털화된 고속도로에서 대규모 정전사태가 발생할 경우 추가로 발생되는 운영비 항목을 구체적으로 제시하고 각 항목에 대한 예상 가능한 위험비용을 시뮬레이션 추정을 하고자 하였다. 이를 근거로 하여 운영위험을 방지하기 위한 비용예산과 운영계획 측면에서 방안을 제시하고자 하며, 향후 운영의 건전성을 확보할 수 있는 기초자료로 활용을 도모코자 한다. Recently, operation of highway is the complex digital Infrastructure based on complicated IT. The application of IT is increasing more and more in digital Infrastructure. Though IT is very convenient, if unpredicted operating risk of highway occurs, widespread damage can be large. When operating risk of highway occurs, road users are out of smoothly-run service because of the operating interruption. This risk causes unpredicted operating management cost and additional maintenance cost. It will excess over the planned operating cost, which may leads to users's unsafety and operator's insolvency because of income loss. Until now, related studies to find out the risk are not sufficient. The purpose of this study is to suggest risk cost items and to estimate the reasonable risk cost by using simulation method in case of occurring the huge power failure at the operating digitalized highway. This study indicates the several plans to hedge against risk cost and the management of highway project. From now on, it will be used as basic data to confirm the soundness of operating system in Digital Infrastructure.
최윤석 ( Yun Seok Choi ),임원석 ( Won Suk Lim ),진상윤 ( Sang Yun Jin ),이준호 ( Joon Ho Lee ),이애영 ( Ai Young Lee ),이승호 ( Seung Ho Lee ) 대한피부과학회 2011 大韓皮膚科學會誌 Vol.49 No.9
Pacinian neuroma, also known as hyperplasia and/or hypertrophy of pacinian corpuscles is a rare skin condition usually occurring in the hand. Although it is known to cause pain and tenderness on the affected skin, asymptomatic cases have also been reported. We report a 46-year-old male monk who presented with asymptomatic skin lesions of paler color than the adjacent normal skin on the tips of the fingers of both hands. The 3 mm punch biopsy conducted on the lesion showed an increased number of onion bulb-like structures with a nerve fiber in each center. The patient was diagnosed with pacinian neuroma and has been under regular follow up without treatment. (Korean J Dermatol 2011;49(9):847~849)
최윤석 ( Yun Seok Choi ),임원석 ( Won Suk Lim ),진상윤 ( Sang Yun Jin ),이준호 ( Joon Ho Lee ),이승호 ( Seung Ho Lee ),이애영 ( Ai Young Lee ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.9
Fixed drug eruption is a distinctive and clinically recognizable entity that is characterized by well-demarcated erythematous plaques recurring in exactly the same sites as on previous occasions. Unlike the pigmenting form of fixed drug eruption, nonpigmenting fixed drug eruption leaves no pigmentation when it resolves. We now report the case of a 44-year-old man who presented with diffuse ill-defined erythematous patches on both hands, feet and lower legs with a burning sensation, which is considered an atypical manifestation for fixed drug eruption. The patient had a history of similar skin lesions developing after medications on the corresponding regions. The patch test with suspected drugs showed negative reactions on both lesions and unaffected sites. The lesions were reproduced on the oral provocation test with codeine and resolved without pigmentation. The patient was diagnosed with nonpigmenting fixed drug eruption due to codeine. (Korean J Dermatol 2011;49(9):822~825)
최윤석 ( Yun Seok Choi ),임원석 ( Won Suk Lim ),진상윤 ( Sang Yun Jin ),이준호 ( Joon Ho Lee ),이승호 ( Seung Ho Lee ),최종순 ( Jong Sun Choi ),김어진 ( Eo Jin Kim ),이애영 ( Ai Young Lee ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.4
Atypical fibroxanthoma is an uncommon spindle cell tumor that has a clinically benign course despite the presence of bizarre xanthoma cells. A 90-year-old female presented with a 2-month history of an ulcerative plaque on the right cheek. The initial punch biopsy revealed a benign histological appearance with prominent xanthomatous cells, but the specimen excised afterwards showed malignant features with a spindle and epithelioid cell proliferation with pleomorphism and atypia. The tumor cells stained positively for vimentin and CD68, they were partially positive for CD99 and CD10 and they were negative for CD34, S100, p63, desmin and actin. We report here on a case of atypical fibroxanthoma masquerading as xanthogranuloma. (Korean J Dermatol 2011;49(4):360∼364)