건일로딘 정(미결정에토돌락 200 mg)에 대한 에토돌 정의 생물학적동등성

이정애,이윤영,조태섭,박영준,문병석,김호현,이예리,이희주,이경률,Lee, Jung-Ae,Lee, Yun-Young,Cho, Tae-Seob,Park, Young-Joon,Moon, Byoung-Seok,Kim, Ho-Hyun,Lee, Ye-Rie,Lee, Hee-Joo,Lee, Kyung-Ryul 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.4

A bioequivalence of $Etodol^{TM}$ tablets (Yuhan corporation) and $Kuhnillodine^{TM}$ tablets (Kuhnil Pharm. Co., Ltd.) was evaluated according to the guideline of Korea Food and Drug Administration (KFDA). Single 200 mg dose of etodolac of each medicine was administered orally to 24 healthy male volunteers. This study was performed in a $2{\times}2$ crossover design. Concentrations of etodolac in human plasma were monitored by a high-performance liquid chromatography. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 24 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was performed using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Etodol^{TM}/Kuhnillodine^{TM}$ were 1.01-1.10 and 0.87-1.06, respectively. This study demonstrated a bioequivalence of $Etodol^{TM}$ and $Kuhnillodine^{TM}$ with respect to the rate and extent of absorption.

아동프로그램의 효과성 검증연구에서 도출된 구성요소 분석

이정애(Lee, Jung Ae),강현아(Kang, Hyunah),노충래(Nho, Choong-Rai),우석진(Woo, Seokjin),전종설(Chun, JongSerl),정익중(Chung, Ick-Joong) 경성대학교 사회과학연구소 2020 社會科學硏究 Vol.36 No.1

본 연구는 다양한 현장에서 아동을 대상으로 진행된 효과적 프로그램의 구성요소를 학술지 논문을 통해 분석하였다. 이를 위해, 최근 17년간 발표된 논문에 나타난 효과적 아동프로그램 구성요소의 실태를 분석하였다. 연구대상은 2000년부터 2017년까지 전국 주요학술지에서 검색된 사회복지, 심리, 상담 영역의 254개의 논문이다. 내용분석을 활용하여 조사된 논문을 아동프로그램에 대한 기술적 특성, 프로그램 효과성 검증을 위해 사용된 통계분석 방법, 프로그램 내용 3가지를 중심으로 분석하였다. 그 결과, 기술적 특성에서 치료프로그램(37.4%)이 프로그램 유형에서 가장 많았고, 통계분석 방법 측면에서 유사실험설계(64.6%)와 t검정(36.2%)을 가장 많이 사용한 것으로 나타났다. 프로그램 내용 측면에서 보호요인은 416개, 위험요인은 162개로 나타나 보호요인에 대한 개입이 월등하게 많았고, 보호요인의 66.1%, 위험요인의 79.0%가 개인영역 변수로 구성되어 있었다. 마지막으로 연구결과에 대한 논의와 아동프로그램의 유용성과 효과성을 높이기 위한 제언을 제시하였다. The purpose of this study was to analyze the components derived from studies of effective programs for children at various fields. For the purpose of this study, research articles were searched during the last 17 years, which have dealt with effectiveness of programs. 254 research articles were found in social welfare, psychology, and counseling psychology, from 2000 to 2017. Using the content analysis, we paid attention to three areas: Technical characteristics of children’s programs, statistical analysis method for verifying effectiveness, and program contents. Results were as follows: First, in terms of technical characteristics, treatment programs (37.4%) were found to be the most common type of program. Second, quasi-experimental design (64.6%) and t-test (36.2%) were the most used research design and statistical method. Third, in terms of program contents, there were 416 protective factors and 162 risk factors, indicating that protective factors were used far greater in interventions. In addition, 66.1% of the protective factors and 79.0% of the risk factors consisted of individual variables. Based on the results, this study discussed ways to improve the usefulness and effectiveness of children"s program.

Is Radiotherapy Necessary for Stage 1 Testicular Seminoma?

