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이소성 ACTH 생산에 의해 야기된 Cushing 증후군이 동반된 소세포 폐암
곽영임 ( Young Im Kwak ),임영혁 ( Young Hyuck Im ),천영국 ( Young Kug Cheon ),이가희 ( Ka Hee Yi ),남현석 ( Hyeon Seok Nam ),이춘택 ( Choon Taek Lee ),강윤구 ( Yoon Koo Kang ),이진오 ( Jhin Oh Lee ),강태웅 ( Tae Woong Kang ) 대한결핵 및 호흡기학회 1995 Tuberculosis and Respiratory Diseases Vol.42 No.6
Effect of Buan Mulberry on Metabolic Improvement in Streptozotocin-Induced Diabetic Rats
Ju Taek Lee(이주택),Jae-Sung Ryu(류재성),Dong Hoon Kwak(곽동훈),Yun Jum Park(박윤점),Seong Sun Kang(강성선),Pyoung Jun Kim(김병준),Kyung-A Hwang(황경아),Young-Kug Choo(추영국) 한국생명과학회 2010 생명과학회지 Vol.20 No.12
본 연구에서는 streptozotocin (STZ)에 의해 유도된 당뇨병 흰쥐를 이용하여 부안산 오디의 항 당뇨효과를 in vivo 실험을 중심으로 조사하였다. 기존의 연구는 주로 in vitro 실험을 통해 이루어 졌으며 일부 지역의 오디는 STZ에 의해 유도된 당뇨병 흰쥐에서 신진대사 증진, 항산화 및 체내 지방 저하 효과가 있음이 시사 되어졌다. 먼저, Sprague-Dawley 수컷 흰쥐를 난괴법을 통해 하나의 정상군(Normal)과 대조군(Diabetic), 인슐린 처리군(Insulin), 0.5% 오디 투여군(0.5% Mulberry), 1.0% 오디 투여군(1.0% Mulberry) 그리고 2.0% 오디 투여군(2.0% Mulberry) 등으로 분류 한 후 STZ로 당뇨병을 유도하였다. 부안산 오디를 STZ에 의한 당뇨병 흰쥐에 4주간 투여한 후 정상군과 비교 했을때 다양한 농도의 오디를 투여한 그룹에서 몸무게, 혈중 인슐린의 농도는 감소했지만, 신장무게, 혈당량, 요량 및 음수량은 증가하였다. 추가적으로 STZ에 의한 당뇨병 흰쥐와 이들 동물들에게 오디를 투여한 그룹을 비교한 결과 오디를 투여한 그룹은 신장 무게, 혈당, 요량 및 음수량이 확연히 감소하였다. 또한 오디를 투여한 그룹에서의 인슐린 농도는 대조군과 비교하여 유의적으로 증가하였다. 이와 같은 연구결과로부터 부안산 오디는 향후 당뇨 합병증을 억제하기 위한 기능성 식품의 원료로 사용 되어질 가능성을 시사한다. This study was designed to evaluate the anti-diabetic effects of Buan mulberries by using an insulin- dependent diabetes mellitus animal model. Several studies have shown that mulberries have metabolism- improving, antioxidant, and lipid-lowering properties in rats with streptozotocin (STZ)-induced diabetes. In this study, Sprague-Dawley male rats were randomly assigned to 1 normal control group and 5 STZ-induced diabetes groups: rats that had STZ-induced diabetes and did not receive any agents (diabetic group; negative control), rats that had STZ-induced diabetes and received insulin (insulin group; positive control), rats that had STZ-induced diabetes and received 0.5% mulberry extract (0.5% mulberry group), rats that had STZ-induced diabetes and received 1.0% mulberry extract (1.0% mulberry group), and rats that had STZ-induced diabetes and received 2.0% mulberry extract (2.0% mulberry group). Mulberry extracts were administered to the diabetic animals for 4 weeks. The rats that received mulberry extracts showed lower body weights and insulin levels, as well as higher kidney weights, blood glucose levels, urine quantities, and water intake in comparison with the normal controls. Further, the insulin concentrations in the mulberry-fed animals were higher than those in the diabetic group, and the kidney weights, blood glucose levels, urine quantities, and water intake in the mulberry-fed animals were lower than the corresponding values in the diabetic controls. These results suggest that mulberry may be an effective functional food to prevent diabetes-related complications.
