성인 원발성 미세변화신증후군의 검사실소견의 특징

박경태(Kyung Tae Park),박희상(Hee Sang Park),진기천(Kee Chun Jean),이시억(Si Eok Lee),권혁(Hyuk Kwon),김기현(Ki Hyun Kim) 대한내과학회 1989 대한내과학회지 Vol.37 No.2

N/A To investigate the characteristics of the laboratory findings of minimal change nephrotic syndrome (MCNS), we analysed retrospectively the laboratory findings of 43 patients with MCNS confirmed by renal biopsy, and we also studied those of 20 patients with nephrotic syndrome of other histopathologic finding as the control group. The characteristics of the laboratory finding of MCNS were as follows: 1) On urinalysis, the total amount of urine protein per day in MCNS patients was 10.0±6.8 gm and this showed a significantly increased value compared with the control group value of 6.3±3.5 gm (p<0.01), and the cases of severe proteinuria above 11 gm/day were more frequent in MCNS patients (34.8%) than in the control group (10.0%). 2) Serum total protein value was 4.1±0.9 gm/dl in MCNS patients and 4.7±1.2 gm/dl in the control group and was slightly lower in MCNS patients than in the control group. The serum albumin value in MCNS patients was 1.8±0.7 gm/dl and showed a significantly decreased value compared with 2.5±0.8 gm/dl in the control group (p<0.01), and the cases of severe hypoalbuminemia below 1.5 gm/dl were more frequent in MCNS patients (46.5%) than in the control group (15%). 3) On blood lipid study, total cholesterol, LDL and VLDL values in MCNS patients were 461.4±155.2 mg/dl, 988.2±539.0 mg/dl and 341.4±198.8 mg/dl and showed a significant increase compared with the control group values of 336.4±132.5 mg/dl, 632.1±291.2 mg/dl and 187,2±147.7 mg/dl respectively (p<0.01, p<0.05, p<0.05). 4) BUN was 22.9±15.9 mg/dl in MCNS patients and 16.8±7.0 mg/dl in the control group and was significantly increased in MCNS patients compared to the control group (p<0.05). There was no difference between MCNS patients and the control group in serum creatinine value and creatinine clearance rate. 5) Hemoglobin and hematocrit in MCNS patients were 15.5±1.5 gm/dl and 45.6±5.2% respectively and showed a significantly increased over the control group values of 13.1±1.9 gm/gl and 37.9±5.6% respectively (p<0.01, p<0.01). There were 11 cases of eosinophilia among 43 MCNS patients (25.6%) but there were no cases in the control group. 6) The positive rate of HBsAg in MCNS patients was 11.6% and showed a lower value compared with the control group value of 35.0%. 7) Serum IgG in MCNS patients was 493±266 mg/dl and showed a significantly decreased value compared with the control group value of 871S613 mg/dl (p<0.0l). IgM in MCNS patients was 197±82 mg/dl and this was significantly increased compared with the control group value of 141±63 mg/dl (p<0.05), and the IgE value was more increased in MCNS patients (678S385 mg/dl) than in the control group (544±378 mg/dl) (p>0.05). The C3 value was 96±20 mg/dl in MCNS patients and 75±19 mg/dl in the control group and it was significantly increased in MCNS patients compared with the control group (p<0.01).

간 질환들에 있어서 HBs 항원 및 HBs 항체 공존예에 관한 관찰

정정명(Jung Myung Chung),최하진(Ha Jin Choi),박경태(Kyung Tae Park),이시억(Si Eok Lee),진지천(Gi Chun Chin),강기상(Ki Sang Kang),설상영(Sang Yung Seol) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.1

N/A A clinica] analysis was made, by enzyme immunoassay, of 64 cases of coexistence of HBs antigen and HBs anti-body in the same serum with the subtype in 12 cases of them being observed. The results were as follows: 1) The overall incidence of coexistence in one period was 1.9% (64/3,395). 2) The highest occurrence rate of coexistence was found in age group of 5th decade: 14 cases (21.9%); in age group of 6th decade: 17 cases (26.6%); and the ratio of male to female was 2.4:l. 3) The diagnostic distributions were 18 cases of liver cirrhosis, 12 cases of hepatoma, 6 cases of chronic active hepatitis, 6 cases of acute viral hepatitis, 7 cases of healthy carrier, and 15 cases were suspected to be chronic hepatitis not confirmed by liver biopsy. 4) In 64 cases of coexistence we studied Hbe antigen and Hbe anti-body in 32 cases. In this study Hbe antigen positive and Hbe antibody negative was found in 18 cases (56.3%); Hbe antigen negative and Hbe antibody positive in 11 cases (34.4%); both Hbe antigen and Hbe antibody vere positive in 1 case (3.1%) and negative in 2 cases (6.2%). 5) The results of subtype were as follows: in 12 cases of HBs antigen positive only, 8 cases were of ay type and the other 4 cases of ay/ad complex type. And in 12 cases of HBs antibody positive onlv, 5 cases v:ere found to be of anti-y type. 5 cases of anti-d type, 1 case of anti-a type and 1 case of anti-y/anti-d complex type. And in 12 cases of HBs antigen and HBs antibody coexistence, ay type antigen were found in 8 cases, and antibody types of these antigen were 8 cases of anti-y type, and 1 case of anti-y/anti-d complex type. In conclusion, although the results of these studies are those of the screening test and have geographic limitation. The coexistance of HBsAg and anti-HBs is considered mostly as a form of seroconversion and rarely as a result of the superinfection with another subtype.

