전이된 담도암 환자의 패혈증을 한다열소탕 및 우담과 항생제를 병행하여 치료한 환자 1례

이수민,최성헌,송안나,이지영,채진,정의홍,이수경,Lee, Soo-Min,Choi, Seong-Heon,Song, An-Na,Lee, Ji-Young,Chae, Jin,Jung, Eu-Hong,Lee, Soo-Kyung 사상체질의학회 2013 사상체질의학회지 Vol.25 No.4

Objectives Despite the treatment with antibiotics, patients with sepsis has a high mortality (80%) in the underlying disease group. The aim of this study was to report the improvement of septic condition of the cholangiocarcinoma patient after the treatment with Handayeolso-tang, Fel Tauri, and antibiotics. Methods We retrospectively reviewed the medical records. The patient's subjective symptoms such as chilling and abdominal pain were evaluated by NRS and the performance status was evaluated by ECOG. This case was literally compared with relevant published studies on prognosis of sepsis. Results Despite poor prognostic factor(MEDS score 18), the patient's symptoms such as fever, chilling, abdominal pain, and diarrhea and ECOG(Eastern Cooperative Oncology Group) improved. The patient was hemodynamically stabilized on 3rd day from the treatment, and her laboratory test results were normalized on 7th day. Conclusions A female patient of metastatic cholangiocarcinoma came to the hospital for cholangitis, later causing septic shock. Both her symptoms and laboratory tests showed significant improvement after the treatment of antibiotics, Handayeolso-tang and Fel Tauri. To our knowledge, this is the first case reporting the synergistic combination of Korean oriental medicine and Western medicine approaching to sepsis.

목질바이오매스의 초임계수 처리에 의한 리그닌의 화학적 변환

이수민(Lee, Soo-Min),이오규(Lee, Oh-Kyu),최석환(Choi, Seok-Hwan),최준원(Choi, Joon-Weon),최돈하(Choi, Don-Ha) 한국신재생에너지학회 2008 한국신재생에너지학회 학술대회논문집 Vol.2008 No.05

The modified supercritical water treatment method is adopted for hydrolysis of wood powder, Populus albatimesglandulosa. This modified method is containing 0.05% HCl or HNO₃ as acid catalyst. The supercritical water treatment(SCW) was performed for 1 min. with 350?C, 380?C, 400?C and 425?C, respectively, under 230 pm 10 atm using continuous flow system. When acid was added to powder prepared for SCW treatment, the yields of monomeric sugars were significantly increased. The lignin remained after supercritical treatment was applied to gel permeation chromatography(GPC) for molecular weight distribution analysis. Compared to the lignin produced from SCW treatment without acid catalyst, the average molecular weight of lignin compounds treated with acid was clearly decreased. Particularly, Mn/Mw ratio is decreased. This result shows supercritical water treatment of wood powder can change the molecular weight of lignin to small size. However, it is necessary to be further studied for exactly characterizing the lignin produced from supercritical water treatment.

사상인 체질병증 험위증(險危證) 중 악성 종양으로 유발될 수 있는 증(證)에 대한 고찰

이수민,박소라,이수경,Lee, Soo-Min,Park, So-Ra,Lee, Soo-Kyung 사상체질의학회 2015 사상체질의학회지 Vol.27 No.3

Objectives The purpose of study was to identify cancer related symptoms of Sasang Constitution based on the classic of Sasang Constitutional Medicine (SCM). Methods The bibliographical study was performed with "Dongyisoosebowon-Shinchukbon(東醫壽世保元 辛丑本)", Dongyisoosebowon-Sasangchobongwon(東醫壽世保元 四象草本券), "Cancer", and several review articles. The perspective on severe illness in SCM was investigated. And 'the critical state' of constitutional symptoms based on "Dongyisoosebowon" was identified as cancer related symptoms. Results and Conclusions The perspective on severe illness of SCM was focused on the human being itself, compared with symptom based traditional Chinese medicine. The preservation of requisite energy (保命之主) was a vital factor of longevity to maintain healthy status and the classification of severity of disease. And critical state was an important indicator to control severe illness. Regarding cancer related symptoms in SCM, Janggwol(臟厥), Eumsung-gyeokyang(陰盛隔陽證), Janggyeol(藏結證) of Soeumin symptoms, Hwangdal(黃疸), Haso(下消), Eumheo-oyel(陰虛午熱證), Gochang, Tohyul(吐血) of Soyangin's symptoms, Joyeol(燥熱證), Bokchang-bujong(腹脹浮腫) of Taeeumin's symptoms, and Eolgyek of Taeyangin's symptoms could be shown the association with cancer. According to the prognosis on disease severity, regimens of daily life, behavior modifications as well as medications were also emphasized with great importance to control severe illness in SCM. These holistic approach for controlling severe illness in SCM could lead to the improvement of treatment outcome.

