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- 저자 : 원왕연 ( Wang Youn Won ) (검색결과 3 건)
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금연이 혈중 Leptin, Ghrelin, Glucagon-Like Peptide 1, Nerve Growth Factor의 농도에 미치는 영향
이희미,원왕연,김대진,Lee, Hee-Mi,Won, Wang-Youn,Kim, Dai-Jin 대한생물정신의학회 2011 생물정신의학 Vol.18 No.2
Objectives It is well-known that tobacco smoking is related to various disease entities including chronic obstructive pulmonary disease, inflammation, cardiovascular disease, and neoplasms. The prohibition of smoking is important for the protection of these health problems. Regarding leptin, ghrelin, glucagon-like peptide 1 (GLP-1), and nerve growth factor (NGF) levels, correlations with the smoking are suggested but the reports on the effects after smoking cessation are not sufficient. Method The changes of plasma levels of leptin, ghrelin, GLP-1, and NGF levels were analyzed after quitting smoking in Korean adults. Eleven participants succeeding in quitting smoking among 37 male smokers were included in the final analysis. The plasma levels of NGF, leptin, ghrelin, and GLP-1 were measured before and after 8-weeks period of smoking cessation. Results The plasma level of leptin increased after 4 weeks of smoking cessation. In addition, the plasma level of NGF increased after 8 weeks of smoking cessation (p < 0.05). Conclusion Our results suggested that smoking cessation induces increases in leptin and the NGF level after smoking cessation. Many toxic materials including nicotine in the cigarette may be related to these changes of plasma level of leptin and NGF, playing a key role in neurogenesis and synaptic plasticity.
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최적화 화소 기반 형태분석 방법을 이용한 알츠하이머 병환자의 회백질 용적감소의 정량적 분석
임현국(Hyun Kook Lim),윤동환(Dong Whan Yoon),원왕연(Wang Youn Won),이철(Chul Lee),이창욱(Chang Uk Lee) 대한노인정신의학회 2009 노인정신의학 Vol.13 No.1
Objective : Optimized voxel based morphometry (VBM) has been increasingly applied to investigate differences in brain morphology between a group of Alzheimer's Disease (AD) patients and control subjects. Optimized VBM permits comparison of gray matter (GM) volume at voxel-level from the entire brain. The purpose of this study was to assess the regional GM volume loss measured by optimized VBM in AD compared to controls Methods : Twenty-three AD patients and 20 cognitively normal elderly control subjects included in this study. To improve the VBM performance, the study specific template and the probability maps were generated from the control subjects. Results : Optimized VBM analysis revealed GM loss, including hippocampus, amygdala, anterior cingulate, posterior cingulate, insula, frontal lobe and middle temporal complex in the AD group as compared to normal control group Conclusion : The VBM results confirmed previous findings of temporal lobe and limbic lobe atrophic changes in AD, and suggest that these abnormalities may be confined to specific sites within that lobe, rather than showing a widespread distribution.
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황용일 ( Yong Il Hwang ),김현정 ( Hyun Jung Kim ),원왕연 ( Wang Youn Won ),조준성 ( Joon Sung Joh ),오연목 ( Yeon Mok Oh ),정기석 ( Ki Suck Jung ),이상도 ( Sang Do Lee ) 대한내과학회 2012 대한내과학회지 Vol.83 No.4
Background/Aims: Chronic obstructive pulmonary disease (COPD) often coexists with co-morbid conditions that significantly affect the prognosis. Although depression frequently coexists with COPD, little about how to screen for depression in COPD patients is known. We report the effectiveness of depression screening in patients with COPD and of the instruments used for this purpose. Methods: We performed a systematic literature review of the domestic (Research Information Sharing Service, KoreaMed, and Kmbase) and international (Medline, Embase, Cochrane library) databases using COPD AND depression AND screening tools as key words. Results: No study directly evaluated the effectiveness of screening for depression in COPD patients. However, depression was present more frequently in patients with COPD. COPD patients with depression were also more likely to be in poor health. A total of eight screening instruments for depression were translated into Korean. All had similar reliabilities and internal consistencies. Conclusions: Screening of COPD patients for depression is necessary because individuals with this condition are more likely to suffer from depression, which has a negative impact on health. The choice of depression screening instruments may need to be based on considerations of simplicity. (Korean J Med 2012;83:468-475)
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