임상연구 : 부인과 수술 후 오심 및 구토의 예방에 대한 Ramosetron과 Ondansetron의 효과 비교

유정희 ( Jung Hee Ryu ),박금숙 ( Kum Suk Park ),도상환 ( Sang Hwan Do ),서정훈 ( Jeong Hun Suh ),강매화 ( Mae Hwa Kang ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.52 No.5

Background: In this randomized, double-blinded study, we evaluated the efficacy of ramosetron and ondansetron for preventing postoperative nausea and vomiting (PONV) in gynecologic patients. Methods: Sixty patients undergoing total abdominal hysterectomy or myomectomy, ASA physical status I or II, aged 30-65 yr, received IV ramosetron 0.3 mg (group R) or ondansetron 4 mg (group O) at the end of surgery (n = 30 each). A standard general inhalational anesthesia and postoperative IV patient-controlled analgesia were used. At postoperative 3, 24 and 48 hours, we assessed pain score (VAS), incidence of PONV, rescue drug consumption, adverse events associated with study medications and overall satisfaction scores. Results: The incidence of PONV showed no difference between groups at each time points after surgery (overall incidence; 59% in group R, 69% in group O). There was no difference in the severity of nausea, pain score and analgesic drug usage. However, the consumption of rescue drug in the ramosetron group was markedly less than that of ondansetron group at postoperative 3 hrs (none vs. 8 patients). No clinically serious adverse events were observed in either of the groups. Overall satisfaction scores were also comparable in both groups (6.5 ± 3.0 vs. 6.2 ± 2.7). Conclusions: Prophylactic therapy with ramosetron is as effective and safe as conventional prophylactic therapy with ondansetron for preventing PONV in women undergoing general anesthesia for gynecologic surgery. Severity of PONV seems significantly less with ramosetron than with ondansetron in the early postoperative period. (Korean J Anesthesiol 2007; 52: 561~5)

한국 재래 검정콩의 지방질 조성에 관한 연구

이경임(Kyung-Im Lee),유정희(Jung-Hee Ryu),이숙희(Sook-Hee Rhee),최홍식(Hong-Sik Cheigh) 한국식품영양과학회 1988 한국식품영양과학회지 Vol.17 No.3

검정콩을 chloroform-methanol(2:1, v/v) 용매로 추출하여 얻은 총지방질을 SACC로 중성지방 질, 당지방질 및 인지방질로 분획하고, 이들의 조성을 TLC에 의하여 분별하였으며, GC에 의하여 지방산 조성을 분석한 결과는 다음과 같다.<br/> 검정콩의 총지방질중 중성지방질은 88.5~89.2%, 당지방질은 2.4~2.5%, 인지방질은 8.4~9.0% 였다. 중성지방질 조성중 triglycerides가 주된 성분이었으며, diglycerides, sterols, steryl esters, free fatty acids, hydrocarbons 등을 함유하고 있었다. 당지방질 성분으로는 monogalactosyl diglycerides 및 esterified steryl glycosides, cerebrosides 및 steryl glycosides, digalactosyl diglycerides 등이 분별정 량되 었으며, 인 지방질에서는 phosphatidyl ethanolamine, phosphatidyl choline, phosphatidyl inositol, phosphatidyl serine 및 lysophosphatidyl choline 이 분별정량되었다. 검정콩의 지방산 조성은 중성지방질의 경우 linoleic acid 함량이 가장 높고, oleic acid가 상당량 함유되어 있으며, 당지방질도 이와 비슷하나 oleic acid 함량이 다소 낮은 반면 palmitic acid 와 linolenic acid 함량이 약간 높았다. 또한 인지방질은 linoleic acid 와 palmitic acid 함량은 높으나 그외는 적은량 함유되어 있었다. Total lipids of Korean black soybean were extracted, purified and fractionated into three lipid classes (Neutral lipid, NL; glycolipid, GL;phospholipid, PL) and the composition of lipid class and fatty acid were studied. Total lipids of black soybean consisted of 88.5% NL, 2.5% GL and-9.0% PL. In the NL, triglycerides were predominant(80.4%) and also sterol esters, hydrocarbons, diglycerides, free fatty acids and sterols were identified. The major component of GL were monogalactosyl diglycerides and esterified steryl glycosides, and then cerebrosides, steryl glycosides, digalactosyl diglycerides were also found. As major component of the PL, phosphatidyl ethanolamine and phosphatidyl choline were observed, other compounds such as phosphatidyl inositol, phosphatidyl serine and lysophosphatidyl choline were also determined. The major fatty acids in the NL and GL were linoleic acid, oleic acid and palmitic acid, however, PL contained higher relative content of palmitic acid and lower level of oleic acid compared with those of NL and GL.

