국립중앙도서관 귀중서고 내 알데히드류 및 휘발성유기화합물(VOCs)에 대한 건강위해성평가

이혜원,임희빈,이귀복,박소연,전정인,이철민,Lee, Hye-Won,Lim, Hui Been,Lee, Kwi-Bok,Park, So Yeon,Jeon, Jeong In,Lee, Cheol Min 한국환경과학회 2020 한국환경과학회지 Vol.29 No.6

This study investigates the concentration distribution of aldehydes and volatile organic compounds (VOCs) in the archive of the National Library in Korea and evaluates the health risks to workers from hazardous chemicals. Acetaldehyde had the highest concentration among the nine species of aldehydes present in the archive and the concentration of toluene was the highest among the six species of VOCs. Most of the detected substances showed that their indoor concentrations were higher than the outdoor ones, suggesting the possibility of indoor sources of aldehydes and VOCs. The evaluation of health risks for workers based on these measurement results showed that not all substances were hazardous to the human body. However, considering the possibility of the presence of indoor sources and the potential limits of our study owing its short period, it is necessary to conduct long-term studies on the concentration distribution of indoor pollutants in the archive environment.

유지 치주치료에 대한 환자 협조도 분석

이혜원,박진우,서조영,이재목,Lee, Hye-Won,Park, Jin-Woo,Suh, Jo-Young,Lee, Jae-Mok 대한치주과학회 2009 Journal of Periodontal & Implant Science Vol.39 No.2

Purpose: The purpose of this study was to evaluate the compliance to maintenance schedules recommended supportive periodontal therapy(SPT) and to determine differences in the characteristics of compliant and non-compliant patients. Methods: 414 patients commencing SPT after active periodontal treatment from 2003 to 2005 were included in this study. Based on their compliance with the suggested maintenance schedule, patients were classified as compliant and non-compliant groups. Also patients classified by gender, age, degree of alveolar bone loss and treatment rendered. The association between compliance and patient characteristics was assessed by odds ratio in logistic regression analyses. Results: Only 47% of the initial patient was found to be compliant at the end of August 2008 and 20.8% patients were lost in the first year of SPT. There were significant differences between compliant and non-compliant regard to age, degree of alveolar bone loss and treatment rendered. Conclusions: In conclusion, compliance with SPT generally poor and patients who were older, treated surgical therapy and with mild alveolar bone loss are more compliant to SPT.

장수풍뎅이 유충의 분변에 존재하는 방선균의 다양성 및 항균활성

이혜원,안재형,김민욱,원항연,송재경,이성재,김병용,Lee, Hye-Won,Ahn, Jae-Hyung,Kim, Minwook,Weon, Hang-Yeon,Song, Jaekyeong,Lee, Sung-Jae,Kim, Byung-Yong 한국미생물학회 2013 미생물학회지 Vol.49 No.2

