A case of rapidly progressed granulomatosis with polyangiitis misdiagnosed as fungal infection

윤현지,김성현,조영준,조화진 대한내과학회 2022 대한내과학회 추계학술대회 Vol.2022 No.2

엔트리를 활용한 초등 도형 수업이공간 감각과 수학적 태도에 미치는 영향 -초등 5학년 도형의 합동과 대칭을 중심으로-

윤현지,손교용 대구교육대학교 초등교육연구소 2023 초등교육연구논총 Vol.39 No.1

The purpose of this study is to discover the effects of a class about geometric shapes using ENTRY on the students’ spatial sense and mathematical attitude at the level of fifth-grade elementary students. Each lesson of “Congruence and Symmetry”, the third chapter in the fifth-grade second semester math syllabus, was reconstructed into classes using entries and was applied. Thereafter, the effects of using ENTRY in a class about geometric shapes on spatial sense and mathematical attitude were examined by analyzing the students’ questionnaires and comments. This study will allow to lay the foundation on which spatial sense and appropriate mathematical attitude can be formed. The results of the study led to the conclusions below.First, considering the spatial sense post-test results of the experimental and comparison class, a class on geometric shapes using ENTRY on the chapter “Congruence and Symmetry” had significant effects on spatial sense. There were significant effects in the sub-region of spatial sense - spatial visualization, spatial orientation – and it helped to improve mental rotation, mental transformation, shape-background perception in spatial visualization, and sense of direction, distance, and position in spatial orientation. Second, considering the spatial sense post-test results of the experimental and comparison class, a class on geometric shapes using ENTRY on the chapter “Congruence and Symmetry” had a significant effect on improving the students’ mathematical attitude. There were significant effects in the sub-region of mathematical attitude - interest, willingness to learn and self-efficacy – and the analysis as the comments and student questionnaires showed that it had positive effects on improving students’ mathematical attitude. In summation, a class on geometric shapes using ENTRY had a positive effect on the improvement of students' spatial sense and mathematical attitude. 본 연구는 엔트리를 활용한 수학 도형 수업이 초등학교 5학년 학생들의 공간 감각과 수학적 태도에 미치는 효과를 알아보고 초등 도형 교수·학습에서 엔트리의 활용 가능성을 확인하고자 하였다. 이를 위해 초등학교 5학년 도형의 합동과 대칭 단원을 엔트리를 활용한 수업으로 재구성하였으며 연구대상은 D광역시 소재 K초등학교 5학년 2학급 42명을 선정하여 실험반은 엔트리를 활용한 도형 수업을 진행하였으며, 비교반은 교과서 중심의 도형 수업을 실시하였다. 연구 결과는 다음과 같다. 첫째, 합동과 대칭 단원에서 엔트리를 활용한 수학 도형 수업이 학생들의 공감 감각 향상에 긍정적인 영향을 주었다. 특히, 공간 감각 하위 영역 중 정신적 회전(2D), 정신적 변환(2D-2D), 도형-배경 지각 능력, 방향 감각, 위치 감각 요인에서 통계적으로 유의미한 차이를 보였다. 둘째, 엔트리를 활용한 수학 도형 수업이 학생들의 수학적 태도의 흥미, 효능감, 학습 의지에 유의미한 효과가 있었다. 셋째, 엔트리를 활용한 수학 도형 수업이 학생들이 수학에 대한 흥미, 자신감에 도움을 주며 수학에 대한 긍정적 태도를 가질 수 있게 해 주었다.

응급실 확장공사가 응급실 과밀화와 환자 흐름에 미치는 영향

윤현지,이현심,박준민,김지훈,이지환,박인철,정성필,김민정 대한응급의학회 2020 대한응급의학회지 Vol.31 No.4

Objective: Overcrowding in the emergency department (ED) has been a long-standing global problem, but has yet to be resolved. This study was undertaken to investigate whether expansion of the ED can affect overcrowding. Methods: This was a retrospective study comparing two 10-month periods: before (September 2015 to June 2016) and after (September 2017 to June 2018) the ED expansion in an urban tertiary hospital. The ED expansion included expansion of the ambulatory area and establishment of a 25-bedded emergency ward dedicated to patients admitted through the ED. Results: Comparing the two study periods, we noted an increase in the number of patients visiting the ED, from 77,078 to 87,027. Moreover, the proportion of patients who returned home untreated significantly decreased from 11.5% to 0.9% (P<0.001). The number of adult patients increased from 40,814 to 60,720; in particular, the number of ambulatory patients increased from 18,648 to 42,944. Conversely, waiting time for X-ray and computed tomography increased (10.0 to 17.0 minutes, and 35.0 to 48.0 minutes, respectively). Other areas with increased time duration include median ED length of stay of total patients (193.0 minutes to 205.8 minutes), and time from consultation to admission decision (122.3 to 161.4 minutes). However, the boarding time decreased from 239.2 to 190.9 minutes. Conclusion: The ED expansion allowed more patients to be treated, and the boarding time of admitted patients was reduced through operation of the emergency ward. However, due to increase in the number of visiting patients, the time required for medical treatment increased concurrently.

