직장에 발생한 심재성 낭성 대장염(Colitis Cystica Profunda) 및 연소성 정류 용종(Juvenile Retention Polyp)의 혼재형 1례

이창진,김병찬,문진수,김정은,최경단,고재성,강경훈,김우선,서정기,Lee, Chang-Jin,Kim, Beyong-Chan,Moon, Jin-Soo,Kim, Jeong-Eun,Choi, Kyung-Dan,Ko, Jae-Sung,Kang, Gyeong-Hoon,Kim, Woo-Sun,Seo, Jeong-Kee 대한소아소화기영양학회 2002 Pediatric gastroenterology, hepatology & nutrition Vol.5 No.1

저자들은 최근 본원에서 항문으로의 종괴 돌출 및 출혈을 주소로 내원한 7개월 여자 환아에서 직장내시경을 시행함으로써 다수의 큰 용종을 발견하였다. 내시경적 절제를 시행하여 조직병리학적으로 심재성 낭성 대장염과 연소성 정류 용종이 혼재한 것을 관찰하였고, 추적 내시경을 시행하여 남은 용종을 제거하였다. 영아에서 첫 증례이며, 내시경으로 진단 및 치료를 행함으로써 성공적으로 치료되어 이에 보고하는 바이다. Colitis cystica profunda is a rare benign condition characterized by the presence of mucus-filled cysts in the submucosa of the colon and the rectum. Although it may diffusely involve the entire colon, this disease primarily affects the pelvic colon and rectum. It has rarely been described in the pediatric literature. The surgical treatment has been widely advocated. We report a 7-month-old case, successfully treated by colonoscopic polypectomy without complication. Histologically, components of juvenile retention polyp were mixed with colitis cytsica profunda.

Carberry Type 생물반응기에서 암모늄 이온 제거에 의한 돼지유행성설사병 바이러스 백신 생산성 증대

이창진 ( Chang Jin Lee ),정연호 ( Yeon Ho Jeong ) 한국화학공학회 2011 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.49 No.5

The porcine epidemic diarrhea virus(PEDV) production yield in spinner flask cultures using Vero cells immobilized on microcarriers was improved by the selective adsorption of ammonium ions in a Carberry type bioreactor which was equipped with Phillipsite-Gismondine synthetic zeolite. Though the apparent cell growth seemed to be lower than that of control due to the aggregation of microcarriers between impeller shaft and the adsorbent, zeolite was found to not to be toxic to Vero cell, considering estimated glucose and lactate changes. Zeolite was observed to remove ammonium ions effectively in both steps of cell growth and virus production. In virus production, the virus titer with zeolite was two times higher than that without zeolite. Consequently, zeolite was found to be an ideal adsorbent for higher production of virus vaccine with the effective removal of ammonium ions.

저인산혈성 구루병에 대한 임상적 고찰

이창진,조희연,강주형,신충호,하일수,정해일,양세원,최용,Lee Chang-Jin,Cho Hee-Yeon,Kang Ju- Hyung,Shin Choong-Ho,Ha Il-Soo,Cheong Hae-Il,Yang Sei-Won,Choe Yong 대한소아신장학회 2004 Childhood kidney diseases Vol.8 No.2

