율무의 파종기(播種期)와 재식밀도에 따른 생육 및 수량(收量)

이은섭(Eun Sub Yi),이준석(Jun Seok Lee),이효승(Hyo Sung Lee) 한국약용작물학회 1997 한국약용작물학회지 Vol.5 No.3

근치적절제술을 시행한 췌장암환자의 예후인자로서 Flow Cytometry를 이용한 DNA Ploidy 검사의 의의

이은섭(Eun Sub Lee),송시영(Si Young Song),정재복(Jae Bock Chung),박영년(Young Nyun Park),강진경(Jin Kyung Kang),박인서(In Suh Park),박찬일(Chan Il Park) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.2

N/A Background/Aims: Only about 5 l0% of all the patients with pancreatic carcinoma that under- went radical resection survive for more than five years. Various factors related to the prognosis arc presently known, such as size, location, stage, multicentricity, cell type, histologic grading, mitotic activity, type of surgery, intraoperative irradiation, performance status, sex, etc. Recently DNA analysis using flow cytometry has widely been used to evaluate the prognostic factors in various malignancies, and there appears to be a relationship between DNA aneuploid and decreased survi- val. However the results are still controversial. Thus we conducted this study to evaluate the prognostic effect of DNA ploidy and synthetic phase fraction in patients with pancreatic cancer who underwent radical operation. Methods: Flow cytometric DNA analysis was performed using formalin fixed paraffin-embedded specimens of 14 cases of pancreatic carcinoma that underwent radical resection. In addition, clinicopathological review was done to determine the usefulness of this technique in predicting biologic behavior and prognosis. Results: Aneuploidy was noted in 6 cases(4'2.9/c) and diploidy in 8 cases(57.1%). The S-phase fraction(SPF) in aneuploid tumor(23.7 /n) was significantly higher than that in diploid tumor(9.5%). The median survival was 32.9 months and l5.7 months in diploid and aneuploid tumor respectively, and 44.3 months and 20.1 months in S-phase fraction below and above median value(l 1.0%) respectively. Aneuploidy and higher S-phase fraction were frequently encountered in cases with recurrence within 24 months after operation than in cases without recurrence during the entire follow-up period[mean 48(9- l20) months). Comparing various parameters related to the recurrence, higher rate of recurrence was noted in case.I with larger tumor size, advanced T or N stages, poor histologic grading, aneuploidy and higher S-phase fraction. Conclusion: These findings suggest that flow cytometric DNA analysis may be helpful in predicting the recurrence and in selecting patients with resectable pancreatic carcinoma who will benefit from operation. (Korean 3 Gastroenterol 1995;27:237- 244)

‘-고 싶-’ 구문의 성격에 대한 재고

이은섭(Lee, Eun-Sub) 한국어문학회 2021 語文學 Vol.- No.151

컨테이너貨物에 대한 船荷證券記載의 效力

이은섭(Lee Eun-Sub),김선옥(Kim Sun-Ok) 한국무역학회 1998 貿易學會誌 Vol.23 No.1

Liraglutide 치료군에서 매주 L-Arginine 주사의 추가 치료에 대한 효능

이은섭(Eun-Sub Lee),정민(Jung-Min Choi),주남석(Nam-Seok Joo) 대한기능의학회 2020 Journal of Korean Institute for Functional Medicin Vol.3 No.1