남다운 것

윤현지 수필미학 2015 수필미학 Vol.10 No.-

Nanohybrids based on carbonized bacterial cellulose and Nb₂O<SUB>5</SUB> nanoparticles for asymmetric Li-ion storage devices

윤현지,이민의,김나래,안홍주,최준호,진형준 한국고분자학회 2017 한국고분자학회 학술대회 연구논문 초록집 Vol.42 No.1

Enzymatic preparation and antioxidant activities of protein hydrolysates from hemp (Cannabis sativa L.) seeds

윤현지,박규현,이유림,이정민,안현림,이승욱 한국식품저장유통학회 2023 한국식품저장유통학회지 Vol.30 No.3

Hemp (Cannabis sativa L.) seeds have recently been attracting attention as a new high-value-added food material owing to their excellent nutritional properties, and research on the development of functional food materials using hemp seeds is actively progressing. This study aimed to evaluate the antioxidant properties of hemp seed protein hydrolysates. Protein hydrolysates were prepared from defatted hemp seed powder (HS) by enzymatic hydrolysis using five different proteases (alcalase, bromelain, flavourzyme, neutrase, and papain). 2,4,6- trinitrobenzene sulfonic acid (TNBS) assay and SDS-PAGE analysis revealed that HS showed a high degree of hydrolysis after treatment with each enzyme except papain. The total polyphenol content of the protein hydrolysates (<3 kDa) and the RC50 values obtained from two different antioxidant tests showed that alcalase hydrolysate (HSA) had a relatively high level of antioxidant capacity. In addition, treatment with HSA (25-100 μg/mL) significantly inhibited linoleic acid peroxidation. These results suggest that hemp seed protein hydrolysates are potential sources of natural antioxidants. Future studies will focus on the identification of active peptides from HSA.

2 단 적층 Si Die 가 본딩된 유연전자소자의 뒤틀림 해석

윤현지(H. J. Yun),서승호(S. H. Seo),이원준(W. J. Lee) Korean Society for Precision Engineering 2019 한국정밀공학회 학술발표대회 논문집 Vol.2019 No.10월

통사 점화가 영어 L2 학습자의 문법 지식 발달에 미치는 영향: 연구종합

윤현지(Yoon, Hyeonji),이상기(Lee, Sang-Ki),성상희(Seong, Sanghui) 한국언어학회 2017 언어 Vol.42 No.3

This study aimed to make a comprehensive overview of the effects of syntactic priming on acquiring L2 grammatical structures. A total of 20 primary studies published in peer-reviewed journals (and 27 independent experiments from them) were retrieved through the systematic and comprehensive literature search. The meta-analysis of the primary studies revealed a medium-sized effect of syntactic priming (d=0.54). That is, assuming that the chance of each competing structure to occur is equal, the average weighted odds ratios of the target structure X to the alternate structure Y increased by 22.75%. Meanwhile, the effects of syntactic priming were found more robust with a greater effect size (d=1.09) when the primed condition was contrasted with the unprimed condition, showing that the chance for the target structure to occur increased by 37.85% under the primed condition. Other detailed findings and their implications are discussed.

암종양유전자 SETDB1과 FosB 발현에 대한 p53의 음성 조절기작

윤현지(Hyeon Ji Yun),나한흠(Han-Heom Na),김근철(Keun-Cheol Kim) 한국생명과학회 2020 생명과학회지 Vol.30 No.12