목적: 저인산혈성 구루병 환아의 임상상, 각종 혈액화학 검사 수치 및 방사선 검사 소견, 치료에 대한 반응 등을 살피고 효과적인 치료에 도움이 되는 정보를 얻고자 본 연구를 시행하였다. 방법: 1983년 7월부터 2004년 2월까지 서울대학교병원 소아과에서 저인산혈성 구루병으로 진단받고 내과적인 치료를 받은 환아들의 의무기록지를 후향적으로 분석하였다. 결과: 대상환자는 56명이었고, 남녀의 비는 1:3 이었다 주소는 대부분 하지만곡과 저신장이었고, 혼자 걷기 시작하면서 발견된 경우가 가장 많았다. 진단시 평균연령은 5년 2개월 이었으며 12개월 이전에 진단 받은 경우는 없었다. 14명(25%)에서 가족력이 있었다. 진단받은 연령과 신장의 표준편차 점수는 통계적으로 의미있는 음의 상관관계가 있었다(r=-0.47, p=0.005). 생화학적 검사에서 정상 혈청 칼슘, 혈청 인의 저하, alkaline phosphatase의 상승, 세뇨관에서 인산 재흡수의 감소 및 정상 범위의 $1,25(OH)_2D_3$ 치를 보였다. 방사선 검사는 구루병에 합당하였다. 치료제로 Joulie 용액과 비타민 D 대사체를 복용하였다. 치료를 시작한 후 혈청 인과 alkaline phosphatase는 통계적으로 의미있는(P<0.05) 호전을 보였고, 방사선 검사는 구루병의 치유를 보였으나, 신장 표준편차 점수는 의미있는 변화를 보이지 않았다(.p=0.224). 치료의 부작용으로 신석회화(34%), 부갑상선호르몬의 상승(77%), 고칼슘뇨증(45%) 등이 발생하였다. 16명이 절골술을 통한 변형의 교정을 시행하였고, 그 중 4명은 하지연장을 함께 시행하였다. 결론: 증상의 시작과 진단 사이에는 수 년간의 지연이 있었다 조기치료가 환자의 예후에 가장 중요하므로, 가족력이 있는 경우 증상 발현 이전에 생화학적 검사로 조기 진단 및 치료를 하도록 해야 한다. 치료 중에는 정기적인 모니터링과 용량의 조절을 통해 합병증에 대처해야 한다. Purpose: Hypophosphatemic rickets is a hereditary disease, characterized by hypophosphatemia due to renal phosphate wasting, impaired renal production of 1,25-dihydroxyvitamin $D_3$, rachitic bone deformities and impaired growth. The purpose of this study is to provide clinical profiles of patients with hypophosphatemic rickets in our hospital. Methods: Between July 1983 and February 2004, 56 patients were diagnosed as having hypophosphatemic rickets. The medical records of these patients were reviewed retrospectively. Clinical manifestations, family histories, laboratory data, treatment outcomes were described. Results: Fifty six patients were enrolled in this study. The average age at symptom onset and diagnosis were 20 months and 5 years respectively. Fourteen patients had family histories. The main clinical manifestations were bow legs and short stature. There was a significant negative correlation between the ages and the height z-scores at the time of diagnosis(r=-0.47, P=0.005). Initial laboratory data showed normocalcemia, hypophosphatemia, elevated serum alkaline phosphatase, decreased tubular reabsorption of phosphate and a normal range of 1,25-dihydroxyvitamin $D_3$ Radiographic examinations of bone revealed fraying, widening and cupping of the metaphyseal ends. Treatment consisted of Joulie solution and vitamin D metabolites, and resulted in improved biochemical and radiographic findings. However, height z-scores remained essentially unchanged(P=0.224). Complications of treatment were frequently observed, including hyperparathyroidism, nephrocalcinosis, and hypercalciuria. Sixteen patients had corrective osteotomy and 4 of them underwent leg lengthening together. Conclusion: There was a gap of several years between the onset of symptoms and the diagnosis. Early treatment seems to be essential to growth. For the earlier treatment, the offsprings of affected parents should be followed up closely.

Retraction to : 디옥틸테레프탈산 제조공정에서 분진폭발 특성에 관한 연구

이창진,김래현,Lee, Chang Jin,Kim, Lae Hyun 한국화학공학회 2021 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.59 No.1

골형태분석법과 micro-CT를 이용한 골소주 특성에 대한 연구

송영한,이완,이창진,지정현,이병도,Song, Young-Han,Lee, Wan,Lee, Chang-Jin,Ji, Jung-Hyun,Lee, Byung-Do 대한영상치의학회 2007 Imaging Science in Dentistry Vol.37 No.1

Purpose : The research was done to investigate the effectiveness of 2D bony morphometry and microstructure of micro-computed tomography (micro-CT) on the osteoporotic bony change. We performed the bone morphometric analysis of proximal femur in ovariectomized rabbits with BMD and micro-CT examination. Materials and Methods : Twenty-one female (Newzealand, about 16 weeks old, 2.9-3.4kg) rabbits were used. Three rabbits were sacrificed on the day when experiment began (Baseline). The remaining 18 rabbits were divided into two groups. One group was ovariectomized bilaterally (OVX) and the other animals were subjected to sham operation (Sham). Bone specimens were obtained from the right and left femur of sacrificed rabbits. At intervals of 1, 2, 3, 5, 6 months respectively, BMD tests were performed on the proximal femur by using PIXlmus 2 (GE Lunar Co. USA), 2-dimensional bone morphometric analysis by custome computer program and 2D/3D bone structure analysis by micro-CT (Skyscan 1072, Antwerpen, Belgium). Statistical analysis was carried out for the correlation between bone morphometry, micro-CT and BMD Result : BV/TV, Tb.Th, Tb.N of micro-CT parameters showed higher values in sham group than OVX group. N.Nd/Ar.RI, N.NdNd, N.NdTm, N. TmTm, PmB/Ar.RI, 3-D BoxSlope of 2D morphometric parameters showed higher values in Sham group than OVX group. The micro-CT parameters of Tb.Sp, Tb.N were statistically significant correlated with BMD respectively. Several 2D morphometric parameters were statistically significant correlated with BMD respectively. Conclusion : Several parameters of 2D bony morphometry and micro-CT showed effective aspects on the osteoporotic bony change.