실시간 일정압력 제어기술을 적용한 냉난방장치의 피크부하 저감과 에너지 효율 향상을 위한 시스템 개발
최선영(Sun-Young Choi),이영국(Young-Kug Lee),최명광(Myeong-Gwang Choi),최태원(Tae-Won Choi) 한국조명·전기설비학회 2015 조명·전기설비학회논문지 Vol.29 No.11
Systemic heating and cooling air conditioning systems are popular in various industrial fields and even home. Recently, the rate of supply of this kind of multi-heat pump has been increased under ESCO financing supporting system. Generally the heat pumping system has a structural simplicity and easy installation benefits. and has good running efficiency under normal designed condition. But under extreme climate condition (over +30℃, under -10℃), this system exposes abnormal power consumption. It causes high progressive electric power rates and resultant peak power capacity of power plant. In this paper, a novel system concept of buffering refrigerant accumulator and constant pressure control system to relieve peak power load is proposed and this system’s utility is verified with an prototype experimental system
식물 및 곤충세포 발현시스템을 이용한 암 진단 및 치료용 항체 생산
이정환(Jeong-Hwan Lee),김득수(Deuk-Su Kim),이재혁(Jaehyouk Lee),명순철(Soon-Chul Myung),황경아(Kyung-A Hwang),추영국(Young-Kug Choo),고기성(Kisung Ko) 대한비뇨기종양학회 2012 대한비뇨기종양학회지 Vol.10 No.2
Therapeutic proteins can prevent or treat wide ranges of diseases from cancer and viral or bacterial infections. Production of the therapeutic proteins has been well established mainly in mammalian and bacterial cells including transgenic organisms by recombinant DNA techniques. Recent plant and insect biotechnology and advanced molecular immunology have established molecular biofarming system as an alternative way to produce recombinant pharmaceutical proteins such as immunotherapeutic monoclonal antibodies (mAb). The plants and insects as an expression system have several advantages, which include the lack of animal pathogenic contaminants, low cost of production, and ease of agricultural scale-up compared to other currently available systems. Thus, the paradigm of plant is being shifted as a food source to so-called plant bioreactor for production of therapeutic proteins. Currently, we have successfully developed a plant and insect cell expression system for production of anti-cancer and anti-virus monoclonal antibodies. The effective heterologous production system for recombinant therapeutics requires the appropriate expression machinery with optimal combination of transgene expression regulatory conditions such as control of transcriptional and post transcriptional events. In this paper, the possibility of targeting proteins to the ER and possibly storing them to the protein storage vacuoles with glycosylation modification are discussed in plant and insect cells.
주령별 쥐 대뇌피질 신경 조직의 초기 발달단계에서 UDP-GlcNAc 함량 및 단백질의 O-GlcNAc 수식 변화
이윤희 ( Yoon Hee Lee ),김성민 ( Sung Min Kim ),박제권 ( Jae Kweon Park ),김성욱 ( Sung Oog Kim ),도수일 ( Su Il Do ),추영국 ( Young Kug Choo ),박용일 ( Yong Il Park ) 한국키틴키토산학회 2009 한국키틴키토산학회지 Vol.14 No.4
체내 포도당 영양분 대사와 이로 인한 UDP-GlcNAc의 생성 대사와 단백질들에 대한 O-GlcNAc 수식 및 세포표면 당 단백질의 시알산 발현은 신경계 기능에 중요한 영향을 미치게 된다. 이러한 대사의 변화를 이해하는 것은 뇌의 비정상적인 발달에 의한 선천성 뇌신경계 질환 혹은 알츠하이머병과 같이 특징적인 뇌대사의 저하를 보이는 병의 진단 및 평가에 중요하나, 현재 이에 관련된 기작이 명확하게 밝혀져 있지 않다. 이를 위한 기초연구로서, 본 연구에서는 임신한지 18일 되는 태아쥐와, 생후 하루, 4주, 8주째의 신생쥐 및 청년기쥐로부터 대뇌피질 조직을 분리하여 초기 뇌조직 발달에 있어서 UDP-GlcNAc 함량 변화, 단백질의 O-GlcNAc 수식 변화 및 시알산 발현 변화를 조사하였다. 단백질의 O-GlcNAc의 양은 쥐의 나이가 증가함에 따라 점차 증가하는 양상을 보인 반면, 전구체가 되는 UDP-GlcNAc의 양은 감소하는 양상을 보였으나, O-GlcNAc과는 반대로, 역시 UDP-GlcNAc을 전구체로 하여 생합성 되는 시알산의 경우는 뇌조직이 발달해 감에 따라 UDP-GlcNAc의 감소와 함께 점차 감소하는 경향을 보였다. 