Jung Ae Lee(이정애),Won Park(박원),Do Hoon Lim(임도훈),Yong Chan Ahn(안용찬),Seung Jae Huh(허승재),Jeong Il Yu(유정일),Han Yong Choi(최한용),Hyun Moo Lee(이현무),Eun Yoon Cho(조은윤) 대한방사선종양학회 2009 Radiation Oncology Journal Vol.27 No.2

목 적: 제 1 병기 성인 고환 정상피종 환자에 대한 임상적 고찰과 함께 근치적 고환절제술 후 보조적 방사선 치료와 고환절제술 단독치료의 결과를 후향적으로 분석 비교하고자 하였다. 대상 및 방법: 1996년 1월부터 2005년 9월까지 삼성서울병원에서 제 1 병기 정상피종으로 진단을 받은 환자 32명의 순수 정상피종(pure seminoma) 환자를 대상으로 하였다. 근치적 고환절제술 후 22명은 보조적 방사선 치료를 시행하였고, 10명은 추가치료 없이 종양표지자와 복부골반 전산화단층촬영을 이용한 정기적 추적관찰을 행하였다. 방사선 치료는 10∼15 MV 광자선을 사용하였으며 일일치료선량 1.8∼2 Gy로 총 24∼30.6 Gy (중앙값, 25.2Gy)를 대동맥주위림프절(L1∼L5)에 이문조사하였다. 전체 추적관찰기간은 근치적 고환절제술 시행일을 기준으로 24∼155개월(중앙값, 96개월)이었다. 결 과: 환자의 연령은 22∼58세(중앙값 34세)였고, 임상적으로 진단 전 주증상은 음낭 종괴 및 불편감이 대부분이었다. 이중 2명에서 잠복고환의 병력이 있었으며, 병리적으로 32명 중 23명에서 정상피종에 관내배아세포종(intratubular germ cell neoplasia)이 동반되어 있었다. 술후 보조적 방사선 치료를 시행한 군은 분석시점에 모든 환자가 무병상태로 100%의 국소제어율 및 생존율을 보였다. 술후 추적관찰만을 시행한 군은 10명 중 1명에서 좌측대동맥주위 림프절에 재발하여 구제 항암화학요법 후 완전관해되었으며 국소제어율 88.9%, 생존율 100%를 보였다. 결 론: 제 1 병기 정상피종에서 근치적 고환절제술 후 보조적 방사선 치료를 시행한 군과 추적관찰만을 시행한 군간에 생존율의 차이는 없었다. 환자수가 적고 추적관찰기간이 짧기는 하지만 재발 후 항암화학요법으로 구제가 잘되고, 방사선 치료시 이차암의 가능성이 있음을 고려한다면 정기적인 추적관찰이 가능한 환자에서 수술 후 방사선치료를 생략할 수도 있겠다. Purpose: To report on the clinical outcome of patients with stage I testicular seminoma by postoperative radiotherapy (PORT) or surveillance after radical inguinal orchiectomy. Materials and Methods: This study is a retrospective review of 32 stage I pure seminoma patients treated between 1996 and 2005 at the Samsung Medical Center. Twenty two of the patients were treated by PORT, which was directed at the paraaortic lymphatics with a median dose of 25.2 Gy in 14 fractions for 3 weeks. The 10 remaining patients were managed by surveillance. The median follow-up period was 96 months with a range of 24 to 155 months. Results: Clinically, most patients presented with a testicular mass or discomfort. Two of the patients had a history of undescended testes. Pathologically, 23 of the patients had intratubular germ cell neoplasia with seminoma. Both recurrence-free survival (RFS) and overall survival (OS) rates of patients treated by PORT were 100%. In the control group, 1 of the 10 patients suffered a para-aortic lymph node relapse. The RFS and OS rates of the surveillance group were 88.9% and 100%, respectively. Conclusion: No difference in survival was observed between the two groups. Moreover, symptom recurrence was only observed in 1 patient in the control group. The use of PORT may reduce the risk of relapse. With the availability of effective diagnostic and salvage modalities, surveillance monitoring may be considered for patients in good compliance.

가정외보호 퇴소청소년의 자립에 관한 질적 메타분석

이정애(Lee, Jung ae),김시아(Kim, Si ah),김지선(Kim, Ji sun),정익중(Chung, Ick joong) 한국아동복지학회 2019 한국아동복지학 Vol.- No.65

