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Reserpine 投與로 因한 上皮小體 主細胞의 分泌機構變化에 關한 超微形態學的硏究
이귀란,박재복,김중길,곽정식,서인수,손태중 慶北大學校 醫科大學 1983 慶北醫大誌 Vol.24 No.2
저자들은 분비 항진시에 있어서 상피소체의 분비 기구와 형질막의 동태 및 방출방식을 알아보기 위하여 체중 200∼250gm정도의 성숙한 Sprague-Dawley계의 흰쥐에 reserpine을 체중 ㎏당 5㎎을 복강내에 투여한 후 상피소체를 시간의 경과에 따라 적출하여 이를 광학 및 전자현미경으로 검색하였다. 그 성적을 요약하면 다음과 같다. 광학현미경으로는 특기할 만한 소견은 관찰되지 않았다. 전자현미경으로는 형질막에는 interdigitation의 증가가 reserpine 투여후 10분부터 관찰되었는데, 이중 interdigitation의 증가와 확장은 출현 후 점차 현저해져서 1시간에 최고에 달하고 그후 감소하기 시작하여 6시간에 이르러서는 대조군의 것과 거의 같게 되었고, 개구현상은 1시간에서 4시간 사이에 간혹 관찰되었다. RER에서는 소포성 성분은 reserpine 투여후 10분째부터 증가하여 1시간째에는 층상 및 공포성 성분보다 현저히 많아지고 층상구조물은 reserpine 투여후 20 분부터 증가하기 시작하여 역시 1시간에 가장 현저하였고, 공포성 성분은 2시간 부터 증가하였다. 이들 구조물은 6시간부터는 모두 대조군의 것과 유사한 비율로 되었다. RER-Golgi transitional elements는 reserpine 투여후 1시간 및 2시간에 다수 출현하였고, 커져서 2시간까지 계속되다가 4시간 이후에는 대조군의 것과 유사하게 되고, 이때 구조물의 분포는 RER의 그것과 유사하였다. 분비과립은 reserpine 투여후 10분부터 Golgi장치 주위에서 분비전 과립의 수가 증가하기 시작하여 2시간에 가장 많이 관찰되었고, 그후 감소하여 8시간 이후는 대조군의 그것과 같아지고 성숙분비 과립의 수는 reserpine 투여 10분부터 감소하여 6시간까지 지속하고 그 후 다시 출현하였다. Free ribosome은 reserpine 투여후 10분부터 polysome이 증가하기 시작하여 30분에 가장 현저하여졌고, 이후 감소하여 4시간에는 대조군의 것과 유사하였다. Multivesicular body, lipid droplet, lipofuscin granule 및 glycogen particle은 reserpine 투여후 30분부터 다소 감소하는 경향을 나타내고, condensing vacuole은 관찰되지 않았다. 이상의 연구성적으로 보아 reserpine을 투여하면 상피소체의 주세포에 분비가 항진되며, 형태학적으로 성숙 분비과립의 감소, RER 및 Golgi장치의 소포화, Golgi장치 주위의 분비전 과립의 증가, free polysome의 증가등이 나타나는 것으로 보아 내분비세포인 상피소체 주세포에 있어서의 분비 단백의 합성 및 분비 경로는 RER→RER―Golgi transitional elements→Golgi장치→presecretory granule→mature secretory granule→exocytosis의 순이라 믿어지며, 그 분비주기는 2시간 이상으로 생각된다. 그리고 상피소체에 있어서의 분비단백의 방출양식은 개구에 의한 방출을 암시하는 소견이 관찰되었다. Ultrastructural changes of plasma membrane and cell organelles participating secretion of protein and pattern of secretion of chief cells in parathyroid gland in enhanced secretion were studied in adult female Sprague-Dawley rats. These investigations included light and electron microscopic examination. The reserpine, 5 ㎎ per ㎏ of body weight, was administered to all experimental groups of animals weighing 200 to 250 gm. The parathyroid glands were observed periodically. Light microscopically, there was no appreciable change. Electron microscopically, in plasma membrane, interdigitation was pronounced at 10 minutes after reserpine administration, after then more pronounced. Extent occurring interdigitation and its complexity became the highest degree at 1 hour. Afterwards these changes began to decrease and were nearly similar to that in control group at 6 hours after reserpine administration. Exocytosis was occasionally seen at time between 1 hour and 4 hours after reserpine administration. In RER, vesicular component was increased at 10 minutes and was markedly abundant vacuolar components at 1 hour after administration. Lamellar component began to increase in amount at 20 minutes and most prominent at 1 hour after administration. And vacuolar component was began to increase at 2 hours after administration. Distribution of these organelles showed similar proportion to that in control group at 6 hours after administration. RER-Golgi transitional elements appeared in large numbers at 1 to 2 hours and emlarged in size until 2 hours after administration, and 4 hours later these were similar to that in control group. By this time distribution of these elements was similar to RER. In secretory granules, presecretory granules began to increase in number around Golgi areas at 10 minutes after administration and most prominent at 2 hours and later decreased. Eight hours later, distribution of presecretory granules was similar to that in control group. Mature secretory granules were began to decrease in number at 10 mintes and it was sustained until 6 hours after administration and later reappeared. In free ribosomes, the polysomes began to increase in number at 10 minutes and most prominent at 30 minutes and 4 hours later these were similar to that in control group. Multivesicular bodies, lipid droplets, lipofuscin granules, and glycogen particles tended to decrease in number and amount at 30 minutes. Condensing vacuoles were not observed. From the above results, it is believed that the reserpine stimulates secretion of chief cells in parathyroid gland and that pathway of protein synthesis and secretion in these cells as an endocrine cells, similar to that in pancreatic exocrine cells but dissimilar to that in submaxillary gland, is sequentially RER→RER-Golgi transitional element→Golgi apparatus→presecretory granule→mature secretory granule→exocytosis that is evidenced morphologically by vesiculation of RER and Golgi apparatus and increase of presecretory granules around Golgi areas and of polysomes. The cycle of secretion is considered over 2 hours. In addition, there are morphological changes suggesting that the pattern of secretion of chief cells in parathyroid gland is exocytosis.
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"변증록(辨證錄)" 권지이(卷之二)의 중풍(中風), 비증(?證), 심통(心痛), 협통(脇痛), 두통(頭痛), 복통(腹痛), 요통(腰痛)에 대(對)한 연구(硏究)
이귀인,박동석,금경수,Lee, Gu-In,Park, Dong-Seok,Keum, Kyung-Soo 대한한의정보학회 2010 大韓韓醫情報學會誌 Vol.16 No.2
"Byun Jeung Rok(辨證錄)" is composed of 14 volumes. In relation to the contents, it is organized into 126 gates(門) and 700 remaining syndromes(餘證) where internal medicine, external medicine, pediatrics, gynecology(內科 外科 小兒 婦人), etc. are divided into sub-sections of cold damage, cold stroke, wind stroke(傷寒 中寒 中風), etc. For every syndrome, the symptom, cause of disease, method of treatment, prescription, construction of prescription, instruction of medicine and prognosis.(症狀 病因 治法 處方 處方構成 服用法 預後) were explained thoroughly. This study, as an inquiry of the second volume, deals with wind stroke(中風), impediment disease(?證), heart pain(心痛), side pain(脇痛), headache(頭痛), abdominal pain(腹痛), lumbago(腰痛) It was written very logically so it is easy to understand. The analysis of the symptoms are brief and appropriate. Also, in the usage of the medicine, the sovereign, minister, assistant and courier(君臣佐使) method was used as the basis for the prescriptions. Therefore, it is considered to have significant clinical value for future generations and is thus being applied by them.
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