재생불량성빈혈 환자에서 Klebsiella pneumonia에 의한 피부감염

정호주 ( Ho Joo Jung ),이지범 ( Jee Bum Lee ),김성진 ( Seong Jin Kim ),이승철 ( Seung Chul Lee ),원영호 ( Young Ho Won ),윤숙정 ( Sook Jung Yun ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.11

Klebsiella pneumonia is an opportunistic pathogen that can lead to severe diseases such as septicemia, pneumonia, urinary and hepatobiliary track infection, in mainly hospitalized, immunocompromised patients. It has been reported to produce cellulitis, ecthyma gangrenosum in cutaneous manifestions, which are more commonly induced by bacteremia and spreading from other internal organs than primary inoculation. Herein, we present a case of a 75-year-old man with aplastic anemia, which progressed to septic shock and secondary cutaneous infection caused by Klebsiella pneumonia, but showed similar skin lesions to systemic fungal infection with dispersed erythematous macules and vesicular change on the center of his erythema. (Korean J Dermatol 2013;51(11):885∼888)

얼굴피부염 환자에서 피부접촉검사 결과에 대한 고찰

정호주 ( Ho Joo Jung ),윤숙정 ( Sook Jung Yun ),이지범 ( Jee Bum Lee ),김성진 ( Seong Jin Kim ),이승철 ( Seung Chul Lee ),원영호 ( Young Ho Won ) 대한피부과학회 2013 大韓皮膚科學會誌 Vol.51 No.4

Background: Patch test is usually performed in order to differentiate allergic contact dermatitis from other facial skin diseases; however, there are only infrequent comparative studies regarding the positive allergens patch tested between allergic contact dermatitis and other facial skin diseases. Objective: The purpose of this study was to investigate the positivity of patch test in patients with facial dermatitis and to analyze the valid positive allergen patch tested in allergic contact dermatitis compared to other facial skin diseases. In addition, we evaluated the difference of positive allergen according to clinical features, such as age, sex, site of the lesion and duration of disease, in patients with allergic contact dermatitis. Methods: A total of 409 patients tested with facial dermatitis patch were retrospectively reviewed for medical recordings, including clinical features, occupational history, clinical photos and the results of a Korean standard series of patch tests. Results: Compared with other facial skin disease, patients diagnosed with allergic contact dermatitis showed higher rate in the patch test, responding to 2 or more allergens. They also had more statistically valid positive allergens, such as phenylendiamine base, cobalt, colophony, thimerosal and isothizolinone. In addition, there were a few allergens which revealed significant differences in the positivity of the patch test according to the clinical features in patients diagnosed with allergic contact dermatitis. Conclusion: Based on these results, we could receive help in order to classify the positive allergens as relevant allergens in the patch test for the differentiation of allergic contact dermatitis from other facial skin disease. (Korean J Dermatol 2013;51(4):233∼242).

소아 제2형 당뇨병에서 발생한 발진황색종

정호주 ( Ho Joo Jung ),윤숙정 ( Sook Jung Yun ),김성진 ( Seong Jin Kim ),이승철 ( Seung Chul Lee ),원영호 ( Young Ho Won ),이지범 ( Jee Bum Lee ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.4

Diabetes mellitus (DM) can be complicated by a variety of cutaneous manifestations. Various xanthoma can appear, according to different subtypes of hyperlipopoteinemia, which is caused by only primary causes, like familial hyperlipoproteinemia, but also secondary causes that is DM, thyroid gland disorder, and diet. Dermatologic findings may even precede any clinical or biological evidence of DM. Thus, cognition of specific dermatologic findings, like xanthoma, can help identify DM, especially in children. We report a case of type IV hyperlipoproteinemia and eruptive xanthoma, associated with DM in a 12-year-old female. She was diagnosed of type IV hyperlipoproteinemia, through a lipid profile, electrophoresis and eruptive xanthoma from a skin biopsy. Although she showed overweight in BMI and had a mother with Type 2 DM, she was too little to have DM, and showed normal urine test. We examined thyroid function test and fasting blood sugar to rule out secondary hyperlipoproteinemia. Fasting blood sugar was increased enough to diagnose her with DM. (Korean J Dermatol 2012;50(4):374∼376)