DCA-MOD 방법으로 제조된 YBCO 박막의 미세조직에 미치는 열처리 효과

김병주,김혜진,조한우,유석구,유정희,이희균,홍계원,Kim, Byeong-Joo,Kim, Hye-Jin,Cho, Han-Woo,Yu, Seok-Koo,Ryu, Jung-Hee,Lee, Hee-Gyoun,Hong, Gye-Won 한국초전도학회 2007 Progress in superconductivity Vol.9 No.1

[ $YBa_2Cu_3O_{7-{\delta}}$ ] films have been prepared on $LaAlO_3$ (100) single-crystal substrates by a metalorganic deposition using dichloroacetate precursors (DCA-MOD). Calcination conditions were varied in order to optimize the microstructure and the superconducting properties of YBCO film. Coated films were calcined at various temperatures ranging from $400{\sim}700^{\circ}C$ in flowing humid oxygen atmosphere. Ramping rate to calcination tempertures was $2.22^{\circ}C/min$. Conversion heat treatment was performed at $800^{\circ}C$ for 2 h in flowing Ar gas containing 1000 ppm oxygen with a humidity of 9.45%. Observations of surface and cross sectional SEM microstructure showed that the particle size in the calcined film increased in the range of 100-200 nm with heating rate and the calcination temperature. SEM EDS analysis showed that 13 a/o of chlorine was contained in the calcined film. It was also observed that the porosity increased with the heating rate and temperature. Porous microstructure was developed when YBCO films were prepared using porous calcined film. Dense microstructure and high $J_c$ over $1\;MA/cm^2$ was obtained when calcination was carried out at the temperature of $500^{\circ}C$ with a heating rate of $2.22^{\circ}C/min$.

DCA-MOD 법으로 YBCO 박막 제조시 하소열처리의 승온속도 효과

김병주,김혜진,조한우,권연경,유정희,이희균,홍계원,Kim, Byeong-Joo,Kim, Hye-Jin,Cho, Han-Woo,Kwon, Youn-Kyung,Ryu, Jung-Hee,Lee, Hee-Gyoun,Hong, Gye-Won 한국초전도학회 2007 Progress in superconductivity Vol.8 No.2

High $J_c\;YBa_2Cu_3O_{7-x}$ superconducting films have been fabricated $LaAlO_3(100)$ substrate by MOD method using dichloroacetic acid(DCA) as chelating solvent for preparing precursor solution. Heating rate was varied in order to optimize the calcination heat treatment condition in DCA-MOD method. Coated films were calcined at lower temperature up to $500^{\circ}C$ in flowing humid oxygen atmosphere. The heating rate was calcined from $13.3^{\circ}C/min\;to\;0.28^{\circ}C/min$. Conversion heat treatment was performed $800^{\circ}C$ for 2 h in flowing Ar gas containing 1000 ppm oxygen with a humidity of 9.45%. Surface and cross sectional SEM microstructures showed that particle sizes were increased with heating rate at a calcination step. The amount of pores was increased with heating rate in the calcined films. Dense microstructure and sharp texture were developed in an YBCO films after conversion heat treatment. A high critical current density (Jc) of $1.26MA/cm^2$ (@77 K and self-field) was obtained for the YBCO film which was prepared with a heating rate of $0.28^{\circ}C/min$.

백내장 수술 중 구후차단(Retrobulbar Block) 후 발생한 전율 (증례보고)

정승혜 ( Seung Hye Jung ),유정희 ( Jung Hee Ryu ),안원식 ( Won Sik Ahn ) 대한마취과학회 2008 Korean Journal of Anesthesiology Vol.55 No.2

잣 지방질의 산화 안정성에 관한 연구

김명(Myung Kim),이숙희(Sook-Hee Rhee),유정희(Jung-Hee Ryu),최홍식(Hong-Sik Cheigh) 한국식품과학회 1988 한국식품과학회지 Vol.20 No.6

미세혈관감압술 후 오심 및 구토의 발생률

주진덕(Jin-Deok Joo),한정호(Jung Ho Han),김영훈(Young-Hoon Kim),김택균(Tackeun Kim),김재용(Chae-Yong Kim),오창완(Change Wan Oh),유정희(Jung Hee Ryu),전영태(Young Tae Jeon) 대한두개저학회 2012 대한두개저학회지 Vol.7 No.2

