한국 청년층의 UVB에 의한 최소홍반량에 따른 광피부형의 분류

윤재일 ( Jai Il Youn ),오준규 ( Jun Gyu Oh ),김병국 ( Byoung Kook Kim ),정진호 ( Jin Ho Chung ),오선진 ( Sun Jin Oh ),김진준 ( Jin Jun Kim ),강세훈 ( Seh Hoon Kang ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.6

Background: We predicted that t.he self reporting questionnaire proposed by Fitzpatrick might not be appropriate for classifyin~v; the skin phoiotype in Korean people. Objective : We classified the skin phototypes in Korean people by measuring the minimal erythema dose (MED) of UVB on t.he basis of MEDs of skin type proposed by Pathak and Fitzpatrick. Methods : Two hundred and eighty-four male Korean rnedical students participated in this study. We irradiated UVB with Waldmann UV 800 and measured MEDs after 24 hours. Results : The mean MED was 70.1+21.3 mJ/cm2. Most of the MEDs were 70, 60, 50 mJ/cm in the order of frequency. On the basis of the skin type proposed by Pathak and Fitzpatrick, the most frequent phototype was the skin type V(56.3%) by MED. 20.8% and 13.8% of the subjects eorresponded to the skin types UV and III, respectively. 9.1% of the subjects fell into the UV sensitive group, skin type l and II. Conclusion : Using these results as groundwork, simple and precisely applicable classification of skin phototype in Korean people needs to be established. (Kor J Dermatol 1996;34(6): 893-897)

한국인에서 8 % Homomenthyl Salicylate 로숀의 광원에 따른 광방어지수의 비교

윤재일 ( Jai Il Youn ),김병국 ( Byoung Kook Kim ),서대헌 ( Dae Hun Suh ),오선진 ( Sun Jin Oh ),김진준 ( Jin Jun Kim ),강세훈 ( Seh Hoon Kang ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.1

Background: The need for using sunscreen is increasing today, but we know little about the effect of sunscreens on the skin of Korean people. Objective : We tried to estimate and compare the SPF of 8% homomenthyl salicylate lotion, which was recommended as the control in SPF experiments by the FDA, USA, in Koreans according to different light sources Methods : After application of 8% homomenthyl salicylate lotion to the back, 33 men of the third decade were irradiated by xenon arc solar simulator or by fluorescent sunlamp, We estimated the SPF of them 24 hours later. Results : The SPF of 8% homomenthyl salicylate lotion was 4.8+0.8 with the solar simulator, 2.7+0.6 with the fluorescent sunlamp. Conclusion : We confimed that the SPF of 8% homomenthyl salicylate lotion with xenon arc solar simulator can be used as a control value in Koreans, and found out that the SPF with the fluorescent sunlamp was significantly lower than that with the xenon arc lamp. So it should be taken into consideration that differences of SPF according to light sources exists in studying sunscreens. (Kor J Dermatol 1996;34(1): 46-51)

Retinoid - 변형 Ingram 법에 의한 건선의 치료효과 및 호전기간

김병국 ( Byoung Kook Kim ),윤재일 ( Jai Il Youn ),장승호 ( Seung Ho Chang ) 대한피부과학회 1996 大韓皮膚科學會誌 Vol.34 No.2

Background: Although treatment with etretinate or modified Ingram method is effective for psoriasis, both regimens have limitations beeause of the risk of long-term toxicity. Objective : We performed retinoid-modified Ingram combination therapy expecting greater therapeutic efficacy and less side effect. Methods : Thirty three plaque-form psoriasis patients were included. Pretreatment with etretinate for 1 to 2 weeks was followed by modified Ingram therapy in combination with etretinate. Results : l. Among 33 patients, clearing was shown in 26 patients(78.8%), 4 patients(12.1%) was improved, and 3 patients(9.1%) showed failure. The number of cleared patient was 13/15 (86.7% ) in moderate group, and 13/18 (72.2%) in severe group. 2. In cleared patients, the mean numbers, duration, and total dose of UVB therapy reaching grade 4 were 11.9, 24.5 days, 1348.5 mJ/cm in trunk, and 13.5, 29.1 days, 1733.3 mJ/cm in extremities. Their differences between trunk and extremities were not statistically significant (p>0.05). 3. In cleared patients, the mean numbers, duration, total dose of phototherapy, and total close of etretinate reaching grade 4 in severe group were not significantly higher than them in moderate group (p>0.05). 4. There were some side effects of etretinate such as cheilitis, dry mouth, and side effects of modified Ingram therapy such as erythema, pruritus. But there was no discontinuation of therapy due to side effect. 5. In 22 patients who were followed up at least,one year, the mean remission time was 14.9 months in moderate group and 6.9 months in severe group. Conclusion : Our study suggests that retinoid-modified Ingram regimen is effective and tolerable in the treatment of psoriasis, especially in severe group. (Kor J Dermatol 1996;34(2): 240-247)

