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금속나노입자-유전체 이층 구조 구현을 위한 반투명 Cu 나노입자층 형성에 관한 연구
윤혜련,조윤이,윤회진,이승윤,Yoon, Hye Ryeon,Jo, Yoon Ee,Yoon, Hoi Jin,Lee, Seung-Yun 한국전기전자재료학회 2020 전기전자재료학회논문지 Vol.33 No.6
This study reports the fabrication and application of semitransparent Cu nanoparticle layers. Spin coating and subsequent drying of a Cu colloid solution were performed to deposit Cu nanoparticle layers onto Si and glass substrates. As the spin speed of the spin coating increases, the density of the nanoparticles on the substrate decreases, and the agglomeration of nanoparticles is suppressed. This microstructural variation affects the optical properties of the nanoparticle layers. The transmittance and reflectance of the Cu nanoparticle layers increase with increasing spin speed, which results from the trade-off between the exposed substrate area and surface coverage of the Cu nanoparticles. Since the glass substrates coated with Cu nanoparticle layers are semitransparent and colored, it is anticipated that the application of a Cu nanoparticle-dielectric bilayer structure to transparent solar cells will improve the cell efficiency as well as aesthetic appearance.
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류마티스 질환에서 항 TNF-α 치료가 만성 HBV 감염의 경과에 미치는 영향
윤혜련 ( Hye Ryeon Yun ),김태종 ( Tae Jong Kim ),김태환 ( Tae Hwan Kim ),최호순 ( Ho Soon Choi ),배상철 ( Sang Cheol Bae ) 대한류마티스학회 2007 대한류마티스학회지 Vol.14 No.3
Objective: To assess the safety of anti-tumor necrosis factor (TNF)-α therapy in patients with rheumatic disease and chronic Hepatitis B virus (HBV) infection. Methods: We used infliximab or etanercept therapy in patients with rheumatic disease and chronic HBV infection. Records concerning these patients were retrospectively reviewed for the duration of disease, treatment, serological status and biological data. Results: Six relevant cases with chronic HBV infection were identified: three of RA; three of AS. Four patients had received etanercept; two had been given etanercept after infliximab. One of the cases treated with lamivudine before anti-TNF-α therapy for chronic hepatitis B treatment. His hepatitis status was maintained stable after he initiated anti-TNF-α therapy. Five of the cases started anti-TNF-α therapy without lamivudine. Two of these five cases were received lamivudine during anti-TNF-α therapy due to elevation of HBV DNA titer without liver function test abnormality and then HBV DNA was normalized. Three cases without lamivudine continued to show the stable level of liver enzyme but, one of the three cases showed persistently elevated HBV DNA titer. Conclusion: Prophylactic or early intervention strategies with anti-viral agent and regular monitoring of aminotransferases and viral load are needed for patient with evidence of chronic HBV infection.
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류마티스 관절염 환자에서 HLA-DRB1의 유전적 변이와 Etanercept 치료 반응과의 연관성: 예비 연구
윤혜련 ( Hye Ryeon Yun ),강창수 ( Chang Soo Kang ),이경화 ( Kyung Wha Lee ),이혜순 ( Hye Soon Lee ),김태환 ( Tae Hwan Kim ),배상철 ( Sang Cheol Bae ) 대한류마티스학회 2006 대한류마티스학회지 Vol.13 No.1
Objective: To investigate the roles of genetic variation in the HLA-DRB1 as predictors of response to etanercept treatment in rheumatoid arthritis (RA) patients. Methods: Clinical responses of 66 patients treated with etanercept were determined according to the ACR criteria (ACR20 and 70). HLA-DRB1 typing and further subtyping of all alleles were performed by polymerase chain reaction, sequence-specific oligonucleotide probe hybridization, and direct DNA sequencing analysis. We tested whether genetic variation in the HLA-DRB1 influenced on the responses to 12 weeks of etanercept therapy. Univariate and multivariate analyses were performed to compare allele and genotype distribution between responders and nonresponders. Results: When allelic association with etanercept response was analyzed with ACR20 and ACR 70 criteria for shared epitope alleles (HLA-DRB1 *0101, *0401, *0404, *0405, *0410, *1001, and *1406 alleles) and protective alleles (HLA-DRB1*0701, *0802, *1301, *1302, *1403, and *1405 alleles), there was no association with etanercept efficacy. When ACR20 nonresponders were compared with ACR70 responders, there was no significant association. Next, we tested genotypic association for shared epitope carriage status. The presence of HLA-DRB1 alleles encoding the shared epitope (1 and 2 copies) was marginally associated with nonresponse effect for ACR 70 response (OR=0.27, 95% CI=0.08∼0.93, P=0.045). Conclusion: There was no influence of genetic variation in the HLA-DRB1 on the response to treatment of RA with etanercept.