본 연구는 국내 가정외보호 퇴소청소년의 자립에 관한 질적 메타분석(qualitative meta-synthesis)의 첫 번째 시도로서, 이들의 자립경험을 종합적이고 총체적으로 이해하고자 하였다. 분석대상은 2007년부터 2018년까지 국내에서 발간된 학술지 및 박사학위 논문의 질적연구 15편이고, 지금까지 체계적으로 통합되지 않았던 가정외보호 퇴소청소년의 자립경험에 관해 범주를 나누어 살펴 보았다. 연구절차에 따라 각 연구의 결과를 분석하여 종합하였고, 질적 메타분석 결과는 다음과 같다. 가정외보호 퇴소청소년들은 자립과정에서 홀로서기를 시도하면서 개인과 이들을 둘러싼 환경에 영향을 받고 있었다. 이들의 자립경험은 개인과 환경 차원에서 6개의 영역이 도출되었다. 개인 차원은 심리, 생활, 진로 영역으로 나누었고, 환경 차원은 관계, 자원, 인식 영역으로 나눌 수 있었다. 각 영역에서 내용을 부정-긍정 경험으로 대비할 수 있었고, 이를 통해 ‘암(暗)과 명(明): 긴 터널 속 멀리 보이는 빛 한 줄기’라는 종합주제를 도출하였다. 이러한 결과를 바탕으로 가정외보호 퇴소청소년들의 자립경험이 암(暗)에서 명(明)으로 나아갈 수 있도록 사회복지 정책적·실천적 함의를 제안하였다. The purpose of this study was to understand independent living experiences of youth discharged from out-of-home care with an integrated and total point of view. This study is the first attempt of qualitative meta-synthesis in Korea. This study analyzed 15 qualitative research studies from journal articles and doctoral dissertations published in Korea from 2007 to 2018, and categorized them according to the independent living experiences of youth discharged from out-of-home care, which have not been systematically organized. The results of each study were analyzed and pulled together according to the research process, and the results were as follows. Youth discharged from out-of-home care, trying to stand alone in their independent living, were affected by individual and environmental factors. The independent living experiences of these youth were divided into individual and environmental domains with six subcategories. Individual domain was divided into psychology, living, and career, and environmental domain was divided into relationships, resources, and awareness. Each subcategory was categorized into negative and positive experiences. The main theme was, “dark and light: a gleam of light seen in a long tunnel.”. Based on the results, this study proposed social welfare policy and practice implications for youth discharged from out-of-home care in order to improve their conditions from darkness to light for independent living.

보건교사의 DISC 행동유형별 교사효능감과 직무스트레스

이정애(Jung-Ae Lee),유인영(In-Young Yoo) 한국생활환경학회 2011 한국생활환경학회지 Vol.18 No.4

The purpose of the study was to investigate teacher-efficacy and job stress according to DISC (Dominance, Influence, Steadiness, Conscientiousness) behavioral types in health teacher. The subjects consisted of 119 elementary health teacher working in Jeonbuk. The data were collected from August 11 to 12, 2010 and analyzed by the SPSS 18.0. The average age of the subjects was 42.7 years and health teacher’s experience was 16 years. Of the participants, D, I, S and C in behavioral type were 10.9%, 31.1%, 45.4% and 12.6% respectively. The teacher-efficacy and job stress were significantly different according to age and health teacher’s experience. Job stress was negatively correlated with ‘instruction efficacy’ (r=-0.331, p=0.000), ‘health service efficacy’ (r=-0.272, p=0.003), ‘task-interpersonal efficacy’ (r=-0.398, p=0.000) and ‘community connection efficacy’ (r=-0.326, p=0.000). The ‘task-interpersonal efficacy’ was significantly different according to DISC behavioral types. Based on the results of this study, it is useful to develop program to promote teacher efficacy according to DISC behavioral types.

국내 육성 사과 신품종 ‘썸머킹’, ‘그린볼’, ‘아리수’의 경북 영주지역에서의 생육 특성

이정애(Jung-Ae Lee),우병용(Byong-Yong Woo),전우영(Woo-Yeong Jeon),김병각(Byeong-Gak Kim),이갑수(Kab-Soo Lee),권순일(Soon-Il Kwon) 한국원예학회 2013 한국원예학회 학술발표요지 Vol.2013 No.5

