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위내시경으로 진단된 소화성 궤양환자 1501명에 대한 임상적 관찰
김영건(Young Kun Kim),이복희(Bok Hee Lee),김성철(Sung Chul Kim),박헌진(Hun Jin Park),안정기(Jeong Ki Ahn),이헌영(Houn Young Lee) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.3
N/A The epidemiology and clinical aspect of peptic ulcer is ever-changing along with changes in environment. Therefore, we had a clinical analysis in 1501 patients, who were diagnosed as peptic ulcer with gastroscopy in Chungnam National University Hospital from January 1984 to June 1988. The results were as follows: 1) Of the total 8912 cases of endoscopy, the numbers of patient with gastric ulcer were 784(8.8%), with duodenal ulcer, 591(6.6%) and with combined ulcer, 126(1.4%) 2) The mean age of patients with gastric ulcer was 50.9+14.9, and that with duodenal ulcer was 41.76+13.8. 3) The ratio of males to females was 3.7: 1 in gastric ulcer group and 2.4: 1 in duodenal ulcer group. 4) The most common stympom was epiagastric pain, 48.3% of gastric ulcer patients and 47.2% of duodenal ulcer patients, And the patients with hematemesis and/or melena were 19.5% of gastric ulcer patients and 12.9% of duodenal ulcer patients 5) During the period 1984-1988, the annual proportion of gastric ulcer were 58.8%, 51.4%, 53.3%, 50%, and 50.7%. And that of duodenal ulcer were 36.5%, 39.4%, 38.2%, 40.5%, and 41.1%. 6) The patients with multiple ulcers were 26.5% of gastric ulcer group and 15.7% of duodenal ulcer group. 7) The patients of 78.1% of total peptic ulcer was in active stage, 11% in healing stage, and 10.9% in scarring stage. 8) In 30.8% of gastric ulcers, the size of ulcer was within 1.0 to 1.4 cm and in 31.6% of duodenal ulcers the size of ulcer was less than 0.4 cm. 9) The most common site of gastric ulcer was angle of stomach (42.7%), and that of duodenal ulcer was bulb (98.6%). 10) The proportion of patients with combined ulcer of stomach and duodenum was 8.3% of total patients and that of channel ulcer was 3.1%.
위선종과 위암에서 면역조직화학적 염색을 이용한 p53 단백 발현율의 비교
김진희(Jin Hee Kim),서광식(Kwang Sik Seo),김성걸(Seong Gul Kim),임의혁(Euyi Hyeog Im),육은주(Eun Ju Yook),정현용(Hyun Yong Jeong),이헌영(Houn Young Lee),김영건(Young Kun Kim),이충식(Choong Sik Lee) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.5
N/A Backgrounds: The mutation of p53 gene and p53 protein accumulation is discovered in dysplasia of stomach and gastric cancer. We compared p53 protein expression rate with gastric adenoma and gastric cancer using the immunohistochemical stain and tried to know the correlation of the malig- nant potential of gastric adenoma with p53 protein expression. Methods: We obtained 52 tissues from 22 gastric cancers and 30 gastric adenomas. Accumulation of p53 protein was detected by immunohistochemistry using Anti-Human p53 monoclonal antibody(Pab 1801; Pharmingen). Results: p53 immunoreactivity was detected in 33.3% of gastric adenomas and in 59.l% of gastric cancers. But, threre was no significant difference between two groups(p=0.065). The rate of p53 expression according to various stages, differentiations, cell types in gastric cancers was not significantly different. Also, p53 expression rate according to cell types, size in gastric adenomas showed no significant difference. Conclusions: We suggest that mutation of the p53 gene is an early event in stomach tumorigenesis. But there is to be required more research about the correlation of the malignant potential of gastric adenoma with p53 protein expression. (Korean J Gastroenterol 1995;27: 509 - 516)
육은주(Eun Ju Yook),전준식(Joon Sik Jeon),김성걸(Seong Gul Kim),김진희(Jin Hee Kim),김남재(Nam Jae Kim),정현용(Hyun Yong Jeong),이헌영(Houn Young Lee),김영건(Young Kun Kim),김응중(Eung Jung Kim),이영(Young Lee) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.1
We report two cases of Morgagnis hernia comprising the protrusion of omentum alone. The treated patients were 65- and 64-year old women. They were referred to our hospital due to epigastric discomfort, or dypnea accompanied by an abnormal shadow in right cardiophrenic angle on chest roentgenogram. Surgery through an abdominal approach was preferred and the post- operative course was benign. (Korean J Gastroenterol 1996;28: 148 150)
만성신부전에서 남성 Hormone 분비기능에 관한 연구
이헌영,노흥규 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.1