Intense Pulsed Light와 Metronidazol 국소도포로 치료한 경증의 딸기코종 1예

정호주 ( Ho Joo Jung ),윤숙정 ( Sook Jung Yun ),김성진 ( Seong Jin Kim ),이승철 ( Seung Chul Lee ),원영호 ( Youn H Ho ),이지범 ( Jee Bum Lee ) 대한피부과학회 2013 大韓皮膚科學會誌 Vol.51 No.8

딸기코종(rhinophyma)은 결합조직과 피지샘이 점진적으로 증식하여 코의 하반부에 충혈된 비후성 결절이 형성되고, 모공이 확장되는 질환으로 정상적인 코의 모습에 심각한 변형을 초래하여 미용 및 기능적으로 일상생활에 지장을 줄 수 있다. 딸기코종은 약물 및 연고치료와 같은 일반적인 주사의 치료에 효과가 적으며 수술 및 레이저 등을 이용하여 결절을 직접적으로 제거하는 것이 주된 치료이다1,2. 환자는 50세의 남자로 내원 6년 전부터 주사로 진단받고 약물 및 연고치료를 지속하였으나 호전과 악화를 반복하였으며, 2년 전부터는 코 끝에 발진으로 시작하여 비후성 결절로의 진행 양상을 보이는 병변이 발생하여 내원하였다. 내원 당시 이마와 양쪽 뺨에 구진 및 농포가 산재해 있었으며 코 끝에 모공 확장 및 불규칙한 표면을 동반한 결절이 관찰되어 만성적인 구진농포성(papulopustular)주사로 인해 발생한 경증의 딸기코종으로 진단하였다(Fig. 1). 코와 이마, 양쪽 뺨의 병변에 처음 4개월간 2주 또는 3주 간격을 두고 intense pulsed light (Rex primeTM,Korea)로 치료(single mode, 560 nm, 13∼15 J) 시행하였으며 6회 치료 후부터 주사 및 딸기코종의 호전소견 관찰할 수 있었다(Fig. 2A). 그 후 2개월 간격을 두고 추가로 6회의 시술을 시행하였으며 metronidazol 0.75% gel (Rozexⓡ)은 IPL 치료 초기부터 코와 이마, 양쪽 뺨에 꾸준히 도포하도록 하였다. 치료 후 환자의 이마 및 뺨의 병변은 거의 호전 보인 상태로 재발은 없으며 딸기코종도 발진 및 모공의 감소와 함께 표면이 매끄러워지고 결절이 다소 감소한 양상을 보였다(Fig. 2B). Intense pulsed light (IPL)은 xenonlamp를 이용하여 여러 파장대의 광선을 조사하는 치료로서 안면 홍조와 주사의 치료에 있어 IPL은 비교적 안전하고 효과적인 치료법 중 하나이지만 피지샘과 섬유조직의 과증식이 주된 병적 소견인 딸기코종에서 IPL의 치료 효과는 아직까지 불분명하다3. Cribier4는 혈관의 불안정성으로 인한TGF-β1의 진피 내 국소상승이 딸기코종의 섬유화의 주된 원인일 수 있음을 보고하였으며 따라서 본 환자의 경우 560nm 파장대 이상의 빛을 조사하여 복합적인 효과를 기대할 수 있었던 IPL이 혈관 병변 및 교원질의 재형성(collagenremodeling)에도 도움을 주어 경증의 딸기코종의 악화를 억제할 수 있었을 것으로 판단된다. 또한 IPL과 병합한 국소 metronidazole도포는 항 염증효과가 있을 뿐 아니라 피지샘이 확장되어 있어 demodex의 집락이 용이한 딸기코종 환자에서병변의 악화를 억제하는데 역할을 하였을 것으로 판단된다5. 일반적으로 딸기코종은 비가역적인 진행을 하는 질환으로 알려져 있으며 본 환자에서와 같은 IPL과 metronidazol 국소도포가 섬유화나 피지샘의 증식을 효과적으로 감소시킬 수 있는 일반적인 치료는 아닐 것으로 생각된다. 하지만 초기경증의 딸기코종에 있어서는 이와 같은 보존적인 치료들로 악화를 억제하는 것이 본연의 코의 모습으로 회복하는 데 있어 도움이 될 수 있을 것으로 생각되어 보고하는 바이다.

