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이정한(Jung-Han Lee),금지혜(Ji-Hye Geum),우현준(Hyeon-Jun Woo),이창훈(Chang-Hoon Lee),정종혁(Chong-Hyuk Chung),이명수(Myeung-Su Lee) 척추신경추나의학회 2020 척추신경추나의학회지 Vol.15 No.2
Objectives The purpose of this review was to analyze the trend of clinical research related to fibromyalgia and to suggest the direction of intervention Methods We reviewed the clinical research by searching seven Korean web databases and classified the studies by the year of publication, academic field, and study design. Results A total of 75 clinical studies were selected. Except for 2002, more than one study was annually published; however, the number was below 10. In the academic field, there were 34 in the medical field, 21 in the Korean medicine field, and 15 in the nursing science field. By study design, there were 62 observational studies, mostly case reports and case-control studies. There were 13 experimental studies, including non-random control studies and one group pre and post-test design studies. Conclusions Fibromyalgia-related clinical research requires a greater number of studies, and a study design with a high level of evidence should be conducted along with various observational and intervention studies. Additionally, multidisciplinary and integrated intervention plans and research are needed.
류마티스 관절염의 임상 연구 동향: 2008년 이후 국내 학술 문헌을 중심으로
한윤희 ( Yun-hee Han ),우현준 ( Hyeon-jun Woo ),박수연 ( Soo-yeon Park ),이창훈 ( Chang-hoon Lee ),정종혁 ( Chong-Hyuk Chung ),이명수 ( Myeung-Su Lee ),이정한 ( Jung-han Lee ) 한방재활의학과학회 2021 한방재활의학과학회지 Vol.31 No.3
Objectives To investigate the trends in clinical study on rheumatoid arthritis in all academic fields in Korea. Methods We searched seven Korean web databases for clinical studies published from 2008 to 2021. All identified studies were reviewed and classified by the year of publication, academic field, and study design. Results A total of 347 clinical studies were selected. An average of 26.7 studies were published each year. Regarding the distribution of studies by academic fields, 309 studies were published in the medical field and 17 studies were published during the same period in Korean medicine, and 21 studies were published in other fields. The distribution of studies by study design was as follows: 8 studies, meta-analyses; 5 studies, systematic reviews; 16 studies, experimental studies; and 318 studies, observational studies. Conclusions Multidisciplinary access and management are required for the early diagnosis of rheumatoid arthritis, effective management of disease progression, and prevention of rheumatoid joint deformities. Additionally, study design with high-level of evidence on the intervention of rheumatoid arthritis are warranted. (J Korean Med Rehabil 2021;31(3):19-29)
임신성 당뇨병 선별검사에서 비정상 50 gm 경구 당 부하 검사의 임상적 의의
이정한 ( Jung Han Lee ),황정혜 ( Jeong Hye Hwang ),김승룡 ( Seung Ryong Kim ),박문일 ( Moon Il Park ),정성로 ( Sung Ro Chung ),황윤영 ( Yeon Young Hwang ),안유헌 ( You Hern Ahn ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.2
목적 : 임신성 당뇨병 선별검사인 50 gm 경구 당 부하검사에서 비정상이나, 100 gm 경구 당 부하 검사에서 임신성 당뇨병으로 진단되지 않은 산모들의 일반적 특성과 임상적 의의를 알아보고자 하였으며, 또한 거대아, 자간전증, 제왕절개술의 위험인자를 알아보고자 하였다. 연구 대상 및 방법 : 1999년 3월부터 2001년 2월까지 한양대학교 구리병원에서 임신성 당뇨병의 진단을 위하여 경구 당 부하 검사를 시행하고, 분만한 산모 812명 중 50 gm Objective : The purpose of this study was to compare the clinical significance of pregnant women who had abnormal 50 g oral glucose tolerance test (GTT) but normal 100 g oral GTT with those who had normal 50 g oral GTT. Materials and Methods : Between Mar
자궁 내막에서의 저 용량 아스피린과 클로미펜이 신경세포유착물질 ( NCAM )의 발현에 미치는 영향
이정한(Jung Han Lee),황정혜(Jung Hye Hwang),김승룡(Seung Ryong Kim),문영진(Young Jin Moon),박문일(Moon Il Park),정성로(Sung Ro Chung),문형(Hyung Moon),황윤영(Youn Yeung Hwang),장세진(Se Jin Jang),박일규(Il Kyu Park) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.9