Objective : We searched the incidence of postoperative nausea and vomiting(PONV) after microvascular decompression(MVD), which might potentially results in an increased risk of postoperative intracranial hemorrhage and neurologic dysfunction. METHODS : Between 2004 and 2010, a total of 109 patients were diagnosed as having a neurovascular cross compression, and were treated with lateral suboccipital craniotomy with MVD. The incidence of PONV and the use of rescue antiemetics were identified at 1, 24 and 48 hours after surgery. RESULTS : Seventy-one(65.1%) patients were female, and the mean age of the patients was 49±10 years(range, 20~69). The overall incidence of development of PONV within postoperative 48 hours was 69.7%. The incidences of PONV at 1, 24, and 48 hours after surgery were 31.1%, 56.8%, 44.0%, respectively. PONV was most prevalent at 24 hours after surgery, and then the incidence decreased over time. In the early postoperative period, female was significantly more susceptible to PONV than male, especially at 1 hour after surgery(p=0.035). CONCLUSION : The incidence of PONV was high enough to be actively managed, especially within 24 hours after MVD. PONV was more prevalent in female in the early postoperative period.

Effects of Tianeptine on The Activity of Glutamate Transporter EAAT3 Expressed in Xenopus Oocytes

Bon-Wook Koo(구본욱),Hyo-Seok Na(나효석),Jung-Hee Ryu(유정희),Jung-Seok Choi(최정석),Sang-Hwan Do(도상환),Zhiyi Zuo(주오지이) 대한생물치료정신의학회 2020 생물치료정신의학 Vol.26 No.3

배경:티아넵틴(tianeptine)은 최근 주목받고 있는 항우울제로 기존의 모노아민 항우울제(monoaminergic antidepressants)와 달리 케타민(ketamine)과 같이 글루타메이트(glutamate)의 신경전달에 영향을 미치는 것으로 알려져 있다. 글루탐산염 전달체, 특히 흥분성 아미노산 전달체 3형(Excitatory Amino Acid Transporter 3, EAAT3)에 대한 연구가 계속되어 왔지만 티아넵틴이 EAAT3에 미치는 영향에 대한 연구는 부족하다. 방법:개구리(Xenopus laevies) 난모세포에 EAAT3의 mRNA를 세포질내 주입하여 발현시킨 후, 2개의 전극을 이용한 전압클램프를 사용하여 L-glutamate 투여 전, 중, 후로 막전위를 측정하였다. 반응값은 막전위의 변화를 적분하여 구하였으며, microcoulomb 단위로 제시하였다. 데이터는 평균 ± 표준오차로 표기하였다. 결과:티아넵틴은 EAAT3의 활성도를 농도의존적으로(0.1~100μM) 감소시켰으며 1mM 티아넵틴을 72시간 동안 노출 시켰을 때 Km(27.0±7.6 vs. 23.3±4.9mM, n=84, p=0.72)의 변화없이 Vmax(6.9±0.6 vs. 4.8±0.3mC, n=84, p<0.05)를 유의미하게 줄였다. 결론:개구리 난모세포에 티아넵틴을 72시간 동안 노출시켰을 때 농도의존적으로(1~100mM) EAAT3의 활성도를 감소시켰다. 이번 연구의 결과는 티아넵틴이 EAAT3의 이용 가능한 수나 회전률을 감소시킴으로써 활성도를 감소시키는 것을 시사한다. Objectives : Tianeptine is an antidepressant that has drawn attention recently. Unlike traditional monoaminergic antidepressants, tianeptine is known to affect glutamate neurotransmission like ketamine. However, there has been paucity of studies investigating the role of tianeptine on glutamate transporters, especially excitatory amino acid transporter type 3 (EAAT3). Methods : After expression of EAAT3 by intracellular injection of EAAT3 mRNA, we investigated the effect of tianeptine on the activity of EAAT3, by measuring membrane current in response to L-glutamate administration using Xenopus oocyte expression system and two-electrode voltage clamps. Results : Tianeptine (1mM for 72h) significantly reduced Vmax (6.9±0.6 vs. 4.8±0.3mC, n=14-22, p<0.05) without changing Km (27.0±7.6 vs. 23.3±4.9mM, n=14-22, p=0.72). Conclusion : When tianeptine was exposed for 72h, it decreased the activity of EAAT3 in a concentration-dependent manner (1-100mM). Our results suggest that tianeptine decreases EAAT3 activity by reducing the available number or turnover rate of EAAT3.