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이창현(C. H. Lee),김학범(H. B. Kim),장용준(Y. J. Jang),정우성(W. S. Jung) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11
Conducting of Reduced Scale Tunnel-Fire Experiments are not easy due to risk for fire in door. In the study, Tunnel fire were simulated by applying buoyancy of helium-air mixture to the reduced scale tunnel experiment for safety. Helium-air mixture. Velocity vectors were measured with PIV at the near fire position
강원구(W. K. Kang),이창현(C. H. Lee),우종수(J. S. Woo),권광일(K. I. Kwon) 대한약학회 1998 약학회지 Vol.42 No.1
This study was designed to compare the absorption fraction and extent of ketoprofen gels and a matrix typed ketoprofen plaster patch. 3g (90mg as ketoprofen) of the two gels which has oleohydrogel or hydrogel as a base, respectively, and 3 pieces of plaster patches (90mg as ketoprofen) were, applied in the area of 210cm2 on forearm in 12 volunteers by cross over design. Blood samples were collected serially up to 24 hours and the plasma concentrations of ketoprofen were analyzed by HPLC using flurbiprofen as an internal standard. The detection limit of the assay was 1ng/ml of ketoprofen in plasma. The pharmacokinetic parameters (e.g. AUC24hr, AUMC24hr, MRT, Fraction Absorbed) were calculated from the plasma concentrations time data of each volunteer. The oleo-hydrogel showed significantly higher absorption fraction and extent of ketoprofen than the current hydrogel. The mean plasma concentrations of the oleo-hydrogel were increased to 98.46+/-23.15ng/ml by 6 hour after application, and increased futher to 100.61+/-18.65ng/ml at 24 hour. On the other hand, those of the hydrogel were increased 17.61+/-18.65ng/ml at 5 hour to 34.68+/-9.65ng/ml at 24 hour gradually. Therefore the plasma concentrations of oleo-hydrogel at each measured time were 3~7 times greater than those of the hydrogel with statistical significance. The AUC24hr (1797.26+/-52.09ng.h/ml) of the oleo-hydrogel was 3.5 times greater (P<0.05) than that (516.17+/-104.52ng.h/ml) of the hydrogel. The plaster patches showed higher bioavailability (AUC24hr 2877.37+/-578.27ng.h/ml) than the olea-hydrogel (AUC24hr 1797.26+/-52.09ng.h/ml) without statistical significance. But the absorption fraction of the oleo-hydrogel was rather higher than that of the plaster patches during the first 6 hours after administration. These results suggest that newly developed ketoprofen gel which is used oleo-hydrogel as a base would show excellent skin permeation on topical application for the corresponding clinical indications and could be absorbed as well as plaster patches.
대심도 지하역사에서 화원 위치에 따른 연기거동 특징 연구
김학범(H.B. Kim),장용준(Y.J. Jang),이창현(C.H. Lee),정우성(W.S. Jung) 한국전산유체공학회 2009 한국전산유체공학회 학술대회논문집 Vol.2009 No.4
In this study, Numerical simulations were pelf armed 10 analyze the characteristics of fire driven smoke flow for different location of fire source in the deeply underground subway station with using FDS code. The fire driven smoke-flow which was simulated by using Parallel Computational Method for fast calculation and LES for turbulence model. In this research, the fire location to obstruct a suitable egress from the fire disaster were discussed.
권순박(S.-B. Kwon),송지한(J.H. Song),강석원(S.-W. Kang),정락교(R.-G. Jeong),김학범(H.-B. Kim),이창현(C.H. Lee),서동관(D.-K. Seo) 한국전산유체공학회 2013 한국전산유체공학회지 Vol.18 No.1
Personal Rapid Transit (PRT) is the emerging personal transport vehicle operating on the loop automatically. The PRT system utilize the electrical power from super capacity or battery, it is important to manage the power or energy. In this regards, the management of high temperature occurred by the operation of system is significantly important to prevent from serious damage of component. In this study, we studied the adequate shape of underbody which can reduce the heat accumulation by pickup coil and condenser using natural air cooling. We suggested the additional air pathway, air inlet and flow separator to decrease the temperature of the heat source components. It was found that suggested system can decrease the temperature of PRT under body by 16% during the static mode and by 10% during the running mode at 30㎞/h. It is expected that the findings of this study will feed into final design of newly built Korean PRT vehicle.