암세포에 항암제를 처리하게 되면, 세포증식, 이동성 또는 약물 내성과 관련된 많은 유전자들의 발현 변화가 발생하며, 유전자 발현 변화는 상호간의 조절 네트워크에 의해 밀접하게 연결될 수도 있다고 추측된다. 본 연구에서 p53 유전자 유무가 다른 A549와 H1299 인간 폐암세포에 독소루비신을 처리하면, 원종양유전자인 FosB의 발현은 증가하지만, 원종양유전자인 SETDB1의 발현은 감소하지만, 단백질 발현의 양적인 차이가 발생한다는 사실을 알 수 있었다. TF motif binding 분석 프로그램을 이용하여 SETDB1과 FosB 프로모터지역에서의 p53단백질의 결합가능성을 분석한 결과, SETDB1의 경우 18부위, FosB의 경우 21 부위의 p53 결합부위를 예측할 수 있었다. SETDB1과 FosB 프로모터의 subcloning하여 luciferase 분석을 수행한 결과, p53은 SETDB1과 FosB을 음성적으로 조절한다는 사실을 알 수 있었다. 또한, H1299 세포에 p53의 과발현은 SETDB1 과 FosB의 발현을 감소시킬 수 있음을 RT-PCR, western blot, qPCR, 면역염색 실험을 통해 확인하였다. 이러한 결과를 종합하여 본다면, p53에 의한 SETDB1과 FosB 유전자 발현 조절은 항암제 처리과정에서 나타나는 암세포의 사멸과 생존에 대한 기능적 조절 네트워크로 사료된다. Treatment with anticancer drugs changes the expression of multiple genes related to cell proliferation, migration, and drug resistance. These changes in gene expression may be connected to regulatory networks for each other. This study showed that doxorubicin treatment induces the expression of oncogenic FosB and decreases the expression of oncogenic SETDB1 in A549 and H1299 human lung cancer cells, which are different in tumor suppressor p53 status. However, a small difference was detected in the quantitative expression of those proteins in the two kinds of cells. To examine the potential regulation of SETDB1 and FosB by p53, we predicted putative p53 binding sites on the genomic DNA of SETDB1 and FosB using a TF motif binding search program. These putative p53 binding sites were identified as 18 sites in the promoter regions of SETDB1 and 21 sites in the genomic DNA of FosB. A luciferase assay confirmed that p53 negatively regulated the promoter activities of SETDB1 and FosB. Furthermore, the results of RT-PCR, western blot, qPCR, and immunostaining experiments indicated that the transfection of exogenous p53 decreases the expression of SETDB1 and FosB in H1299 cells. This indicates that p53 negatively regulates the expression of SETDB1 and FosB at the transcriptional level. Collectively, the downregulation of SETDB1 and FosB by p53 may provide functional networks for apoptosis and for the survival of cancer cells during anticancer drug treatment.

한국인 스페인어 학습자의 중간언어 연구: 3인칭 대격 접어의 구현 방식에 대하여

윤현지 ( Hyun Jee Yoon ) 고려대학교 스페인·라틴아메리카연구소 2011 스페인라틴아메리카연구 Vol.4 No.-

El presente estudio hace un analisis contrastivo del objeto directo del coreano y del clitico de caso acusativo del espanol con referencia a un objeto inanimado e investiga la interlengua de espanol de los estudiantes coreanos que aprenden espanol como L2. Para el analisis contrasitivo con datos confiables, el presente estudio se basa en seis tipos de corpus; el corpus del espanol de los hablantes del espanol como L1, el corpus del espanol de los coreanos que estudian espanol como L2, el corpus paralelo alineado espanol-ingles, el corpus del espanol de los hablantes del ingles como L1 que estudian espanol como L2, el corpus paralelo alineado espanol-coreano y el corpus del coreano de los hablantes del coreano como L1. Asimismo, basandose en la comparacion de los datos de la representacion linguistica de estos cuatro grupos de hablantes, hemos hecho hincapie especial en la discrepancia de las funciones informativas del pronombre del objeto directo del coreano y del clitico de caso acusativo del espanol. Como consecuencia, suponemos que el motivo fundamental de la interlengua de los estudiantes coreanos se asienta en el fracaso de percibir las diferentes propiedades informativas del pronombre de objeto directo del coreano y del clitico de caso acusativo del espanol. Por lo tanto, los aprendientes del espanol que hablan coreano como L1 tienen dificuldad en la adquisicion del uso del clitico de caso acusativo del espanol por el esfuerzo de hacer coincidir los elementos de las estructuras superficiales de su L1 y L2. El presente estudio ayudara a los estudiantes a percibir la importancia de las estructuras informativas de un modelo gramatical en el proceso del aprendizaje del espanol como L2. Por otro lado, esta investigacion nos proporcionara la posibilidad de hacer un analisis especifico de la interlengua de los hablantes del coreano como L1. Por ultimo, este estudio nos ofrecera una base critica de las propiedades contrastivas de ambas lenguas que desempenan un papel importante en el aprendizaje del espanol como L2.