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신동맥분지협착에 의한 신혈관성고혈압 예에서 캅토프릴투여후 99mTc - DMSA 신 스캔
양원석(W . S . Yang),김연수(Y . S . Kim),엄재호(J . H . Earm),김상은(S . E . Kim),이동수(D . S . Lee),한진석(J . S . Han),정준기(J . K . Chung),김성권(S . K . Kim),이명철(M . C . Lee),이정상(J . S . Lee),고창순(C . S . Koh) 대한핵의학회 1990 핵의학 분자영상 Vol.24 No.2
N/A Radionuclide renal scintigraphies were performed in a 24-year-old man with right renal artery branch stenosis. Captopril enhanced Tc-99m-DTPA renal scintigraphy revealed no abnormal finding in the right kidney But, Tc-99m-DMSA renal scintigraphy showed regional cortical photon deficient area corresponding to the area supplied by the stenotic branch artery. The defect size increased in captopril enhanced Tc-99m-DMSA renal scintigrphy and nearly disappeared after successful transluminal renal angioplasty. This case suggests that the captopril enhanced Tc-99m- DMSA renal scintigraphy may be a useful method in the evaluation of renovascular hypertension, especially due to branch renal srtery stenosis.
이정상(J. S. Lee),김종암(C. Kim),노오현(O. H. Rho) 한국전산유체공학회 2003 한국전산유체공학회지 Vol.8 No.2
In this work, we propose a new idea of flapping airfoil design for optimal aerodynamic performance from detailed computational investigations of flow physics. Generally, flapping motion which is combined with pitching and plunging motion of airfoil, leads to complex flow features such as leading edge separation and vortex street. As it is well known, the mechanism of thrust generation of flapping airfoil is based on inverse Karman-vortex street. This vortex street induces jet-like flow field at the rear region of trailing edge and then generates thrust. The leading edge separation vortex can also play an important role with its aerodynamic performances. The flapping airfoil introduces an alternative propulsive way instead of the current inefficient propulsive system such as a propeller in the low Reynolds number flow. Thrust coefficient and propulsive efficiency are the two major parameters in the design of flapping airfoil as propulsive system. Through numerous computations, we found the specific physical flow phenomenon which governed the aerodynamic characteristics in flapping airfoil. Based on this physical insight, we could come up with a new kind of airfoil of tadpole-shaped and more enhanced aerodynamic performance.
신기능장애 및 혈액투석환자에서의 Pyrazinamide 의 약력학적 연구
김대중(D . J . Kim),김성권(S . K . Kim),이정상(J . S . Lee),한용철(Y . C . Han),이문호(M . H . Lee),이선희(S . H . Lee),신상구(S . G . Shin),박찬웅(C . W . Park) 대한내과학회 1986 대한내과학회지 Vol.31 No.1
The pharmacokinetics of single oral dose(lgm) of pyrazinamide was studied in 20 patients with various degrees of renal insufficiency including 6 patients on long-term hemodialysis. The average 24 hr urinary recovery of pyrazinamide in patients with creatinine clearance 10 to 30 ml/hr/kg, and patients with creatinine clearance lesser than 10 ml/hr/kg were 7.5 and 0.9% of administered dose respectively. Serum half-life of the drug was slightly, but significantly(p<0.05), prolonged in patients with creatinine clearance lesser than 10 ml/hr/kg(half-life; 11.25±2.55 hr) compared with normal subjects(half-life; 8.21±1.38 hr) previously reported. The mean serm half-life of pyrazinamide in patients on longterm hemodialysis was 12.26±2.92 hr. The half-life fell to 3.52±1.17 hr during hemodialysis. It was estimated that approximately 41% of drug in the body was removed into dialysate during 4 hr dialysis. The mean dialysance of pyrazinamide was 91.40±2.83 ml/min. From the observed pharmacokinetics of pyrazinamide in patients with impaired renal function, it is suggested that adjustment of dosage regimen may not be required for patients just with impaired renal function. However, replacement of dialysed fraction of pyrazinamide would be required for the maintenance of adequate serum level.
급성(急性) 신부전(腎不全)이 동반(同伴)된 근양사(筋壤死)에 있어서의 $^{99m}Tc$-MDP 골주사(骨走査)
문희범,한진석,김삼용,조보연,이정상,고창순,조경삼,Moon, H.B.,Han, J.S.,Kim, S.Y.,Cho, B.Y.,Lee, J.S.,Koh, C.S.,Cho, K.S. 대한핵의학회 1980 핵의학 분자영상 Vol.14 No.2
We studied four patients with muscle necrosis associated with acute renal failure to evaluate the diagnostic value of the bone scan in this disease. The illness followed carbon monoxide poisoning in two patients, acute physical exertion in one and contaminated intramuscular injection in the other. Whole-body rectilinear bone scans using technetium 99m-methyldiphosphonate were done. In all patients, increased muscle labelling at the regions of suspected muscle injury was showed, and in one, it was after normalization of serum muscle enzyme levels. In one patient, the bone scan was rechecked 8 months later and showed no residual abnormality. Above all, the site and precise extent of muscle injury could be detected and the degree of muscle labelling seemed to correlate with the severy of muscle injury. These findings suggest that isotope scanning may be useful in the diagnosis of patients with acute muscle necrosis.