The serum prolactin, LH, FSH and testosterone were measured by RIA method for the evaluation of the hypothalamo-pituitary-testicular axis through the LHRH stimulation test before and after intramuscular injection of 50 mg of testosterone propionate(T.p.) in normal controls and patients with chronic renal failure (CRF) before specific treatment. 1. The basal level of the serum prolactin was significantly higher in the patients with CRF (124.9±46.3 ng/ml, M±S.E.) compared with normal controls(11.2±2.1 ng/ml). 2. The basal level of serum LH in normal controls was 7.1±1.4 mIU/ml and the peak level was 46.5±3.9 mIU/ml at 30 min. after iv injection of 100㎍ of LHRH. In patients with CRF, the basal serum level of LH was 15.5±2.7 mIU/ml and peak level was 37.1±5.4 mIU/ml at 180 min. after administration of LHRH, showing delayed response to LHRH stimulation in patients with CRF. After administration of T.p., the response of LH to LHRH stimulation in normal controls was suppressed, while in the patients with CRF, there was no significant difference between the responses before and after injection of T.p. 3. Basal serum FSH levels in normal controls was 3.2±0.4 mIU/ml, and at 60 min. after LHRH stimulation, level of the FSH was elevated to peak level significantly. The basal serum level of FSH in patients with CRF was 2.9±0.9 mIIU/ml and elevated more slowly with LHRH stimulation compared with normal controls. After injection of T.p., the basal levels of serum FSH and the responses to LHRH stimulation were not changed significantly in normal controls and the patients with CRF. 4. The basal serum level of testosterone was 5.2±0.4 ng/dl in normal controls. In the patients with CRF, the basal level of testosterone was significantly lower(3.5±0.8 ng/ dl) than that of normal controls. The serum testosterone level was not changed within 3 hours with LHRH stimulation in both normal controls and patients with CRF. After administration of T.p., the basal levels of testosterone in patients and controls were elevated significantly but there was no response to LHRH stimulation. With the above results, it can be concluded that the abnormal response of the pituitary gland to the change of testosterone level, elevated serum prolactin level, increased LH level, and abnormal response to LHRH stimulation contribute to the abnormal sexual functions in patients with CRF.
간경화증 환자에 병발된 Cryptococcal meningitis의 1례
이헌영,김선영 충남대학교 의과대학 지역사회의학연구소 1982 충남의대잡지 Vol.9 No.1
The most common fungal etiology of central nervous system infection is C. Neoformans and above a half of whole cases are complicated in immunosuppressive disease. A case of cryptococcal meningitis, complicated in liver cirrhosis, was presented with review of references. The chief complaint was drowsy mental state and physical findings were severe general weakness, blindness of left eye, deafness of left ear, decreased liver dullness, neck stiffness, positive Kernig sign and right Babinski sign, urinary incontinence and decreased calculation power. Diagnostic work up was performed under the impression of liver cirrhosis accompanied by meningitis. C. S. F. smear and culture for cryptococcus revealed as positive. After administration of garlic oil and amphotericin-B, illness was recovered progressively exception of deafness, blindness and mild degree of walking disturbance.
송민호,이헌영,김삼용,김영건,이복희 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.1
Eleven patients with advanced gastric cancer, five patients with esophageal cancer were treated with Etoposide, Aclacinimycin (or Adraimycin), and Cisplatin(EAP) combination chemotherapy. The results were as followings: 1. The response rate was 64% in advanced stomach cancer and 60% in esophageal cancer. The overall response rate was 63% in total patients. 2. The toxicites of the EAP combination regimen were evaluated by ECOG(Eastern Cooperative Oncology Group) toxicity criteria. The toxicities were as following in order of frequency: anemia 44%, nausea and vomiting 37%, leukopenia 13%, genitorinary toxicites 7%, thrombocypenia 6%. 3. The median duration of survival was 7.5+ months stomach cancer and 8+ months in esophageal cancer in responded patients. 4. The median duration of partial remission were 4+ months and 5+ months in stomach cancer and esophageal cancer in respectively. In conclusion. the EAP combination chemotherapeutic regimen have substantial effects on advanced stomach and esophageal cancer.