최근 3년간 피부질환으로 응급실에 내원한 환자에 대한 통계학적 고찰(2010∼2012)

이현주 ( Heun Joo Lee ),정호주 ( Ho Joo Jung ),남재희 ( Jae Hui Nam ),박지혜 ( Ji Hye Park ),이가영 ( Ga Young Lee ),김원석 ( Won Serk Kim ) 대한피부과학회 2015 대한피부과학회지 Vol.53 No.1

Background: An increasing number of patients visit the emergency department (ED) for dermatological complaints. However, there is a paucity of data regarding the skin conditions presenting to the ED. Objective: This study aimed to describe the characteristics of skin complaints seen in the ED of a tertiary hospitalin Korea. Methods: We retrospectively reviewed 1,663 new dermatological emergency patients who visited the ED of ourhospital from January 2010 to December 2012. All skin conditions were diagnosed by a dermatologist and not byan emergency medicine specialist. Results: A total of 1,663 patients with skin problem were seen, corresponding to 1.5% of total ED visits. The meanage was 41.8 years and there was a slight female predominance (61.2%). The peak arrival time was between 9 pmand midnight. In terms of visit length, 68.9% of patients stayed less than 2 hours. Patients most commonly presentedwith urticaria/angioedema (53.8%) followed by herpes zoster (14.0%), contact dermatitis (7.2%), drug eruption(6.5%), and cellulitis/erysipelas (4.0%). Urticaria/angioedema patients were most commonly aged 21 to 40 years andherpes zoster patients were most commonly aged 51 to 70 years. Admissions occurred in 8.1% of cases, mostfrequently for herpes zoster. Conclusion: This retrospective study provides insight into the types of cases being evaluated by dermatologists inthe ED of a tertiary hospital. An awareness of these characteristics may assist physicians working in the ED inevaluating patients who present to the ED with skin disease. (Korean J Dermatol 2015;53(1):10∼15)

A New Analytical Method for Location Estimation Using the Directional Data

이호주,김영대,박철순,Lee Ho-Joo,Kim Yeong-Dae,Park Cheol-Sun The Korea Institute of Military Science and Techno 2004 한국군사과학기술학회지 Vol.7 No.4

This paper presents a new analytical method for estimating the location of a target using directional data. Based on a nonlinear programming (NLP) problem formulated for the line method, which is a well known algorithm for two-dimensional location estimation, we present a method to find an optimal solution for the problem. Then we present a two-stage method for better location estimation based on the NLP problem. In addition, another two-stage method is presented for location estimation problems in which different types of observers are used to obtain directional data based on the analysis of the maximum likelihood estimate of the target location. The performance of the suggested method is evaluated through simulation experiments, and results show that the two-stage method is computationally efficient and highly accurate.