영캐주얼웨어 웹사이트의 시각적 웹스타일가이드 강화 연구

이정애(Jung Ae Lee),이정희(Jung Hee Yi) 한국디자인문화학회 2009 한국디자인문화학회지 Vol.15 No.3

영캐주얼 패션브랜드는 10-20대의 소비자군을 형성하고 있으며, 유행에 민감한 패션산업은 빠른 제품주기를 보이고 있다. 그럼에도 불구하고 아이덴티티 구축에 성공한 영캐주얼 브랜드는 점유율 상위권을 차지하며 시간이 지날수록 가치창출에 성공하며 파워브랜드로 거듭나고 있다. 연구목적은 영캐주얼 패션브랜드의 온라인 및 오프라인 컨셉이 소비자에게 일관성 있게 전달되었는지 조사하기 위하여 진행되었다. 연구방법 및 범위는 수도권 거주하는 남 87명(40.0%), 여 129명(60.0%) 총 216명이며 주요구매자인 대학생 중심으로 2009년 6월1일부터 6월15일까지(15일간) 설문지 조사를 실시하였다. 첫번째, 국내브랜드를 대상으로 영캐주얼 브랜드가 형성하고 있는 웹스타일가이드의 시각적 측면을 조사하였다. 그 결과, 시각적 컨셉, 색상, 폰트, 레이아웃, 그래픽 요소, 인터랙티브 디자인 등 웹아이덴티티 측면에서 대부분 잘 구축되었다. 두번째, 오프라인에서 형성된 브랜드의 컨셉이 온라인에도 일관성 있게 적용되었는지 알아보기 위하여 온라인과 오프라인의 컨셉이 일치하는지에 관하여 실험하였다. 그 결과, 상위 3개 브랜드는 정확히 일치 하였고 2개 브랜드는 약하거나 다른 컨셉으로 소비자에게 인식 되었다. 향후 이 부분에 대하여 개별 브랜드의 온오프라인의 일관된 컨셉 전달이 요구된다고 볼 수 있다. Young casual wear fashion brand and a consumer group 10-20 formed, and the fashion-conscious fashion industry is a fast product cycle. Nevertheless, successful young casual wear to build brand identity for the dominant share of the top in value as time passed, it has become a power brand. First, the domestic brands and a brand young casual wear the visual aspect of the web style guide was investigated. As a result, the visual concept, colors, fonts, layout, graphic elements, interactive design, build, and I was most in webidentiti. Second, offline, online, even formed the concept of brand has been consistently applied the concept of online and offline to learn about how this match was an experiment. people who are residents of the metropolitan area 87 man(40.0%), 129 woman(60.0%) total 216 their major purchases in 2009, the college June 1 to June 15 years (15 days) was conducted. As a result, the top three brands, and exactly match the two brands to consumers recognized the consistency visual concept of weak or see the other in the future will require the improvement of the individual brands can be found.

인상채득 후 경화시 트레이의 위치에 따른 주모형의 변화

이정애 ( Jung Ae Lee ) 한국치위생학회 2008 한국치위생학회지 Vol.8 No.2

초등학교 고학년 학생의 인터넷 중독정도에 영향을 미치는 요인

이정애(Lee, Jung-Ae),유인영(Yoo, In-Young) 한국보건간호학회 2012 韓國保健看護學會誌 Vol.26 No.3

Purpose: The purpose of this study was to investigate factors influencing internet addiction proneness and condition of internet use in higher grade students at an elementary school. Method: The subjects consisted of 234 sixth grade students at an elementary school in Gyeonggido. SPSS/Win18.0 was used for analysis of data. Results: Among the subjects, 51.3% had used the internet for more than three years, 89.3% used the internet in their home, and 38.5% used the internet for games. In internet addition proneness, 3.1% were potential risk users and 1.3% were high risk users. Internet addiction proneness differed significantly according to gender, period of internet use, internet access location, and purpose of internet use. Internet addiction proneness showed negative correlation with protective factors and positive correlation with risk factors. The factors affecting the internet addiction proneness were degree of internet use, peer protective factor(support from peer), personal protective factor(self-control), internet access location, and family risk factor(negative communication). These factors accounted for 32.9% of internet addiction proneness. Conclusion: Strategies are needed for improvement of the relationship with the peer group and family communication and to encourage self-control for prevention of internet addiction in elementary school students in community mental health service.

소아청소년의 대사증후군 유병률과 위험요인

이정애(Jung-Ae Lee),이영미(Young-Mi Lee) 한국생활환경학회 2017 한국생활환경학회지 Vol.24 No.2

The purpose of this study was to examine the prevalence and associated factors of metabolic syndrome of children and adolescents in Korea. The data of 7,709 children and adolescents were selected from the database of the Korean National Health and Nutrition Examination Survey from 2008 to 2014 and were analyzed using descriptive statistics, χ 2-test, ANOVA and logistic regression with the SPSS WIN 19.0 program. The risk factors of metabolic syndrome as age, weight, blood pressure, fasting glucose, and triglyceride were significantly different from 2008 to 2014. The odds ratio of children and adolescent with obesity was over 11 times significantly higher than that of children and adolescent with normal BMI. The prevalence of metabolic syndrome of girls was higher than that of boys from 2008 to 2013. But in 2014, the prevalence of metabolic syndrome of boys and girls was reversed. It is necessary to monitor the prevalence and risk factors for th management of metabolic syndrome in children and adolescents.