단신 : 고에너지밀도 펠릿제조를 위한 목재칩 반탄화 특성

이재원 ( Jae Won Lee ),김영훈 ( Young Hun Kim ),이수민 ( Soo Min Lee ),이형우 ( Hyoung Woo Lee ) 한국화학공학회 2012 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.50 No.2

본 연구에서는 소나무 혼합수종을 이용하여 에너지 밀도 증가, 균일한 품질의 바이오매스 제공을 위해 무산소 조건에서 반탄화를 실시하였다. 반응온도는 240, 260, 280˚C로 하여 30분 동안 반응시킨 후반탄화 바이오매스 특성을 조사하였다. 침엽수혼합수종의 반탄화는 무처리 바이오매스와 비교하여 발열량이 향상되었음을 확인하였다. 반탄화 온도가 증가할수록 반탄화된 바이오매스의 탄소함량은 최대 46.55%에서 55.73%로 증가하였다. 반면 수소와 산소의 함 량은 각각 6.00%에서 5.87%, 30.55%에서 27.21%로 감소하였다. 반탄화 과정에서 주로 헤미셀룰로오스와 휘발성 물 질이 제거되었다. 280˚C에서 30분 동안 반응하였을 때 최대 발열량 5,132 kcal/kg을 나타냈다. 이것은 처리전 바이오 매스의 발열량 보다 약 13% 증가하였음을 나타내고 있다. 중량감소율과 에너지수율을 고려하여 비교한 결과 240˚C 에서 30분 동안 처리하였을 때 효과적인 반탄화가 이루어졌다. In this study, torrefaction of mixed softwood chips under anoxic condition was performed to improve energy density and maintain consistent quality of biomass. Characteristics of torrefied biomass depending on reaction time (30 min) and temperature (240, 260, 280˚C) were investigated. Torrefaction of mixed softwood chips significantly improved the heating value compared to that of untreated biomass. As the torrefaction temperature was increased, the carbon content of torrefied biomass increased from 46.55 to 55.73%, while its hydrogen and oxygen contents decreased from 6.00 to 5.87% and from 30.55 to 27.21%, respectively. Most of hemicelluloses and volatile compounds were removed during torrefaction. The highest heating value was 5132 kcal/kg when torrefaction was performed at 280˚C for 30 min. It implied that the heating value increased by 13% compared to that of original biomass. However, the condition of effective torrefaction was at 240˚C for 30 min when weight loss and energy yield was considered.

임신 28주에 자기공명영상으로 진단한 파열되지 않은 흔적 자궁각임신

이수민 ( Soo Min Lee ),박인양 ( In Yang Park ),신종철 ( Jong Chul Shin ),권지영 ( Ji Young Kwon ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.10

Pregnancy in rudimentary horn is rare. Rupture tends to occur in the second trimester. Only a few cases of the diagnosis of unruptured third-trimester rudimentary horn pregnancy have been reported. We experienced a case of unruptured rudimentary horn pregnancy at 28+3 weeks gestation confirmed by MRI. Successful delivery of a live male fetus weighing 955 g by cesarean section and excision of the rudimentary horn with ipsilateral salpinx were carried.

