http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
유방의 침윤성 관암종에서 TGF-β isoforms의 발현에 관한 면역조직화학적 연구
박행렬,이태진,박언섭,김미경,유재형,박현숙,송계용 중앙대학교 의과대학 의과학연구소 1996 中央醫大誌 Vol.21 No.3
To study the roles of TGF-β related with the aggressiveness of the cancer behavior, the expression of TGF-β isoforms were examined by immunohistochemically in the thirty five cases of infiltrating duct carcinoma of the breast. Analyzed prognostic parameters of the breast cancer along with TGF-β immunohistochemistry were tumor size, axillary lymph node metastasis, clinical stage, histological grade, nuclear grade, estrogen receptor and progesterone receptor status. The results were noted as follows : 1) Of 35 cases of infiltrating duct carcinoma of breast, 34 cases (97.1%) expressed pan TGF-β, 33 cases (94.3%) expressed TGF-β1, 34 cases(97.1%) expressed TGF-β2, and 34 cases(97.1%) expressed TGF-β3. 2) The staining indices (extent X intensity) of TGF-β isoforms were 4.89±2.4 in panTGF-β, 4.69±2.35 in TGF-β, 5.91±2.54 in TGF-β2, and 3.97±2.27 in TGF-β3. 3) The expression of panTGF-β, TGF-β1, and TGF-β2 were closely related to clinical stage and presence of axillary lymph node metastasis(P,0.05). 4) The TGF-β expression was not related to tumor size, histologic grade, nuclear grade, estrogen receptor and progesterone receptor statue(P>0.05). Therefore, the above results suggested that TGF-β expression in infiltrating duct carcinoma of breast may closely related with important prognostic factors, such as lymph node metastasis and clinical stage by increasing the invasiveness of cancer cells.