지도모양 혀와 균열 혀를 동반한 전신성 농포성 건선 2예

김병국,윤재일 ( Byoung Kook Kim,Jai Il Youn ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.2

Generalized pustular psoriasis is a rare disease, even psoriasis involving oral mucosa is very rare. There are many reports of tongue lesions in patients with psoriasis that are clinically and histologically indistinguishable from geographic tongue, and there are many reports of fissured tongue in association with psoriasis. It has been debated whether oral psoriasis exists or not, or occurs as part of generalized pustular psoriasis. We experienced two cases of combined geographic tongue and fissured tongue in patient with generalized pustular psoriasis, and report these cases with review of the literature about the oral lesions in psoriasis, geographic tongue, and fissured tongue. (Kor J Dermatol 1997;35(2): 383-387)

윤상 농포성 건선 4예

김병국 ( Byoung Kook Kim ),윤재일 ( Jai Il Youn ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.1

Annular pustular psoriasis is a rare variant of the generalized pustular psoriasis characterized by subacute onset of annular lesions with pustules on the advancing edge. Compared with the Zumbusch type, annular type is less severe and has a more benign course, and it is known to respond more rapidly to therapy. Histologically, spongiform pustules are seen in the epidermis and discrimination from subcorneal pustular dermatosis may be difficult. We report four cases of annular pustular psoriasis. Two cases were adult female patients who had been given long-term systemic corticosteroid therapy. In the other two patients who were a 9-year-old female and a 10-year-old male respectively, we could not find any provocating factor of pustular psoriasis. There was a past history of psoriasis vulgaris in three cases, although none had any family history of psoriasis. (Kor J Dermatol 1996;34(1): 155-159)

UVB 에 의한 홍반반응 및 색소반응의 Dose - response Angle과 피부의 자외선 감수성 지표들과의 상관관계에 관한 연구

김병국,박석범,윤재일 ( Byoung Kook Kim,Seok Beom Park,Jai Il Youn ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.6

Background: There are many predictors of sensitivity to UVR, but controversies exist about their objectivity, correlation bet,ween them, and applicability to various races. Objective : In 42 healthy volunteers, we assessed the validaty of dose response angle of erythe ma(DRAE) and delayed tanning(DRADT) after UVB irradiation, and also evaluated the correlation hetween dose-response angb s and other predictors of UV sensitivity. Methods : We measured erythema and melanin index using reflectance spectrophotometer aft,er irradiation of UVB on the back of 42 males. When the erythema index and melanin index were plotted against UV doses for each patient, a dose response curve was obtained. Linear regression analysis was used to calculate the slope of those curves for erythema and delayed tanning, which were called DRAE and DRADl respectively. Also we checked predictots of UV sensitivity such as skin type, MED, MMD, consiitutional and facult,ative skin color, then analyzed the relation be tween dose response angles and other predictors. Results : Statistically significa it linear regression lines were obtained from 41 subjects regar d- ing to erythema and frorn 31 subjects regarding to delayed tanning. As for the relationship he tween the pvedictors of UV senitivity, only the MED correlated well with DRAE. Conclusion : We found that dose response angles, especially DRAE, were an objective and adequate predictor of cutaneous LJV sensitivity, but could not find validity of skin type and skin color in Koreans. A more organized study with a larger number of subjects is needed to clarify the usefulness of the predictors. (Korean J Dermatol 1997;35(6): 1177-1183)

한국 청년층에서 reflectance spectrophotometer에 의한 UVB 조사 광량에 따른 홍반지수 및 색소지수

박석범,김병국,은희철,윤재일 ( Seok Beom Park,Byoung Kook Kim,Hee Chul Eun,Jai Il Youn ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.4