Background: Recently, liraglutide is considered as an efficient treatment option to control body weight in the obese. However, no data were reported for additional effect of L-arginine injection in the liraglutide treatment patients. Methods: We have designed observational trial to evaluate the difference of body composition by additional L-arginine intravenous injection (15 g, every week) in the liraglutide use patients (3.0 mg everyday) for six months. A total of 130 subjects, we selected the data of 113 subjects who completed six months’ treatment. The data were composed of one university hospital (liraglutide group, n=21) in Suwon city and one obesity clinic (liraglutide+L-arginine group, n=92) in Seoul. Results: After six months, body weight (liraglutide vs liraglutide+L-arginine; -4.6 kg vs. -5.6 kg; P=0.286), lean body mass (liraglutide vs liraglutide+L-arginine; -0.7 kg vs. -1.1 kg; P=0.940), and body fat mass (liraglutide vs liraglutide+L-arginine; -3.5 kg vs. -3.7 kg; P=0.618) were not different between the two groups. Conclusion: No additional body compositional changes were observed after additional L-arginine injection in liraglutide treatment patients. 연구 배경: Liraglutide 피하주사는 비만환자에서 체중감량 조절에 유용한 치료방법이다. 그러나 현재까지 liraglutide 와 함께 L-arginine 정맥주사를 병행하여 치료한 연구는 없었다. 따라서 본 연구는 liraglutide를 쓰는 환자에서 L-arginine 정맥주사를 병행했을 때 추가적인 체중 감량 및 체성분 변화가 있는지를 평가하였다. 방법: 본 연구는 관찰연구로서 6개월간 liraglutide (3.0 mg, 매일)를 단독 피하 주사한 군과 liraglutide (3.0 mg, 매일)과 L-arginine (15 g, 매주)을 병행주사한 군의 체성분 변화를 비교하였다. 총 130명의 환자 자료에서 6개월간 치료를 완료한 113명의 자료를 선별하였다. 대상자는 수원시 소재 일개 대학병원(liraglutide군, n=21)과 서울시 소재 일개 비만클리닉 (liraglutide+L-arginine군, n=92)에 내원한 비만환자였다. 결과: 6개월의 치료 후, 체중(liraglutide vs. liraglutide+ L-arginine; -4.6 kg vs. -5.6 kg; P=0.286), 제지방량(liraglutide vs. liraglutide+L-arginine; -0.7 kg vs. -1.1 kg; P=0.940), 체지방량(liraglutide vs. liraglutide+L-arginine; -3.5 kg vs. -3.7 kg; P=0.618)은 두 군 사이에 유의한 차이가 없었다. 결론: Liraglutide 사용 환자에게 L-arginine 주사를 추가하였을 때 liraglutide 단독 치료와 비교하여 추가적인 체중 감량 및 체성분 변화는 없었다.

2003년 한국의 돼지콜레라 전국적 확산에 대한 기술역학

박최규,이은섭,윤하정,위성환,송재영,문운경,최은진,김현수,이주호,안수환,Park, Choi-Kyu,Lee, Eune-Sub,Yoon, Hachung,Wee, Sung-Hwan,Song, Jae-Young,Moon, Oun-Kyeong,Choi, Eun-Jin,Kim, Hyun-Soo,Lee, Joo-Ho,An, Su-Hwan 대한수의학회 2006 大韓獸醫學會誌 Vol.46 No.3

In March 2003, classical swine fever (CSF) infection was reported in a piggery located at Iksan city, Jeollabuk-do in Korea. Subsequently, a total of 72 infected farms were confirmed between March and December, 2003. Based on epidemiological investigation of the earlier confirmed infected farms, the source of infection was shown to be from a breeding farm. Targeted surveillance of 82 piggeries that had acquired pigs from this breeding farm showed 44 piggeries were infected with CSF virus. CSF virus was introduced into this breeding farm by movement of selected breeder pigs from its 12 contracted farms which were located in areas that had been affected by CSF epidemic in late 2002. CSF had then spread through out the country mainly by direct transmission through the sale and movement of pigs from this breeding farm. Consequently, 47 (62%) among 72 CSF affected farms were associated, directly and indirectly, with this breeding farm. This study showed that inadequate control for breeding farms and transport restriction in CSF outbreak areas resulted in the nationwide spread of CSF and the failure of the eradication campaign that has been underway for several years by the Korean animal hygiene authority as well as the fanners. Improvements of control policy through further research of the 2003 CSF epidemic will be needed to reestablish the Korean CSF eradication program in the future.

이하선 Warthin 종양의 세침흡인검사 후 발생한 육아종성 괴사 1예

오현식(Hyeon Sik Oh),이은섭(Eun Sub Lee),조용태(Young Tae Jo),권민수(Minsu Kwon) 대한두경부종양학회 2018 대한두경부 종양학회지 Vol.34 No.2

Fine needle aspiration is usually performed as a preoperative cytologic evaluation in salivary gland tumors, and complications of the lesion after fine needle aspiration are scarcely developed. The secondary change of tissue by fine needle aspiration can make the diagnostic and subsequent therapeutic difficulties for clinicians and require a careful approach. Fine needle aspiration can cause variety of changes in Warthin tumor, and it is presumed that those changes are mainly caused by the infarction of the mass due to vascular injury and following inflammatory reactions. We would introduce our experience of granulomatous and necrotic change after fine needle aspiration on parotid Warthin tumor with consequent difficulties in diagnostic and surgical approach to the patient.