방선균은 의약, 농업 및 식품 생산 등에 유용하게 사용되는 이차대사물질을 생산하는 미생물 자원으로 자연환경 내에서 많은 생물들과 긴밀한 상호작용을 유지하고 있다. 본 연구에서는 장수풍뎅이 유충의 분변에 존재하는 방선균의 다양성과 기능성을 조사하기 위해서 비배양적 접근과 배양적 방법으로 실험을 수행하였다. 먼저 시료로부터 직접 추출한 community DNA에서 방선균-특이 primer를 이용하여 방선균의 16S rRNA 유전자를 PCR로 증폭, 클로닝한 후에 각 clone에 삽입된 염기서열을 분석하였다. 총 37개의 염기서열을 얻었으며 계통분류학적 분석을 수행한 결과, 15속 24종으로 분류되었다. 아울러 53개의 방선균 균주를 장수풍뎅이 유충 분변으로부터 분리하였다. 형태학적 특징을 비교하여 최종적으로 27개의 균주를 선발하여 다양성, 항균활성 및 생화학적 특징을 검정하였다. 분리된 균주들은 4속 14종으로 분류되었으며, 24균주(89%)는 Streptomyces 속으로 분류되었다. 대다수의 균주들이 식물병원성 곰팡이와 그람양성 세균에 대해 길항 효과를 보였다. 또한 많은 균주들이 셀룰로오스와 카제인을 분해하는 생화학적 특징을 보였다. 본 연구를 통해, 장수풍뎅이 유충의 분변 시료로부터 다양한 방선균이 분리될 수 있으며, 분리된 균주들은 다양한 항균효과 및 효소활성을 지니고 있다는 것을 확인하였다. 결론적으로 본 연구는 장수풍뎅이와 같은 곤충의 장과 분변은 다양한 방선균의 서식처이며, 이곳에서 유용한 생리활성 물질을 발견할 수 있다는 것을 제시한다. Actinomycetes produce diverse secondary metabolites which have the primary importance in medicine, agriculture and food production, and key to this is their ability to interact with other organisms in natural habitats. In this study, we have investigated the taxonomical and functional diversity of actinomycetes in fecal sample of rhinoceros beetle larvae (Allomyrina dichotoma L.) by using culture-dependent and -independent approaches. For the culture-independent approach, the community DNA was extracted from the sample and 16S rRNA genes of actinomycetes were amplified using actinomycetes-specific PCR primers. Thirty-seven clones were classified into 15 genera and 24 species of actinomycetes. For the culture-dependent approach, 53 strains were isolated from larval feces, of which 27 isolates were selected based on morphological characteristics. The isolates were classified into 4 genera and 14 species, and 24 isolates (89%) were identified as the genus Streptomyces. Many of the representative isolates had antimicrobial activities against plant pathogenic fungi and Gram-positive bacteria. In addition, most of the isolates (78%) showed biochemical properties to hydrolyze cellulose and casein. The results demonstrated that diverse and valuable actinomycetes could be isolated from insect fecal samples, indicating that insect guts can be rich sources for novel bioactive compounds.

매쉬업을 적용한 기관 내 정보검색시스템 통합 방안 연구 - 국사편찬위원회 정보시스템을 중심으로 -

이혜원,윤소영,Lee, Hye-Won,Yoon, So-Young 한국과학기술정보연구원 과학기술정보센터 2011 Journal of Information Science Theory and Practice Vol.42 No.1

본 연구에서는 실시간으로 질의를 처리하고, 이용자의 요구에 보다 동적으로 응답한다는 장점을 가진 매쉬업을 이용하여 기관 내부 정보시스템을 통합검색하고자 하였다. 국사편찬위원회 기관 내부의 정보시스템 각각은 개별 도서관시스템에 준하는 정보의 양을 보여주고 있다. 기관 내부의 여러 시스템에 대한 통합검색서비스 또한 매쉬업 등 웹 2.0 기술을 적용하여 기관 외부 정보와 연계하는 통합검색 시도와 같은 맥락에서 볼 수 있다. 본 연구에서는 기관 내부에서 검색서비스를 제공하는 것을 전제로 하여 역사콘텐츠를 위한 국사편찬위원회 OpenAPI를 설계하고 메타데이터 형식 및 내용을 제안하였다. Mashup service provides results by query in real time and responds to users' request in dynamic. In terms of size, each of NIKH(National Institute of Korean History)'s internal Information Systems is equal to individual library system. As adapting mashup for information convergence with external resources, it was accepted for internal integrated search in the same context. This study designated NIKH OpenAPI and proposed metadata format for internal integrated search of historical contents.

온톨로지 구조로 표현된 FRSAD 모형에 관한 연구

이혜원,Lee, Hye-Won 한국비블리아학회 2012 한국비블리아학회지 Vol.23 No.1

FRSAD과 온톨로지 모형간의 연계는 어떠한 정보구현시스템이나 특정 상황에서도 독립적인 상위 계층의 지식구조를 제안하고, 의미 연결, 지식구조, 주제접근, 상호운용성 등을 확보하기 위한 노력이다. FRSAD 모형을 현실적인 정보환경에 적용하고, 도서관 안팎 어디서나 자유롭게 정보를 확인하고 공유하기 위해서는 지식표현 인코딩 체계가 필요하다. 본 연구에서는 웹 온톨로지 언어인 OWL를 사용하여 FRSAD 모형을 온톨로지 구조로 표현하였으며, 이를 확인하기 위해 Prot$\acute{e}$g$\acute{e}$를 사용하여 FRSAD 온톨로지 모형을 시범적으로 구축하였다. Mapping FRSAD and other ontology models intends to suggest a higher knowledge level that is independent of any information implementation system or specific context, and to endeavor to focus on the semantics, knowledge structures, subject access, and interoperability. Providing an application of FRSAD model to information environment and representing and sharing the information within the library sector and beyond, there needs encoding scheme for knowledge representation. This study suggested an OWL based ontology architecture for FRSAD model and demonstrated the pilot FRSAD ontology model using Prot$\acute{e}$g$\acute{e}$ software.

