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인진청간탕(茵蔯淸肝湯)이 HepG2 cell의 인터페론 신호전달계에 미치는 영향
이종훈,김영철,이장훈,우홍정,Yi, Jong-Hoon,Kim, Young-Chul,Lee, Jang-Hoon,Woo, Hong-Jung 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.1
Objectives/Methods : To analyze the effect of Injinchunggantang(IJCGT) to Interferon-${\alpha}/{\beta}$ signal transmission system in HepG2 cells, HepG2 Cell were treated with IJCGT. Also, revelation of MxA, 2'5'-OAS mRNA leaded by Interferon-${\alpha}/{\beta}$ and revelation and activation of Jak1, TYK1, and STAT 1, all main signal transmission factors, were analyzed. Results : The analysis resulted in the following 1. With interferon ${\alpha}/{\beta}$ there was no affect cell propagation of Hep G2 cells. With IJCGT alone, cell propagation of HepG2 was promoted, and cell propagation control function was recovered. 2. With interferon ${\alpha}/{\beta}$ cell death was unaffected. With IJCGT apoptosis of HepG2 cell was restrained, and the cell's reaction to interferon was unaffected. 3. With interferon ${\alpha}/{\beta}$ treatment mRNA revelation of MxA and 2'5'-OAS was induced. When HepG2 cells were injected with IJCGT without interferon ${\alpha}/{\beta}$ treatment, mRNA revelation of MxA and 2'5'-OAS increased in proportion to the treatment density. With pre-treatment of IJCGT, leaded with interferon ${\alpha}/{\beta}$, promoted revelation of MxA, 2'5' -OAS mRNA. 4. Though mRNA revelation of lakl, TYK1 and STAT1 was unaffected with IJCGT, activation of STAT1 was promoted with an increase of phosphorylation of STAT1 protein. With pre-treatment of IJCGT, Jak1, TYK2, STAT1 phosphorylation, leaded with interferon, strengthened. 5. TNF-a, IL-1b and LPS present, revelation of MxA and 2'5'-OAS mRNA leaded by interferon was restrained when HepG2 cells were treated with IJCGT, and the interferon signal transmission system restraint action leaded by inflammatory cytokines was moderated. Conclusion : These results support a role for IJGCT in promotion of anti-virus action through maintainance of the liver's sensibility toward interferon. A clinical study of an interferon treated patient treated also with IJGCT is needed to determine its efficacy.
입체 유사 홀로그램을 이용한 디지털 콘텐츠의 공간증강 전시
이용이(Yong Yi Lee),이종훈(Jong Hoon Lee),주민호(Min Ho Joo),손문구(Mun Gu Son),이관행(Kwan H. Lee) (사)한국CDE학회 2016 한국 CAD/CAM 학회 학술발표회 논문집 Vol.2016 No.동계
The pseudo hologram provides a floating image to audience by reflecting the projected digital content on flat screen. However, this technique fails to provide 3D effect according to the audience’s viewpoint so that it has been mainly used in the field of the stage performance whose viewpoints are fixed. In this paper, we present a framework of the 3D pseudo hologram that can generate natural hologram images according to audience’s viewpoint. We use a 3D physical mock-up as a projection screen and project digital content onto the mock-up to generate the pseudo hologram image having 3D effect. The proposed system is an appropriate technique for digital exhibition to be provided by various viewpoints. In particular, it is expected to be utilized for digital museums, product promotion, and media art.
이용이(Yong Yi Lee),박민기(Min Ki Park),김용휘(Yong Hwi Kim),이종훈(Jong Hoon Lee),최준호(Junho Choi),이관행(Kwan H. Lee) (사)한국CDE학회 2015 한국 CAD/CAM 학회 학술발표회 논문집 Vol.2015 No.동계
A virtual broadcast is usually produced by using a chroma keying technique in a chroma studio. However, this approach not only requires a high cost for the initial configuration and employment of the expertise, but also has a spatial constraint. In this paper, we present a system that can make the virtual broadcast without spatial constraint and in real time. To this end, we use a RGB-D sensor to extract the object of interest from taken scene. We solve the hole and unmatched edge problems occurred in the RGB-D sensor to extract the object clearly. This replaces the existing method of object extraction that relies on the chroma studio. The proposed method is expected to be applied to a variety of applications such as the virtual meeting, e- learning, as well as to overcome the spatial limitations of previous virtual broadcast production system.
시호계지탕(柴胡桂枝湯)으로 치료한 천일홍(千日紅) 과민 환자 1례 보고
왕채하,김동명,이인호,김동환,이종훈,Wang Chai-Ha,Jin Dong-Ming,Yi In-Ho,Kim Dong-Hwan,Lee Jong-Hoon 대한한의학방제학회 2004 大韓韓醫學方劑學會誌 Vol.12 No.2
Gomphrena globosa has not known including allergic substances. In this report, it could induce allergic diseases like itching, redness, edema, dryness all over the body. Allergic patient from Gomphrena globosa gained a complete recovery under the administration of Sihogyejitang.
인진(茵陳)분획물이 간세포활성, 세포주기 및 Fas-mediated Apoptosis에 미치는 영향
김영철,이장훈,우홍정,이종훈,Kim, Young-Chul,Lee, Jang-Hoon,Woo, Hong-Jung,Yi, Jong-Hoon 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.3
Objective : This study was carried out to examine the effect of five fractions of an aqueous extract from Artemisia capillaris $T_{HUNB}$. Methods : The queous extract from Artemisia capillaris $T_{HUNB}$. was fractionized into 5 kinds of material. We observed the effect of each fractions on etoposide-induced apoptosis, cell viability, cell cycle progression and mRNA expression of apoptosis-related genes in human hepatocyte cell line HepG2. Results and Conclusions : The data shows that butanol fraction of Artemisia capillaris $T_{HUNB}$. has no relation with cell cycle, however, it inhibits apoptosis significantly and the action may be due to the suppression of Fas and Sax genes and activation of Bcl-2 gene.