국내 공간디자인 관련 전시회의 주제 분석을 통한 디자인 트렌드 변화 연구

이수민(Lee, Soo-Min),김은빈(Kim, Eun-Bin),박수연(Park, Soo-Yeon),김영주(Kim, Young-Joo) 한국실내디자인학회 2013 한국실내디자인학회 학술대회논문집 Vol.15 No.1

The purpose of this study was to analyze the spatial design trend through the analysis of the themes and the contents of the major spatial design exhibition in Korea - Kyung Hyang Housing Fair and Seoul Living Design Fair- based on the periodical issues in political, economic, and socio-cultural background from 1986 to 2013. Content analysis was used as a research method. Periodical information about each exhibition was collected through the online search and supplementary materials such as guidebook were added for content analysis. The major findings were as follows: Since t980s, there was an increased need and interest for housing and interior design and the 1st Kyung Hyang Housing Fair was opened in 1986. In 1990s, design quality improvement was emphasized based on the issues of IMF and shoddy and fault construction such as collapse of Sam Poong department store. Due to the broad dissemination of internet, globalization, and emergence of diverse household type, demand for housing and interior design was diversified after 2000s. Additionally, the global concepts associated with sustainability, energy saving, and green growth were influenced to spatial design field. Lately, interaction design is rapidly developing due to proliferation of SNS and smart mobile equipment. Meanwhile, there is a continuing trend for emotional design in recent years.

혈관 통과 시간을 활용한 고정확도 제 1심음 및 제 2심음 자동식별 알고리즘 개발

이수민(Soo Min Lee),웨이췬(Qun Wei),박희준(Hee Joon Park) 한국멀티미디어학회 2021 멀티미디어학회논문지 Vol.24 No.11

사염화탄소 유발 급성 간독성 생쥐모델에서 산양삼 에탄올 추출물의 간 보호 효과

이수민(Lee Soo Min),박선영(Park Sun Young),장기석(Jang Gi Seuk),이선영(Ly Sun Yung) 韓國營養學會 2008 Journal of Nutrition and Health Vol.41 No.8

