Sandopart 의 분만유도효과에 관한 임상적 연구

김종우(CW Kim),김승욱(SW Kim) 대한산부인과학회 1978 Obstetrics & Gynecology Science Vol.21 No.12

Most studies report it to be a safe, simple, rapid, and convenient method. Desamino-oxytocin, which was synthesized by Du Vigneaud and regarded as biologically 1.5-2 times more active than oxytocin, was chosen as buccal tablet to induce labor. In the present study Sandopart linguet, containing 50 IU desamino-oxytocin, was administered in the buccal space and the dosage was increased by adding 50 IU every 30 minutes until optimum uterine response was obtained. The results were as follows: 1) Transbuccal Sandopart was administered to 42 patients for the induction of labor. 2) The induction was successful in 29 patients(79%). 3) Mean induction-delivery time in primigravida was 8 hours and that in multigravida was 6 hours and mean induction-onset of delivery time was 3 hours. 4) Uterine hyperactivity and fetal heart tone anomaly were found in 2 patients(4.8%) and 3 patients(7.0%) respectively. Transient asphyxia of newborn infant was observed in 2 patients(4.8%). 5) Uterine hypertonus, postpartum hemorrhage, and lochimetra, were observed in 8 patients.

분만 전후 제대혈청 Cortisol의 동태에 관한 연구

김종우(CW Kim) 대한산부인과학회 1982 Obstetrics & Gynecology Science Vol.25 No.6

Maternal and umbilical cord serum cortisol levels were measured by a radioimmunoassay method in 10 patients who were in spontaneous labor, 7 patients who were electively induced at term with oxytocin, and 8 patients undergoing elective cesarean section without labor. Determinations of maternal serum cortisol levels in the spontaneous or induced labor groups were made at onset of labor and repeated at full cervical dilation. Maternal determinations in the elective cesarean section group were made just prior to the procedure and at the time of uterine incision. Cord blood was taken immediately after birth, with no attempt made to separate it into venous and arterial components. The results were as follows; 1) The mean initial cortisol level in the spontaneous labor group (15.9mg/100ml) was significantly less than the mean initial level of the group electively delivered by oxytocin induction (30.1mg/100ml) and the group electively delivered by cesarean section(29.0mg/100ml). 2) Significant rises of maternal serum cortisol levels were noted at full cervical dilation on the spontaneous or induced labor groups, whereas no significant change occurred in the elctive cesarean section group. 3) The mean cord cortisol level in cases of elective cesarean section with no prior labor(13.3mg/ml) was significantly less than the value for vaginal delivery after spontaneous(27.0mg/100ml) or induced labor(23.3mg/100ml). 4) Significant correlation was found betwen the maternal cortisol at delivery on the one hand and the cord cortisol levels. 5) Cord cortisol levels were not affected by hour of birth. 6) During labor and delivery a considerable rise in the production of cortisol occurred, more marked in primiparous than mutiparous patients.

임신빈혈에 대한 정주용철제 Fesin의 임상적 평가

김종우(CW Kim),이진용(JY Lee),나건영(KY Na) 대한산부인과학회 1976 Obstetrics & Gynecology Science Vol.19 No.12

The purpose of this study was to confirm the effectiveness of intravenous saccharated iron oxide, fesin in 33 patients suffering from pregnancy anemia. The aim of this study can be summerized as follows 1. To inverstigate the safety, tolerance and rapidity of intravenous sacharated oxide of iron. 2. To determine the gain of hemoglobin depeding upon the dose and timing of treatment during gestation with intravenous saccharated iron oxid in all patients the following laboratory tests were carried out periodically serum iron hemoglobin and reticulocyte for evaluation fo drug effect at the same time any side effect wer abserved. 1. The results in all patients, were favorable with an average rise of 2.4+-0.87 gm of hemoglobin per patient within 3 weeks. 2. The degree of response is in general inversely proportional to the severity of the anemia before treatment. 3. The hematologic response showed more favorable response in late pregnancy than in mid-trimeseter 4. Delerious reactoins to the drug were few and negligible and were seen only following too rapid administration. On the basis of the above results it is concluded that not only the saccharated iron oxide is safe unless overdosage is administered but also the most reliable preparation for the treatment of pregnancy anemia. But this form of iron therapy should be reserved for patients not suitable for oral iro therapy.

난소미분화배세포종 재발의 1례

김상연(SY Kim),김유성(YS Kim),박용희(YH Park),전건(K Jeon),임승계(SG Lim),김종우(CW Kim) 대한산부인과학회 1983 Obstetrics & Gynecology Science Vol.26 No.8

We experienced a case of recurrent ovarian dysgerminoma in 26 year old woman recently and report with brief review of literature.

난소의 유피낭포에서 발생한 편평세포암의 1예

이명우(MW Lee),김종우(CW Kim),신순철(SC Shin),이의형(EH Lee) 대한산부인과학회 1976 Obstetrics & Gynecology Science Vol.19 No.6

A case of squamous cell carcinoma arising from a dermoid cyst was reported and a brief review of the literature was herewith presented.