차량간 통신 기반 서비스를 위한 테스트베드 구축

이창진(Lee Chang Jin),김효언(Kim Hyo Un),서현수(Seo Hyun Soo),이상선(Lee Sang Sun) 한국통신학회 2012 한국통신학회 학술대회논문집 Vol.2012 No.6

대학생의 규칙적인 운동참여가 신체적 자기개념과 건강관련체력에 미치는 영향

이창진(Chang Jin Lee),이석희(Suk Hee Lee) 한국발육발달학회 2014 한국발육발달학회지 Vol.22 No.3

The purpose of this study is to investigate the effects of college student``s regular exercise participation on the physical self-concept and health-related physical fitness. For the goal of this study, there was adopted to 79 students among the physical education females and males attend classes, who was participated aerobic exercise program(Power Walking). Survey of physical self-concept was used after validity and reliability analysis. Factor analysis, Cronbach’s α and paired t-test were performed using the outcomes from the questionnaire by IBM SPSS Statistics 20.0 program. The results were as follows. First, after 8 weeks aerobic exercise program participation, male college students were improved almost factors which were muscle strength(right grip Strength), muscle endurance(sit-up), flexibility(trunk forward flexion), cardiopulmonary endurance(step test), body composition(%fat, WHR) among health-related physical fitness factors before exercise participation. And female college students were improved almost factors which were muscle strength(left·right grip strength), muscle Endurance(sit-up), fexibility(trunk forward flexion), cardiopulmonary endurance(step test), body composition(%fat, WHR) before exercise participation. Second, after 8 weeks aerobic exercise program participation, male college students were found to have higher physical confidence in endurance, muscle endurance, sports competence, appearance, body fat, health, flexibility, the body’s overall among physical selfconcept factors before exercise participation. And female college students were found to have higher physical confidence in endurance, appearance, body fat, flexibility, muscle endurance, the body’s overall, sports competence before exercise participation. As a result, female and male college students were improved physical self-concept and health-related physical fitness by 8 weeks aerobic exercise program. Or, regular exercise was improved in short term and also found to have higher physical confidence of mine.

ROC곡선을 이용한 중년여성의 건강체력평가

이창진(Chang Jin Lee) 한국발육발달학회 2016 한국발육발달학회지 Vol.24 No.1

Receiver operating characteristic(ROC) curve, an index that is actively used since the 1960s, and is used to verify the classification accuracy. The aim of present study was to establish the levels of healthrelated physical fitness using a ROC in middle age women. Participants were categorized into either a exercise group (n=80) or a non-exercise group(n=70). In order to examine the physical fitness level of the participants, in the present study was tested physical fitness factors including muscle strength, back muscle strength, muscular endurance, flexibility, cardiopulmonary endurance and body composition. The ROC curve was analyzed using SPSS 20.0. The area under the ROC curve (AUC) of physical fitness factors were muscle strength .501, back muscle strength .489, muscular endurance .634, flexibility .560, cardiopulmonary endurance .425 and body composition .505. Moreover, the sensitivity and specificity of muscle strength in 27.2 kg cutoff value was 51.1% and 45.6%, respectively. In the back muscle strength in 66.2 kg cutoff value, sensitivity and specificity was calculated by 48.9% and 53.3%, respectively. The sensitivity and specificity for muscular endurance in 9.5 cutoff value repetitions was 66.7% and 48.9%, respectively. The sensitivity and specificity for cardiopulmonary endurance in 67.6 second cutoff value was observed by 48.8% and 57.7%, respectively. Finally, cutoff value of percentage body fat, as a body composition was 29.9 %, and sensitivity and specificity was calculated by 51.5% and 52.6%, respectively.

Sodium butyrate에 의한 돼지 전염성 위장염 바이러스 백신의 생산성 향상

이창진(Chang-Jin Lee),김철민(Cheol-Min Kim),정연호(Yeon-Ho Jeong) 한국생물공학회 2011 KSBB Journal Vol.26 No.2

The essential operating parameters in virus vaccine production are multiplicity of infection (MOI), harvest time, and infection time. Stimulating agents also can be applied in order to improve vaccine productivity further. We investigated the optimum operating conditions in porcine transmissible gastroenteritis virus (TGEV) vaccine production and the applicability of sodium butyrate (NaBu) as a stimulating agents for the improvement of vaccine productivity. The optimum MOI, infection time, and harvest time for high production of TGEV by swine testicle (ST) cells were found to be 0.0001 pfu/cell, 3 day after cell inoculation, and 24 hpi, respectively. NaBu is known as a histone deacetylase inhibitor that has been widely used for the high expression of recombinant protein using mammalian cells and for the enhancement of virus propagation. So we tried to examine the potential of NaBu as a stimulating agent and to determine the optimum concentration by comparing TGEV titers with different range of NaBu concentration. TGEV titer with 5 mM NaBu was 1.5 times higher than control. Therefore, we concluded that NaBu can be a promising agent for stimulating various vaccine production including TGEV and the optimum NaBu concentration for TGEV production was determined to be 5 mM.

폴리알킬티오펜 유도체의 합성

이창진(Chang Jin Lee),이서봉(Suh Bong Rhee),김경중(Kyung Joong Kim),주혁종(Hyeok Jong Joo) 한국고분자학회 1995 폴리머 Vol.19 No.5