본 연구에서는 총항산화능 및 DPPH radicals 소거활성도를 통하여 항산화능을 확인한 산양삼 에탄올 추출물이 사염화탄소 투여로 급성 손상이 유도된 생쥐의 간에 대하여 보호 효능이 있는지를 확인하고자 하였다. 생리적 지표물질로 혈장 지질, GPT 활성, 혈장과 간의 TBARS 및 항산화효소 활성, 혈액 백혈구의 DNA fragmentation 등을 측정하여 다음과 같은 결과를 얻었다. 산양삼의 DPPH radicals 소거능은 76.85 ± 1.06%, IC50은 33.3 ㎍/mL였으며 총항산화능은 2.13 ± 0.06 mmoL/㎎으로 양성대조군으로 사용한 아스코르브산 (96.45 ± 0.07%, IC50 = 16.5 ㎍/mL, 3.63 ± 0.06 mmoL/㎎)과 BHT (95.40 ± 0.71%, 3.12 ± 0.02 mmoL/㎎) 보다는 낮았지만 천연물질로써는 높은 수준을 보였다. 장기 무게 및 식이 섭취량은 산양삼 추출물 투여 및 사염화탄소 처치 여부에 따라서 어떤 차이도 보이지 않았다. 혈장의 GPT와 혈중 트리글리세리드의 경우 정상대조군에 비해 사염화탄소단독투여군에서 유의하게 낮았으며, 산양삼 추출물 투여군에서는 큰 차이를 보이지 않았다. 혈청 총콜레스테롤 농도는 사염화탄소단독투여군 (84.5 ± 23.0 ㎎/dL)이 정상 대조군 (140.6 ± 30.3 ㎎/dL)에 비하여 유의하게 감소하였으며, 산양삼 추출물 투여군 (130.68 ± 31.33 ㎎/dL)은 정상대조군과 같은 수준이었다 (p < 0.001). 사염화탄소 단독투여군의 간조직에서 TBARS는 정상대조군 (N)에 비해 28.64% 유의하게 증가하였으며 산양삼 추출물 투여군은 정상대조군과 비슷한 수치를 보였으나 (p < 0.001) 적혈구내의 TBARS는 세 군간의 유의한 차이가 없었다. 간조직의 SOD의 활성은 산양삼 추출물 투여군에서 유의하게 증가하였으며, 적혈구에서는 이러한 차이를 보이지 않았다. 그리고 적혈구내 GPx 활성은 사염화탄소 투여에 의해 20.1% 유의한 감소를 보였으며, 산양삼 추출액을 투여받은 군은 정상대조군의 수준을 유지하였다. 사염화탄소 투여군에서 혈장 백혈구의 tail DNA, tail length, tail moment 모든 값은 정상대조군에 비하여 각각 84.4%, 98.8%, 123.7% 증가하였으며, 산양삼 투여군에서는 이 모든 수치가 대조군의 수준으로 감소하였다 (p < 0.001). 이상의 결과를 종합해 보면 5일간 산양삼 에탄올 추출물을 미리 투여한 후 사염화탄소로 급성 간 손상을 유도하였을 때 혈 중 콜레스테롤 대사를 개선하고, 간의 지질 과산화를 효과적으로 억제하였으며 간의 SOD와 적혈구 GPx의 효소 활성을 대조군 이상으로 유지시키고, 산화적 손상으로부터 DNA를 보호하는 등의 일부생리 활성을 확인하였다. 그러나 이런 산양삼의 항산화 활성의 작용 기전에 대하여 확실히 규명되어 있지 않아 추후보다 세부적인 연구가 필요할 것으로 사료된다. The wild simulated ginseng (WSG) has been effectively used in folk medicine as a remedy against hepatic disease, hypertension and arthritic disease. However, there is still lack of scientific proof about its antioxidant capability. The present study has been conducted to evaluate the protective role of the WSG ethanol extract in the CCl₄-induced oxidative stress and resultant hepatic disfunction in ICR mice. The electron donating abilities and IC50 of WSG etnanol extract were 76.86 ± 1.06% and 33.3 ㎍/mL (that of ascobic acid was 16.5 ㎍/mL), respectively. Total antioxidant status of WSG extract was 2.13 ± 0.06 mmoL/mg, while the values of ascorbic acid and BHT were 3.63 ± 0.06 and 3.12 ± 0.02, respectively. ICR mice (aged 3weeks) were fed for 4 weeks on AIN-93M diet and had free access to food and water. The animals were divided into three groups: normal group (intraperitoneally (i.p) injected with PBS at 100 μL/mouse), group C; CCl₄-induced and without any treatment. (i.p injected only PBS, 100 μL /mice), group G; CCl₄-induced and treated with WSG (i.p injected with 5 mg WSG extract per mouse, suspended in 100 μL phosphate buffer). After the i.p. injection of WSG or PBS (5 times for 7weeks), all mice were administered CCl4 in olive oil at the last day of the experiment, except for normal group. The normal group was administered only olive oil. Determination of plasma triglyceride, total cholersterol, fasting glucose and GPT activity was performed using automatic blood analyzer. To evaluate the protective effect against the oxidative stress, DNA fragmentation and TBARS were determined in blood leucocytes and RBC and hepatocyte, respectively. Body and organs weights and food intake did not show significant differences among the groups. Blood total cholesterol of group G was similar to that of normal group, which was the lowest in group C. The fasting blood glucose level was the highest in normal group (205.20 ± 135.24), which were decreased in group C (134.2 ± 79.31) and group G (126.48 ± 77.05). TBARS values in a red blood cell and hepatic tisuue homogenate were lower in group G comparing to the group C. DNA% in tail, tail length (TL) and tail moment (TM) of blood leucoocytes showed the highest values in group C (20.11 ± 2.47, 17.36 ± 2.58, 94.11 ± 12.29) and they were significantly diminished in group G (9.63 ± 1.19, 7.04 ± 1.50, 38.64 ± 7.60). In conclusion, wild simulated ginseng might be a protective agent against the oxidative stress.

의복형 재활보조기기 광고에서 연령 관련 라벨링이 베이비붐 세대의 제품 태도와 구매 의도에 미치는 영향

이수민(Soo-Min Lee),윤초롱(Chorong Youn) 한국복식학회 2020 服飾 Vol.70 No.6

최적경로 네비게이션 기술을 활용한 건설장비 운영 방안에 관한 연구

이수민(Lee, Soo Min),서종원(Seo, Jong Won) 대한토목학회 2022 대한토목학회 학술대회 Vol.2022 No.10