현장실무용 확률 강우량의 산정

문호주(Mun Ho-Joo),송부호,서주석(Seo Ju-Seok),이종석(Lee Jong-Seok) 대한토목학회 2005 대한토목학회 학술대회 Vol.2005 No.10

단위임무 기반 로봇의 임무 계획 및 자동화 임무 관리 방법론

이호주,박원익,김도종,Lee, Ho-Joo,Park, Won-Ik,Kim, Do-Jong 한국군사과학기술학회 2014 한국군사과학기술학회지 Vol.17 No.1

In this paper, it is suggested a method of mission planning and management for robots based on the unit mission. In order to make robots execute given missions continuously as time goes by, a new concept for planning the mission which is composed of one or more unit missions and an automatic mission management scheme are developed. For managing robot's missions in real time, six management methods are devised as well in order to cope with the mismatches, which occur frequently during the mission execution, as to the initial plan. Without the operator's involvement, any mismatch can be adjusted automatically by applying one of the mission management methods. The suggested concept of mission planning and mission management methods based on the unit mission are partially realized in the Dog-Horse robot system and it is checked that it can be a viable one for developing effective robot operation systems.

방향탐지장비의 삼차원 최적 배치

이호주,김창근,강성수,Lee, Ho-Joo,Kim, Chang-Geun,Kang, Sung-Su 한국정보통신학회 2011 한국정보통신학회논문지 Vol.15 No.4

본 논문은 삼차원 공간에서 방향정보를 이용하여 위치측정을 위한 방향탐지장비의 최적배치 방법을 제시한다. 방향탐지장비는 전파를 발신하는 적의 위치를 탐지하는 장비로써 현재 육군에서 전력화되어 운용 중에 있다. 위치측정을 위해서는 두 대 이상의 장비를 동시에 운용해야 한다. 만일 한 대 이상의 장비를 공중에서 운용할 경우, 보다 나은 장비배치 형상을 이룸으로써 위치측정 정확도를 향상시킬 수 있다. 제안된 방법에서는 이차원 위치측정 알고리즘을 비선형계획법을 활용하여 삼차원으로 확장하고 수리적으로 그 해를 구하였다. 삼차원 위치측정 알고리즘을 토대로 시뮬레이션 기법과 탐색 기법을 융합한 최적배치 알고리즘을 고안하였다. 실험을 통하여 제안된 최적배치 방법은 적이 존재하는 지역에 대한 위치측정 정확도를 향상시킴으로써 방향탐지장비의 운용효과를 증대시킬 수 있음을 확인하였다. In this paper, a simulation-based method is presented to dispose direction finders in three dimensional space for locating targets using the directional data. A direction finder(DF) is a military weapon that is used to find locations of targets that emit radio frequencies by operating two or more DFs simultaneously. If one or more DFs are operated in the air, the accuracy of location estimation can be enhanced by disposing them in a better configuration. By extending the line method, which is a well-known algorithm for 2-D location estimation, into 3-D space, the problem of 3-D location estimation is defined as an nonlinear programming form and solved analytically. Then the optimal disposition of DFs is considered with the presented method in which methods of simulation and search technique are combined. With the suggested algorithm for 3-D disposition of DFs, regions in which targets exist can be effectively covered so that the operation effect of DF be increased.

디지털지형정보 기반의 실시간 자율주행 격자지도 생성 연구

이호주,이영일,박용운,Lee, Ho-Joo,Lee, Young-Il,Park, Yong-Woon 한국군사과학기술학회 2011 한국군사과학기술학회지 Vol.14 No.4

In this paper, a method of generating path planning map is developed using digitalized geographic information such as FDB(Feature DataBase). FDB is widely used by the Army and needs to be applied to all weapon systems of newly developed. For the autonomous navigation of a robot, it is necessary to generate a path planning map by which a global path can be optimized. First, data included in FDB is analyzed in order to identify meaningful layers and attributes of which information can be used to generate the path planning map. Then for each of meaningful layers identified, a set of values of attributes in the layer is converted into the traverse cost using a matching table in which any combination of attribute values are matched into the corresponding traverse cost. For a certain region that is gridded, i.e., represented by a grid map, the traverse cost is extracted in a automatic manner for each gird of the region to generate the path planning map. Since multiple layers may be included in a single grid, an algorithm is developed to fusion several traverse costs. The proposed method is tested using a experimental program. Test results show that it can be a viable tool for generating the path planning map in real-time. The method can be used to generate other kinds of path planning maps using the digitalized geographic information as well.