N/A Objective : The treatment with low-dose aspirin in the patients with unexplained infertility has been reported to improve the pregnancy rate and implantation rate via increasing the blood flow in the endometrium. But there are little known about the relationships between low-dose aspirin and cell adhesion molecules, NCAM. The aim of this study was to evaluate the effect of low-dose aspirin and clomiphene citrate treatment on the expression of NCAM in the endometrium. Methods : The patients with unexplained infertility (N=37) were grouped into 3 groups: clomiphene citrate and low-dose aspirin treated group (N=8), clomiphene citrate treated group (N=10), and natural cycle group (N=10, no treatment). As control group, the proliferative and menopausal endometrium was used. Each endometium was obtained by endometrial biopsy performed in late luteal phase and immunohistochemical staining with NCAM was performed. Results : In the stromal cells, the staining intensity of NCAM expression and the number of vessels were significantly increased in the endomterium treated with clomiphene citrate and low-dose aspirin compared with other groups (p<0.05). And the expression of NCAM in the prolifertive and menopausal endometrium showed very weak staining. Conclusion : The expression of NCAM in the stromal cells and the number of vessels were increased in the endometrium of unexplained infertility patients treated with clomiphene citrate and low-dose aspirin. These findings may suggest low-dose aspirin has an important role during the secretory phase of endometrium to improve the implantation via increasing the expression of cell adhesion molecules, especially NCAM and increasing the number of vessels.
이정한 ( Jung Han Lee ),조동찬 ( Dong Chan Jo ),고연석 ( Youn Seok Ko ),차윤엽 ( Yun Yeop Cha ),정원석 ( Won Suk Chung ),신병철 ( Byung Cheul Shin ),전찬용 ( Chan Yong Jeon ),고호연 ( Ho Yeon Go ),선승호 ( Seong Ho Sun ),장보형 ( 한방재활의학과학회 2013 한방재활의학과학회지 Vol.23 No.2
Objectives :This study was aimed to review the trend of occupational health in korean medicine and to suggest the strategic approach. Methods : We collected 40 articles on occupational health in the internet site OASIS using the keyword ‘workplace’, ‘worker’. Then we analyzed them. Results : There were 40 papers that were published between 2000 and 2012. Published papers on the korean journal of oriental preventive medicine were more than the other journals. Affiliation of the first author of the published papers was concentrated to one. Clinical research papers accounted for 90% of the total study. Papers on health management were more than half. Conclusions : Related to occupational health, high quality and large amount of research and development is needed and the active policy of the government should be supported in Korean medicine.
고농도 산소 공급량 변화에 따른 남/녀 혈중 산소 포화도의 차이
이정한(Jeong-Han Yi),최미현(Mi Hyun Choi),김지혜(Ji Hye Kim),이수정(Su-Jeong Lee),양재웅(Jae-Woong Yang),정순철(Soon-Cheol Chung),임대운(Dae-Woon Lim),이동형(Dong-Hyung Lee),민병찬(Byung-Chan Min) 한국산업경영시스템학회 2009 한국산업경영시스템학회지 Vol.32 No.4
The purpose of this study was to examine differences between male and female in blood oxygen saturation due to 93% oxygen administration of the three levels (1L/min, 3L/min, 5L/min) Ten healthy male (25 0±1 8 years) and ten female (23 7±1 9 years) college students were selected as the subjects for this study The experiment consisted of three runs, ie, the three levels of 93% oxygen administration, respectively The each run consisted of three phases, ie, Rest 1 (5 min), Hyperoxia (10 min), and Rest 2 (5 min) Blood oxygen saturation sere measured throughout the three phases By increasing the supply rate of highly concentrated oxygen, rising rate of blood oxygen saturation was increased Blood oxygen saturation of female was higher than male regardless of supply rate of highly concentrated oxygen and phases