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이규인(K.I Lee),이종용(JY Lee),이태호(TH Lee) 대한산부인과학회 1982 Obstetrics & Gynecology Science Vol.25 No.7
자궁외임신의 조기진단을 위하여 조직진으로 확진된 32예의 자궁외임신예의 B-hCG치의 분포, 요임신진단 및 발생부위와의 관계에 대하여 연구한 바 그 결과를 아래와 같이 요약한다. 자궁외임신 32예의 평균 B-hCG치, 범위 및 표준편차는 각각 761.6mIU/ml, 150~3,500mIU/ml, +-828.6mIU/ml로 치의 변동이 매우 심하여 안정치를 인정할 수 없었다. 요임신반응 양성예는 14예로 43.6%, 음성예는 18예로 56.4%를 점하였다. 요임신반응 양성예의 평균 B-hCG치는 음성예의 그것보다 높은 경향을 보였다. 자궁임신의 발생부위별 B-hCG치는 난관팽대부와 난관협부가 각각 377.5 및 343.3mIU/ml로 근사한 치를 보였다. 자궁외임신 32예중 24예, 즉 75.0%가 B-hCG치 599mIU/ml이하이었다. 이상의 성적으로 미루어 자궁외임신을 제외할 수 있는 B-hCG치의 하한을 대략 100mIU/ml에 둠이 타당할 것으로 사료된다. Retrospective studies were made on B-hCG values of 32 ectopic pregnancies,which were diagnosed by biopsy of surgical specimen, for an aid of early diagnosis of ectopic pregnancies. The results summarized were as follows: Mean,range and standard deviation of B-hCG values in 32 cases of ectopic pregnancies were 761.6 miu/ml,150~3500 miu/ml and +-(*)828.6 miu/ml respectively,suggested highly unstable values. Positive pregnancy test for urine was 14 cases or 43.6% and that of negative was 18 cases or 56.4% Beta-hCG values, according to the siteof nidation with 377.5 miu/ml in ampulla portion and 343.3 miu/ml in isthmic portion revealen very similar results. One particular finding was 24 cases out of 32 cases of ectopic pregnancies or 75.0% showed B-hCG values under 599 miu/ml. Judging from the data obtained it is resonable to set the low limit of excluding ectopic pregnancy roughly around the 100 miu/ml.
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GATA-3 is a Key Factor for Th1/Th2 Balance Regulation by Myristicin in a Murine Model of Asthma
이규,이창민,정인덕,정영일,천성학,박희주,최일환,안순철,신용규,이상율,염석란,김종석,박영민,Lee, Kyu,Lee, Chang-Min,Jung, In-Duk,Jeong, Young-Il,Chun, Sung-Hak,Park, Hee-Ju,Choi, Il-Whan,Ahn, Soon-Cheol,Shin, Yong-Kyoo,Lee, Sang-Yull,Yeom, S Korean Society of Life Science 2007 생명과학회지 Vol.17 No.8
Myristicin은 육두구에서 발견되는 고농축 정유 중 하나인 물질이다. 하지만 Th1/Th2 면역반응에서 육두구의 항알레르기 효과는 아직 밝혀지지 않았다. 최근에 Th1/Th2 전사인자로서 T-bet, GATA-3가 밝혀졌는데 이번 실험에서 myristicin이 ovalbumin(OVA)으로 유도한 천식(asthma) 생쥐모델에서 Th1,Th2 싸이토카인과 유전자 발현을 조절할 수 있는가에 대하여 알아보았다. 또한 기관지 폐포 세척액을 회수하여 백혈구의 수적 변화, 제2형 협조T세포(Th2 cell)가 생산하는 IL-4, IL-5의 생산에 미치는 영향과 폐조직에서 matrix metalloproteinase (MMP)-9 활성을 측정하였다. 그 결과 기관지 폐포 세척액에서 OVA로 감작하여 천식을 유도한 실험군에서는 호산구의 현저한 증가, Th2 형 싸이토카인(IL-4, IL-5)의 증가가 관찰되었다. 그러나 myristicin을 투여한 그룹에서는 OVA의 감작에 의하여 증가한 각종 염증성 지표들이 감소하거나 정상화 되었다. 또한 OVA에 의하여 증가된 기도저항성이 myristicin 투여에 의하여 감소하였으며 폐조직의 염증성 소견도 뚜렷하게 감소되었다. 이와 같은 연구 결과는 myristicin이 천식의 치료에 유용하게 쓰일 수 있음을 시사해준다. Myristicin, l-allyl-3,4-methylenedioxy-5-methoxybenzene, was one of the major essential oils of nutmeg. However, its anti-allergic effect in the Th1/Th2 immune response was poorly understood. Recently, it was shown that T-bet and GATA-3 was master Th1 and Th2 regulatory transcription factors. In this study, we have attempted to determine whether myristicin regulates Th1/Th2 cytokine production, T-bet and GATA-3 gene expression in ovalbumin (OVA)-induced asthma model mice. Myristicin reduced levels of IL-4, Th2 cytokine production in OVA-sensitized and challenged mice. In the other side, it increased $IFN-{\gamma}$, Th1 cytokine production in myristicin administrated mice. We also examined to ascertain whether myristicin could influence eosinophil peroxidase (EPO) activity. After being sensitized and challenged with ovalbumin (OVA) showed typical asthmatic reactions. These reactions included an increase in the number of eosinophils in bronchoalveolar lavage fluid, an increase in inflammatory cell infiltration into the lung tissue around blood vessels and airways, and the development of airway hyper-responsiveness (AHR). The administration of myristicin before the last airway OVA challenge resulted in a significant inhibition of all asthmatic reactions. Accordingly, these findings provide new insight into the immunopharmacological role of myristicin in terms of its effects in a murine model of asthma.
