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간 질환들에 있어서 HBs 항원 및 HBs 항체 공존예에 관한 관찰
정정명(Jung Myung Chung),최하진(Ha Jin Choi),박경태(Kyung Tae Park),이시억(Si Eok Lee),진지천(Gi Chun Chin),강기상(Ki Sang Kang),설상영(Sang Yung Seol) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.1
N/A A clinica] analysis was made, by enzyme immunoassay, of 64 cases of coexistence of HBs antigen and HBs anti-body in the same serum with the subtype in 12 cases of them being observed. The results were as follows: 1) The overall incidence of coexistence in one period was 1.9% (64/3,395). 2) The highest occurrence rate of coexistence was found in age group of 5th decade: 14 cases (21.9%); in age group of 6th decade: 17 cases (26.6%); and the ratio of male to female was 2.4:l. 3) The diagnostic distributions were 18 cases of liver cirrhosis, 12 cases of hepatoma, 6 cases of chronic active hepatitis, 6 cases of acute viral hepatitis, 7 cases of healthy carrier, and 15 cases were suspected to be chronic hepatitis not confirmed by liver biopsy. 4) In 64 cases of coexistence we studied Hbe antigen and Hbe anti-body in 32 cases. In this study Hbe antigen positive and Hbe antibody negative was found in 18 cases (56.3%); Hbe antigen negative and Hbe antibody positive in 11 cases (34.4%); both Hbe antigen and Hbe antibody vere positive in 1 case (3.1%) and negative in 2 cases (6.2%). 5) The results of subtype were as follows: in 12 cases of HBs antigen positive only, 8 cases were of ay type and the other 4 cases of ay/ad complex type. And in 12 cases of HBs antibody positive onlv, 5 cases v:ere found to be of anti-y type. 5 cases of anti-d type, 1 case of anti-a type and 1 case of anti-y/anti-d complex type. And in 12 cases of HBs antigen and HBs antibody coexistence, ay type antigen were found in 8 cases, and antibody types of these antigen were 8 cases of anti-y type, and 1 case of anti-y/anti-d complex type. In conclusion, although the results of these studies are those of the screening test and have geographic limitation. The coexistance of HBsAg and anti-HBs is considered mostly as a form of seroconversion and rarely as a result of the superinfection with another subtype.
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김환태(Hwan Tae Kim),신형규(Hyoung Gyu Shin),표지수(Ji Soo Pyo),김규환(Gyu Hwan Kim),류승환(Seong Hwan Ryoo),이상혁(Sang Hyuk Lee),설상영(Sang Yung Seol),정정명(Jung Myung Chung),최하진(Ha Jin Choi) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.4
The multiple gastric cancer have several clinicopathological characteristics which differ from those of patients with solitary cancer,' in particular, elderly men had a relatively high in- cidence of multiple cancer and early cancer of the elevated, well differentiated type was most common. A careful preoperative evaluation with both radiography and endoscopy enables de- tection of about 70% of synchronous EGC, and perhaps increased awareness of this phenome- non can lead to better results. We reported on a case of synchronous EGC type I and Iia origi- nating from lower body and antrurn.(Korean J Gastroenterol 1994; 26: 737 741)
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위암종에서 Vascular Endothelial Growth Factor(VEGF)와 Ki-67에 관한 연구
윤혁진,박성재,최경환,최정식,설상영,이선경 인제대학교 1999 仁濟醫學 Vol.20 No.1
혈관 형성이 종양의 성장, 진행에 중요한 역할을 한다는 것이 알려져 있다. 저자들은 혈관 형성성 인자인 Vascular endothelial growth factor(VEGF)의 발현과 위암종의 진행 및 핵 증식인자인 Ki-67과의 관계를 조사하여 VEGF 발현은 위암종의 진행과 관련이 있어 예후 인자로서 가치가 있으나, 종양세포의 악성도 표지자는 아니라는 결론을 얻었다. Many studies have shown that angiogenesis plays an important role in the growth, progression and metastasis of malignant tumors. Recently, several angiogenic factors have been identified. VEGF is thought to be a angiogenic factor and is also thought to be a selective mitogen for endothelial cells. The author investigated the correlation between the expression of VEGF and the progression of gastric carcinoma, and between expression of VEGF and index of Ki-67 of gastric carcinoma. The specimens used in this study were 98 cases of gastric carcinoma diagnosed during from 1995 to 1997 at surgical pathology section of Pusan National University Hospital. These specimens were investigated by staining with polyclonal antibody against the VEGF and a monoclonal antibody against the Ki-67. The expression of VEGF was not correlated with type of gastric carcinoma according to Lauren's classification, and not correlated with degree of differentiation of tumor cells. The expression of VEGF was significantly higher in advanced gastric carcinoma than in early gastric carcinoma. The expression of VEGF was not related with index of Ki-67. These findings suggested that expression of VEGF may be a good prognostic indicator for patient with gastric carcinoma but suggested that it may not be an indicator of tumor cell differentiation.
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