원발성 Aldosterone증의 임상적 고찰

이시억,김수찬,이재관,김동수,이경순,강창일 인제대학교 1989 仁濟醫學 Vol.10 No.3

원발성 aldosterone증은 비교적 드물 질환으로 부신피질의 선종이나 비후로 주로 발생한다. 저자들은 1985년 1988년 사이에 본원에 내원하여 부신선종으로 인한 원발성 aldosterone증으로 밝혀진 6예를 검토하여 그 결과를 분석하여 타 문헌들과 비교 및 고찰하여 보았다. Six patients of primary aldosteronism were investigated, who man confirmed by laboratory, radiologic studies & operative findings in 1985-1988. The results are as follows ; 1) This disease was most common in 6th decade and 1 case was man and 5 cases were women. Blood pressure was in the range of 170/100-200/120mmHg and in 2 cases cerebral infarction and cereabral hemorrhage were combined. 2) Headache was the most common symptom and then there were weakness, general arch, palpitation and facial puffiness. In all cases hypokalemic and LVH findings in EKG and increased serum aldosterone level, decreased serum renin activity, hypokalemia and hypernatremia were noticed, in 2 cases the results of arterial blood gas were metabolic alkalosis. 3) All cases were suspected adrenal adenoma in radiologic studies, but on adrenal venography 1 case of them showed the findings of suggestion for hyperplasia. 4) 5 cases were operated and on biopsy finding all were diagnosed as adenoma. 5) Post-operative serum and urinary results were returned to normal but in blood pressure 3 cases were completely controlled and 2 cases were recurred after 2 months of operation.

pH가 Bacillus Cereus의 Enterotoxin 생산에 미치는 영향

김을수,이시억,이언탁,이명수,오양효 인제대학교 1988 仁濟醫學 Vol.9 No.3

Bacillus cereus에 의한 식중독의 진단에는 원인균의 분리 동정은 물론 신속한 enterotoxin의 검출이 필수적인데 enterotoxin의 생산은 배지나 배양 조건에 영향을 많이 받는다. 본 실험에서는 CAYE-2배지에서 pH 8.5에서 가장 많은 양의 enterotoxin이 생산되었다. Cell-free culture filtrates of enterotoxin producing strain of Bacillus cereus biotype I were detected by RPLA test for the production of enterotoxin. The media used were CAYE-2, Biken No. 2 and BHI medium. The results obtained were as follows : 1) Among CAYE-2, Biken No. 2 and BHI medium, enterotoxin production was the highest in CAYE-2 medium. Enterotoxin production was appreciably diminished at or below pH 6.0 and at above pH 9.0 of the various test media. 2) B. cereus produced high levels of enterotoxin when grown in CAYE-2 medium pH initial pH at 85 and the 512-1014ng quantity of enterotoxin per ml can be detected by the RPLA method.

皮膚筋炎(Dermatomyositis) 1例 報告

박상길,이시억,설상영,김기현,전종휘,백종현,성호석 인제대학교 1987 仁濟醫學 Vol.8 No.2

Dermatomyositis is an uncommon connective tissue disorder of unknown etiology charactrerized by erythematous and edematous changes in the skin, in association with inflammation and degeneration of the skeletal muscles. A 30 yera-old female with dermatomyositis without underlying malignancy is presented with a brief review of the literatures. The patient was admitted to the department of Internal Medicine via the department of Dermatology on February 25 1987, with chief complaints of progressive muscle weakness of both extremities, dysphagia, dyspyonia and characteristic cutaneous findings with heliotrope erythema and swelling of eyelids. The diagnosis was made chiefly by typical clinical findings with aid of elevated muscle enzymes, muscle biopsy and electromyographic findings. The patient has been placing on prednisolone and other symptomatic measures with remarkable improvement.

신혈관근지방종의 1례

김상정,이시억,박희상,김기현 인제대학교 1998 仁濟醫學 Vol.9 No.4

A 55 year-old male was admitted with complaints of gross hematuria arid right flank pain for 5 days. After laboratory and radiologic studies, we presumed renal cell carcinoma and performed embolization and nephrectomy. Histologic examination turned out to be an angiomyolipoma. So we report this case with review of literatures.