말기암 환자 가족에 대한 호스피스 팀의 정보적 지지 제공 효과

이혜원,Lee, Hye-Won 한국호스피스협회 2001 호스피스 학술지 Vol.1 No.1

To evaluate the effect of informational support by hospice team on family caregivers of terminally ill cancer patients, 22 family caregivers of D University Hospital in Daegu city were participated. The research was conducted from Aug. 16th to Oct. 28th 2000 by using self-reported questionnaires. The instruments used in this study were the Weinert's scale of perceived social support, Spielberger's state anxiety inventory, CES-D, and Ellison and Paloutzian's spiritual well-being scale. The intervention was designed to give educational and counselling program up to 7 times within 4 weeks. Educational and counselling booklets which made by the researcher were used step by step by hospice team. The data were analysed frequency, percentage, Wilcoxon Singed Ranks Test Test with SPSS Win 10.0/PC. The results obtained from this study were as follows: 1.The perceived social support of family caregivers was significantly increased after ready planned informational support was applied by hospice team(z=-3.045, p=0.002). 2.The anxiety of family caregivers was significantly reduced after ready planned informational support was applied by hospice team(z=-3.348, p=0.001). 3.The depression of family caregivers was significantly reduced after ready planned informational support was applied by hospice team(z=-3.641, p=0.000). 4.The spiritual well-being score of family caregivers was not significantly improved after ready planned informational support was applied by hospice team(z=-0.422, p=0.673). In conclusion, the results of this study clearly suggests that the informational support provided by hospice team not only increased the family caregivers' who are caring for terminally ill cancer patients. Therefor the informational support program designed by researcher for family caregivers who are caring for terminally ill cancer patients should be utilized and expended.

Nut류의 항산화 및 항균효과

이혜원,최무영,차배천,Lee, Hye-Won,Choi, Moo-Young,Cha, Bae-Cheon 한국생약학회 1998 생약학회지 Vol.29 No.1

It has been known that diseases related with aging or cancer result, at least in part, from free radicals, and antioxidants may reduce or prevent the abnormalities associated with free radical formation via its scavenging action. Thus, this study was carried out to investigate the antioxidative and antimicrobial activities of nut species for the purpose of developing antioxidant from natural products. Antioxidant activities of four kinds of nuts such as chestnut, groundnut, walnut and acorn were examined by measuring the radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. The extracts from chestnut hull and acorn barnyard millet showed strong antioxidative activities among 10 samples tested. Because of their highest antioxidative activity among 10 samples, radical scavenging effects of 4 different extract compartments (Hexane, EtOAc, BuOH and $H_2O$ extracts) from chestnut hull and acorn barnyard millet, were further examined by DPPH method. EtOAc and BuOH extracts exhibited antioxidative activities similar to those of natural, tocopherol or synthetic antioxidants, BHA. These findings demonstrates that major fraction of the antioxidative activity of chestnut hull or acorn barnyard millet was the EtOAc and BuOH extract compartments. However, antimicrobial activities against food-related bacteria and yeasts was relatively weak.