이는 포도당 영양분의 공급 및 UDP-GlcNAc 대사와 단백질의 O-GlcNAc 수식화(O-GlcNAcylation)와 시알산 발현이 보다 복잡한 메카니즘에 의해 조절됨을 의미하며, 관련된 조절 단백질, 혹은 효소에 대한 더욱 많은 연구가 필요할 것으로 사료된다. 이들의 대사 관계 및 조절에 대한 기작이 밝혀 진다면 알츠하이머 등 노화에 따른 인지능력 저하나 청소년기 비정상적인 발달에 따른 기형아 등 선천성 신경계 질환을 예방하거나 치료할 수 있는 단서를 제시할 수도 있을 것으로 사료된다. The extrinsic glucose supply, the biosynthesis of UDP-GlcNAc, protein O-GlcNAcylation and sialylation of cell surface proteins are now increasingly important aspects for normal function of brain neuronal system. As a preliminary study, we investigated changes in protein O-GlcNAcylation, sialylation and the content of UDP-GlcNAc in the rat brain cortical tissues of different ages, embryonic(E18), new-born(P0), 4-week(P4W) and 8-week-old(P8W) rats. As the rats grow up to young adult(8-week-old), O-GlcNAcylation in total proteins and number of protein species gradually increased along with sharp decrease in UDP-GlcNAc content. In contrast to O-GlcNAcylation, total sialic acid content in total proteins of each tissue showed an increase from E18 to P0 and then gradually decreased. These results may suggest that UDP-GlcNAc metabolism and protein O-GlcNAc modification and sialic acid expression are controlled by rather complicate mechanism during the normal development of early post-natal brain tissues. Elucidating the mechanisms of the metabolic processes between these factors and their regulation would be beneficial for the prevention and treatment of neurodegenerative diseases such as hereditary and Alzheimer`s diseases.
전이성 또는 재발성 식도암에 대한 Cisplatin , Etoposide 및 5 - Fluorouracil ( PEF ) 복합화학요법의 치료 효과
류백렬(Baek Yeol Ryoo),임영혁(Young Hyuck Im),강윤구(Yoon Koo Kang),정상훈(Sang Hoon Jeong),김현각(Hyun Kag Kim),이창희(Chang Hee Lee),윤종길(Jong Kil Yoon),천영국(Young Kug Cheon),김서운(Seo Woon Kim),김유철(You Cheoul Kim),김창민(C 대한내과학회 1996 대한내과학회지 Vol.51 No.4
N/A Esophageal cancer is widely disseminated in more than 80% of patients at the time of diagnosis and the prognosis of advanced esophageal cancer is dismal with a median survival of 5 to 8 months. Therefore, systemic chemotherapy has assumed an important role in the treatment of these patients. Among various combination chemotherapy regimens, the combination of cisplatin and 5-fluorouracil has been one of the most effective for esophageal cancer because of their synergism. Etoposide, although reported ineffective as a single agent, has been shown to be synergistic with cisplatin in vitro and in vivo. So, we conducted a phase 2 trial to evaluate the effect of a combination of cisplatin, etoposide and 5- FU (PEF) in patients with metastatic or recurrent esophageal cancer. Thirty-four patients with measurable lesion(s) received cisplatin (20㎎/㎡ i.v. Day 1~5), etoposide (100㎎/㎡ i.v. Day 1, 3 & 5) and 5-FU (800㎎/㎡ continuous i.v. for 12 hours, Day 1~5). Of 30 evaluable patients, 1(3.3%) had a complete response and 11(37%) had partial responses. The median duration of response was 29 weeks. The overall median survival was 34 weeks and the survival time in the responders was longer significantly than that of the non-responders. There was no significant prognostic factor influencing the response rate. Among total 135 cycles of chemotherapy, leukopenia was observed in 36% and thrombocytopenia in 4%. There was no treatment-related death. Main non-hematologic toxicities were neurotoxicity (17%), nephrotoxicity (3%), and stomatitis (10%) and diarrhea (10%). All the toxicities were mild and well tolerated. Conclusion: A combination chemotherapy of cisplatin, etoposide and 5-FU (PEF) was effective and well tolerated in patients with metastatic or recurrent esophageal cancer.
