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이지해,박광훈,김기찬,신찬영,정지혜 한국분자세포생물학회 2018 Molecules and cells Vol.41 No.5
Recently, we have reported that animals with telomerase reverse transcriptase (TERT) overexpression exhibit reduced social interaction, decreased preference for novel social interaction and poor nest-building behaviors—symptoms that mirror those observed in human autism spectrum disorders (ASD). Overexpression of TERT also alters the excitatory/inhibitory (E/I) ratio in the medial prefrontal cortex. However, the effects of TERT overexpression on hippocampal-dependent learning and synaptic efficacy have not been investigated. In the present study, we employed electrophysiological approaches in combination with behavioral analysis to examine hippocampal function of TERT transgenic (TERT-tg) mice and FVB controls. We found that TERT overexpression results in enhanced hippocampal excitation with no changes in inhibition and significantly impairs long-term synaptic plasticity. Interestingly, the expression levels of phosphorylated CREB and phosphorylated CaMKIIα were significantly decreased while the expression level of CaMKIIα was slightly increased in the hippocampus of TERT-overexpressing mice. Our observations highlight the importance of TERT in normal synaptic function and behavior and provide additional information on a novel animal model of ASD associated with TERT overexpression.
특징적인 소용돌이 배열을 보인 역분화 지방육종 -1예 보고-
이지신,김영복 대한병리학회 2003 Journal of Pathology and Translational Medicine Vol.37 No.5
A dedifferentiated liposarcoma is a uncommon neoplasm characterized by the coexistence of a well-differentiated liposarcoma and non-lipogenic sarcomas. A peculiar neural-like or meningothelial-like whorling pattern of dedifferentiation has recently been reported. We report a case of dedifferentiated liposarcoma with a peculiar whorling pattern in the scrotum of a 76-year-old man. Histologically, the tumor consisted of areas of a well differentiated liposarcoma admixed with areas of a morphologically non-lipogenic sarcoma. The whorls were scattered throughout the tumor. The cells in the whorls and dedifferentiated area showed a significant nuclear PCNA and p53 protein reactivity.
이지신,최명숙 대한병리학회 2003 Journal of Pathology and Translational Medicine Vol.37 No.2
Adenomyoepithelioma of the female breast is a rare tumor. With rare exceptions, the tumor is uniformly solid. We describe a large grossly cystic adenomyoepithelioma in a 67-year-old female. The tumor was histologically benign. The characteristic microscopic finding was the proliferation of rounded tubules lined by both epithelial and myoepithelial cells. Immunohistochemical findings confirmed the presence of two cell population.
역사문화지구의 퍼블릭 아트에서 나타나는 표현 특성과 아이덴티티 연구 - 징더전 시 도계천을 중심으로 -
이지엔화,윤지영 한국콘텐츠학회 2020 한국콘텐츠학회논문지 Vol.20 No.2
This study takes the identity and characteristics of public art in historical and cultural regions as the research object. Through the theoretical investigation and research on the public art of historical and cultural regions, six evaluation factors that shape spatial identity and characteristics were drawn: Environmental characteristics, public characteristics; Symbolic characteristics; Artistic characteristics;.Historical characteristics; Interactivity. The identity and characteristics of Taoxichuan public art in Jingdezhen was analyzed and evaluated. The results show that the " public art " of seven large chimneys is consistent with the historical structure of the industry. Among them, environmental, public characteristics, symbolic, artistic and historical characteristics of the Industria park have a high degree of preservation value and can be recognized as the historical landmark of the park. In the new public art, the artistic quality of public art, the environment, and the public characteristic of public art, are also at a moderate level, but it is comparatively weak. Public art recreated as an industrial heritage has formed an identity that can communicate spiritual sympathy to the public by forming a time-space communication between the public with historical relics and ceramic elements, and the new public art for local rehabilitation has given new artistic flavor to the city, but the new identity has not been shown. 본 연구는 역사문화지구 퍼블릭 아트의 특징과 아이덴티티를 연구 대상으로 역사문화구역의 퍼블릭 아트에 대한 이론 연구와 조사를 통해 징더전 도계천이 대표하는 역사문화지구 퍼블릭 아트의 특성을 연구하였다. 공간적 특성과 아이덴티티를 형성하는 여섯 가지 평가요인인 환경성, 공공성, 상징성, 예술성, 역사성, 상호작용성을 중심으로 도계천 퍼블릭 아트의 특성과 아이덴티티를 분석과 평가하였다. 연구 결과 산업 유산물로 재탄생 한 7개 큰 굴뚝의 퍼블릭 아트는 완전히 보존된 산업역사 건물과 어울린다. 그중, 환경성, 공공성, 상징성, 예술성, 역사성이 명확한 구현을 갖추고 있으며 단지의 역사적 상징물로서 보존 가치와 식별가능성이 높아 일반 퍼블릭 아트의 행사나 체험기능을 더하지 않아도 된다. 지역 재생을 위한 신 퍼블릭 아트 중 퍼블릭 아트의 예술성, 환경성, 공공성이 높게 나타났고 환경성도 중간 수준을 보이고 있지만, 역사성이 높지 않고, 상호 작용성이 약하다. 산업 유산물로 재탄생한 퍼블릭 아트는 역사유적 퍼블릭 아트로 산업유산과 도자기 요소로 대중들의 시공간과소통을 형성하면서 대중에게 정신적 공감을 전달할 수 있는 아이덴티티를 형성하였으며, 지역재생을 위한 신 퍼블릭 아트는 도계천에 새로운 예술적 정취를 부여하였으나 새로운 아이덴티티는 나타내지 못하는 것으로 평가되었다.