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이양근 의과학연구소 1989 全北醫大論文集 Vol.13 No.2
Bronchial challenge of allergen(ovalbumin)-sensitized guinea pigs induced a triphasic reduction in specific airways conductance (sGaW) with maximal reductions being observed at 2, 17 and 72hr. accompanied by infiltration of the airways with neutrophils at 17hr. and eosinophils at 17 and 72hr. Nedocromil sodium(100mg m^-1) inhaled before challenge inhibited the 2 and 17hr. sGaw response and the neutrophil influx. When inhaled 6hr. after challenge, Nedocromil inhibited the 17hr. sGaw response but not neutrophil influx. The sGaw response and eosinophil accumulation at 72hr. was also inhibited by Nedocromil given at this time. We suggest that Nedocromil sodium inhibit early and late asthmatic reacion and cellular infiltration provoked by allergen challenged guinea-pigs, and being of action of anti-asthmatic drug.
Overlap Between Asthma and COPD: Where the Two Diseases Converge
이양근,김소리 대한천식알레르기학회 2010 Allergy, Asthma & Immunology Research Vol.2 No.4
Asthma and chronic obstructive pulmonary disease (COPD) are traditionally recognized as distinct diseases, with some clearly separate characteristic. Asthma originates in childhood, is associated with allergies and eosinophils, and is best treated by targeting inflammation, whereas COPD occurs in adults who smoke, involves neutrophils, and is best treated with bronchodilators and the removal of risk factors. However, the distinction between the two is not always clear. Patients with severe asthma may present with fixed airway obstruction, and patients with COPD may have hyperresponsiveness and eosinophilia. Recognizing and understanding these overlapping features may offer new insight into the mechanisms and treatment of chronic airway inflammatory diseases.