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      • KCI등재후보

        한국의 제2형 당뇨병 환자에서 continuous subcutaneous insulin infusion 치료시 혈당 / 인슐린 지수와 당질/인슐린 비에 관한 연구

        김선두(Sun Doo Kim),이길도(Kil Do Lee),김순제(Soon Je Kim),최의광(Ewi Kwang Choi),최수봉(Soo Bong Choi),박선민(Sun Min Park) 대한내과학회 2000 대한내과학회지 Vol.59 No.6

        N/A Background : According to the results of Diabetes Control and Complication Trial, the best strategy to prevent and/or delay diabetic complications is to maintain the normal blood glucose levels. This led to emphasize the necessity of intensive management of diabetes. The purpose of the study was to determine blood glucose/insulin index and carbohydrate (CHO)-to-insulin ratios after normalization of blood glucose levels, and to select the factors to influence the blood glucose/insulin index and CHO-to-insulin ratios in Korean type 2 diabetic patients with continuous subcutaneous insulin infusion (CSII) treatment using insulin pump and CHO counting as a meal management. Methods : Fifty-five type 2 diabetic patients who started CSII therapy checked their blood glucose levels before and after three meals, and recorded the amounts of insulin injected in fasting and each meal and the amounts of carbohydrates consumed in each meal. Actual blood glucose/insulin index and CHO-to-insulin ratio were determined using the records, and also they were calculated using Functional Insulin Treatment Training Methods (FITTM) proposed by Howorka. Calculated values were compared to actual values. The meaningful factors to influence the actual values were selected by backward stepwise regression analysis. Results : The average age of the subjects was 49.9±12.5 years, and the duration of diabetes was 8.7±4.5 years. Their body mass index was 22.5±3.6 kg/m2. Daily insulin requirements to normalize the blood glucose levels reached to maximum levels at l0 day CSII treatment, and they were reduced and stabilized after 20 days of the treatment. The quotient K, representing insulin sensitivity, was also decreased after CSII treatment. The basal insulin index was 0.21 IU/kg at 10 days and 0.16 IU/kg at 20 days in our study, and these values were lower than the value from FITTM, 0.35 IU/kg The blood/glucose index was -2.5 mmol/L at 10 day CSII treatment, and it was decreased to -4.4 mmol/L at 20 day treatment to the stable levels. CHO-to-insulin ratio provided by FITTM was 2.59 IU/CHO exchange unit and the ratio was 3.12 IU/CHO exchange unit at 10 days, which was decreased to 1.84 IU/CHO exchange unit at 20 days in our study. CHO-to-insulin ratios at breakfast from carbohydrate counting were higher than those of lunch and dinner, and the ratios were 1.5 to 2.5 IU/CHO exchange unit. According to the stepwise regression analysis, the blood glucose/insulin index was affected by gender, age, body mass index (BMI), fasting blood glucose levels and fasting c-peptide levels, and CHO-to-insulin ratios were influenced by gender, age, BMI, post-prandial blood glucose levels and post-prandial c-peptide levels. Conclusions : CSII treatment can make blood glucose levels maintain in normal ranges in Korean type 2 diabetic patients, and can improve insulin sensitivity. Basal insulin requirements were lower and prandial insulin requirements were higher than those calculated from FITTM. This difference between Korean and the Western can be related to difference of insulin secretion from pancreas and nutrient intake.(Korean J Med 59:602-611, 2000)

      • 전격성 경과를 취한 만성 호산구성 폐렴 환자 1예

        윤호상,진춘조,유광하,이상엽,이수인,정상만,김선두,이순제,이길도,전혜정 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-

        Chronic eosinophilic pneumonia(CEP) is a rare disease of unknown etiology characterized by chronic infiltration of the lung with eosinophils. It presents with profound systemic symptoms comprising fever, night sweats, weight loss, dyspnea and blood eosinophilia with nonsegmental air-space consolidation confined to the outer third of the lung, the "photographic negative of pulmonary edema". Histopathologic features of chronic eosinophilic pneumonia are intraalveolar and interstitial infiltrations with eosinophils, histiocytes, giant cells, scattered lymphocytes and plasma cells. Glucocorticoid therapy cause prompt resolution of symptoms as well as disappearans of blood eosinophils, elevated serum Ig E levels and the roentgenographic lesions. Infrequent radiographic findings include nodular infiltrates, consolidations, cavitations, atelectasis and pleural effusions. Deaths from CEP although rare, have been reported, but the majorities of CEP have benign courses and do not need a therapy with ventilator. We report a case of chronic eosinophilic pneumonia, which had a sudden course associated with diffuse pneumonic consolidations on the both lung and bilateral pleural effusion.

      • SCOPUSKCI등재

        급성 A형 간염에 동반된 Gianotti-Crosti 증후군 1예

        이재동,이길,송해준,이길도,김선두,김순제,류하근,박봉안,유재등,류주성,박형석,진춘조 대한소화기학회 2000 대한소화기학회지 Vol.36 No.4

        Patient with Gianotti-Crosti Syndrome (GCS) presents with a distinctive self-limiting acral papular or papulovesicular eruption. Patient with GCS is associated with an underlying viral and bacterial illness. GCS is a self-limiting cutaneuous response to different infections. Its clinical differences are probably due to individual characteristics of each patient rather than the causative infections agents. GCS in patients infected with hepatitis A virus has not been reported previously in Korea. We report a case of 16-year-old girl who developed an erythematous papular eruption on her extremities a week after an epidemic of hepatitis A. The patient had the characteristics which resembled clinical and histopathologic findings of GCS. Hepatitis A virus RNA was detected by nested reverse transcription-polymerase chain reaction of tissue from lesion site of the patient.

      • KCI등재
      • KCI등재

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