Background: Methods of estimating the erythema and pigmentation reactions, such as MPE (Minimal Perceptible Erythema), MED(Minimal Erythema Dose) and MMD(Minimal Melanogenic Dose), are vulnerable to the variations of subjective visual measurements. Objective : By using objective and quantitative methods, the erythema and pigmentaton responses were investigated. Methods : A sunlight, fluorescent lamp(Waldmann UV 800) was used as a UVB light source. Multiple sites of the lower back were irradiated with an increasing dose by a constant amount, With a reflectance spectrophotometer (DermaSpectrometer), erythema and melanin indices at control, MPE, MED, MMD sites were assessed. The dose-response angle of erythema and pigmentation were calculated. Results : The erythema and pigmetation indices at the control, MPE, MED and MMD sites were 8.7+2.0AU/30.5+2.6AU, 10.5+2.7AU/32.6+3.6AU, 13.2+3.5AU/32.6+3.3AU, and 10.4+3.0AU/ 33.5+2.7AU, respectively. The calculated dose-response angle accurately measured the response of skin to UVB irradiation. Conclusion . In this study, use of a reflectance spectrophotometer appeared to be a more sensitive and effective method than visual assessment, in addition, dose-response angles may be an objective index for determination of skin responses to UVB irradiation. (Kor J Dermatol 1997;35(4): 729-735)

접촉피부염 환자에서 화장품 및 향료 항원군 이외의 부가항원 첩포시험 결과에 대한 고찰

은희철,김병국,서대헌,정진호,박경찬,조광현,윤재일 ( Hee Chul Eun,Byoung Kook Kim,Dae Hun Suh,Jin Ho Chung,Kyoung Chan Park,Kwang Hyun Cho,Jai Il Youn ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.2

Background: There are few epidemiological studies on patch test with additional batteries in Korea. Objective : We report the results of patch tests with additional batteries which are relatively uncommonly used in contact dermatitis patients. Methods : Standard patch testing was performed with Finn chamber on Scanpor tape. We used additional batteries including cosmetic and fragrance series which are commonly used, and the others including 14 batteries(so-called other batteries). Results : Over the last 8 years, 719 patients(male 184, female 535) were tested in our contact, dermatitis clinic. 178 patients(24.8%) were tested with both Standard and other batteries, In other batteries, rubber additive series were most frequently used(9.2%), and textile colours finish(4.3%) and hairdressing series(3.6%) were used in order of frequency. Rarely performed batteries were(meth) acrylate ser ies, photographic chemicals series, wood set, oil & cooling fluid series, and various allergens. Patients tested with steroid batteries did not show positive reactions. Conclusion : We suggest that 6 batteries((meth)acrylate series, photographic chernicals series, wood set, oil & cooling fluid series, various allergens, steroid battery) have law testing frequencies and positive rates. A more organized multicenter study is required. (Kor J Dermatol 1997;35(2): 279-283)

한국 청년층에서의 UVA에 의한 최소 즉시 색소침착량

김병국,윤재일 대한피부과학회 1999 대한피부과학회지 Vol.37 No.2

Background : The xenon arc solar simulator is the most commonly used light source in studies on immediate tanning, but there has been no report on the immediate tanning response in Korean skin induced by UVA from that source. Objective : This study was conducted to measure the minimal immediate tanning dose(MITD) for UVA in Korean, brown skin. Methods : UVA irradiation was performed on normal back skin of twenty-six healthy Korean young adults, with increasing doses from 0.5J/㎠ to 4.5J/㎠ using xenon arc solar simuiator equipped with appropriate filters. Visual assessment of MITD was done by two investigators. Results : The mean and standard deviations of MITD were 2.38±0.65J/㎠ in 26 subjects. MITDs distributed from 1.1J/㎠ to 3.5J/㎠. There were no significant differences of MITD between skin type III and IV. Conclusion : Conclusively, we obtained the data on the MITD in Korean skin induced by UVA from the solar simulator. The results of this study may be valuable for the research into phatomedicine and useful data for evaluating sunscreens.

족부백선에 대한 Terbinafine 경구요법의 치료효과

문승현,박병순,김병국,정진호,김정애,윤재일 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.2

In this open trial, a new orally active antifungal agent, terbinafine was used in the treatment of tinea pedis. Thirty adults over the age of 18 years with symptoms and signs of tinea pedis and positive potassium hydroxide wet mount were treated with terbinafine, 250mg, once a day for 2 weeks. All patients finished the study mediations and were available for evaluation of efficacy and side effects at follow-up weeks later. At 5 weeks, 24 out of 30 patients(80%) were mycologically negative(microscopy and culture). The clinical symtom improved significantly from the first week of therapy and had improved continuously by the time of the end of study. Overall efficacy assessed by the investigator and patient was evaluated as more than good in 87% of patients by both of them, and overall tolerability as more evaluated as more than good in 100% and 97% over patients respectively. In conclusion, oral terbinafine is effective and safe in the short-terms (2 weeks) treatment of tinea pedis.