http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
파킨슨씨병 모델 흰쥐에서 줄무늬체 도파민 수용체의 발현에 대한 연구
오창완,한대희,정천기,조사선,박경한,김용식,박찬웅,Oh, Chang-Wan,Han, Dae Hee,Chung, Chun Kee,Cho, Sa-Sun,Park, Kyeong-Han,Kim, Yong-Sik,Park, Chan-Woong 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.2
This study was designed to investigate the underlying mechanisms for the temporal changes of the striatal dopamine D2 receptors in the rat model of parkinsonism. After injection of the 6-hydroxydopamine into the substantia nigra of adult rats, we measured the receptor binding capacity(Bmax), mRNA and protein of the D2 receptor at 2, 4 and 8 weeks. Following the lesion, mRNA and protein were elevated simultaneously on both sides of the striata. They showed more increase on the normal side at 2 and 4 weeks, and then they were almost equally abundant on both sides at 8 weeks. We also observed their increased production in the diffuse cortical and subcortical regions. The Bmax value also increased bilaterally in both striata, and was higher on the normal side at 2 weeks and then on the lesioned side at 4 and 8 weeks. These findings suggest that production of the striatal D2 receptor is regulated at the transcriptional level in this animal model. They also imply that this control may be mediated through a pathway which can have influence on the whole brain, rather than the local control of the dopamine content alone. The measured functional activity(Bmax) of the D2 receptor was not proportional to the amount of the receptor mRNA and proteins produced. This difference may be explained by the post-translational modification of the receptor proteins, which may be controlled by such factor as the local concentration of dopamine.
방재승,오창완,김명수,최기영,조병규,홍승관,한대희,Bang, Jae Seung,Oh, Chang-Wan,Kim, Myoung Soo,Choe, Ghee Young,Cho, Byung-Kyu,Hong, Seung-Koan,Han, Dae Hee 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.7
Intraventricular arachnoid cyst has been rarely reported. Here we present two cases of symptomatic intraventricular arachnoid cysts in the fourth ventricle and right lateral ventricle. The first patient was a 38-year-old female who complained of headache and left facial hypesthesia. Computed tomography and MR scan revealed large cystic lesion in the fourth ventricle. After cyst wall removal, facial hypesthesia disappeared immediately and headache improved slowly. The second patient was a 9-year-old girl who complained of headache, vomiting and paresthesia in her right low extremity. Cystic lesion in the right lateral ventricle was detected in the CT and MR scan. The symptoms improved after cyst wall removal. Surgical findings of these two cases showed that the cyst walls were attached firmly to the choroid plexus. Symptomatic intraventricular arachnoid cyst must be treated appropriately and we recommend complete cyst wall removal.
김재용,오창완,정영섭,권오기,한대희,Kim, Chae-Yong,Oh, Chang-Wan,Chung, Young Seob,Kwon, O-Ki,Han, Dae Hee 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.3
Objective : Stroke is leading cause of death and more importantly it is cause of serious disability. The effective treatment of acute ischemic stroke still remains a challenge to modern medicine. Recent clinical trials have shown that carotid endareterctomy(CEA) provide overwhelming benefits compared with medical therapy in preventing subsequent stroke for symptomatic carotid stenosis. For the asymptomatic ones, the data are less compelling, but highly suggestive that CEA do have benefits in properly selected patients. Materials and Methods : To investigate the clinical manifestations of carotid stenosis and results of CEAs, authors analyzed retrospectively 19 CEAs in 16 patients from June 1986 to June 1999. Age of patients ranged from 55 to 76 years(median, 66) and male to female ratio was 14 to 2. The duration of follow-up was 1 to 144 months (median, 26). All of CEAs were done on the side of stenosis more than 80% and bilateral CEAs were done in three. Six CEAs were performed in asymptomatic patients. Results : Seventeen of 19 CEAs showed excellent results and complication rate was low although ipsilateral ischemic stroke occurred in two. Conclusion : CEA may be a valuable surgical treatment for ischemic stroke caused by carotid stenosis and also for prevention of stroke of asymptomatic patients with carotid stenosis.
권오기,한대희,정영섭,오창완,한문희,Kwon, O-Ki,Han, Dae Hee,Chung, Young Seob,Oh, Chang Wan,Han, Moon Hee 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.8
Objective : The authors reviewed 280 cases with intracranial arteriovenous malformations(AVMs) to identify risk factors of hemorrhage. Patients and Methods : From 1983 to 1997, a total 280 patients with AVMs were treated. Among them, 64% had a history of hemorrhage. Angiograms were retrospectively analyzed with particular attention to the size of the AVM, venous drainage, the location of the AVM and presence of associated aneurysm or varix. These characteristics were statistically analysed in relation to occurrence of hemorrhage. Results : A single variate analysis demonstrated that small size(p=0.0003), deep venous drainage(p=0.025) and periventricular location(p<0.0001) had a strong positive correlation. Associated aneurysms and varices were not found as hemorrhagic risk factors. A multivariate analysis revealed that the size of the AVM was most significant hemorrhagic factor(p=0.0003) followed by deep venous drainage(p=0.025). AVMs with small size and deep venous drainage bled more frequently regardless of their locations. Conclusion : These data would be useful in identifying patients at higher risk for developing hemorrhage of intracranial AVMs.
