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토끼에서 신델라 겔 ( 송아지의 제단백혈액추출물 황산 미크로노아이신 = 20 1 혼합물 ) 의 피부자극성시험
남석우(Suk Woo Nam),이영진(Young Jin Lee),고영권(Young Kwon Ko),장만식(Man Sik Chang),최완수(Wahn Soo Choi),김규봉(Kyu Bong Kim),우태욱(Tae Wook Woo),한정환(Jeung Whan Han),홍성렬(Sung Youl Hong),이향우(Hyang Woo Lee) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.4
This study was conducted to investigate the skin irritation toxicity of Syndella gel, a combination topical drug containing a deproteinised dialysate of calfs blood and micronomicin sulfate in the ratio of 20 to 1, in New Zealand White rabbits. In the primary skin irritation test with male New Zealand White rabbits, there was no treatment-related effect on clinical sign, and body weight was not significantly changed. The Primary Irritation Index (PII) was 0.33, indicating that Syndella gel was a mildly irritating formulation.
랫트에 있어서 신델라 겔 ( 송아지의 제단백혈액추출물 황산 미크로노마이신 = 20 1 혼합물 ) 의 피하급성독성시험
남석우(Suk Woo Nam),서동완(Dong Wan Seo),안성훈(Sung Hoon Ahn),장만식(Man Sik Chang),최완수(Wahn Soo Choi),김규봉(Kyu Bong Kim),우태욱(Tae Wook Woo),한정환(Jeung Whan Han),홍성렬(Sung Youl Hong),이향우(Hyang Woo Lee) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.4
Single subcutaneous administration to S.D rats of both sexes was performed to investigate the acute toxicity of Syndella gel, a new topical drug containing deproteinised dialysate of calfs blood and micronomicin sulfate. LD_(50) values for S.D rats were 23,047 ㎎/㎏ for male and 23,725 ㎎/㎏ for female. The death occurred within 24 hours after administration at doses over 19,200 ㎎/㎏. The main cause of death seemed to be respiratory disturbance by acute shock. Major general symptoms induced by injection subcutaneously with Syndella gel were underactivity, decreased respiratory rate, salivation, tremor and loss of consciousness. No significant body weight changes and gross findings of internal organs in treatment groups in comparison with those of control groups was observed at any dose levels in Syndella gel.
크레메진의 투석도입 지연효과에 따른 진행성 신부전증환자의 비용감소분 추계
조우현,이선미,김형종,이호영,우태욱,강혜영,Cho, Woo-Hyun,Lee, Sun-Mi,Kim, Hyung-Jong,Lee, Ho-Yong,Woo, Tae-Wook,Kang, Hye-Young 대한예방의학회 2006 예방의학회지 Vol.39 No.2
Objectives : We wanted to evaluate the economic value of a pharmaceutical product, Kremezin, for treating patients with chronic renal failure (CRF) by estimating the amount of cost savings due to its effect for delaying the initiation of dialysis treatments. Methods : We defined a conventional treatment for CRF accompanied by Kremezin therapy as 'the treatment group' and only conventional treatment as 'the alternative group.' The types of costs included were direct medical and nonmedical costs and costs of productivity loss. The information on the effect of Kremezin was obtained from the results of earlier clinical studies. Cost information was derived from the administrative data for 20 hemodialysis and 20 peritoneal dialysis patients from one tertiary care hospital, and also from the administrative data of 10 hemodialysis patients from one free-standing dialysis center. Per-capita cost savings resulting from Kremezin therapy were separately estimated for the cases with delay for the onset of hemodialysis and the cases with immediate performance of peritoneal dialysis. By computing the weighted average for the cases of hemodialysis and peritoneal dialysis, the expected per-capita cost savings of a patient with CRF was obtained. Using a discount rate of 5%, future cost savings were converted to the present value. Results : The present value of cumulative cost savings per patient with CRF from the societal perspective would be $18,555,000{\sim}29,410,000$ Won or $72,104,000{\sim}112,523,000$ Won if Kremezin delays the initiation of dialysis by 1 or 4 years. Conclusions : The estimated amount of cost savings resulting from treating CRF patients with Kremezin confirms that its effect for delaying the onset of dialysis treatments has a considerable economic value.
특발성 혈소판감소성 자반병과 쇼그렌씨 증후군이 동반된 원발성 담즙성 간경변증 1예
우태욱,김병호,심재준,김윤화,조경삼 대한내과학회 2004 대한내과학회지 Vol.66 No.1
저자들은 특발성 혈소판감소성 자반병을 가진 환자에서 전형적인 일차성 원발성 담즙성 간경변증의 양상이 나타나 혈청검사, 자가면역항체, 간조직 검사 등을 통해 특발성 혈소판감소성 자반병과 쇼그렌 증후군이 동반된 원발성 담즙성 간경변증 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Primary biliary cirrhosis (PBC) is rare in Korea. Although its pathogenesis is not fully understood, immunologic dysregulation is suspected because it is frequently associated with other immunologic disorders. A few cases of primary biliary cirrhosis associated with idiopathic thrombocytopenic purpura (ITP) has previously been reported. However, PBC associated with ITP and Sjo¨gren's syndrome simultaenously has not been reported yet. We experienced a 72-year-old woman had been finally diagnosed as PBC, ITP and Sjo¨gren's syndrome. To the best of our knowledge, this is the first case in the world. We report this case with review of related literature.
백서 신장 조직내 Na^+-K^+ ATPase에 대한 Furosemide의 간접적 억제 기전
백행운,윤경식,우태욱,김재욱,이재범,백형환,조용호 慶熙大學校 大學院 1994 高凰論集 Vol.15 No.-
It is presented that the subcellular localization and distribution of the specific activity of Na^+-K^+ ATPase in whole homogenate, the soluble fraction and mitochondrial fraction of the renal tissues in normal adult rat isolated by differential centrifugal method were studied. The effect of furosemide compound on their enzymatic activity was evaluated by the Fiske SubbaRaw method. The specific activity of Na^+-K^+ ATPase of rat renal tissues was found to be about 92.2 umol/g protein/hr. The specific activity of microsomal fraction of rat renal tissue is showed approximately 1.5-fold higher than the value in the other fraction. The effect of furosemide was found to decrease proportionally the specific activity of Na^+-K^+ ATPase in rat renal tissue as the increment of the concentration of furosemide to luM in the microsomal fraction. The effect of the other diuretics is showed the same inhibition pattern. When the incubation time is increased from 15min to 60min in the same drug treated Na^+-K^+ ATPase, specific activity of Na^+-K^+ ATPase is increase but the inhibition rate of the enzyme is decreased. In view of the above finding, it is clear that the furosemide, well known as diuretic agent, selectively inhibits the activity of the microsomal Na^+-K^+ ATPase in accordance with dose-dependent effect. The mechanism of action appears to be due to indirect inhibition. Indirect inhibition means that the transport protein of cellularion in membrane is inhibited by the furosemide and so indirectly activity of Na^+-K^+ ATPase is inhibited by that. Consequently, the effect of the furosemide on the rat renal tissue Na^+-K^+ ATPase is non-specific inhibition by indirect inhibition of transport protein.