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2000년대 초에 유행한 Orientia tsutsugamushi에 의한 간염
박재일,한성희,조승철,조용현,홍상모,이학현,윤혜련,양선영,윤재훈,윤영섭,문지용,조경란,백상현,손주현,김태화,이동후 대한간학회 2003 Clinical and Molecular Hepatology(대한간학회지) Vol.9 No.3
목적: Orientia tsutsugamushi 감염은 삼림에 서식하는 매개충인 진드기(Leptotrombidium)의 유충이 우연히 사람의 피부를 통하여 전파되어 생기는 급성 발열 질환이다. 저자들은 지난 3년 동안 쯔쯔가무시병으로 진단된 환자들에서 간 기능 이상을 확인하고 가을철 간염환자의 감별진단 특히 non-A, non-B, non-C 간염의 진단에 주의를 환기하고자 관찰 결과를 보고하는 바이다. 대상과 방법: 한양대학교 서울병원과 구리병원에 2000년 10월부터 2002년 11월까지 hemagglutinin법으로 쯔쯔가무시병으로 진단된 환자 22명을 조사 대상으로 삼아 그 진료기록을 조사하였다. 결과: 남녀 비는 1:3.4로 여자가 많았다. 연령(범위 31-83세)은 56.4±2.6(평균±표준오차)세였다. 입원시기는 9월 23일부터 11월 15일 사이였고 10월 중순 이후 11월 상순 사이가 제일 많았다. 증상은 발열이 21예로 가장 많았고, 근육통 13예, 관절통 12예, 오한 6예, 피부발진 6예 순이었다. 잠복기는 7-9일이 10예로 가장 많았고 13-15일이 4예, 10-12일 3예, 3일 이내 3예, 4-6일 2예였다. ALT(범위 18-345 IU/L)는 93.2±17.3 IU/L(평균±표준오차)였고, AST(범위 34-255 IU/L)는 92.5±11.7 IU/L, GGTP (범위 19-251 IU/L)는 132.2±14.5 IU/L로 상승하였지만 혈중 총 빌리루빈은 정상이었다. 모든 환자들은 doxycycline 투여로 호전되었다. 결론: Orientia tsutsugamushi 감염은 대부분, 경도의 간 기능 이상을 동반하므로 특히 가을철 간 기능 이상을 보이는 열성 질환 환자들에게서 다른 간 질환과 감별해야 할 질환으로 인지하는 것이 중요하다. Background/Aims: Orientia -tsutsugamushi infection is an acute febrile disease due to the accidental transmission through human skin of forest dwelling vector Leptotrombidium larva. The authors observed liver dysfunctions in patients diagnosed with tsutsugamushi disease (Scrub typhus) in the past 3 years and report the data in the hope of bringing attention to this disease in the differential diagnosis of autumn-season hepatitis, especially of non-A, non-B and non-C hepatitis. Methods: Medical records of 22 patients diagnosed with tsutsugamushi disease by the hemagglutinin method between October 2000 and November 2002 were reviewed. Results: Female gender was dominant in the ratio of 3.4:1. Mean age was 56.4±2.6. Admission was between 23rd September and 15th November with the peak between mid October and early November. Fever, being the most common symptom, was observed in 21 cases, myalgia in 13, arthralgia in 12, chills in 6, and skin rash in 6. An incubation period of 7-9 days was most common (10 cases), 13-15 days (4), 10-12 days (3), within 3 days (3), and 4-6 days (2). Average ALT, AST and GGTP were increased to 93.2±17.3 IU/L (18±345 IU/L), 92.5±11.7 IU/L (34-255 IU/L) and 132.2±14.5 IU/L (19-251 IU/L), respectively, but total bilirubin was normal. All the patients improved with doxycycline therapy. Conclusions: since it usually shows liver dysfunction, it is important to take Orientia tsutsugamushi into consideration in differential diagnosis of autumn-season, febrile hepatic disease.(Korean J Hepatol 2003;9:198-204)
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