추체사대 수막종의 수술과 관련하여 뇌 정맥조영상의 의미
황승균,곽호신,백선하,오창완,이상형,김동규,김현집,정희원,Hwang, Sung-Kyun,Gwak, Ho-Shin,Paek, Sun Ha,Oh, Chang-Wan,Lee, Sang Hyung,Kim, Dong Gyu,Kim, Hyun Jib,Jung, Hee-Won 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.10
Objective : A thorough understanding of the related venous structure is mandatory for successful removal of the petroclival meningiomas. This study was planned to investigate the guideline for safe ligation and incision of transverse or sigmoid sinuses and the importance of drainage pattern of vein of $Labb{\acute{e}}$ in surgical removal of petroclival meningiomas. Patients and Methods : The authors reviewed the venogram of the consecutive 37 cases of petroclival meningiomas and retrospectively analyzed their surgical findings. The drainage pattern of confluence of Herophili was classified as Type A(confluent & equal on both sides), Type B(confluent & non-dominant on tumor side), Type C(confluent & dominant on tumor side) and Type D(unilateral drainage only) as these findings gave the information on safe ligation and resection of the sinus. Usefulness of intraoperative test clamping of sinus for safe ligation was also reviewed. The vein of $Labb{\acute{e}}$ was analyzed with respect to its draining point and its collaterals to other superficial veins. Results : Contraindications of the sinus ligation and resection according to the drainage pattern at the confluence of Herophili were Type C(n=10, 27%)and Type D(n=4, 11%). Patients with Type A(n=12, 32%)and Type B(n=11, 30%) were tolerable to sinus ligation ipsilateral to tumor, if the test clamping proved to be safe. Identification of no brain swelling, after intraoperative test clamping of the sinus for more than 30 minutes performed in 7 out of 11 cases, was a reliable indicator of safe sinus ligation. The drainage pattern of the vein of $Labb{\acute{e}}$, especially low-lying type, could predict the possibility of postoperative hemorrhage and infarction. Its drainage into tentorium or superior petrosal sinus, however, made the transtentorial approach impossible, leading to restricted operative field. Conclusion : For a successful removal of the petroclival meningiomas preoperative venogram should be examined carefully. The extent of exposure in a planned approach can be estimated by analyzing the variation of sinuses and the drainage pattern of vein of $Labb{\acute{e}}$.
임상 : 상전두개저 종양 절제술; 전통적인 두개안면절제술과 내시경적 두개안면절제술의 비교
최호용 ( Ho Yong Choi ),김재용 ( Chae Yong Kim ),이철희 ( Chul Hee Lee ),조성윤 ( Sung Yun Cho ),오창완 ( Chang Wan Oh ) 대한뇌종양학회 2011 대한뇌종양학회지 Vol.10 No.2
Tumors of the anterior skull base are rare. Most neurosurgeons and ENT surgeons use traditional craniofacial resection (TCFR) to remove anterior skull base tumors. Recently, endoscopic craniofacial resection (ECFR) also has been used for resection of the tumors of the nasal side; this strategy facilitates superior visualization, avoids facial incisions, and preserves local structures. The purpose of this study was to compare the outcome of these two approaches. A retrospective analysis was conducted to identify patients undergoing resection of anterior skull base tumors between September 1996 and May 2010. Demographic data, pathology, surgical approach, operative time, estimated blood loss, hospital stay, and complications were analyzed. Recurrence and mortality rates were also investigated. Eight patients were managed with ECFR, and 24 patients were treated with TCFR. Differences were observed between the two groups with respect to the operation time, estimated blood loss, and hospital stay. Complications were encountered in 1/8 (12.5%) and 4/24 (16.7%) patients in the ECFR and TCFR groups, respectively. Recurrence was observed in 4/8 (50%) and 10/24 (41.7%) patients in the ECFR and TCFR groups, respectively. Mortality rates were 2/8 (25.0%) and 13/24 (54.2%), in the ECFR and TCFR groups, respectively. Consequently, ECFR was significantly better than TCFR with respect to the operation time, estimated blood loss, and hospital stay. The rate of complications, recurrence, and mortality were not statistically different between the two groups. This comparison suggests that the ECFR approach might be an alternative surgical treatment option for the removal of anterior skull base tumors.
주진덕(Jin-Deok Joo),한정호(Jung Ho Han),김영훈(Young-Hoon Kim),김택균(Tackeun Kim),김재용(Chae-Yong Kim),오창완(Change Wan Oh),유정희(Jung Hee Ryu),전영태(Young Tae Jeon) 대한두개저학회 2012 대한두개저학회지 Vol.7 No.2
Objective : We searched the incidence of postoperative nausea and vomiting(PONV) after microvascular decompression(MVD), which might potentially results in an increased risk of postoperative intracranial hemorrhage and neurologic dysfunction. METHODS : Between 2004 and 2010, a total of 109 patients were diagnosed as having a neurovascular cross compression, and were treated with lateral suboccipital craniotomy with MVD. The incidence of PONV and the use of rescue antiemetics were identified at 1, 24 and 48 hours after surgery. RESULTS : Seventy-one(65.1%) patients were female, and the mean age of the patients was 49±10 years(range, 20~69). The overall incidence of development of PONV within postoperative 48 hours was 69.7%. The incidences of PONV at 1, 24, and 48 hours after surgery were 31.1%, 56.8%, 44.0%, respectively. PONV was most prevalent at 24 hours after surgery, and then the incidence decreased over time. In the early postoperative period, female was significantly more susceptible to PONV than male, especially at 1 hour after surgery(p=0.035). CONCLUSION : The incidence of PONV was high enough to be actively managed, especially within 24 hours after MVD. PONV was more prevalent in female in the early postoperative period.