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이완,Hyo-Im Choi,Mi-Jin Kim,박승윤 생화학분자생물학회 2008 Experimental and molecular medicine Vol.40 No.1
The mutation and reduction of mitochondrial DNA (mtDNA) have been suggested as factors in the car-cinogenesis. However, whether the depletion of mtDNA induces multidrug resistance in cancer cells has not been fuly investigated. To elucidate the asso-ciation of cellular mtDNA content and drug resistance, a marked decrease in cellular mtDNA and ATP content, concomitant with a lack of mRNAs encoded by mtDNA. The mtDNA-depleted cels showed a decreased sensi-tivity and accumulation of anti-cancer drugs, sugest-ing that mtDNA depletion could develop multidrug re-sistance (MDR) phenotype in HCT-8 cells. We found that the expression level of MDR1 mRNA and its trans-lated product P-glycoprotein was increased in the sensitivity and accumulation of anti-cancer drug in the mtDNA-depleted cells might be due to a substantial in-crease in the expression of P-glycoprotein. Further-more, increased expression of MDR1 mRNA and P-gly-coprotein was due to an increase of mRNA stability rather than transcriptional activation. Taken together, these results indicate that mtDNA depletion can induce an increased P-glycoprotein expression via an in-crease of mRNA stability and suggest that the mtDNA depletion in cancer cells plays an important role in the induction of MDR phenotype.
이완,이병도,이강규,고광준 대한영상치의학회 2014 Imaging Science in Dentistry Vol.44 No.1
Purpose: This study was designed to evaluate whether magnetic resonance imaging (MRI) is appropriate for detecting early changes in the mandibular bone marrow and pulp tissue of rats after high-dose irradiation. Materials and Methods: The right mandibles of Sprague-Dawley rats were irradiated with 10 Gy (Group 1, n=5) and 20 Gy (Group 2, n=5). Five non-irradiated animals were used as controls. The MR images of rat mandibles were obtained before irradiation and once a week until week 4 after irradiation. From the MR images, the signal intensity (SI) of the mandibular bone marrow and pulp tissue of the incisor was interpreted. The MR images were compared with the histopathologic findings. Results: The SI of the mandibular bone marrow had decreased on T2-weighted MR images. There was little difference between Groups 1 and 2. The SI of the irradiated groups appeared to be lower than that of the control group. The histopathologic findings showed that the trabecular bone in the irradiated group had increased. The SI of the irradiated pulp tissue had decreased on T2-weighted MR images. However, the SI of the MR images in Group 2 was high in the atrophic pulp of the incisor apex at week 2 after irradiation. Conclusion: These patterns seen on MRI in rat bone marrow and pulp tissue were consistent with histopathologic findings. They may be useful to assess radiogenic sclerotic changes in rat mandibular bone marrow. Purpose: This study was designed to evaluate whether magnetic resonance imaging (MRI) is appropriate for detecting early changes in the mandibular bone marrow and pulp tissue of rats after high-dose irradiation. Materials and Methods: The right mandibles of Sprague-Dawley rats were irradiated with 10 Gy (Group 1, n=5) and 20 Gy (Group 2, n=5). Five non-irradiated animals were used as controls. The MR images of rat mandibles were obtained before irradiation and once a week until week 4 after irradiation. From the MR images, the signal intensity (SI) of the mandibular bone marrow and pulp tissue of the incisor was interpreted. The MR images were compared with the histopathologic findings. Results: The SI of the mandibular bone marrow had decreased on T2-weighted MR images. There was little difference between Groups 1 and 2. The SI of the irradiated groups appeared to be lower than that of the control group. The histopathologic findings showed that the trabecular bone in the irradiated group had increased. The SI of the irradiated pulp tissue had decreased on T2-weighted MR images. However, the SI of the MR images in Group 2 was high in the atrophic pulp of the incisor apex at week 2 after irradiation. Conclusion: These patterns seen on MRI in rat bone marrow and pulp tissue were consistent with histopathologic findings. They may be useful to assess radiogenic sclerotic changes in rat mandibular bone marrow.
이완,이병도 대한구강악안면방사선학회 2008 Imaging Science in Dentistry Vol.38 No.1
The Warthin tumor is a benign neoplasm that occurs mostly in the parotid gland. The tumor frequently occurs in the tail of the parotid gland. A 75-year-old man was referred to Wonkwang dental hospital with a chief complaint of swelling on the right submandibular area. Numerous salivary stones were observed in the right submandibular gland on computed tomography(CT). And the two tumorous lesions were incidentally found in the parotid gland bilaterally. The tumorous lesions showed homogeneous enhancement on the CT and intermediate signal intensity on both T1- and T2-weighted magnetic resonance (MR) images. This tumorous lesions also showed contrast enhancement on fat suppressed T1 weighted MR images. We report common CT and MR features of this case of Warthin tumor in the parotid gland with literature review.
웹 서비스 코리오그래피의 상호운용성 지원을 위한 XML 언어 개발
이완,정범석,박종헌 한국경영정보학회 2007 한국경영정보학회 학술대회논문집 Vol.2007 No.-
웹 서비스가 현재 산업에서 주요한 분산 컴퓨팅 기술로 대두되면서, 그에 따른 연구가 활발히 이루어지고 있다. 특히, 비즈니스 프로세스 관점에서 BPEL4WS (Business Process Execution Language for Web Services)와 같은 오케스트레이션의 연구가 많이 이루어지고 있다. 또한, 웹 서비스의 주요 구성 요소중에 하나인 코리오크래피에 대한 부분은 W3C (World Wide Web Consortium)에서 현재 후보 권고안 수준인 WS-CDL (Web Services Choreography Description Language) 관련 연구가 이루어지고 있다. 이런 가운데 DERI (Digital Enterprise Research Institute)에서 WSMX (Web Services Execution Environment) 기반의 시맨틱 웹 서비스 분야의 코리오 그래피 연구를 시작하였고, 코리오그래피 불일치 (Mismatch)를 개념적으로 해결하는 방안인 프로세스 미디에이션 (Process Mediation)의 연구가 있었다. 이러한 연구들을 바탕으로 서로 다른 WS-CDL 상에서 특정 참여자가 코리오그래피 미디에이션을 하기위해서 개발된 XML 언어 WS-CML (Web Services Choreography Mediation Language)을 본 논문에서 제안한다.