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인병현 ( Byeong Hyun In ),이양덕 ( Yang Deok Lee ),이양근 ( Yang Keun Rhee ) 전북대학교 의과학연구소 2001 全北醫大論文集 Vol.25 No.2
연구 배경: 알레르기 질환에서 알레르겐을 확인하는 것은 알레르기 질환의 정확한 진단 뿐 아니라 그 원인적 치료를 위해 필요하다. 피부반응시험은 알레르기 질환의 원인 항원을 검색하는데 가장 기본적인 진단 도구로 사용되고 있으며, 국내외적으로 아토피 유무 판정과 역학적 조사를 비롯한 연구 목적으로도 널리 이용되는 방법이다. 그러나 연령이나 성별에 있어서 어떠한 차이가 있는지에 대해서는 연구가 미미한 실정이다. 저자들은 천식환자에서 피부단자 시험의 결과에 연령과 성이 어떠한 영향을 나타내는지를 알아보고자 이 연구를 시행하였다. 방법: 1998년 2월부터 2000년 2월 사이에 전북대학교병원 호흡기내과에서 기관지 천식으로 진단받은 570명의 환자를 대상으로 하였다. 피부단자시험은 영국 Bencard사의 제품을 이용하여 총 150여종 (흡인성 항원 97종, 음식물 항원 57종)의 알레르겐에 대하여 환자의 등에 시행하였다. 팽진의 평균 직경이 히스타민(1mg/ml)에 의한 대조반응과 비교하여 Northern (Scandinavian) Society에서 추천한 반정량 등급체계를 기준으로 2+이상을 양성으로 판정하였다. 결과: 피부단자시험결과, 내인성 천식은 275명 (남:134, 여:141)이었고 외인성 천식은 295명(남:144, 여:151)로 내인성 천식과 외인성 천식에서 남녀간 성비의 차이는 없었다. 외인성 천식환자에서 연령이 증가함에 따라 양성반응시험결과의 수가 감소하는 경향을 보였으나 성별에 따른 차이는 없었으며, 히스타민에 의한 팽진의 크기는 연령이 증가함에 따라 증가하였으나 성별에 따른 차이는 없었다. 결론: 본 연구에서는 피부단자시험의 결과가 연령에 의한 영향은 받았지만 성별에 따른 영향은 받지 않았다. Background: In clinical practice, the skin prick test is a commonly used procedure for assessing a specific sensitization. However, there were few data about the relationship between the atopy and age and sex. The purpose of the present study was to evaluate retrospectively the influence of aging process and sex on sensitization, determined by immediate hypersensitivity reaction. Method: We analyzed the skin prick test results of 570 asthma patients (265 males and 305 females) from February, 1998 to February, 2000. Subjects had a mean age of 55 ±7 (SD) yr. Skin prick tests were performed using 150 allergens (Bencard, U.K.); wheal size was measured at 20 min and compared with that produced by a histamine control. Skin prick test reactivity was defined as a mean wheal size ≥ 2+ according to Northern Society for Allergology recommended Semi-quantitative Grading Systems. Results: The following results were obtained. 1) 275 were intrinsic asthma (134 males and 141 females) and 295 were extrinsic asthma (144 males and 151 females). 2) Among the patients with extrinsic asthma, 32% had a mono-allergy, 22% were sensitized against two allergens, 16% against three, and 30% against four or more allergens. 3) The number of positive tests decreased with age. 4) There was no significant relation between the allergen sensitization and sex. 5) The size of the histamine-elicited reactions increased with age, but no differences were noted between males and females.
인병현 ( Byung Hyun Im ),박민찬 ( Min Chan Park ),최석훈 ( Suk Hoon Choi ),박용범 ( Yong Beom Park ),이수곤 ( Soo Kon Lee ) 대한류마티스학회 2002 대한류마티스학회지 Vol.9 No.4
In dermatomyositis, involvement of the skeletal muscles of upper esophagus has been reported in many literatures. However, a number of published reports have suggested that motility disturbances of distal esophagus may also be a cause of dysphagia in dermatomyositis and dysphagia in these cases are mainly caused by crico-pharyngeal obstruction or hypomotility of esophagus. The nutcracker esophagus is the one of common esophageal hypermotility disorders causing dysphagia which is characterized manometrically by high pressure in distal esophagus. Recently, we experienced a patient with dermatomyositis who had complained of dysphagia and was diagnosed as having nutcracker esophagus by mannometry. The association of nutcracker esophagus and dermatomyositis has not been reported in the literature. Moreover, the mechanism of nutcracker esophagus differs with that of esophageal involvement in dermatomyositis. Thereby, we report a patient with dermatomyositis who had nutcracker esophagus in the course of her disease.