역사용어 온톨로지 모형 적용 방안 연구 - 한국근현대사 인물을 중심으로 -

이혜원,윤소영,Lee, Hye-Won,Yoon, So-Young 한국비블리아학회 2011 한국비블리아학회지 Vol.22 No.1

본 연구에서는 역사인물 중심의 온톨로지를 구축하기 위해 기존의 한국역사용어시소러스의 문제점을 분석하는 동시에 한국역사용어시소러스 및 국편의 다양한 정보검색 시스템을 활용하는 전문가들의 인터뷰를 실시하였다. 한국역사용어시소러스의 개념 표현 기준과 전문가들이 작성한 마인드맵을 분석하여 현재 시스템과 전문가간의 정보 표현의 차이를 확인하였다. 이를 바탕으로 역사정보 이용자들의 정보요구에 부합하고 잠재력 있는 정보검색시스템에 적용할 역사용어 온톨로지 모형을 설계하였다. 본 연구에서는 먼저 클래스, 속성을 정의하고, 인스턴스 입력시 고려해야 할 점들을 나열함으로써, 역사정보가 갖는 고유한 특성들을 정리하였다. 또한 온톨로지의 장점인 개념 확장을 활용하여 역사정보의 다양한 특성들을 조합하고 이를 통해 새로운 정보를 제공할 수 있는 가능성을 제시하였다. The purpose of the study is to construct a History Ontology Model for historical person to analyse issues of Korean History Thesaurus and interview history specialists who are use information systems in National Institute of Korean History. This study verifies the difference between both descriptions through comparative analysis of term concept in Korean History Thesaurus and mind-map written by history major. Based on this, we build history ontology model to meet users' information needs and adapt to information retrieval system. First, to organize unique features of history, we define class and attribute and then enlisted considerations for instance input. The study suggests a possibility of new service through combination multiple features using concept extension that is a strength of ontology.

가토 간내 선택적 담관결찰후 간부피의 변화에 대한 실험적 연구

이혜원,윤엽,고영태,최우석,임주원,오주형,임형택,김윤화,이석환,Lee, Hye Won,Yoon, Yup,Ko, Young Tae,Choi, Woo Suk,Lim, Joo Won,Oh, Joo Hyeong,Rim, Heyong Teck,Kim, Youn Wha,Lee, Seok Hwan 대한영상의학회 1998 대한영상의학회지 Vol.39 No.6

Purpose : To evaluate the role of bile duct obstuction in the development of atrophy of the liver, using ananimal model. Materials and Methods : Seven rabbits were divided into two groups : group 1(n=5), in which therewas selective bile duct ligation, and group 2(n=2), which underwent a sham operation. Each group was evaluatedusing CT for changes in hepatic volume after selective bile duct ligation or a sham operation. In group I, thediameter of dilated bile duct was measured 2, 4, 8, 12 and 16 weeks after bile duct ligation, while gross andhistologic change were evaluated in all cases. Results : In group 1, bile duct dilatation was seen on CT two weeksafter selective bile duct ligation, and did not change significantly during follow-up. In four of five cases, CTrevealed no evidence of significant atrophy of the involved segment. Pathologic specimens, however, revealeddilatation of the bile duct, periductal fibrosis, infiltration of chronic inflammatory cells, and periportalfibrosis. One of five cases showed segmental liver atrophy after selective bile duct ligation. In addion to theabove pathologic findings, there was obstruction of the portal vein by foreign body reaction. In group 2, noevidence of dilated bile duct or liver atrophy was revealed by CT or pathologic specimen after a sham operation.Conclusion : During long-term follow-up of 16 weeks, obstruction of the bile duct did not play a major role in thedevelopment of lobar atrophy in the rabbit.

목록의 집중기능을 향상시키는 '원형' 개념에 관한 연구

이혜원,Lee, Hye-Won 한국비블리아학회 2011 한국비블리아학회지 Vol.22 No.3

저작은 목록의 집중기능에 중요한 역할을 하는 서지 개체이다. 본 연구에서는 저작의 개념을 재분석하고, 이미 공표된 FRBR 저작의 개념을 보완할 수 있는 새로운 방안을 모색하고자 하였다. 저작의 집중기능을 향상시킬 수 있는 방안으로 저작보다 한 차원 높은 '원형' 개체를 선언하였고, 원형과 관련된 속성 및 관계를 FRBR 모형과 연결하여 설명하였다. Work is a bibliographic entity serving a key role for the collocation function of catalog. This study analyzed the concept of work, provided a new device to complement conventional FRBR work. The 'prototype' was suggested to enhance the collocation function of catalog, the highest level in FRBR. This study explained the definition, attributes of prototype, and relationships between prototype and work within FRBR model.