전류-모드 피드백을 이용한 저전압 고효율 DC-DC Boost Circuit

봉지혜(Jihye Bong),이은섭(Eun-Sub Lee),민경식(Kyeong-Sik Min) 대한전자공학회 2010 대한전자공학회 학술대회 Vol.2010 No.6

2002년 한국에서 발생한 돼지콜레라의 역학적 특성

박최규,송재영,위성환,이은섭,윤하정,문운경,최은진,남향미,Park, Choi-Kyu,Song, Jae-Young,Wee, Sung-Hwan,Lee, Eune-Sub,Yoon, Hachung,Moon, Oun-Kyeong,Choi, Eun-Jin,Nam, Hyang-Mi 대한수의학회 2006 大韓獸醫學會誌 Vol.46 No.2

This paper described the epidemiological characteristics of 2002 outbreak of classical swine fever (CSF) in Korea. A total of thirteen CSF-infected farms could be classified into two clusters according to the location and time of outbreak. Two farms located in the same county of Gangwon province and 11 farms located in several different districts of Incheon metropolitan/Gyeonggi province were identified as CSF-infected from April 16 to 30 and from October 7 to December 21 in 2002, respectively. As the result of epidemiological analysis, the two clusters of outbreaks were turned out to be independent epidemics which had different sources of virus introduction. Three farms were found to have been infected primarily; one located in Cheolwon county of Gangwon province and two located in Kangwha county of Incheon metropolitan area. The most likely factors of virus introduction into these primary infected farms were considered to be direct or indirect contact by foreign workers and/or owners of the infected farms who had come back from traveling in China before outbreaks. This was supported by the genetic typing of CSF viruses isolated from the pigs of infected farms. All the virus isolates of 2002 outbreak were found to be genetic type 2, whereas the viruses isolated before 2000 were type 3 and the reference strains, such as attenuated live vaccine virus (LOM strain) and high virulent challenge virus (ALD strain), were type 1. Accordingly, we concluded that the 2002 CSF outbreak must have been caused by a newly introduced virus from overseas and the type 3 virus must have been eradicated after the last outbreak of 1999 by the national CSF eradication campaign which were implemented since 1996. Based on the combined analysis of epidemiological data and genetic typing, the transmission routes of classical swine fever virus were found to be the movement of vehicles (60%) and persons (10%), neighbourhood spread (20%) and unknown (10%). It is expected that the analyzed data and findings of classical swine fever outbreak epidemic could be very useful to establish the disease control and eradication program for the country in the future.

영상진단을 이용한 담석의 성분예측에 관한 연구 - 초음파, 전산화단층촬영 및 자기공명영상을 중심으로 -

박승우(Seung Woo Park),송시영(Si Young Song),강진경(Jin Kyung Kang),유형식(Hyung Sik Yoo),정재복(Jae Bock Chung),박인서(In Suh Park),이은섭(Eun Sub Lee) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.2

N/A Background/Aims: To predict the gallstone composition for nonsurgical treatment, various imaging techniques have been used. One such technique that several researchers have recently showed interest in magnetic resonance imaging(MRI). However, the usefulness of this technique has yet to be studied. Thus, the purpose of this study is to compare the effectiveness of ultrasonography(LJS), computed tomography(CT), and MRI for the prediction of gallstone composition. Methods: Thirty- nine cases of gallstones removed surgically were used. The findings of each imaging studies in vitro were compared with the type of stone classified according to the cholesterol content measured by infrared spectrophotometry. Results: Infrared spectrophotometry showed that seventeen cases were cholesterol, 8 mixed, and 14 pigment stones. When US findings were classified into shooting star, crescent, half-moon, full-moon and star-dust pattern, a single pattern was noted in l9 cases, and two or three patterns were noted in the remaining 20 cases. There was no correlation between the US patterns and gallstone types. CT findings were classified into dense(7 cases), faint(4 cases), hypodense(4 cases), rimmed(lO cases) and laminated(4 cases) patterns. Higher incidence of cholestero1 stones was found in hypodense(4/4) and rimmed(6/lO) patterns, while the occurrence of pigment stones was higher in the dense(l 1/l7) pattern. In MRI, while Tl-weighted images showed visibly incrcased signal in 34 of the 39 cases, 17 cases were signal void on T2-weighted images. There was no correlation between signa1 intensity and cholesterol or calcium content. MRI findings were categorized into dark(5 cases), faint(l case), bright(2 cases), rimmed(7 cases), laminated(13 cases) and central sunburst(l3 cases) patterns. There was higher incidence of Cholesterol stones in the central sunburst pattern(lO/l l), while pigment stones occurred more in rimmed(5/7), laminated(6/l3), and bright(2/2) patterns. The sensitivity, specificity, positive and negative predictive value for the prediction of cholesterol stone were 58.8%, 8l.8%, 71.4% and 72.0% by CT, and 64.7/o, 95.5%, 9I.7% and 77.8% by MRI, respectively. Conclusions: US has no value in predicting the composition of gallstones, while CT and MRI seem to have some predictive power. However, MRI has higher specificity and negative predictive value than CT, and therefore MRI is expected to have more clinical usefulness. (Korean J Gastroenterol 1995;27: 213 - 227)