국소적으로 진행된 식도암 환자에서 Cisplatin , Etoposide 및 5 - Fluorouracil ( PEF ) 선행화학요법의 효과 ; A Pilot Study
정상훈(Sang Hoon Jeong),임영혁(Young Hyuck Im),강윤구(Yoon Koo Kang),손태용(Tae Yong Son),곽영임(Young Im Kwak),천영국(Young Kug Cheon),김현각(Hyun Kag Kim),류백렬(Baek Yeol Ryoo),김유철(You Cheoul Kim),이춘택(Choon Taek Lee),김창민( 대한내과학회 1996 대한내과학회지 Vol.51 No.4
N/A The prognosis of esophageal cancer is very poor. Even for those with localized disease who are potentially curable, 5-year survival rates are under 20% in almost all series. We conducted a pilot study to evaluate the safety and possibility of efficacy of neoadjuvant chemotherapy followed by surgery in patients with locally advanced esophageal cancer. Two or three cycles of neoadjuvant combination chemotherapy with cisplatin (20㎎/㎡/day i.v., D1-5), etoposide (100㎎/㎡/day i.v., D1,3,5), and 5-fluorouracil (800㎎/㎡/day continuous i.v., D1-5) were planned to be given before surgery. Total 21 patients entered this trial. Three patients were lost to follow-up after 1 cycle of chemotherapy to make eighteen patients evaluable. Thirteen out of eighteen patients (72%) had objective improvement after neoadjuvant chemotherapy and four (22%) had no change and one (6%) had progression. Among 18 evaluable patients, surgery was performed in 11 patients. Surgery could not be done in 7 patients because of patient's refusal (5), progression of disease (1), and development of lung abscess (1). In 13 patients who were candidates for surgery, curative resection was done in 10 patients to make curative resection rate 10/13 (77%). One of eleven patients having surgical resection had no pathologic evidence of tumor (pathologic complete remission 9%). Postoperative complications of wound dehiscence and anastomotic site fistula developed in 2 patients. Three courses of postoperative adjuvant chemotherapy with PEF regimen were administered to 9 patients. The median survival time for all 18 patients was 60 weeks. Toxicities of PEF neoadjuvant chemotherapy were leukopenia, nausea/vomiting and alopecia, but they were mild and reversible. There was no treatment-related deaths. In conclusion, neoadjuvant chemotherapy with PEF regimen were tolerable, safe and possibly effective in locally advanced esophageal cancer. Based on this study, we will perform phase 2 or 3 study to assess the efficacy of PEF neoadjuvant chemotherapy for locally advanced esophageal cancer.
간세포암의 비수술적 치료후 생존율 평가에 의한 UICC 병기의 타당성에 관한 후향적 연구
윤종길(Jong Kil yoon),김현각(Hyun Kag Kim),이창희(Chang Hee Lee),천영국(Young Kug Cheon),김유철(You Cheoul Kim),김창민(Chang Min Kim),홍원선(Weon Seon Hong),이진오(Jhin Oh Lee),강태웅(Tae Woong Kang),최수용(Soo Yong Choi) 대한내과학회 1996 대한내과학회지 Vol.51 No.4
N/A Objectives: The management of hepatocellular carcinoma(HCC) has been frequently complicated due to the variable hepatic dysfunction from underlying chronic liver disease. The validity of UICC staging system based on the anatomical extent of malignant lesion has been questioned because of the poor correlation between stages and clinical outcomes. The purpose of this study is to elucidate the validity of UICC staging system as a prognostic factor and to compare with Child`s classification which represents the functional status of liver. Methods: A total of 831 patients with HCC who received no specific anti-cancer treatment, TACE and/or systemic chemotherapy, between January 1988 and December 1991, were analyzed retrospectively. Factors influencing the prognosis were analyzed by Cox proportional-hazard regression model. Results: Median survival of overall HCC patients was 4 months. There was no significant difference in overall median survival between UICC stage III and IVA; but significant differences between Child A and B, Child B and C were found. UICC staging system for HCC gave less significant clinical value in predicting the survival of HCC patients regardless of the treatment modalities given. In contrast, Child`s classification was better correlated with the survival of HCC patients who received systemic chemotherapy and no specific treatment. In Cox proportional-hazard regression model, Child`s classification was the most influential prognostic factor exceeding the role of UICC system.. Conclusion: UlCC staging system is not a good system for the staging of HCC. We beIieve that the poor correlation between stages and survival originated from the neglect of hepatic dysfunction which is the major prognostic factor in HCC. It is necessary to develop a new staging system which can represent the prognosis better.