양수의 세균발육억제 작용에 관한 연구

임승계(SG Lim),김종우(CW Kim) 대한산부인과학회 1980 Obstetrics & Gynecology Science Vol.23 No.7

The bacteriostatic effect of amnionic fluid was studied using three pathogenic organisms thich are encountered in the perinatal period, E. coli, S. aureus, and K. pneumoniae. Another organism, S. typhimurium, was included to find an antibacterial spectrum. Amnionic fluid inhibited the growth of all four organisms, with a wide degree of individual variation among specimens. The greatest degree of inhibition was noted for S. aureus and the least for K. pneumoniae at 6 hours incubated. At 24 hours incubated the former was noted for K. pneumoniae and the latter for S. typhimurium. The ability of amnionic fluid to inhibit the growth of certain pathogenic organisms may be significant in prevention of perinatal infection.

질식분만과 제왕절개시의 제대혈청 Cortidol치

전건(K Jeon),김종우(CW Kim) 대한산부인과학회 1980 Obstetrics & Gynecology Science Vol.23 No.6

Cortisol을 만삭임부의 제대혈청에서 방사면역측정법을 이용하여 측정했다. 자연진통이 와서 질식분만을 한 23예의 산모에서 cortisol치의 평균과 수준오차는 혈청 100ml당 26.2±1.54μg이었다. 이 cortisol치는 oxytocin유도로 질식분만을 한 19예의 평균치와 표준오차(23.0±1.45μg/dl)에 비하여 유의하게 틀리지 않았다. 진통이 없이 선택적 제왕절개를 시행한 15예의 평균치와 표준오차(12.8±1.21μg/dl)는 자연진통이 온 경우든지 oxytocin으로 유도한 group이든지 간에 질식분만예에 비하여 유의수준으로 낮게 나왔다. 무뇌아의 임부로서 자연진통이 안 와서 45주에 제왕절개로 분만을 종결지은 임부의 제대혈청 cortisol치는 4.57μg/dl였다. 진통과 질식분만은 제대혈청 cortisol치를 상승시키는 원인이 되며, 질식분만에서는 자연분만군과 유도군의 사이에 유의한 차가 없었음을 확인했다. 이상의 결과는 인간의 임신에서도 다른 종의 동물에서처럼 태아의 cortisol합성이 자연진통 직전에 증가하고 이에 진통의 유발을 시키는 원인이 된다는 가설을 뒷받침할 수가 없었다. Cortisol was determined by a radioimmunoassay method in umbilical cord serum from pregnacies of 38 or more weeks gestation. In 23 cases of vaginal delivery following spontaneous labor the mean±S.E. of cortisol values was 26.2±1.54μg per 100ml of serum. This cortisol level was not significantly different form that observed in 19 cases of vaginal delivery after oxytocin-induced labor(23.0±1.45μg per 100ml). The mean cortisol level in cases of elective cesarean section with no prior labor(12.8±1.21μg per 100ml) was significantly less than the value for vaginal delivery after spontaneous or induced labor. The cord serum concentration of cortisol in a pregnancy complicated by fetal anencephaly and terminated at 45 weeks by cesarean section was 4.57μg per 100ml. It is concluded that labor and vaginal delivery resulted in a significant increase in cord serum cortisol levels but there was no significant difference between spontaneous and induced labor. These findings do not support the hypothesis that a surge in fetal cortisol production immediately precedes and initiates spontaneous labor in human pregnancy.

대장의 이상회전을 수반한 Rokitansky-Kuster-Hauser증후군과 자궁 섬유근종을 합병한 1예

문영환(YW Moon),김상연(SY Kim),신영관(YK Shin),김종우(CW Kim),박용희(YH Park) 대한산부인과학회 1983 Obstetrics & Gynecology Science Vol.26 No.5

A large leiomyoma and malrotation of viscera was found in a patient with Rokita- nsky-Kuster-Hauser syndrome during exploratory laparotomy. Leiomyoma associated with the syndrome have been reported only four times previously in the world and did the first with malrotation of the colon. We have recently encountered such a rare case of Rokitansky-Kuster-Hauser syndrome and leiomyoma associated with malrotation of the colon, and present it with a brief reviews of the literatures.

Sarcoma Botryoides의 1례

박병철(BC Park),김정애(JA Kim),박영순(YS Park),김미경(MK Kim),김종우(CW Kim) 대한산부인과학회 1984 Obstetrics & Gynecology Science Vol.27 No.13

만 18세 여아의 자궁경부에 발생한 Sarcoma botryoides 1예를 경험하였기에 문헌적 고찰과 아울러 보고하는 바이다. Sarcoma botryoides is highly malignant tumor occuring almost exclusively in children under the age of 5 years. A few young adults having a typical botryoid tumor are reported. In that cases, lesions seem to develops in the cervix rather then the vagina. Recently, a case of sarcoma botryoides which was originated from the uterine cervix of 18 years old numarried girl has been experiened, and presented with a brief review of the literature.

산욕기 경산부에서 발견된 거대난소낭종의 1 례

박용해(YH Park),김태일(TI Kim),김종우(CW Kim),이정모(CM Lee),정호순(HS Chung) 대한산부인과학회 1985 Obstetrics & Gynecology Science Vol.28 No.3

The association of ovarian tumor and pregnancy is rare. And ovarian tumor complicating pregnancy is often entirely unsuspected. Careful examination of all pregnant woman should eliminate a large proportion, but not all, of these errors. If an ovarian tumor doesn`t occupy the pelvis, diagnosis through pelvic examination is especially difficult. Ovarian tumors may be serious complications of pregnancy, may undergo torsion, and may pose insuperable obstacles to vaginal delivery. Moreover, even after spontaneous labour and delivery, they may give rise to disturbances during the puerperium. Recently, we experienced a case of huge ovarian cyst in a puerperal woman, and its literatures are reviewed briefly.