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인슐린 비의존형 당뇨병환자의 혈장아미노산 농도에 관한 연구
김유리(Yoo Lee Kim),조용욱,김현만(Hyeon Man Kim),임승길(Sung Kil Lim),김경래(Kyung Rae Kim),이현철(Hyun Chul Lee),허갑범(Kap Bum Huh),정미라(Mi Ra Chung),이귀녕(Kui Nyung Lee),이해선(Hae Sun Lee) 대한내과학회 1989 대한내과학회지 Vol.36 No.2
N/A In 105 non-insulin dependent diabetics, composed of 20 under-weight, 66 non-obese, and 19 obese diabetics admitted to Severance Hospital, Yonsei University College of Medicine, plasma amino acid levels were measured by HPLC (High Performance Liquid Chromatography) in the fasting state before control of the blood sugar level. The following results were observed: 1) Plasma levels of branced chain amino acids-leucine, isoleucine, and valine-were higher in the diabetic group than in the control group (p<0.05) 2) Plasma levels of tyrosine, phenylalanine, tryptophan, glutamate, and serine were also higher in the diabetic group than in the control group (p<0.05). 3) The plasma level of threonine was lower in the diabetic group than in the control group (p<0.05). 4) In under-weight, non-insulin dependent diabetics, plasma levels of threonine, lysine, and alanine were lower than in the eontrol group (p<0.05). It could be concluded that in non-insulin dependent diabetics, both the uncontrolled state of the diabetes and the nuritional state influnence the changes of plama amino acid levels.
장염환자에서의 Campylobacter fetus subsp . jejuni 분리율
이귀녕,정윤섭,이삼열 대한미생물학회 1982 大韓微生物學會誌 Vol.17 No.1
C. fefus subsp. Jejuni has been reported to be an important enteric pa.thogen in many parts of the world. Although the infection has been reparted in Korea, the incidence is not known. In this :study the reaults of stool culture during the period oi August 1981 to July 1982 at Yonsei Medical Center was ana.lyzed and the foliowing resuits were obtaioed. 1. C. fetus subsp. Jejuni was isolated from 0. 8/a of stool specimens. The isolation rate was lower than that of salmonella (3.3%) and shigella (7.1%). The isolation was most frequent in June and from 15-year-old patients. 2. All of the isola.tes from the patients were susceptible to chloramphenicol aod erythromycin. It was noteworthy that 4 isolates were resistant to all of the aminoglycosides, I,e., amikacin, gen- tamicin, kanamycin and tobramycin. 3. We also isolated C. fetus subsp. Jejuni iram chicken. When the susceptibility of the isolates was compared to that of tbe isolates from human the former were less susceptible to erythro- myein (34.1%) and tetracycline (38.6%).
정윤섭,이귀녕,이삼열 대한감염학회 1980 감염 Vol.12 No.1
Shigella remains to be the most frequently isolated enteric pathogen in Korea. Most of the recent shigellosis are known to be due to ampicillin - or co-trimoxazole-resistant strains. Rifampicin has been reported effective to cure the infection and to erradicate the organism from intestine. However, there has been no reported studies of rifampicin susceptibility on the recently isolated strains of Shigella in Korea. Poor correlations of a rifampicin disc diffusion test and an agar dilution test were reported. However, most of such studies were done with organisms other than Shigella. This study was conducted to see firstly, if the recent local strains of Shigella were susceptible to rifampicin and secondly if a disc diffusion test would correlated with an agar dilution method in Shgella. The following results were obtained. 1. A total of 193 Shigella strains isolated during 1978-80 were tested. The minimum inhibitory concentraion (MIC) of rifampicin in 175 strains(90.7%) was 16μg/ml or less. In 3 strains (1.6%), it was greater than 128μg/ml. 2. Cross resistance of rifamicin with ampicillin or with co-trimoxazole did not seem to exist. 3. The correlation between a disc diffusion test and an agar dilution test was poor. 4. Highly resistant strains, such as those with MIC of over 128μg/ml showed no inhibitory zone even to a 30μg disc. It is concluded that when rifampicin is used for the treatment of shigellosis one should understand the presence of rifampicin resistant strains. Disc diffusion test could only be used to screen those highly resistant strains.
정윤섭,이귀녕,이삼열 최신의학사 1975 最新醫學 Vol.18 No.6
Enteropathogenic bacteria continue to be important pathogens in many parts of the world and Korea is no exception. Isolation of the bacteria from clinical specimens not only aids definitive etiologic diagnosis but also helps the choice of proper antibiotics for the treatment of individual patients. Accumulated data from isolation of the bacteria could provide some information on the status of occurence of the diseases and on the nature of the pathogens. The data on the enteropathofenic bacteria isolation at Yonsei Medical Center for the year 1969-1973 was analysed retrospectively, and the following results were obtained. 1. During the 5 year period, 6104 stool or rectal swab specimens were received for enteropathogenic bacteria isolation and 871 specimens (844 patients) were positive for Salmonella, Shigella, EPEC, or V. parahaemolyticus. 2. The most frequently isolated bacteria were Shigella (571) and Sal. typhi (201). Annual isolation figures did not show any tendency to decline. 3. Among the Shigella isolates, subgroup B was most numberous. The proportion of D was definitely increasing. 4. Monthly isolation rates showed peaks in June and November for Sal. typhi and July for Shigella. 5. EPEC was isolated from 49 patients. Most frequently isolated serogroups were 0128, 0126, and 055. 6. V. parahaemolyticus isolations were made from only 15 patients, probably due to the nature of the infection. 7. Chloramphenicol and ampicillin resistant Sal. typhi were rarely found. Many Shigella strains showed resistance to various antibictics and simultaneous resistance to chloramphenicol, streptomycin and tetracycline. However, most of them were susceptible to ampicillin.