폐암에 의한 폐절제 후 운동부하 폐기능 검사 - 4 주 및 6 개월 추적검사 -
인병현(Byeong Hyun In),문성기(Sung Gi Moon),김현중(Hyun Jung Kim),김형식(Hyeong Sik Kim),이홍(Hong Lee),이길홍(Kil Hong Rhee),이흥범(Heung Bum Lee),이용철(Yong Chul Lee),이양근(Yang Keun Rhee) 대한내과학회 1998 대한내과학회지 Vol.54 No.3
N/A Objectives: At present, the overall incidence of lung cancer is increasing, causing the age-adjusted lung cancer death rate to double every 15 years. Surgical resection of the tumor offers the best prospect of long-term survival in patients with lung cancer. Accurate prediction of postoperative ventilatory function should be helpful in determining in which patients the risk of surgery are acceptable. Exercise pulmonary function test has been widely applied to objective measure of work capacity, and can be extremely helpful for investigating exertional dyspnea. But no attempt is made to assess the contribution of the lung to be resected to performance, and it has been advocated as an additional predictor of postoperative complications. The present investigation was designed to evaluate the factors such as FEV1, FVC, VEmax, Vo2max, anaerobic threshold, heart rate reserve, breathing reserve and the corelation between FEV1 and VO2max at 4 weeks and 6months after resection in patients with lung cancer. Methods : The eighteen of patients with lung cancer who considered surgically resectable underwent progressively incremental exercise test to symptom-limited stage before opera-tion, and also have done at surgical resection after 4 weeks, and 6 momths. Measurements were made of metabolic, cardiorespiratory, blood gases and symptoms during exercise test. Results: 1) There were significant decreases in FEV1, FVC, VC2max, VE max in 4 weeks operation and were more decreased in FEV1, FVC, VE max with significance, but fall in VO2max without significance in 6 month after operation. 2) There was a significant correlation between the decrease of FEV1 and that of VO2max in 6 month after operation. Conclusions This result suggests that change of FEV1 is a relatively useful predictor of change in exercise performance after lung resection in 6 month after operation.
최정기,인병현,이흥범,이용철,이양근 의과학연구소 1999 全北醫大論文集 Vol.23 No.1
Chronic eosinophilic pneumonia is a rare disorder characterized by striking systemic and pulmonary ma-nifestations such as fever, weight loss, dyspnea, blood eosinophilia and peripheral opacities on chest radiog- raph. Roentgenographic lesion rapidly disappeared with corticosteroid and recurrence occasionally occured in the same location. Histopathologic feature of chronic eosinophilic pneumonia include dense aggregates of eosinophils, histiocytes, and multinucleate giant cells within alveolar spaces, interstitium, and bronchioles associated with scattered lymphocytes and plasma cells. Recently we had the opportunity to observe one case of chronic eosinophilic pneumonia combined with blood eosinophilic and one case without eosinophilia whose presentation resulted in diagnostic dejay so we reported these case with brief review of literature (Key Words : Chronic Eosinophilic Pneumonia)
전북지방 Allergy 환자에 대한 Allergen의 변화 : 1985년/1997년 1985년/1997년
최광호,최수미,인병현,이용철,이양근 의과학연구소 1999 全北醫大論文集 Vol.23 No.1
Allergens are by definition antigens which react with specific lgE antibodies. Allergens originate from a diverse range of animals, insects and plants, and it is now becoming increasingly apparent that various allergens have features in common. Skin tests provide a rapid and sensitive means of assessing the preseturies, with a substantial rise of up to 5% per annum in reported symptoms and diagnosed asthma occurring in chileren in Wales, England, Australia, and New Zealand. Those findings may reslut froma the air and industrial pollution, and increased exposure to allergen. Rhee reported allergens in Chonbuk provincial area by skin allergic test and specific lgE test at 1985. In this study, 339 patients were enrolled, we evaluated the changes of allergens in Chonbuk provincial area after 12 years from the previous document by skin allergic test and radioallergosorbent test(RAST). There were relatively decreased prevalence of house dust mite(25.3% in skin test, 23.5% in RAST) compared to 1985(66.15 in skin test. During about 10 years, there were many changes of population, occupation, and life style to the western. Which may affect the prevalence of allergic diseases and allergen types.