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이규신 ( Kyu Shin Lee ),이주원 ( Joo Won Lee ),박희명 ( Hi Myung Park ),최명부 ( Myung Boo Choi ),김경식 ( Kyung Shik Kim ),이상규 ( Sang Kay Lee ) 대한내과학회 1969 대한내과학회지 Vol.12 No.4
A review was made on 57 cases of so-called pseudoinfarction seen among 12,491 cases with various conditions subjected to electrocardiographic examination. In most of the cases the pseudoinfarction patterns were seen in the right precordial leads, and in ab
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이종용(JY Lee),이규인(K.I Lee),이승호(SH Lee),이태호(TH Lee) 대한산부인과학회 1982 Obstetrics & Gynecology Science Vol.25 No.6
1981년 1월 1일부터 동년 6월 30일까지 골반내종양환자중 수후 조직진으로 확인된 23예의 이미 얻어진 초음파상이 특징을 분석한 바 그 성적을 아래와 같이 요약한다. 자궁근종초음파상중 가장 흔한 것은 fill in pattern으로 23예중 21예, 91.3%에서 관찰 할 수 있었고, 이하 자궁증대상의 78.3%, 제광의사 echo상의 65.2%, 제광변형상의 30.4%의 순 이었다. 자궁근종이 outline이 명료한 것이 43.5%, nodular한 것이 30.4%, hazy한 것이 26.1%이었 다. 자궁근종이 종양부위와 건전 자궁의 경우는 불명료한 예가 65.2%로 약 2/3을 점하였 다. 종양후벽의 초음파상은 78.3%가 불명료하였다. 이상의 성적으로 미루어 자궁근종의 초음파진단상의 중요소견은 fill in pattern, 자궁증대 상 및 종양후벽상, 종양경우상이며 그 외에 자궁근종의 수형, 제광변형상 및 제광의사 echo 상도 좋은 참고가 된다고 생각된다. Retrospective analysis was made on characteristic findings of 23 cases of Uterine myoma by ultrasonograph, during Jan. 1981 to June 30 1981. The results summarized were as follows. The most frequent ultrasonographic finding encountered in 23 cases of uterine myoma was fill in pattern, 21 cases out of 23 cases or 91.3% The next frequent finding was enlarged uterine picture 78.3%, pseudoecho of bladder 65.2% and picture of bladder distoriton 30.4% in order of respectively. Outline of uterine myoma, there was pattern of clean, nodular and hazy which showed frequency of 43.5% and 26.1% respectively. Borderline between myoma node and normal uterus had 65.2%o of unclear pattern. Picture of posterior wall of uterine myoma revealed unclear pattern of 78.3%. It was concluded that important features of ultrasonographic findings for diagnosis of uterine myoma were fill in pattern, enlargement of uterus, picture of tumor posterior wall, picture of tumor borderline and other findings that of tumor outline, picture of bladder distortion, pseudo bladder echo will be a good criterias for diagnosis of uterine myoma.
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Ultrasonographic Study on Uterine Myoma
이종룡(J.R Lee),이규인(K.I Lee),이성호(S.H Lee),이태호(T.H Lee) 대한산부인과학회 1982 Obstetrics & Gynecology Science Vol.25 No.1
Retrospective analysis was made on characteristic findings of 23 cases of uterine myoma by ultrasonograph, during Jan. 1981 to June 30 1981. The results summarized were as follows. The most frequent ultrasonographic findings encountered in 23 cases of uterine myoma was fill in pattern, 21 cases out of 23 cases or 91.3%. The next frequent finding was enlarged uterine picture 78.3%, pseudoecho of bladder 65.2% and picture of bladder distortion 30.4% in order of respectively. Outline of uterine myoma, there was pattern of clean, nodular and hazy which showed frequency of 43.5% and 26.1% respectively. Borderline between myoma node and normal uterus had 65.2% of unclear pattern. Picture of posterior wall of uterine myoma revealed unclear pattern of 78.3%. It was concluded that important features of ultrasonographic findings for diagnosis of uterine myoma were fill in pattern, enlargement of uterus, picture of tumor posterior wall, picture of tumor borderline and other findings that of tumor outline, picture of bladder distortion, pseudo bladder echo will be a good criterias for diagnosis of uterine myoma.
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이규신 ( Kyu Shin Lee ) 대한내과학회 1968 대한내과학회지 Vol.11 No.9
The electrocardiographic findings of hypopotassemia were studied in 122 patients with various conditions in which serum potassium levels were likely to be low, and the following results were obtained. Rather characteristic and common electrocardiographic f
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이규면 ( Kyoo Myun Lee ),정규원 ( Kyu Won Chung ),전종휘 ( Chong Hwee Chun ) 대한내과학회 1969 대한내과학회지 Vol.12 No.1
The authors were conducted the clinical studies of 102 cases of acute pancreatitis, admitted to the department of internal medicine, St. Mary`s Hospital, during the period between January, 1963 and July, 1966. The following results were made and the litera
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